3842results about How to "Promote dissolution" patented technology

The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical. The invention provides a drug formulation comprising a solid pharmaceutical agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral cavity, delivering the pharmaceutical agent by absorption through a patient's oral mucosal tissue. The formulation and method provide for improved oral mucosal delivery of the pharmaceutical agent.

The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

The invention discloses a preparation method of a raw dendrobium officinale pulp beverage. The preparation method comprises the following steps of: (1), baking a fresh dendrobium officinale branch to be purple, adding water to the baked fresh dendrobium officinale branch for pulping, so as to obtain a primary serous fluid; (2), carrying out insulation treatment on the primary serous fluid, boiling and filtering the primary serous fluid, so as to obtain filter residue; (3) adding water to the filter residue for pulping, boiling and filtering the filter residue again to obtain the filter residue, repeating the sub-steps for a plurality of times, adding water to the final filter residue for the pulping, so as to obtain secondary serous fluid; (4), adding a cellulolytic enzyme into the secondary serous fluid for carrying out enzymolysis, so as to obtain an enzymolysis solution; (5) boiling and filtering the enzymolysis solution, to obtain the filter residue; (6) adding water into the filter residue for the pulping, boiling and filtering the filter residue again, to obtain the filter residue, and repeating the sub-steps for a plurality of times; (7) mixing all the filter solutions, boiling and sterilizing the mixed filter solution, so as to obtain the raw dendrobium officinale pulp beverage. The preparation method provided by the invention has the advantages that dendrobium officinale is baked, the filter residue is subjected to enzymolysis treatment, the extraction rate of functionality polyose and flavone is improved, the content of dietary fiber in the beverage is increased, and the prepared beverage color is bright and stable.

The present invention relates to a solvent system with improved disintegration degree and dissolution ratio of a hardly soluble drug by highly concentrating the drug through partial ionization, and by establishing optimal conditions for enhancing bioavailability of the drug, such as the co-relation between the acid drug and the accompanied components, ionization degree of a solvent system, use of an appropriate cation acceptance, water content, selection of optimal mixing ratio of the respective components and use of specific surfactants, and to a pharmaceutical preparation comprising the same. The solvent system of the invention has advantages in that it can enhance bioavailability by improving the disintegration degree and dissolution ratio of a hardly soluble drug and also provide a capsule with a sufficiently small volume to permit easy swallowing.

A method for extracting silicon dioxide, alumina and gallium oxide from high-alumina fly ash relates to the technology fields of environmental mineralogy and material, chemical industry and metallurgy. The method comprises the main steps as follows: causing the high-alumina fly ash to react with sodium hydroxide solution; filtering the solution; introducing CO2 to the filtrate for full gelation; cleaning, purifying, drying, grinding and calcining the silica gel after gel filtration to obtain finished white carbon black; adding limestone and a sodium carbonate solution into the filter mass after the reaction and filtration of the high-alumina fly ash and the sodium hydroxide solution; ball grinding the mixture into raw slurry; dissolving out the clinker obtained by baking the raw slurry; subjecting the filtrate to deep desiliconization to obtain sodium aluminate extraction liquid; filtrating the sodium aluminate extraction liquid after subjecting the sodium aluminate extraction liquid to carbon dioxide decomposition; baking the aluminum hydroxide after washing the filter mass to form the aluminum hydroxide product; and extracting the gallium oxide from the carbon dioxide decomposition mother solution and desiliconized solution. The method has the advantages of low material price, simple operating procedures, low investment, low production cost, low energy consumption and less slag.

An oral delivery system for Class II drugs that have low oral bioavailability due to their insolubility in water and slow dissolution kinetics and method for making such a drug delivery system are disclosed herein. The formulation may be a controlled release or immediate release formulation. The immediate release formulation contains a Class II drug, together with a hydrophobic polymer, preferably a bioadhesive polymer. In one embodiment, the drug and polymer are co-dissolved in a common solvent. The solution is formed into small solid particles by any convenient method, particularly by spray drying. The resulting particles contain drug dispersed as small particles in a polymeric matrix. The particles are stable against aggregation, and can be put into capsules or tableted for administration. The controlled release formulations contain a BCS Class II drug and a bioadhesive polymer. The controlled release formulations may be in the form of a tablet, capsules, mini-tab, microparticulate, or osmotic pump. Enhancement of oral uptake of the drug from use of bioadhesive polymers occurs through (1) increased dissolution kinetics due to stable micronization of the drug, (2) rapid release of the drug from the polymer in the GI tract; and (3) prolonged GI transit due to bioadhesive properties of the polymers. The combination of these effects allows the preparation of a compact, stable dosage form suitable for oral administration of many class II drugs.

A solid preparation which comprises (i) a pharmaceutically active ingredient, (ii) one or more water-soluble sugar alcohols selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, and (iii) low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight; which exhibits excellent buccal disintegration and dissolution and also appropriate strength.

A pair of environment-friendly popcorn bridging shoes and a production process thereof are provided. The upper of each bridging shoe comprises an inner bootie, which is composed of a lining and an inner pad formed by single injection molding, and a vamp; the collar of the inner bootie is fixedly connected with that of the vamp, and the lower edge of the vamp wrapped by a PU bridging layer extends to the bottom surface of the inner pad fixedly connected with the same; the upper and a popcorn sole made of mixed PU and TPU popcorn particles are integrally connected by the PU bridging layer. The shoe making process is simpler, and firmer bonding and better shock absorbing performance of the shoes are achieved; the vamp and the sole can well wrap the foot; and the dissolution proportion of shoes is increased by increasing the consumption of the PU material.

A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweeteners and specified amounts of bioactive agents, for erectile dysfunction. A flexible film dosage form containing sildenafil citrate, tadalafil or Vardenafil is presented. The film system is enabled to be used in various applications such as oral, mucosal and external environments.

The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.

The invention discloses a stable medicinal combination which contains active ingredient riluzole and pharmaceutical auxiliary material. The medicine combination is mainly used for the clinical treatment of amyotrophic lateral sclerosis.

The invention relates to a Pu'er tea extract, and a preparation method and application thereof. The Pu'er tea extract is high in active ingredient content and can reduce blood sugar and blood fat obviously. By the preparation method of the Pu'er tea extract, the active ingredients are completely and effectively converted and dissolved out and the original flavor of the Pu'er tea is maintained. The process of the Pu'er tea extract has the advantages of guaranteeing the clarity of the finished products which are dissolved in cold water and hot water and reducing the work load of later centrifugation, along with low cost, industrialization and stable and controllable quality.

The invention discloses a preparation method of ganoderma lucidum polysaccharide with high yield, which comprises the following steps: firstly, crushing ganoderma lucidum fruiting bodies into ganoderma lucidum powder, then sequentially extracting the ganoderma lucidum powder by adopting a microwave-assisted hot water extraction method and an ultrasonic-assisted hot water extraction method, and carrying out concentration, impurity removal, concentration, alcohol precipitation and drying on the obtained extracting solution to obtain water-soluble ganoderma lucidum polysaccharide; and extracting the ganoderma lucidum residues by adopting an alkali extraction method, and carrying out neutralization, dialysis, concentration, impurity removal, alcohol precipitation and drying on the obtained extracting solution to obtain alkali-soluble ganoderma lucidum polysaccharide. The method is used for extracting the ganoderma lucidum polysaccharide by combining microwave heating action and ultrasonic cavitation and extracting the alkali-soluble polysaccharide in the ganoderma lucidum by utilizing the alkali extraction method, thereby reducing the loss of the ganoderma lucidum polysaccharide; and the prepared ganoderma lucidum polysaccharide has the characteristics of high production yield, strong immunological activity and the like.

Immunomodulator formulations for use in the treatment of disease of the GI tract. The formulations comprise a hydroxylase inhibitor and / or an immunosuppressant. Exemplary formulations comprise hydralazine as a hydroxylase inhibitor and / or cyclosporin A as an immunosuppressant.

The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.

Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

The invention relates to fresh flower food and the preparation method and the usage, which uses edible fresh flower petal of rose flower, safflower, chrysanthemum, lily, honeysuckle, sweet osmanthus, Chinese peony, apple blossom, shrubalthea flower or jasmine flower and other flowers as raw material and edible natural plants extractant of dogbane leaf, black currant leaf, sea buckthorn, medlar, dried dates, liquorice, rhodiola root, balm mint, Chinese yam, aloe and other plants as auxiliary material and adds honey and cane sugar through a plurality of yeasts and acetic acid bacteria mixing and fermenting. The invention takes order of principle for homology of medicine and food and realizes active ingredient dissolution and enhancing for drugs through modern biotechnology, overcomes prior problem of insufficient technology for fresh flower food and health care products. The fresh flower food and the preparation method and the usage has the advantages of having simple production technology, natural product color and pleasant flavor, benefiting qi and nourishing blood, maintaining the skin and restoring hair, resisting fatigue and depression and reducing blood fat and other corresponding healthcare functions, meeting requirements of different multitude and being widely used in production of healthcare products and cosmetic products.

A process for leaching laterite ores containing limonite and saprolite in a two stage process. The first stage consisting of mixing and reacting the ore with concentrated mineral acid, and the second stage consisting of preparing a slurry of the acid / ore mixture in water and leaching the mixture to dissolve nickel and cobalt. Iron is efficiently separated from nickel and cobalt in the solid leach residue primarily as an oxide or hydroxide of ferric iron other than jarosite.

A bilayer tablet comprises a first layer formulated for instant release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix and a second layer formulated for instant release of the calcium channel blocker amlodipine from a disintegrating or eroding tablet matrix.

The invention discloses a method for extracting rice protein by using rice, which comprises the following steps: soaking and grinding, rice milk adjustment, primary liquefying, centrifugal separation, homogenizing, washing, centrifuging, enzymolysis, enzyme inactivation, screen separation, washing, centrifuging, drying, crushing and packing so as to obtain the rice protein. The method overcomes the defects that the high-concentration alkali liquor has damage effect on rice protein amino acid in an alkali extraction process, the quality of the extracted rice protein is poor, and the purity and sanitary index of the extracted protein cannot reach the edible standard; and in other methods for extracting the rice protein by using enzyme preparations, the rice milk is liquefied at a temperature of over 95 DEG C and then is dried at the high temperature, so the rice protein is denatured, the color is darkened, and the function of the rice protein is damaged. The extracting method of the invention keeps good physical functionality of the rice protein, implements industrialization of the extraction and production of the rice protein, and meanwhile improves the production conversion rate and quality of rice starch sugar.

The present invention provides a rose sauce and the preparation process thereof. The rose sauce is produced by novel edible rose through the following steps: cleaning; beating; using 3% citric acid solution to adjust the pH value of slurry to 3.7 to 5.5; based on mass ratio, mixing a slurry obtained by 10 parts of fresh rose through the above-mentioned steps with 8 to 12 parts of white sugar, 4 to 8 parts of grape syrup, 1 part of honey, 0.01 parts of potassium sorbate, putting into a fermentation cylinder, heating to 65 DEG C-85 DEG C for sterilizing 10 to 30 minutes, cooling to 20 DEG C-50 DEG C; according to a proportionality that each g of fresh rose using 0.1-0.2u of cellulase and 0.2-1.0u of tannase , entirely dispersing and dissolving the two enzymes required by 10 parts of rose in 0.5 parts of sterile water; pouring the sterile water in the fermentation cylinder and mixing uniformly, hydrolyzing the mixture in the pot, wherein, the hydrolysis temperature is 20-50 DEG C, the hydrolysis time is 24-240 hours; and then heating to 90 DEG C, heat preservation 5 minutes to kill the enzymes activity, and then obtaining the products after cooling down to room temperature.

The invention discloses a gefitinib dispersible tablet, a preparation method and an application thereof. The gefitinib dispersible tablet of the invention comprises the following components by weight: 10-65% of gefitinib, 1-30% of fillers, 10-50% of disintegrants, 1-60% of acidifiers, 0.1-20% of adhesives, and 0.1-30% of lubricants and glidants. According to the invention, gefitinib is wrapped bythe acidifier or gefitinib and the acidifier are wrapped with each other so as to reach the embedding effect. Compared with commercially available common tablets, the gefitinib dispersible tablet of the invention does not contain surfactants, has good dissolvability, dispersibility and disintegrability, and can be disintegrated completely within one minute. The gefitinib dispersible tablet prepared by the method of the invention has a high dissolution rate, good bioavailability, rapid distribution in vivo, and stable quality, and the preparation method is simple and practical, and is applicable to industrial production.

The pharmaceutical compositions of the present invention comprise rectally and vaginally administerable dosage forms that contain effervescent agents as penetration enhancers for drugs. Effervescence occurs in the rectum or vagina, once the dosage form is administered or at a predetermined time following administration. The effervescent agents can be used alone or in combination with pH adjusting substance, which further promote dissolution and absorption of the active ingredient.

The invention belongs to the food processing field, and particularly relates to a microwave treatment method before oil crop seeds are cold-pressed to produce oil. A method for pre-treating oil crop seeds by using microwave is characterized by comprising the following steps of: (1) adjusting the mass water content of the oil crop seeds to between 7 and 30 percent, and stirring the oil crop seeds uniformly; (2) uniformly spreading the oil crop seeds after the water content adjustment in a container, adjusting microwave power and microwave time, and performing microwave treatment on the oil crop seeds to obtain a final temperature of between 80 and 150 DEG C; and (3) spreading and cooling the oil crop seeds after the microwave treatment, and then performing cold pressing or peeling and cold pressing to produce oil. The method for treating the oil crop seeds is favorable for increasing the yield of cold-pressed oil and improving the quality of the cold-pressed oil.

The invention discloses a preparation method for a tea extract, belonging to the technical field of extraction of effective components of tea leaves. The preparation method comprises the following steps: firstly, carrying out low-temperature rapid freezing treatment on high-quality commercial tea leaves; then immediately crushing; then combining a high-voltage pulsed electric field (PEF for short) technology, an ultrasonic treatment technology and a low-temperature enzymolysis technology; and carrying out low-temperature extraction in a whole process. According to the preparation method for the tea extract, the loss of effective components, caused by high-temperature processing, is avoided, and the extraction rate of the effective components of the tea leaves is also improved. The process is simple and low in cost; the introduction amount of extraneous food additives, processing auxiliary agents and chemical substances is reduced; the natural nutritional ingredient and the flavor of the tea leaves are kept to the greatest extent, the low-carbon production is realized and the environment is protected.

The invention discloses a CoFe2O4 / N / C hollow nanosphere and preparation and application thereof. The preparation comprises: complexing dopamine with cobalt and iron metal ions under the condition of pH8-9 on a template as a SiO2 nanometer sphere to form a polymer shell layer, carbonization annealing to form N-doped carbon material loaded with CoFe2O4 metal nanoparticles, and finally, removing the SiO2 template with strong alkali to obtain CoFe2O4 / N / C hollow nanosphere. In the invention, the N / C matrix hollow structure is prepared by using the SiO2 nanosphere as the sacrificial template, theCoFe2O4 / N / C hollow nanosphere has a relatively large specific surface area and porosity, and can improve the distribution of CoFe2O4 nano metal particles loaded on the shell layer, enhance adsorption and catalytic activity on organic pollutants in waste water, and broaden the pH application range; the CoFe2O4 / N / C hollow nanosphere can be recycled due to magnetic performance, thus saving resources.

The invention discloses a catalytical ozonization catalyst prepared by utilizing multi-source sludge and an application thereof, and establishes a method for preparing a sludge group active carbon catalyst for catalytical ozone oxidation organic industrial waste water. The method comprises the following steps of: utilizing multi-source sludge such as surplus sludge generated by urban sewage factory biochemical treatment and a metal sludge generated by a Fenton oxidation method, preparing a skeleton which is a sludge group active carbon through steps such as organic substance adding, actification, dehydration, drying, mixing, roasting and screening, wherein a surface layer contains a solid catalyst of metallic oxide, and the ratio of the sludge group active carbon and the metallic oxide in parts by weight is 1:(0.3-0.5). The catalyst is used for catalyzing ozone oxidation treatment organic industrial waste water and has higher catalytic activity and stability, the processing range is wide, the realization and popularization and application are easy, and the economic benefits are improved in an organic industrial waste water processing procedure.

The invention provides a method for extracting polysaccharides from bagasse, the method is: after degreasing the bagasse, using one or more of cellulase, papain and pectinase at pH 4-6, Hydrolyze at 40-80°C for 0.5-1.5 hours, then treat with ultrasonic waves with a frequency of 59KHz for 0.5-1.5 hours, filter, and finally use ethanol to precipitate polysaccharides in the filtrate. The method of the invention adjusts the type and amount of enzymes and the technological conditions of enzyme treatment and ultrasonic extraction on the basis of the process of extracting fungal polysaccharides, and finds a low energy consumption and high-efficiency method for extracting bagasse polysaccharides.