The longevity medicated wine and its manufacture method, which uses 60 - 65 Deg. C pure valley white liquor, adding furl seal's kidney, deer's muscle, the winter Chinese caterpillar fungus, the melinda officinalis, Beiqi, Tianma, the seahorse, the gecko and so on 75 kinds of Chinese native medicines raw material for soaking, latter adds the white sugar and the tap water configuration. This invention medicated wine enhances men's and women's sexual dive energy, strengthens the human body vigor for mainly, makes up cloudyly and fortifies female, the synthesis recuperates the human body vital organs of the human body, expels sickness and builds up strength, thus achieves the benefit goal which prolongs the life. Its manufacture method is simple, the medicated wine soaking output contains Chinese native medicine ingredient content which obtains is high, the medicated wine palatableness is good, the feeling in the mouth is pure, preserves long. Long-time drinking can nourish the human body in vital organs, as well balances human body distributed masculine and feminine elements, and promotes metabolism, makes up the vitality, the strong physique, which prevents disease and expels sickness, the effect of prolonging the life. Regarding the hypertension, sleepless, the sexual impotence, the kidney empty lumbago, the prostate gland disease, the rheumatic arthritis, the asthma, the woman post-natal is weak, irregular menses and so on sickness also has the effect of better treatment. Stopping from pain also is its advantage.