261 results about "Aortic aneurysm" patented technology

A prosthesis assembly for deployment in an aorta to span an aortic aneurysm. The prosthesis assembly has at least first and second members (2,4) with an end portion (12) of one member (2) to be joined to an end portion (24) of the other member (4) when in and when expanded within a lumen of a patient. Each member (2,4) has a stent arrangement (10,25) associated with a graft arrangement (8,26). The end portion of one member has at least part of its stent arrangement on the inner surface of its graft arrangement and the end portion of the other member has at least part of its stent arrangement on the inner surface of its graft arrangement. Advantageously two stents are overlapped. The joining portions of the first and second members can have the same diameter.

The present invention is a system, apparatus, and method for treating, repairing, and/or replacing an aneurysm, preferably an aortic aneurysm, the most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a first prosthesis or stent gasket, and at least one second prosthesis for bypassing the aneurysm, and at least one third prosthesis for establishing a fluid flow channel from the abdominal aorta into another artery, such as a renal artery.

A system, apparatus, and method for treating, repairing, an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm as described herein. The systems, devices, and methods described herein include a first prosthesis or stent gasket, and at least one second prosthesis for bypassing the aneurysm. The first prosthesis is configured and adapted to accommodate a section of artery upstream of the aneurysm, wherein the section is unsuitable for anchoring a typical first prosthesis.

A system and method for treating and repairing complex anatomy characterized by a plurality of vessel portions oriented at various angles relative to each other. The system including a graft device that is capable of being assembled in situ and has associated therewith a method that avoids the cessation of blood flow to vital organs. A delivery catheter system and various graft supporting, mating and anchoring structures are additionally included.

An endograft for a vessel having a vascular branch extending from the vessel is provided. The endograft includes a main body having a wall separating interior and exterior surfaces and adapted to be inserted within the vessel. The main body is characterized by a single proximal opening and a single terminal opening and at least one aperture extending through the wall. At least one stent is secured to the main body that upon expansion pressure fits the main body into the vessel. An open tunnel is secured to the interior surface of the main body around the main body aperture and secured somewhere along the tunnel length to provide fluid communication between the interior and exterior surfaces of the main body through the aperture and with the vascular branch in proximity to the main body aperture. The tunnel is readily formed independent of an expandable stent. Through the addition of further apertures and tunnels, an endograft is well suited for revascularizing the superior mesenteric artery and renal arteries for the treatment of a suprarenal aortic aneurysm. The insertion of a sleeve positioned partly within the tunnel and extending beyond the exterior surface of the main body into the vascular branch assures continued fluid flow to the vascular branch.

An endoluminal prosthesis includes two stent grafts with a flexible bridge extending between and connected to the stent grafts. The prosthesis can be part of a prosthesis assembly for treatment of branched vascular systems and can function as an interconnected leg extension prosthesis in combination with a main bifurcated prosthesis. In treating abdominal aortic aneurysms, the prosthesis can be deployed within both iliac arteries.

A device, method, and system for treating abdominal aortic aneurysms is described, where the device is an endovascular graft implant that one or more adjustable elements. The adjustable elements provide improved performance, for example, reduced leaking. The adjustable elements are adjustable within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. Examples of suitable types of energy include, for example, acoustic energy, radio frequency energy, light energy, and magnetic energy.

An external aneurysm support scaffold is implanted around an exterior surface of an aneurysm and prevents substantial dilation or progression of the AAA. Minimally invasive delivery is used via port-access, i.e. for aortic aneurysms along the back, abdomen, or thorax, to a location externally adjacent the aneurysm, such as via laparascopic delivery. The scaffold is unwound or unfolded in-situ to extend partially (e.g. about 270 degrees) or completely circumferentially around the aneurysm. Unique delivery devices allow for deployment around the aneurysm. Gaps between an array of transverse fingers of the scaffold may accommodate branch vessels extending from the aneurismal vessel, such as aortic perforators. An agent is injected to treat an aneurysm, such as by providing support, cell retention or recruitment, and/or angiogenesis. Living cells are delivered to treat an aneurysm. An adjustable graft polymerizes in-situ to support an aneurysm conformed therewith.

An intravascular prosthetic graft is provided which includes a flexible tubular body having a first end defining at least one opening and a second end defining at least one opening. The flexible tubular body may be elongated and define a longitudinal axis. A first ring member is connected to the first end adjacent to the at least one opening of the first end. A second ring member is connected to the second end adjacent to the at least one opening of the second end. The flexible tubular body can be fabricated from a flexible material, such as, for example, DACRON(R), TEFLON(R), or other suitable material. The first and second ring members may be fabricated from a rigid material, such as metals or polymerics. A method of repairing at least a portion of an arterial system, such as, for example, treatment of an aortic aneurysm is disclosed. The method includes the steps of providing an intravascular prosthetic graft; determining a placement position for the intravascular prosthetic graft at an aneurysm site of the arterial system; introducing the intravascular prosthetic graft to the arterial system; delivering the intravascular prosthetic graft to the aneurysm site; positioning the intravascular prosthetic graft for repairing a diseased portion of an aorta at the placement position; expanding the intravascular prosthetic graft to substantially conform to an inner surface of the aorta; and fixing the intravascular prosthetic graft at the placement position. The step of fixing may include tying a suture about the exterior of the aorta. The method may further include the step of suturing the aorta to the intravascular prosthetic graft from exterior to the aorta.

The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to the use of biomarkers, either individually or in combinations with one another to rule in or out diseases of the aorta and its branches, most particularly aortic aneurysm and/or aortic dissection, and for risk stratification in such conditions. Preferred markers include one or more of creatine kinase-BB (CK-BB), creatine kinase-MB (CK-MB), acidic calponin, basic calponin, B-type natriuretic peptide (BNP), NT-proBNP, proBNP, BNP_79-108, BNP_3-108, caldesmon, caspase-3, D-dimer, soluble elastin fragments, endothelial cell-selective adhesion molecule (ESAM), fibrillin-1, heart-type fatty acid binding protein, MMP-9, myeloperoxidase, myoglobin, smooth muscle myosin, smooth muscle myosin heavy chain, TIMP-1, free cardiac troponin I, complexed cardiac troponin I, free and complexed cardiac troponin I, free cardiac troponin T, complexed cardiac troponin T, and free and complexed cardiac troponin T, and preferred assays are configured to detect these markers.

A bilateral intra-aortic bypass graft and method and apparatus for repairing an abdominal aortic aneurysm includes two tubular grafts which are intraluminally delivered to the aorta and secured to the aorta by the expansion and deformation of two expandable and deformable tubular members.

An endoluminal device for affixation to a wall of a body lumen having a neck region defined by a relatively narrow width and a shoulder region that diverges from the neck region to a relatively wider width. The device comprises a shoulder portion, which may be part of a bulbous portion, having a diameter profile that conforms to the shoulder region, and, in some embodiments, a plurality of affixation members in an area of the device that typically extends from a distal end of the device through the shoulder portion. In one embodiment, the device comprises an endograft for repair of an aneurysm, such as an abdominal aortic aneurysm (AAA). Methods of using the endograft to inhibit continued diametric expansion of the aneurysm and to inhibit endoleak formation and migration of the endograft are also described.

An endoluminal graft includes a unitary tube of graft material forming two adjacent legs that are integral and monolithic to each other. The graft can be part of a prosthesis assembly for treatment of branched vascular systems and can function as an integral bifurcated leg extension prosthesis in combination with a main bifurcated prosthesis. In treating abdominal aortic aneurysms, the graft can be deployed within both iliac arteries.