Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

529results about How to "Increased longevity" patented technology

Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead

According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and / or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and / or vagal nerve stimulation therapy or the like.
Owner:MEDTRONIC INC

Methods and Compositions for Mammalian Cell Lines for Transfection and Protein Expression in Serum-Free Medium

Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transfection under serum-free conditions. In preferred embodiments, the cells of use are SpESF or SpESF-X cells.
Owner:IMMUNOMEDICS INC

Squitieri hemodialysis and vascular access systems

A hemodialysis and vascular access system comprises a subcutaneous composite PTFE silastic arteriovenous fistula having an indwelling silastic venous end which is inserted percutaneously into a vein and a PTFE arterial end which is anastomosed to an artery. Access to a blood stream within the system is gained by direct puncture of needle(s) into a needle receiving site having a tubular passage within a metal or plastic frame and a silicone upper surface through which needle(s) are inserted. In an alternate embodiment of the invention, percutaneous access to a blood stream may be gained by placing needles directly into the system (i.e. into the PTFE arterial end). The invention also proposes an additional embodiment having an arterialized indwelling venous catheter where blood flows from an artery through a tube and a port into an arterial reservoir and is returned to a vein via a port and a venous outlet tube distinct and distant from the area where the blood from the artery enters the arterial reservoir. The site where blood is returned to the vein is not directly fixed to the venous wall but is free floating within the vein. This system provides a hemodialysis and venous access graft which has superior longevity and performance, is easier to implant and is much more user friendly.
Owner:HEMOSPHERE

Intravascular prosthetic and method

An intravascular prosthetic graft is provided which includes a flexible tubular body having a first end defining at least one opening and a second end defining at least one opening. The flexible tubular body may be elongated and define a longitudinal axis. A first ring member is connected to the first end adjacent to the at least one opening of the first end. A second ring member is connected to the second end adjacent to the at least one opening of the second end. The flexible tubular body can be fabricated from a flexible material, such as, for example, DACRON(R), TEFLON(R), or other suitable material. The first and second ring members may be fabricated from a rigid material, such as metals or polymerics. A method of repairing at least a portion of an arterial system, such as, for example, treatment of an aortic aneurysm is disclosed. The method includes the steps of providing an intravascular prosthetic graft; determining a placement position for the intravascular prosthetic graft at an aneurysm site of the arterial system; introducing the intravascular prosthetic graft to the arterial system; delivering the intravascular prosthetic graft to the aneurysm site; positioning the intravascular prosthetic graft for repairing a diseased portion of an aorta at the placement position; expanding the intravascular prosthetic graft to substantially conform to an inner surface of the aorta; and fixing the intravascular prosthetic graft at the placement position. The step of fixing may include tying a suture about the exterior of the aorta. The method may further include the step of suturing the aorta to the intravascular prosthetic graft from exterior to the aorta.
Owner:MISHALY DAVID

Rotary facial seal and bearing assembly with plastic ring

A rotary facial seal and a thrust bearing are adapted to be installed between inner and outer concentric relatively movable members, such as, the spindle housing and axle of a motor vehicle, the facial seal having an annular diaphragm made up of an inner seating portion mounted on the axle, an outer plastic or PTFE sealing ring with a lip tapering away from a hinged section in a seal body to engage a radial wall of the housing, and an intermediate resilient wall section between the seal lip and seating portion to yieldingly urge the sealing lip into a thin band of contact with the radial wall under the biasing action of the intermediate wall section; and the thrust bearing includes a bearing member which is installed at the inner bore of the spindle housing and is freely rotatable with respect to the spindle housing when engaged by the end of the shaft and inner seating portion of the facial seal.
Owner:POLYMER SEALING SOLUTIONS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products