233 results about "Trimethylene carbonate" patented technology

The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro/nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloaddition between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and/or other therapeutic agents may be encapsulated within the polymer particles for intravenous therapeutic delivery. The invention also provides a novel synthetic biodegradable polymer, a furan/alkyne-functionalized poly(trimethylene carbonate) (PTMC)-based polymer, whose composition can be designed to meet the defined physical and chemical property requirements. In one example, the particle system self-aggregates from functionalized PTMC-based copolymers containing poly(ethylene glycol) (PEG) segments. The composition of the copolymers can be designed to meet various particle system requirements, including size, thermodynamic stability, surface PEG density, drug encapsulation capacity and biomolecule immobilization capacity.

The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably epsi-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 25%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.4 dl/g. A variety of surgical constructs may be formed from the present copolymers. Surgical sutures made of mono- or multifilament yarns of the present copolymers will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.

A surgical fastener configured to close an opening in tissue is provided. The surgical fastener includes a base defining a central axis at least one pair of legs extending from the base. Each of the legs includes a base portion and a tissue engaging portion. When in a first position, each of the tissue engaging portions is arranged to define an insertion direction and when in a second position, each of the tissue engaging portions extends inward towards the central axis. The surgical fastener is at least partially formed from a shape memory material including a combination of Polydioxanone and Poly(L-lactide) or a combination of Trimethylene Carbonate and Poly(L-lactide). The pair of legs are configured to move from the first position to the second position upon activation of the shape memory material.

A thickened composition and process useful for removing paint, comprising: a carbonate such as propylene carbonate or ethylene carbonate, a thickener such as polyvinyl pyrrolidone (PVP), hydrogen peroxide and water. The composition may include additional cosolvents such as glycol ethers and alcohols such as benzyl alcohol, and/or dibasic ester (DBE).

The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably epsi-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Disclosed are coated surgical constructs including sutures made of multifilament yarns of the present copolymers and coated with nitrogenous copolyesters which will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.

The invention discloses a biodegradable stent composite. The biodegradable stent composite is prepared from biodegradable medical polyurethane and a biodegradable metal material. The weight ratio between the biodegradable medical polyurethane and the biodegradable metal material is 0.1-99%:1-99.9%, preferably 5-90%:10-95%. To regulate the hardness of the material, other high molecular materials, such as polylactic acid, polycaprolactone, poly-p-dioxanone and copolymers thereof (PPDO and P(LA-PDA)), poly trimethylene carbonate, polylactic acid-trimethylene carbonate copolymer, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid and polylactic acid-glycolic acid copolymer, can be added, so that clinical usage is facilitated.

The bioabsorbable polymers and compositions of the present invention may be formed into medical devices such as stents that can be crimped onto a catheter system for delivery into a blood vessel. The properties of the bioabsorbable polymers allow for both crimping and expansion of the stent. The crystal properties of the bioabsorbable polymers may change during crimping and/or expansion allowing for improved mechanical properties such as tensile strength and slower degradation kinetics. Typically, bioabsorbable polymers comprise aliphatic polyesters based on lactide backbone such as poly L-lactide, poly D-lactide, poly D,L-lactide, mesolactide, glycolides, lactones, as homopolymers or copolymers, as well as formed in copolymer moieties with co-monomers such as, trimethylene carbonate (TMC) or ε-caprolactone (ECL).

The invention relates to a biodegradable medical polymer tubing and a preparation method thereof. The invention provides a biodegradable medical polymer tubing with adjustable diameter and controllable wall thickness and a preparation method thereof. The tubing is made from biodegradable medical polymer material, and has inner diameter of 0.5-20 mm and thickness of 0.05-10 mm; and the biodegradable medical polymer material is one of a homopolymer, a copolymer, a star-shaped polymer and a crosslinking polymer of trimethylene carbonate, p-dioxanone, lactide, caprolactone and glycollide.

This invention involves unsaturated cyclic aliphatic carbonate monomer and polymer synthesis and uses, and is biomedical polymer materials. From 2,2 - dimethylolpropionic acid departing, to synthesize 2-methyl-2-allyl-oxygen carbonyl trimethylene carbonate and 2-methyl-2-propargyl oxygen carbonyl trimethylene carbonate, and then through ring-opening polymerization or aliphatic monomers cycloate monomer opening loop and copolymerization, gain copolymer of aliphatic polycarbonate or aliphatic polyester-carbonate that side group contains double and Triple bond. Such polymer has advantage of both aliphatic polyester and carbonate, is biodegradable, degradation products is non-toxic. Use the functional side group of Double and Triple bond can connect drugs, active peptides or other bioactive elements with the polymer, improving the biocompatibility and biological activity of polymer, which may has real application in controlled-release drug, polymer pro-drug and tissue engineering fields.

The invention discloses a preparation method of a quaternary degradable antibacterial agent, and the preparation method comprises the following steps: homopolymerizing cyclic aliphatic carbonate monomers containing bromine functional groups, namely 2,2-dibromo-methyl trimethylene carbonate (DBTC) monomers or copolymerizing the 2,2-dibromo-methyl trimethylene carbonate monomers with aliphatic cyclic ester, or copolymerizing the 2,2-dibromo-methyl trimethylene carbonate monomers with the aliphatic cyclic ester or dihydroxy polyethylene glycol, or copolymerizing the 2,2-dibromo-methyl trimethylene carbonate monomers with the aliphatic cyclic ester or single methoxy polyethylene glycol; and further reacting an obtained polymer with alkylamine, thus obtaining the quaternary degradable polyester antibacterial agent with antibacterial performance. The antibacterial agent provided by the invention integrates the advantages of biocompatibility and degradability and not only has good antibacterial performance, but also has no harm to an environment, thereby being an environment-friendly antibacterial material; as an additive, the antibacterial agent provided by the invention has potential application prospects in food packaging materials, fibers, coatings, medical field and the like.