The invention discloses an extraction method of pawpaw polyphenol. The method comprises the following steps: firstly washing and denucleating pawpaw, cutting into small blocks for standby use, then after mixing the pawpaw small blocks with low congruent melting reagent-water mixed solution, using a stamping machine, preparing into pulp, using a microwave-ultrasonic technology to treat the pulp, filtering to obtain a filter liquor, finally adding salt into the filter liquor, carrying out vortex centrifugal to form an aqueous two phase, after taking the lower phase of the aqueous two phase, adding a certain amount of methyl alcohol therein, carrying out vortex centrifugal, separating a methyl alcohol upper phase, and evaporating a solvent to obtain an extractive rich in pawpaw polyphenol. The pawpaw polyphenol is extracted by adopting the extraction method, the extraction efficiency of the pawpaw polyphenol can be obviously improved, the extraction time is saved, the using of an organic solvent can be reduced furthermore, and the extraction method is more environment-friendly. Moreover, the polyphenol extractive obtained in the invention can be directly applied to the products such as toothpastes, facial cleansers, shampoo, liquid makeup and hand cream without subsequent purification, and the used product has efficient oxidation resistance.