164 results about "Aortic dissection" patented technology

Methods and systems for endovascular, endocardiac, or endoluminal approaches to a patient's heart to perform surgical procedures that may be performed or used without requiring extracorporeal cardiopulmonary bypass. Furthermore, these procedures can be performed through a relatively small number of small incisions. These procedures may illustratively include heart valve implantation, heart valve repair, resection of a diseased heart valve, replacement of a heart valve, repair of a ventricular aneurysm, repair of an arrhythmia, repair of an aortic dissection, etc. Such minimally invasive procedures are preferably performed transapically (i.e., through the heart muscle at its left or right ventricular apex).

Methods and systems for endovascular, endocardiac, or endoluminal approaches to a patient's heart to perform surgical procedures that may be performed or used without requiring extracorporeal cardiopulmonary bypass. Furthermore, these procedures can be performed through a relatively small number of small incisions. These procedures may illustratively include heart valve implantation, heart valve repair, resection of a diseased heart valve, replacement of a heart valve, repair of a ventricular aneurysm, repair of an arrhythmia, repair of an aortic dissection, etc. Such minimally invasive procedures are preferably performed transapically (i.e., through the heart muscle at its left or right ventricular apex).

The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to the use of biomarkers, either individually or in combinations with one another to rule in or out diseases of the aorta and its branches, most particularly aortic aneurysm and / or aortic dissection, and for risk stratification in such conditions. Preferred markers include one or more of creatine kinase-BB (CK-BB), creatine kinase-MB (CK-MB), acidic calponin, basic calponin, B-type natriuretic peptide (BNP), NT-proBNP, proBNP, BNP79-108, BNP3-108, caldesmon, caspase-3, D-dimer, soluble elastin fragments, endothelial cell-selective adhesion molecule (ESAM), fibrillin-1, heart-type fatty acid binding protein, MMP-9, myeloperoxidase, myoglobin, smooth muscle myosin, smooth muscle myosin heavy chain, TIMP-1, free cardiac troponin I, complexed cardiac troponin I, free and complexed cardiac troponin I, free cardiac troponin T, complexed cardiac troponin T, and free and complexed cardiac troponin T, and preferred assays are configured to detect these markers.

Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. The methods have utility in identifying agents that prevent cancer cell metastasis, wound dehiscence, aortic dissection and aid retina attachment and skin replacement and fertility.

An endoluminal medical device comprises a drug release system that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms and aortic dissections.

The invention discloses a kit and a method for detecting sST2 (soluble ST2) in blood of an abdominal aortic aneurysm and / or aortic dissection patient. According to the kit and the method, a pair of antibodies for identifying different epitopes of sST2 is assembled to obtain a double-antibody sandwich ELISA and immune colloidal gold test strip, so as to realize quantitive and qualitative detection of sST2. Tests prove that the ELISA kit and the immune colloidal gold test strip have relatively high specificity and sensitivity in an abdominal aortic aneurysm marker-sST2 protein of human, are simple to operate, can be utilized for detecting abdominal aortic aneurysm, aortic dissection and other diseases in scientific research and clinical application, and have the functions of auxiliary diagnosis, guide treatment and prognosis judgment.

The invention discloses a covered stent for an aortic dissection surgery, a delivery device and a use method thereof. The stent comprises a main body, wherein the main body decreases progressively from the heart near end with a large diameter to a far end with a small diameter, and the superior border of the middle piece of the main body is a rotary island; a tectorial membrane is arranged except the rotary island, and the two ends of the main body and the rotary island are provided with positioning marks. The delivery device comprises a delivery sheathing canal, a suture and a traction guide wire, wherein the suture is sewn on the outer side surface of the covered stent, and the two side edges of the covered stent at the near end of the left subclavian artery are sewn up by the suture; the stent is closed up to be in a semi-contraction state by the traction guide wire through the suture, and the covered stent is closed up and wrapped in the delivery sheathing canal; the delivery sheathing canal is provided with a steeple, and the far end of the traction guide wire penetrates through the handle of the delivery sheathing canal and is fixed. The covered stent for the aortic dissection surgery is used for a dissecting aneurysm surgery of the lesser curvature side of aortic arch and an interventional minimally invasive surgery of an aortic dissection near the brachiocephalic trunk, so that the trauma of a thoracotomy is avoided, and the athe lumen crevasse occlusion is directly implemented.

A bloodstream dilating device 1 is composed of an elastic member 2 extending in a direction of blood flow in a true lumen 115. The elastic member 2 pushes the inner wall of the true lumen 15 outward to dilate the bloodstream. An aortic dissection treating device includes an obturator and a fixing member for fixing the obturator to the inner layer of an aorta. The obturator is inserted up to the point that it can cover an entry port formed in the aorta. The obturator is deformed along the periphery of the entry port in the inner layer by blood pressure to occlude the entry port.

The present invention relates to medical cutting tools for treating aortic septal dissections. The cutting tool is provided with a delivery catheter and has a remotely actuated cutting blade or cutting wire component. The cutting tool is provided with at least one displacement element. The displacement element assists in placement of the cutting tool at a desired location. The displacement element also assists in maintaining contact between the cutting blade and tissue being cut.

Methods and devices for treating an aortic dissection having an entry point downstream of the takeoff of the left subclavian artery. The devices include a catheter that carries an endoluminal implant at a distal region of the catheter. The implant is a self-expanding tubular mesh or strutted stent. A capture sheath holds the stent in a compressed state for percutaneous delivery. The catheter is advanced to position the stent adjacent the entry point of the dissection. The stent is released by withdrawing the capture sheath. The stent expands to engage the intimal lining and press the intima into contact with the outer layers of the aorta and thereby promote healing of the dissection.

The invention discloses an improved CT image aorta segmentation method based on an active shape model. A segmentation and extraction method combining a Support vector machine (SVM) and an active shapemodel (ASM) are used to segment and extract the aortic region from the CT images of patients with aortic dissection accurately, which solves the problem of error caused by the large difference between the model and the actual segmentation target in the existing algorithm. The process is as follows: (1) selecting samples from aortic patient CT images to construct a training set and marking the characteristic points of an aortic region in the training set; (2) constructing a shape vector from the feature points of the sample marks and performing normalized registration; (3) reducing the dimension of the vector to determine the main sample components and constructing a statistical shape model; (4) performing gray-scale sampling ofa square matrix centered on feature points to establish a texture model; (5) constructing a support vector machine classifier in the training process of the model; (6) calculating the probability of the marked point set to the contour of the target, and findingthe best matching position.

The invention discloses a plastic covered aortic dissection stent and an aortic dissection stent.The plastic covered aortic dissection stent comprises a tubular covering membrane and multiple annular supports sequentially sewn on the covering membrane in the axial direction and is characterized in that the annular supports on one part of the covering membrane are semi-sewn supports, the semi-sewn supports are provided with non-sewn areas which can be separated from the covering membrane, and the covering membrane corresponding to the internally-bent side of the non-sewn areas breaks away from the semi-sewn supports to be folded internally in a bent state.The semi-sewn supports are distributed at the bent positions after the plastic covered aortic dissection stent is implanted.The number of the semi-sewn supports is at least two sequentially-adjacent circles.When the plastic covered aortic dissection stent is bent, non-sewn areas of every two adjacent annular supports located on the internally-bent side can be overlapped, and the covering membrane in the non-sewn areas is folded towards the inside of the stent to maintain the bent state of the covered stent.

The invention provides a construction method and application of an aortic dissection segmentation model. The method comprises the following steps: A. acquiring a specified number of CTA images of aortic regions of aortic dissection patients; B, preprocessing the CTA images through a convolutional neural network, and extracting image features of the aorta, a true cavity and a pseudo-cavity of the aortic dissection of the preprocessed CTA images, and acquiring location annotation information of the aorta, the true cavity and the pseudo-cavity divided by the golden standard; and C, performing training according to the image features and the location annotation information through a multi-task network Multi-task UNet to obtain a trained aortic dissection segmentation model. Therefore, a segmentation prediction result of the aortic dissection can be obtained quickly and effectively via the above model, the diagnosis time of a doctor is greatly shortened, and an effective support is providedfor the surgical plan formulation.

The invention discloses a covered stent for aortic dissection surgery, a conveying device and a use method. The stent comprises a body which is a covered stent body. The stent is a conical stent with the diameter gradually reduced from the cardiac proximal portion to the thoracic aorta distal portion. An exposed portion is arranged on the lower portion of the body of the stent and is not covered. Three balloon dilatation stents are connected to the upper edge of the middle of the body. A protective gasket made from polytetrafluoroethylene is arranged at the near end of the body. The three balloon dilatation stents are provided with three catheters respectively. Each catheter is about 2 m long. The conveying device comprises a conveying sheath, the body of the stent is compressed in the conveying sheath, and the three balloon dilatation stents on the middle section of the body are compressed in the conveying sheath. A conveying sheath system is provided with an apex, and notches are formed in the tip end of the conveying sheath system for the body of the stent and guide wires and the catheters of the three balloon dilatation stents. The invention provides the covered stent for aortic dissection surgery. The stent is used for minimally invasive surgery treatment of Stanford A type aortic dissection with a wound among three branch vessels on the arcus aortae, avoids injuries caused by thoracotomy, and can be directly used for intra-cardiac wound occlusion.

The invention discloses a DNA library for detecting pathogenic genes of multiple genetic vascular diseases through a targeted high-throughput semiconductor sequencing technology and application thereof. The operating method specifically comprises the following steps: designing a primer pool according to 151 pathogenic genes of genetic vascular diseases, performing super-multiple PCR amplification on genomic DNA of samples, sequencing the amplification products by utilizing the high-throughput semiconductor sequencing technology, searching pathogenic mutations, and providing genetic and molecular biological theoretical basis for clinical diagnosis. The DNA library disclosed by the invention has the characteristics of accuracy, rapidness, flexibility and low cost, the 151 gene detection areas involved in the invention are capable of detecting multiple genetic vascular diseases such as aortic dissection, arterial aneurysm, hemorrhagic apoplexy and the like, and the DNA library has great significance and clinical values on diagnosis and differential diagnosis of the genetic vascular diseases.

The invention belongs to the field of biomedical engineering, and particularly relates to a method for rapidly preparing an intraoperative individual covered stent for treating aortic arch dissection.The method comprises the following steps: copying a pathologically changed aortic arch of a patient in a proportion of 1: 1 by using a 3D printing technology through CT image data of the patient; marking a blood vessel branch opening, position and size of the aortic arch on a transparent diaphragm by using an aorta 3D model; taking a covered main stent, covering the covered main stent by using amarked sheet, and successively forming holes in positions corresponding to branched blood vessels; and selecting small covered stents of which the diameters are matched with the diameters of the holesof the stent, and separately stitching the small covered stents to the various holes to obtain the individual covered stent which is completely matched with the patient. The purpose of accurately treating Stanford A type aortic arch dissection can be achieved, individual treatment is implemented, time of operation is saved, hemorrhage during operation is relieved, and postoperative complicationsare greatly reduced.

The invention relates to application of polymer salvianolic acid in preparation of drugs used for inhibiting occurrence or development of aortic aneurysm or aortic dissection and a pharmaceutical composition comprising the polymer salvianolic acid used as a pharmaceutical active substance, related desired adjuvant and the like. The pharmaceutical composition can be used for inhibiting occurrence of aortic aneurysm or aortic dissection. The polymer salvianolic acid is dimer salvianolic acid, trimer salvianolic acid or tetramer salvianolic acid, wherein the dimer salvianolic acid is rosmarinic acid, the trimer salvianolic acid is salvianolic acid C, alkannic acid or salvianolic acid A, and the tetramer salvianolic acid is salvianolic acid B.

The invention relates to the technical field of biology, in particular to a purpose of an HSP90 inhibitor in preparation of medicine for preventing and treating aortic diseases. The HSP90 inhibitor is used for preparing medicine or a reagent for preventing or treating aortic dissection. The invention also provides a method for screening potential substances for preventing or treating the aortic diseases, and a method for preventing or treating the aortic diseases of mammal. The invention discloses the purpose of the HSP90 inhibitor for specially inhibiting the aortic dissection cracking for the first time, and discloses the close relevancy of the HSP90 expression to the aortic diseases for the first time, so that a novel target point is provided for the large vessel disease prevention and treatment.

The invention relates to the medical field, in particular to a stent graft. A body of the stent graft comprises a plurality of wavy supporting rings which are arrayed to form a tubular structure. At least one supporting ring is a multi-wave ring. The multi-wave ring comprises a first wave and a second wave which are connected. The stent graft has the advantages that in the endovascular repair treatment process of aortic dissection involving arch, the second wave of the multi-wave ring minimizes the gap between the aorta body stent graft and a chimney graft, the body stent graft can better wrap the chimney graft, and the endoleak occurrence rate is decreased; the first wave of the multi-wave ring makes the radial acting force of the body stent graft on the chimney graft within the fatigue strength range of the chimney graft, the pressure stress of a pipe wall can not be excessively increased, and meanwhile the chimney graft is prevented from being blocked; the small amplitude of the first wave and the large amplitude of the second wave make the stent graft fit the bend of the aortic arch.

The invention discloses a post-operative rehabilitation exercise device for Stanford A-type aortic dissection patients, comprising a bottom plate, wherein an upper part of the bottom plate near one end of the bottom plate is centrally provided with a driving device, and two sets of lower limb exercise devices are arranged at the position close to the upper part of the bottom plate and two sides ofthe driving device symmetrically. The post-operative rehabilitation exercise device combines the passive rehabilitation movement and the active rehabilitation movement organically, can quicken the patient 's recovery speed, and can effectively prevent arteriovenous thrombosis, can accelerate intestinal peristalsis, increase vital capacity, so that phlegm discharge is facilitated and pulmonary complications can be reduced. In addition, the lower limb exercise devices of the two groups are convenient and quick to fix the lower limbs of the patients, so that the rehabilitation exercise device isconvenient to use, and the sponge pad can improve the comfort degree of the rehabilitation exercise device, thereby stimulating the interest of patients in using the rehabilitation exercise device for rehabilitation exercise, so as to achieve the purpose of rehabilitation exercise, which is worth popularizing and popularizing.

The invention belongs to the technical field of cross of medicine and engineering and relates to an in-situ laser pulse artery opening device and application thereof. The in-situ laser pulse artery opening device comprises aorta covered stents including the Valiant stent, the zenith flex stent, the Ankura chest aorta covered stent and the chimney stent and a laser. According to the in-situ laser pulse artery opening device, after the aorta covered stents are released, according to the blood vessel condition, the aorta covered stents corresponding to branch blood vessels can be opened through the laser, and the covered stents or bare stents are planted into the opened branch blood vessels to rebuild blood flows of the branch blood vessels and reduce occurrence of relevant complications. According to the in-situ laser pulse artery opening device, the covered stents of standard specifications are adopted, no anatomical structure is destroyed, a stent system does not need to be customized independently according to the individual special anatomical form, and the in-situ laser pulse artery opening device can be used for treating aortic aneurysm or aortic dissection diseases.

The invention provides an establishment method of an animal model for acute Stanford A-type aortic dissection (AD) accompanied with MODS (multiple organ dysfunction syndrome), a use of emodin for preparing a medicine for treating acute Stanford A-type AD accompanied with MODS as well as a viscera protective agent for acute Stanford A-type AD accompanied with MODS. In the invention, an AD surgery method is improved and meanwhile manually controlled hypertension is formed by continuously pumping adrenaline into veins so as to promote expansion of the AD stripping range and accelerate disease progression, thus acute Stanford A-type AD accompanied with MODS can be rapidly formed so as to successfully make the model. The animal model for acute Stanford A-type AD accompanied with MODS creates conditions for further deep research in application foundation and intervention treatment.

The present invention relates to methods of using medical cutting tools for treating aortic septal dissections.

The invention discloses an intravascular prosthesis. Particularly, the prosthesis comprises i layers of tubular intravascular stents, wherein 2<=i<=8, and the prosthesis is used for treating aortic dissection and arterial aneurysm lesion, particularly ascending aortic aneurysm; the tubular intravascular stents are divided into dense mesh weaved stents and sparse mesh weaved stents, the dense meshweaved stents are large in mesh density, and the sparse mesh weaved stents are small in mesh density; the quantity of the dense mesh weaved stents is m, wherein 1<=m<=4; the quantity of the sparse mesh weaved stents is n, wherein 1<=n<=4, and i=m+n; the dense mesh weaved stents and the sparse mesh weaved stents are coaxially stacked together in the circumferential direction, are used for cooperatively supporting the blood vessel and mutually limit axial stretching or shortening deformation of the stents. By means of the prosthesis in the blood vessel, through a stent interventional operation,the aortic dissection can be effectively treated, particularly the aortic dissection or arterial aneurysm incapable of being subjected to interventional treatment by current clinical medicine.

The invention discloses a combination-type intra-operative on-demand blocking branched stent-type blood vessel. The stent-type blood vessel is used in open-type operations of replacing aorta arches and branch blood vessels thereof during the aortic dissection treatment. The combination-type intra-operative on-demand blocking branched stent-type blood vessel comprises two or three stent-type blood vessel bodies from the distal end of the aorta arch to the proximal end of the aorta arch, can be suitable for individual structures of three branch blood vessels of the aorta arch of a patient, and improves the matching degrees between the stent-type blood vessel and the three branch blood vessels of the human-body aorta arch. When the stent-type blood vessel is used, dissociative brachiocephalic blood vessels can be avoided or reduced, it is unnecessary to replace the aorta arch and branch blood vessels, anastomotic stomas are reduced, and the extracorporeal circulation time and the unilateral cerebral perfusion time are shortened, so that operative manipulation difficulties and operative wounds are reduced, the operation time is shortened, postoperative complications are reduced, and the mortality rate is reduced.

The invention discloses an application of miR-15a as a molecular marker for clinical screening of aortic dissection, wherein the sequence of miR-15a is showed as the SEQ ID NO.1. A kit for clinical screening of aortic dissection is characterized by comprising: a blood plasma general RNA extraction reagent group, an exogenous reference object, a RNA reverse transcription reagent group, a RNA reverse transcription primer group, a realtime quantitative PCR reagent group, a realtime quantitative PCR primer group and a realtime quantitative PCR probe group, wherein the RNA reverse transcription primer group comprises a miR-15a reverse transcription primer and an exogenous reference object reverse transcription primer, the realtime quantitative PCR primer group comprises a miR-15a realtime quantitative PCR primer and an exogenous reference object realtime quantitative PCR primer, and the realtime quantitative PCR probe group comprises a miR-15a realtime quantitative PCR probe and an exogenous reference object realtime quantitative PCR probe.

Aortic dissection (AD) is a dangerous cardiovascular disease, has extremely high clinical mortality, and has a sharp increase in the incidence rate in recent years. The invention discloses an aortic dissection dynamic detection method based on morphology and deep learning. The method comprises the steps of: 1, establishing a CTA sample set; and 2, carrying out deep learning based on CTA images in the CTA sample set, and carrying out disease detection; 2.1, performing deep learning based on the region of interest to obtain a learned convolutional neural network; and 2.2, for the new CTA image, performing disease detection based on the learned convolutional neural network in combination with the region of interest. The aortic dissection dynamic detection method based on the morphology and the deep learning is easy to implement and high in detection efficiency. Experiments show that the adopted deep learning method is far superior to a traditional method, and the method based on DenseNet 121 is more excellent.

The invention provides a method for segmenting and marking a multi-branch tubular structure in a three-dimensional image, and belongs to the field of medical image processing. According to the method,a multi-branch tubular structure is regarded as a set of a plurality of single-branch tubular structures, and for the single-branch tubular structures, a center line is obtained through key point detection and neural network fine adjustment methods; then a cross section image of the tubular structure is acquired along the center line based on the center line, and finally a segmentation result ofthe tubular structure is acquired by using a segmentation network. The specific multi-branch tubular structure existing in the image can be segmented and automatically marked, and especially for someimages with lesions, such as aortic dissection, aortic aneurysm and coronary artery stenosis images, a good segmentation result is achieved.

The invention provides an occluder. The occluder comprises a first occluding part and a second occluding part, a connecting bolt is arranged at the far end of the first occluding part along the direction of the second occluding part, a first external thread is arranged on the side wall of the connecting bolt, a protruding part is arranged at the near end of the second occluding part, a through hole is formed in the protruding part, a second external thread is arranged on the side wall of the protruding part, the thread direction of the first external thread is opposite to that of the second external thread, and the near end of the connecting bolt can penetrate through the through hole to be in threaded connection with a nut. The invention further provides an occluder locking system and a locking method thereof. According to the structure of the occluder, efficient, stable and reliable locking can be achieved under the combined action of a pushing device, so that the service life and the occluding effect of the occluder are prolonged, the risk of postoperative complications is reduced, and the occluder is particularly suitable for occluding treatment of aortic dissection crevasses.