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Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same

ActiveUS20140079774A1Promoting death of cancer cellEfficient packagingBiocideSpecial deliveryLipid formationBinding peptide
The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC +1

Electric hybrid powertrain system

InactiveUS20070093341A1Improves reverse low gear performanceImprove drive performanceAuxillary drivesTransmission elementsElectric vehicleElectric generator
A hybrid electric vehicle powertrain having an engine and an electric motor and generator sub-system, which establish mechanical and electric power flow paths. Multiple-ratio gearing in a power flow path for forward drive enhances vehicle traction torque for heavy-duty vehicle applications. Reverse drive performance is enhanced by torque multiplying gearing in a reverse drive power delivery path.
Owner:FORD GLOBAL TECH LLC

Contoured battery for implantable medical devices and method of manufacture

A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a planar bottom, an open top to receive the cover, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device.
Owner:MEDTRONIC INC
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