781 results about "Longevity" patented technology

A method for altering the lifespan of a eukaryotic organism. The method comprises the steps of providing a lifespan altering compound, and administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the organism is altered. In one embodiment, the compound is identified using the DeaD assay.

Disclosed is a method and structure that identifies relationships between users of a computerized network. The method extracts relationship information from databases in the network. The information includes address book information, calendar information, event information, to-do list information, journal information, and / or e-mail information. The invention evaluates the relationship information to produce relationship ratings of the users of the network. The invention determines the level of reciprocity of relations between different users; a longevity of relations between the different users; how current relations are between the different users; a frequency of relations between the different users; a level of exclusivity of relations between the different users; a level of complexity of relations between the different users; and / or a proximity of the different users.

A trial (test) power toothbrush designed to emulate the performance of a corresponding commercial toothbrush, powered by a non-rechargeable battery. The power to drive the toothbrush is controlled by a control circuit which is responsive to the battery to maintain the drive power at approximately the level of the commercial unit and a short “trial use” period, i.e. one month / 30 days, and then to terminate operation of the power toothbrush. The trial toothbrush may then be readily disposed of by the user, including the battery therein.

A knee prosthesis, methods of implanting the prosthesis, method of treating arthritis of the knee, and a kit therefore are provided. The prosthesis answers many of the limitations of current knee prosthetic devices by providing a two-component (or alternatively, an optional three-component) device, as either a single structure, or as separate pieces. One of the components is constructed of low friction material, while the second is composed of a weight-dissipating cushioning material; the optional third component is constructed of low friction material. The prosthesis is initially attached to surrounding soft tissue in the knee by biodegradable sutures; it is held permanently in place by fibrous ingrowth into a porous collagen rim in the cushioning component. Major improvements provided by the present invention over currently available prostheses include minimal incisions, minimal or no bone cuts, minimal overall dissection (these improvements lead to shorter hospital stays and rapid rehabilitation and fewer potential for side effects), less prosthetic wear, greater longevity, fewer activity restrictions, able to be used on young, large, active patients, ease of revision, ease of conversion into a total knee arthroplasty if needed.

A method for altering the lifespan of a eukaryotic organism. The method comprises the steps of providing a lifespan altering compound, and administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the organism is altered. In one embodiment, the compound is identified using the DeaD assay.

The invention consists of a sensor with multiple indicating (sensing) electrodes covered with a selectively permeable membrane for monitoring fluid concentrations in a biological environment. The indicating electrodes respond to changes in certain analytes, such as glucose, through an enzyme-mediated reaction. The currents generated from the enzyme-mediated reactions are transmitted through radio signals to an external receiver where the information is processed and recorded. Through the use of various biomaterials and biochemicals associated with the sensor, the monitoring accuracy is improved and the overall viability is prolonged. The process of foreign body fibrosis (formation of a scar capsule around the implanted sensor) eventually limits the functional life of the device. We teach methods of delivery of certain biochemicals that can increase the functional life of the sensor by inhibiting the formation of the foreign body capsule or by stimulating the growth of capillaries into the capsule.

The invention consists of a sensor with multiple indicating (sensing) electrodes covered with a selectively permeable membrane for monitoring fluid concentrations in a biological environment. The indicating electrodes respond to changes in certain analytes, such as glucose, through an enzyme-mediated reaction. The currents generated from the enzyme-mediated reactions are transmitted through radio signals to an external receiver where the information is processed and recorded. Through the use of various biomaterials and biochemicals associated with the sensor, the monitoring accuracy is improved and the overall viability is prolonged. The process of foreign body fibrosis (formation of a scar capsule around the implanted sensor) eventually limits the functional life of the device. We teach methods of delivery of certain biochemicals that can increase the functional life of the sensor by inhibiting the formation of the foreign body capsule or by stimulating the growth of capillaries into the capsule.

Apparatus and methods are used to expand and / or connect disc replacement devices in situ, allowing such devices to be inserted through smaller openings including posterior as well as an anterior approaches to the spine. Other embodiments reside in nucleus replacements that do not expand within the disc space, providing improved longevity compared to existing NRs. Embodiments of the invention may be used in the cervical, thoracic, or lumbar spine. The invention may also be used in other joints such as, the knee, prosthetic knees, prosthetic hips, or other joints in the body.

A method and apparatus for prediction of community reaction to a post for an online social community is disclosed. The method comprises receiving a proposed post as input to a generated prediction model prior to the proposed post being posted to an online social community; predicting a community reaction to the proposed post using the prediction model; and displaying the predication, wherein the prediction comprises a sentiment score and at least one of a number of responses, a number of responders to the post, a longevity of the post, or a half-life of the post.

A two step method of coloring hair is described. The hair is first contacted for a period of time with a dye precursor mixture containing an oxidative dye, specific fatty components and one or more water miscible organic solvents. Color is then developed in a second step by contacting the hair with one or more oxidizing agents. Greater color intensity and longevity are achieved when the fatty component in the dye precursor mixture contains at least one fatty amine and the fatty ingredients and organic solvents satisfy the relationship, ΣFC<0.037(ΣOS)2−3.35(ΣOS)+63, where ΣFC and ΣOS are respectively the total weight of fatty ingredients and the total weight of water miscible organic solvents in the precursor mixture.

A method for mimicking the effects of caloric restriction by administration of a food substrate having carnitine or a carnitine derivative and an antioxidant. The food substrate is capable of modulating gene expression in a way similar to caloric restriction.

Novel, nonagglomerated, engineered, ultra fine Cerium Oxide particles the size of approximately 2 to approximately 10 nm and methods for preparation of the particles. The resultant particles enhance the longevity of cells in culture. Applications of the particles include benefits for wound healing, treating arthritis and joint diseases, anti-aging and the treating of inflammations.

A system and method for determining a remaining life estimate of the remaining battery life of a battery of an implantable medical device (IMD). The IMD battery preferably exhibits a highly reproducible monotonically decreasing discharge curve. The estimated remaining life estimates are derived by periodically measuring battery voltage, and estimating the estimated past current drain of the IMD comprising an average of the sum of the quiescent current drain and therapy delivery current drain, and determining the estimated remaining longevity from the measured voltage and the estimated past current drain.

A method of evaluating a permanent life insurance policy including the steps of accessing a policy illustration, establishing an effective life span of the policy illustration, identifying a first amount attributed to death benefit claims, identifying a second amount attributed to premium loads, identifying a third amount attributed to policy expenses, calculating a sum of the first, second and third amounts for a plurality of policy years, averaging the sum for each year throughout the effective life span, calculating a cash value of the policy illustration for the plurality of policy years, identifying a projected investment earnings forecast in the policy illustration, normalizing the projected investment earnings forecast, adding the project investment earnings to the cash value, and recalculating the current cash value of the policy illustration for the plurality of policy years.

The invention relates to an online predicting method of damage and service life of a high temperature pipeline. The method comprises the following implementing steps of: (1) carrying out finite element simulation analysis of damage and coupling to the high temperature pipeline; (2) finding out important monitoring parts according to the analysis results, arranging a sensor and monitoring the strain of the sensor; (3) carrying out finite element analysis (including analytical subprogram of a constitutive equation) for different working conditions and establishing database with damage, strain and residual life and strain; and (4) carrying out online inquiry and comparison to strain values detected online and the value of the load working condition and the data in the database so as to obtain the assessment value of corresponding damage and residual life. The online predicting method has the advantages of being capable of carrying out real-time monitoring to the high temperature pipeline in operation while production is carried out normally, reflecting the deformation and damage of the important parts and key parts in time, making correct estimation to the use life and residual life of the pipeline, being beneficial to guaranteeing safe production, adjusting the production load, planning maintenance reasonably and effectively prolonging the service life of production equipment.

Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transfection under serum-free conditions. In preferred embodiments, the cells of use are SpESF or SpESF-X cells.

A hemodialysis and vascular access system comprises a subcutaneous composite PTFE silastic arteriovenous fistula having an indwelling silastic venous end which is inserted percutaneously into a vein and a PTFE arterial end which is anastomosed to an artery. Access to a blood stream within the system is gained by direct puncture of needle(s) into a needle receiving site having a tubular passage within a metal or plastic frame and a silicone upper surface through which needle(s) are inserted. In an alternate embodiment of the invention, percutaneous access to a blood stream may be gained by placing needles directly into the system (i.e. into the PTFE arterial end). The invention also proposes an additional embodiment having an arterialized indwelling venous catheter where blood flows from an artery through a tube and a port into an arterial reservoir and is returned to a vein via a port and a venous outlet tube distinct and distant from the area where the blood from the artery enters the arterial reservoir. The site where blood is returned to the vein is not directly fixed to the venous wall but is free floating within the vein. This system provides a hemodialysis and venous access graft which has superior longevity and performance, is easier to implant and is much more user friendly.

Under the present invention a set of values is first determined. Such values include: a relative total value that is based on a total quantity of electronic interactions between a first user and a second user of the computerized network; a relative exclusive value that is based on a total quantity of electronic interactions exclusively between the first user and the second user; a relative longevity value that is based on a length of time the first user and the second user have been electronically interacting; and a relative recency value that is based on a recency of electronic interactions between the first user and the second user. Once determined, the values are weighted to yield normalized values. To calculate the relationship strength, the normalized values are summed and compared to a predetermined standard.

A method and system use a combined contribution of multiple disease risk factors to predict the risk of onset of particular diseases in an individual. The prediction models use information from separate studies. Multiple disease predictions for a predetermined number of diseases are made. The predictions are used to calculate the individual's mortality risk and life expectancy. The life expectancy is compared to that of age and gender matched peers to determine the inner age of the individual.

Compositions comprising a Labiatae herb extract and a hop extract containing beta acids and methods of using them to extend the color life and retard the growth of microorganisms in fresh meat, fish and poultry stored in an atmosphere that contains 20% or more oxygen.

An insurance program that provides improved health care and longevity by emphasizing health improvement and maintenance. After a predetermined waiting period from the time health insurance is purchased, during which the health status of the insured is maintained or improved, the insured may link the health insurance policy with one or more other types of insurance policies, such as; life, disability, nursing home, etc. Throughout the life of the policy, portions of the premiums may be deposited in an escrow account, provided that the health of the insured is maintained or improved, which may be utilized to pay or help pay for the linked insurance and may also be utilized for retirement benefits.

The longevity medicated wine and its manufacture method, which uses 60 - 65 Deg. C pure valley white liquor, adding furl seal's kidney, deer's muscle, the winter Chinese caterpillar fungus, the melinda officinalis, Beiqi, Tianma, the seahorse, the gecko and so on 75 kinds of Chinese native medicines raw material for soaking, latter adds the white sugar and the tap water configuration. This invention medicated wine enhances men's and women's sexual dive energy, strengthens the human body vigor for mainly, makes up cloudyly and fortifies female, the synthesis recuperates the human body vital organs of the human body, expels sickness and builds up strength, thus achieves the benefit goal which prolongs the life. Its manufacture method is simple, the medicated wine soaking output contains Chinese native medicine ingredient content which obtains is high, the medicated wine palatableness is good, the feeling in the mouth is pure, preserves long. Long-time drinking can nourish the human body in vital organs, as well balances human body distributed masculine and feminine elements, and promotes metabolism, makes up the vitality, the strong physique, which prevents disease and expels sickness, the effect of prolonging the life. Regarding the hypertension, sleepless, the sexual impotence, the kidney empty lumbago, the prostate gland disease, the rheumatic arthritis, the asthma, the woman post-natal is weak, irregular menses and so on sickness also has the effect of better treatment. Stopping from pain also is its advantage.

Disclosed herein are dietary formulations and methods to mimic the physiological, biochemical and gene expression effects of calorie restriction without altering dietary intake. The formulations include combinations of nutrients that have various intended functions in the body, falling into three or more of the following activities; (1) antioxidant activity; (2) inhibition of glycation damage; (3) reduction of body weight and fat; and (4) promotion of high insulin sensitivity and low blood insulin / glucose; and (5) anti-inflammatory activity.

Provided herein are methods of culturing cells in vitro in order to exploit the biochemical production ability of the cells to make metabolites that are evaluated and harvested for their biological effects. Also provided are systems for evaluating extracts from such cultured cells to characterize their biological activity(s), particularly with regard to impact on health, wellbeing, longevity, DNA maintenance, mitochondrial health and / or biogenesis, and so forth. Biologically active extracts, components thereof, and compositions (such as cosmetic or pharmaceutical preparations) made comprising such, are also provided.

A method of improving longevity and / or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, IGF-I, and IGFBP1 levels, and risk factors for overall mortality, cancer and diabetes are determined. With respect to protein consumption, the relative amounts of protein calories from animal and plant sources are determined. A periodic normal calorie or low calorie but low protein fasting mimicking diet with frequencies of every 2 weeks to 2 months is provided to the subject if the subject's average daily protein intake level and type and / or IGF-I levels, and / or IGFBP1 levels is identified as being greater or lower than a predetermined cutoff intake / level and if the subject is younger than a predetermined age. The method is also shown to alleviate symptoms of chemotoxicity.