4785 results about "Natural product" patented technology

Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

A solid state water soluble formulation in granular or tablet form is provided. The formulation is a natural products formulation containing a green tea plant extract in combination with other ingredients which create an effervescent liquid composition upon dispensing the formulation in a liquid. The liquid form of administration, as well as the effervescent properties of the dissolved formulation increase bioavailability of the advantageous components of the green tea plants such as Polyphenols, by increasing absorption speed and amount in the human body. The formulation may include additional components such as, other plant extracts, vitamins, ionic minerals, and other substances purported to be of a health benefit.

Disclosed are improvements in human nutrition involving a unique combination of natural products constituting anti-inflammatory compositions which can reduce cardiovascular disease risks as well as play a positive role in other conditions and diseases for which key indicators, especially selected from the group consisting of C-reactive protein (CRP) levels, cyclooxygenase-2 (COX-2), 5-lypoxygenase (5-LOX) expression and prostaglandin E2 (PGE-2) biosynthesis or any combination of these, are indicators. Therapeutic compositions preferably comprise curcumin, bilberry extract, grape seed extract, green tea extract and apple extract, in effective amounts individually and combined to provide a therapeutically significant reduction in one or more key indicators. Another exemplified therapeutic composition comprises: omega-3 rich refined fish oil, resveratrol, blueberry extract, grape seed extract, green tea extract and gamma and / or delta tocopherol, in effective amounts individually for the above benefits.

A skincare product containing one or more dairy products, and one or more ingredients such as a natural oil, an herb, a fruit, a vegetable, a grain, honey, sea salt, egg yolk and mixtures thereof, for application to human skin in order to improve the well-being of said skin. The skincare product is applied to the skin in order to cleanse, beautify, promote attractiveness, and / or alter the feel or appearance of the skin. Furthermore, the skincare product is applied to the skin by rubbing, pouring, sprinkling, and / or spraying the skincare product onto the skin.

Processes for preparing extracts of natural products such as plant material, and for preparing purified extracts from crude extracts of natural products, by extraction with hot gas. Apparatus suitable for use in preparing extracts of natural products are also described.

Disclosed are stable, homogeneous dispersions, comprising (a) from about 20 to 90% by weight of a first composition comprising (i) about 60-95% by weight of a first polar solvent, (ii) about 0-40% by weight of one or more second polar solvents, and (iii) water soluble components of a first natural product; and (b) from about 10 to 60% by weight of a second composition comprising: (i) one or more apolar solvents, and (ii) oil soluble organic components of a second natural product; and (c) from about 0.01 to 80% by weight of a non-surface active lipid phosphate or a surface active agent. Also disclosed are methods of forming the stable, homogeneous dispersions of the invention, comprising forming a first composition comprising water soluble components of a first natural product; forming a second composition comprising oil soluble organic components of a second natural product; mixing the compositions and subjecting the mixture to high pressure high shear processing to form a stable, homogeneous dispersion.

A composition is provided that includes particulates from wood, chaff, hulls, crop compost, biochar, or waste residue, wood or crop ash and biochar, and a nitrogen source from waste residue from gasification processes, food processing waste water or other residual by-products of forest, aquatic, food or feed processing. Ideally, all of the components are environmentally friendly, from natural products, and free of manufactured chemicals.

Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

The invention discloses an eremophilane lactone compound with chemical name as 3beta-chiretta acyloxy group-eremophile-7(11)-alkylene-12, 8beta-lactone-14-acid, which can inhibit the biological activity of HL-60, CNE, KB, Hela and P338D1.

The invention involves A 1- beta-keto-5, 11(13)-diene eudesmane-12-acidum who has the structure as formula (1) shows and its medical salt, or solvate and its drug combinations and its medical usage in reducing hepatitis B surface antgien and inhibiting replication activity of aethyl- hepatovirus HBV-DNA medicinal. The invention compounds has strong inhibitory action in hepatitis B surface antgien (HBsAg) externalized by HepG2.2.15 cells and replication of aethyl- hepatovirus deoxyribonucleotide (HBV-DNA) in vitro, its inhibiting ability against HBsAg surpasses that of positive control Lamivudine in the same dose; it has obvious inhibiting ability against replication of aethyl- hepatovirus HBV-DNA under the concentration of 100 mu g / mL,20 mug / mL and 4 mug / mL DNA, it belongs to anti- aethyl- hepatovirus natural products of superactive non-nucleoside, can be expected for producing drugs for treating aethyl- hepatovirus infected disease.

Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds are disclosed. Such medical articles may include urinary catheters, central venous catheters, tracheal catheters, arterial grafts, wound dressings, sutures, or any other medical articles derived from polymeric substrates such as biomedical polyurethane, biomedical polyvinylchloride (PVC), biomedical silicon, biodegradable polymers, polytetrafluoroethylene (PTFE), etc. or from natural products including natural rubber, silk or cotton fiber. Antimicrobial compositions comprising salicylic acid and sesquiterpenoids are also disclosed.

The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. This invention relates to the use of cells and cellular extracts in rejuvenation and healing technologies thereby improving healing and regeneration of all bodily tissues and organs. The present invention relates to compositions and methods of managing, preventing, and treating scars. The invention also relates to prevention of deterioration, damage and malfunction of cells and tissues, and to promote, improve or exceed cellular function in order to promote, improve and exceed appearance, vitality and health. In some embodiments, the invention relates to compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.

The invention discloses an edible and medical fungus cell component comprehensive extraction method and use of extract, which belong to the technical field of natural product extraction and application. The method comprises: breaking walls of the cells of the edible and medical fungi by combining an enzymic process and ultrasonic waves; extracting the extract and fungus slag by processes of water extraction, alcohol extraction and fat extraction in different sequences to obtain various nutritive components and bioactive components, such as cellulose, protein, nucleic acid, polysaccharide and fatty acid. In the invention, due to the adoption of a wall breaking-first and extraction-second scheme, the extraction rate of the cell components of the edible and medical fungi is improved considerably; the extract is extracted by water extraction, alcohol extract and fat extraction in turn and the fungus slag is extracted by fat extraction, alcohol extraction and water extraction in turn, so the flavor of the edible fungi is retained effectively; the various cell components of the edible and medical fungi serving as raw materials are extracted comprehensively and further developed; and the extracted components are natural materials, have both nutritive and health-care and pharmacological effects and can be made into various products according to the characteristics of the extracted components.

The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and / or atmospheric pressure photoionization) for ionizing natural product and organic molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI / APCI multimode sources may include a corona needle shield and / or an auxiliary electrode.

A formulation has been developed for treatment of the symptoms of dry eye which incorporates the natural product jojoba wax, or components thereof, to enhance the spreading of the artificial tear and eyedrop as well as stabilize the eyedrop. The improved performance of the jojoba wax supplemented tear relieves irritation and discomfort as well as sharpens the blurred vision.

The invention provides a method for producing synthetic natural gas and a device thereof. The continuous technological process of the invention is realized in a way that gasified product gas is used as the raw material for producing high methane gas containing more than 94 mol% of methane. The method can well adjust the methanation reaction temperature and avoid the problems of catalyst temperature-runaway sintering and the like due to improper material composition, excessive fluctuation or unexpected accident, thereby reducing the recycle gas amount and enhancing the energy comprehensive utilization efficiency.

A jojoba formulation has been developed for administration to the meibomian gland, for treatment of the symptoms of dry eye, and / or for drug delivery to the meibomian gland. The formulation incorporates the natural product jojoba wax, or components thereof, to enhance the spreading of the artificial tear as well as stabilize the tear film. The jojoba wax tear relieves irritation and discomfort as well as sharpens the blurred vision. Jojoba, because of its close chemical and physical properties to meibomian gland secretions, is effective upon topical application to penetrate the lid margin to reach the gland tissues where it may exert a therapeutic effect with or without an adjunctive agent.

Application of a reference mixture of natural products for systematic analysis and comparison of the properties of biphasic solvent systems in counter-current / partition chromatography. Because the reference mixture is comprised of compounds with varying polarities, functional groups, and structural features it provides a rational method for mapping the optimal resolution polarity range of a particular solvent system. The mapping of optimal resolution polarity ranges of solvent systems provided for the description of the overall optimal resolution polarity range of a solvent system family, comprised of the same solvents in different proportions. By comparing the reference mixture performance in the individual members of a solvent system family, the solvent system that best functions as the representative of, or portal to, the solvent system families is determined. Use of the reference mixture also afforded a method to compare the overall optimal resolution polarity ranges of solvent system families. Based on performance of reference mixture chromatograms, the CCC properties of solvent systems, can be compared and their CCC potential examined. The methods of the invention employing the reference mixture provides was used to identify a quaternary solvent system, hexane / t-butylmethylether / acetonitrile / water (HterAcWat), which was found to be useful for CCC of mixtures containing natural products.

The invention discloses a natural Chinese herbal medicine animal feed additive which comprises the components in parts by weight: 5-40 parts of medicinal plant extract group I, 5-40 parts of medicinal plant extract group II, 1-10 parts of medicinal plant group, and 10-80 parts of natural mineral carriers. The natural Chinese herbal medicine animal feed additive disclosed by the invention can improve the immunity of livestock, prevent diseases, improve the survival rate, accelerate digestive absorption, improve the daily gain and the feed utilization ratio, lower the production cost and improve the meat quality. All raw materials are from natural products which are safe and non-toxic, rich in material and low in cost, so that the additive is convenient to popularize and apply.

Naturally occurring lipids of vegetable and animal origin are broken into smaller molecules, and used as dewatering aids. The process of breaking the molecules include transesterification, interesterification, and saponification followed by acidulation. The modified lipid molecules can adsorb on the surface of the particles to be dewatered and greatly enhance their hydrophobicity, which will help increase the rate of dewatering and hence reduce cake moisture. The modified lipids are more effective dewatering aids than the naturally occurring unmodified lipids, possibly because they can more readily form close-packed monolayers of hydrophobes on the surface of the particles.

Chitosan is a natural product having wide range of applications in the food and cosmetic industries. Food and commodity grade chitosan are laden with pyrogens, such as endotoxins and proteins which limit its applicability in the biological and medical arenas, as minute amounts of endotoxins may induce adaptive and innate responses when contacted with mammalian tissue, pharmaceuticals and biomedical devices. Due to chitosan's ability to avidly bind endotoxin and other pyrogens, they are difficult to remove. The present invention is directed to methods for purifying chitosan from shells, food and commodity grade chitosan into ultra-pure, low endotoxin chitosan having biological and medical applicability. Additionally, the present invention is also directed to a method of determining the pyrogenicity of the ultra-pure low endotoxin chitosan.

A safe and high-efficient environment-friendly feed comprises the following raw materials in terms of weight percentage: 6 to 20 percent of corn gluten feed, 3 to 25 percent of soybean meals, 1 to 20 percent of powder, 0 to 15 percent of rice bran, 0 to 40 percent of corn, 3.5 to 10 percent of rapeseed dregs, 1 to 5 percent of cotton seed meals, 1 to 5 percent of bone meals, 2 to 6 percent of fish meals, 1 to 6 percent of meat meals, 3 to 15 percent of wheat and right amount of additives. According to the required amounts of all nutritional components of the livestock in different growing stages, the invention combines energy feed, protein feed and various additives in equilibrium according to certain percentages by adopting a scientific method, thus leading various livestock to obtain the largest feed digesting rate and leading the livestock to absorb the feed to the largest degree; the excrement after the digestion of the livestock have no obvious smell and cause no pollution to the surrounded environmental sanitation and the environment protection after the feed being eaten is shown; moreover, no banned substances are added in the process of the feed processing and the feed is processed from natural products, which have no residue side effects on the livestock.

Methods for treating an individual having cancer are provided. The method may include administering a cell migration inhibitor and a chemotherapeutic agent to the individual to inhibit migration of cancer cell. Inhibiting cell migration may increase cell division. In this manner, the cell migration inhibitor and the chemotherapeutic agent in combination may have increased efficacy compared to the chemotherapeutic agent alone due to the increased cell division. The cell migration inhibitor may include any of the inhibitors described herein. For example, the cell migration inhibitor may be an organic molecule having a molecular weight of less than about 700, a monoclonal antibody, or a natural product.

The invention relates to the field of the traditional Chinese medicine, in particular to a method for extracting and separating 1-deoxynojirimycin (DNJ) with the purity higher than 98% from natural products comprising mulberry leaves, mulberry twigs, white mulberry root-bark, mulberry fruit and silkworm litter and also preparing a 1-deoxynojirimycin crude product (with the purity more than 35%), protein feeds, crude flavone and refined polysaccharide (with the purity more than 90%). The method mainly comprises the following steps: extracting a raw material of dry powder by a hydrophilic solvent, soaking by anion exchange resin after acidizing and concentrating extracting liquid, carrying out chromatography by a cation exchange column after concentrating effluent liquid and water washing liquid, extracting by an organic solvent, recrystallizing, carrying out chromatography by a gel column and purifying. The content of the 1-deoxynojirimycin in the obtained product is not less than 98%,and the concrete execution already enters intermediate test.

The invention provides an extraction method and a device used for extracting ultrasonic reinforced sub-critical water of effective component of a natural outcome. The method is mainly characterized in that a pre-disposed raw material is arranged in an extraction kettle; the sub-critical water is taken as an extraction solvent to carry out the exaction under the conditions of 1 to 20MPa of extraction pressure, 50 to 500W of ultrasonic power and 20 to 80KHz of ultrasonic frequency. The method has high extraction efficiency and short extraction time. The device is mainly characterized in that the extraction kettle is provided with an ultrasonic reinforced part which comprises an ultrasonic generator and an energy changing head; the ultrasonic generator is arranged on the external surface of the extraction kettle and at the upper part of the extraction kettle; the energy changing head and the extraction kettle cover are processed into a whole; the piezoelectric ceramic wafer of the energy changing head is arranged at the upper end of the extraction kettle cover; the variable-spoke rod of the energy changing head is directly arranged in the extraction kettle by the extraction kettle cover. The device can carry out selectable exaction of the articles to be extracted by changing the extraction parameters (temperature, pressure, time, etc.), thus realizing static extraction or dynamic circulation extraction.

A method of dewatering fine particulate materials is disclosed. In this method, an aqueous slurry of fine particles is treated with appropriate hydrophobizing reagents so that the particulate material becomes moderately hydrophobic. A lipid of vegetable or animal origin is then added to the slurry in solutions of light hydrocarbon oils and short-chain alcohols, so that the hydrophobic lipid molecules adsorb on the moderately hydrophobic surface and, thereby, greatly enhance its hydrophobicity. By virtue of the enhanced hydrophobicty, the water molecules adhering to the surface are destabilized and more readily removed during the process of mechanical dewatering. The moisture reduction can be further improved using appropriate electrolytes in conjunction with the lipids, spraying surface tension lowering reagents onto the filter cake, subjecting the cake to a suitable vibratory means, and using combinations thereof.

The present invention provides silica-based reversed-phase HPLC methods that lead to higher retention of the analytes in the column and longer column lifetimes than usually observed under medium to high pH aqueous mobile phase conditions. The inventive methods comprise eluting the HPLC column using an aqueous mobile phase comprising at least one fluorinated additive. Preferred additives are polyfluorinated alcohols such as 2,2,2-trifluoroethanol and 1,1,1,3,3,3-hexafluoroisopropanol. The methods of the present invention may be used for analyzing, separating, purifying, and / or isolating small organic molecules, natural products, as well as biomolecules such as polypeptides, oligonucleotides and polynucleotides (e.g., DNA fragments).