Apparatuses, systems, and methods for controlling the position of the interface between two or more laminar flow
stream in a microfluidic device. In one embodiment, an apparatus includes a first fluid reservoir shaving an output, a first
pressure sensor connected to the output of the first fluid reservoir, a first
actuator connected to the first fluid reservoir, a
feedback loop connected between the first
pressure sensor and the first
actuator, a second fluid reservoir having an output, a second
pressure sensor connected to the output of the second fluid reservoir, a second
actuator connected to the second fluid reservoir, a
feedback loop connected between the second pressure sensor and the second actuator, and a microfluidic device including a first input connected to the output of the first fluid reservoir, a second input connected to the output of the second fluid reservoir, and an output. In another embodiment, a method includes sensing
fluid pressure from a first fluid reservoir connected to a first input of the microfluidic device, adjusting a first actuator in response to the
fluid pressure in the first fluid reservoir, sensing
fluid pressure from a second fluid reservoir connected to a second input of the microfluidic device, and adjusting a second actuator in response to the fluid pressure in the second fluid reservoir.