The invention discloses a
salvianolic acid A
magnesium salt, specially, relates to the
salvianolic acid A
magnesium salt, a preparation method and a use of the
salvianolic acid A
magnesium salt, and a
salvianolic acid A magnesium salt-containing freeze-dried
powder injection composition, and belongs to the technical field of medicines. The preparation method of the
salvianolic acid A magnesium salt comprises the following steps of adding magnesium
hydroxide into water, feeding CO2 into the magnesium
hydroxide solution until the magnesium
hydroxide solution is clarified, removing the CO2 in the magnesium hydroxide solution by ultrasonic
waves to obtain magnesium
hydrogen carbonate, adding
salvianolic acid A into the obtained magnesium
hydrogen carbonate so that the salvianolic acid A and the obtained magnesium
hydrogen undergo a reaction at a temperature of 20 to 40 DEG C for 20 to 40 minutes to produce a
reaction product solution, adding
ethyl acetate into the
reaction product solution, wherein the volume of the added
ethyl acetate is equal to that of the
reaction product solution, carrying out vortexing, and then carrying out
centrifugal separation and
freeze drying to obtain the salvianolic acid A
magnesium salt. The salvianolic acid A magnesium salt has strong stability in an
aqueous solution, high
solubility and small
irritation. The preparation method of the salvianolic acid A magnesium salt adopts a good preparation technology and has the simple steps. The salvianolic acid A magnesium salt-containing freeze-dried
powder injection composition has good stability and high uniformity, and satisfies
medicine rehydration capability requirements. The salvianolic acid A magnesium salt can be utilized for preparation of medicines for treating
ischemic stroke.