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569 results about "Rosmarinic acid" patented technology

Rosmarinic acid is a chemical compound found in a variety of plants.

Method for separating and purifying salvianolic acid from red sage root liquid extract by one step

The invention relates to a method for furthering separating and purifying salvianolic acid from Danshen extract fluid, which comprises that prepares, breaks and extracts Danshen via water solution, acidifies extract to adjust pH and adds salt to process post-treatment, processes dynamic continuous adsorption and elution on the treated extract at chromatography column stuffed with resin adsorbent, elutes via water, collects and concentrates eluent, elutes via gradient ethanol solution, segmented collects and concentrates eluent, and dries the concentrates solution to obtain product. The invention can simply, effectively and quickly separate and purify various salvianolic acids, wherein test on different salvianolic acid products shows that the highest yields of tanshinol, alkannic acid, rosmarinic acid, salvianolic acid A and salvianolic acid B are 35. 55%, 70.65%, 99.27%, 82.78%, and 89.34%, and relative highest purities are 95.32%, 65.05%, 29.40%, 33.93%, and 82.35%, which are near or higher than the result of purification on the goal of single component.
Owner:TIANJIN UNIV

Preparing technique for separating and purifying rosmarinic acid by big-hole adsorption resin

The present invention relates to a production process of the rosmarinic acid by absorbing the resin with a large hole, separation and purification of the plant containing the rosmarinic acid. The key technical points are: the plant containing the rosmarinic acid is used as the raw material; the extraction liquid is absorbed with a large hole, purified, eluted and vacuum dried to get the refined rosmarinic acid product. The purity of the product can reach above 90 percent. The present invention successfully uses the macroporous absorption technology of the resin in the one-step refinement, separation and purification of the rosmarinic acid. The rosmarinic acid produced in the present invention has the good antioxidant properties; the pharmacological effects of the rosmarinic acid are relatively strong; the effects of the immune inhibition, microbial inhibition, anti-inflammation, anti-thrombotic and anti-platelet aggregation, anti-allergic and other performances are significant. The present invention provides the possibility for the refining production of the large-scale industrialization of the rosmarinic acid product with the high biological activity, and lays the foundation for the further development and the wide application of the active product.
Owner:TIANJIN UNIV OF SCI & TECH

Production technology for acquiring two antioxidant agents from Rosmarinus officinalis L.

The invention discloses a production technology employing a ultrasonic countercurrent extraction process and a membrane separation (molecular sieve) process to acquire two antioxidants from Rosmarinus officinalis L. The production technology comprises adding 30 to 85% of edible alcohol into fresh rosemary branches and leaves, carrying out a ultrasonic counter current extraction process for a mixture of the edible alcohol and the fresh rosemary branches and leaves to obtain an extracted liquid with a solid-to-liquid ratio of from 1:10 to 1:30, and carrying out a membrane separation (molecular sieve) process to separate two antioxidant agents consisting of a rosemary fat-soluble antioxidant agent (comprising carnosic acid as a representative) and a rosemary water-soluble antioxidant agent (comprising rosmarinic acid as a representative) from the extracted liquid, wherein a heating time of the extracted liquid can be reduced through the membrane separation (molecular sieve) process thus a conversion ratio of rosmarinic acid to carnosol is reduced. A content of carnosic acid in the rosemary fat-soluble antioxidant agent is increased through a CO2 supercritical extraction process. The rosemary water-soluble antioxidant agent (comprising rosmarinic acid as a representative) is separated from a liquid obtained through a concentration process under reduced pressure and a solid-liquid separation process, and a content of rosmarinic acid in the rosemary water-soluble antioxidant agent is increased through recrystallization from ethanol. The production technology has the advantages of simple processes, low energy consumption, high production efficiency, production safety, and no harmful residual solvent due to single edible alcohol usage during all production processes.
Owner:YUZHOU SENYUAN BENCAO NATURAL PRODS

Prunella spike extract and its preparation method and use

An extract of prunella spike for treating rheumatoid arthritis and improving immune suppression contains phenolic acid (60-70%) and rosemaric acid (14-21%). Its preparing process is also disclosed.
Owner:JIANGSU KANION PHARMA CO LTD

Method for extracting rosmarinic acid from folia perillae acutae

The invention discloses a method for extracting rosmarinic acid from folia perillae acutae. According to the method disclosed by the invention, a rosmarinic acid product with the purity of more than 98% is prepared by carrying out processes such as cleaning, slicing, ultrasonic extraction, macroporous resin absorption, desorption and concentration, acid water dissolution, extraction and column chromatography on silica gel on a raw material folia perillae acutae at the initial stage of seeding. By utilizing the method disclosed by the invention, a high-purity rosmarinic acid product can be obtained; a rosmarinic acid crude product with the purity of 20-30% and a rosmarinic acid crude product with the purity of 60-75% can be obtained during the production process so as to meet different requirements; and the method provided by the invention is short in extraction time, simple in operation, less in steps, low in production cost and suitable for large-scale industrial production.
Owner:山西金紫苏生物科技股份有限公司

Quality detecting method for traditional Chinese medicine composition for treating hematuresis

The invention relates to a quality detecting method for a traditional Chinese medicine compound preparation, in particular to a quality detecting method for a traditional Chinese medicine composition for treating hematuresis. According to the technical scheme, the quality detecting method for the traditional Chinese medicine composition for treating hematuresis is prepared from cortex phellodendri, lalang grass rhizome, clerodendranthus spicatus and linarin in herba cepbalanoplosis segeti. The invention further provides a method for detecting the content of berberine hydrochloride in cortex phellodendri and the content of rosmarinic acid in clerodendranthus spicatus. High performance liquid chromatography is adopted. According to the method, lalang grass rhizome, cortex phellodendri, clerodendranthus spicatus and herba cepbalanoplosis segeti in the traditional Chinese medicine composition for treating hematuresis are qualitatively detected through thin-layer chromatography, and the method is simple and stable. The high performance liquid chromatography is used for detecting the content of berberine hydrochloride in cortex phellodendri and the content of rosmarinic acid in clerodendranthus spicatus, the method is easy and convenient and high in repeatability and stability, the result is accurate, the method serves as a method for detecting the content of ingredients of the traditional Chinese medicine compound preparation, and the rationality and reliability of the whole quality control method are enhanced.
Owner:云南雷允上理想药业有限公司

Rosmarinic acid, rosmarinic acid-containing common selfheal fruit-spike active ingredient and preparation methods and application thereof to prevention and treatment of cancer postoperative metastasis

The invention discloses rosmarinic acid, a rosmarinic acid-containing common selfheal fruit-spike active ingredient and preparation methods thereof by extraction and separation. Moreover, the invention also discloses the application of the rosmarinic acid or/and the rosmarinic acid-containing common selfheal fruit-spike active ingredient to the preparation of a medicament for preventing or treating cancer postoperative metastasis and discloses a medicinal composition which contains effective doses of the rosmarinic acid or/and the rosmarinic acid-containing common selfheal fruit-spike active ingredient for preventing or treating the cancer postoperative metastasis. The rosmarinic acid and the rosmarinic acid-containing common selfheal fruit-spike active ingredient are obtained by extraction and separation. Pharmacodynamic experiment researches indicate that the rosmarinic acid and the rosmarinic acid-containing common selfheal fruit-spike active ingredient prepared by the method have cancer metastasis resistance and can be used for preparing a medicament for preventing or treating cancer metastasis.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M

Method for detecting traditional Chinese medicine injection for treating cardiovascular and cerebrovascular diseases

The invention relates to a method for detecting a traditional Chinese medicine injection for treating cardiovascular and cerebrovascular diseases. The detection method comprises a thin-layer identification method for medicinal materials including radix salviae miltiorrhizae and safflower carthamus, an inspection method for 5-hydroxymethyl furfural, total solids, heavy metals, harmful elements and the like, a high-performance liquid chromatography method of salvianic acid A sodium, protocatechu aldehyde, 4-cumaric acid, rosmarinic acid, danshinolic acid B and danshinolic acid A and an ultraviolet measurement method for measuring total phenols content. The method for detecting the quality of the traditional Chinese medicine injection provided by the invention is good in stability and repeatability, can be used for accurately qualitatively and quantitatively detecting the content of all effective components and impurity components and can be used for comprehensively and objectively evaluating the quality of the traditional Chinese medicine injection so as to finally guarantee the clinical medication safety and curative effect of the traditional Chinese medicine injection.
Owner:SHANDONG DANHONG PHARMA

Method for using near infrared spectroscopy to measure contents of multiple components in radix et rhizoma salviae miltiorrhizae medicinal material

The invention provides a method for using a near infrared spectroscopy to measure contents of multiple components in a radix et rhizoma salviae miltiorrhizae medicinal material and application feasibility of the method in a Chinese patent medicine raw material quality assurance system is discussed. The method comprises the steps: utilizing a high performance liquid chromatography to measure contents of danshinolic acid B, rosmarinic acid, alkannic acid, tanshinone IIA, tanshinone I and cryptotanshinone in radix et rhizoma salviae miltiorrhizae as contrast values; utilizing near infrared diffusion reflection method to collect a sample spectrum, comparing different spectrum pretreating methods and modeling effects of modeling waveband and optimizing modeling parameters; utilizing a partial least squares (PLS) to respectively establish near infrared quantitative analysis models of danshinolic acid B, rosmarinic acid, alkannic acid and tanshinone components (tanshinone IIA plus tanshinoneI plus cryptotanshinone) in the radix et rhizoma salviae miltiorrhizae and evaluating the models. The quantitative analysis models established by the method disclosed by the invention can meet a requirement of quickly obtaining chemical information of massive radix et rhizoma salviae miltiorrhizae medicinal material samples.
Owner:TIANJIN TASLY PHARMA CO LTD

Frozen minced fillet quality improver and preparation method and application thereof

The invention discloses a frozen minced fillet quality improver which is prepared from, by mass, 0.5-1% of vitamin C, 5-10% of sodium gluconate, 10-20% of sodium caseinate, 1-3% of calcium chloride, 1-3% of kelp polyphenols, 5-10% of trehalose, 5-10% of rosmarinic acid, 3-5% of sucrose ester and the balance soyabean protein. The frozen minced fillet quality improver is scientific and reasonable in formula and high in eating safety, all the components achieve mutual synergistic interaction, and frozen denaturation and oxidation of minced fillet protein can be effectively prevented, so that the jelly strength, the texture, the water holding capacity, the adhesion ability and the like of the frozen minced fillet are greatly improved, the frozen quality of the frozen minced fillet is improved, and the frozen minced fillet quality improved is worthy of being applied and popularized in frozen minced fillet processing. The invention further discloses a preparation method of the frozen minced fillet quality improver. The preparation method comprises the steps of mixing the components according to a ratio so as to obtain the frozen minced fillet quality improver. The technological steps are simple, the requirement for the equipment is low, the operability is high, and the preparation method is suitable for industrial large-scale production.
Owner:OCEAN UNIV OF CHINA
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