A
prosthetic valve assembly for use in replacing a deficient
native valve comprises a replacement valve supported on an expandable valve support. If desired, one or more anchors may be used. The valve support, which entirely supports the valve annulus, valve leaflets, and valve
commissure points, is configured to be collapsible for transluminal delivery and expandable to contact the anatomical annulus of the
native valve when the
assembly is properly positioned. Portions of the valve support may expand to a preset
diameter to maintain coaptivity of the replacement valve and to prevent
occlusion of the coronary ostia. A radial restraint, comprising a wire, thread or
cuff, may be used to ensure expansion does not exceed the preset
diameter. The valve support may optionally comprise a
drug elution component. The anchor engages the lumen wall when expanded and prevents substantial migration of the valve
assembly when positioned in place. The
prosthetic valve assembly is compressible about a
catheter, and restrained from expanding by an outer sheath. The
catheter may be inserted inside a lumen within the body, such as the
femoral artery, and delivered to a desired location, such as the heart. A
blood pump may be inserted into the
catheter to ensure continued
blood flow across the
implantation site during
implantation procedure. When the outer sheath is retracted, the
prosthetic valve assembly expands to an expanded position such that the valve and valve support expand at the
implantation site and the anchor engages the lumen wall.
Insertion of the catheter may optionally be performed over a transseptally delivered guidewire that has been externalized through the arterial vasculature. Such a guidewire provide dual venous and arterial access to the
implantation site and allows additional manipulation of the implantation site after arterial implantation of the prosthetic valve. Additional expansion stents may be delivered by
venous access to the valve.