1699results about How to "Promote maturity" patented technology

Vaccines that target one or more antigens to a cell surface receptor improve the antigen-specific humoral and cellular immune response. Antigen(s) linked to a domain that binds to a cell surface receptor are internalized, carrying antigen(s) into an intracellular compartment where the antigen(s) are digested into peptides and loaded onto MHC molecules. T cells specific for the peptide antigens are activated, leading to an enhanced immune response. The vaccine may comprise antigen(s) linked to a domain that binds at least one receptor or a DNA plasmid encoding antigen(s) linked to a domain that binds at least one receptor. A preferred embodiment of the invention targets HIV-1 env antigen to the CD40 receptor, resulting in delivery of antigen to CD40 positive cells, and selective activation of the CD40 receptor on cells presenting HIV-1 env antigens to T cells.

The invention discloses a flower organic-inorganic slow-release fertilizer as well as the preparation method thereof. The slow-release fertilizer contains the following materials by weight: primary fermentation products of 45 to 70 percent, chemical fertilizers of 2 to 35 percent, a conditioner of 5 to 30 percent, coating materials of 3 to 25 percent, an agglutinant of 1 to 10 percent, active materials of 0 to 15 percent and a sealant of 0 to 12 percent; the primary fermentation products, the chemical fertilizers and the conditioner are mixed for carrying out the secondary fermentation of composting, and then the products of the second fermentation are crushed for press molding; finally, compound fertilizer particles formed by the press molding are evenly sprayed with the coating materials and the agglutinant, thereby obtaining the flower organic-inorganic slow-release fertilizer; the flower organic-inorganic slow-release fertilizer of the invention has the advantages that the nutrition is rich, the composting process is fast, the rotten degree is good, the fertilizer is prone to be absorbed by flowers, the manufacturing process is simple, and the use is convenient.

The present invention pertains to a composition for inducing a pattern of gut barrier maturation similar to that observed with breast-feeding and able to improve gut barrier maturation, e.g. during neonatal stress. In particular, the present invention relates to an infant formula containing a combination of specific ingredients designed to provide a synergistic effect all along gastrointestinal tract and barrier function.

Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

Atherosclerotic plaque and blood vessels may be stabilized by directing vibrational energy, typically ultrasonic energy, into the adjacent blood vessel wall. Application of the vibrational energy, optionally in combination with growth factors, growth factor genes, or other substances which enhance growth instability of a fibrotic cap over the plaque, will reduce the risk of rupture of unstable plaque and inhibit the conversion of stable plaque into unstable plaque.

This invention concerns a method for stimulating barrier integrity in a subject by administering to a subject a composition comprising docosapentaenoic acid (22:5 n3; DPA). Also the invention concerns a composition comprising DPA and eicosapentaenoic acid (EPA).

The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is employed. In particular cases, the chimeric receptor comprises antibody, cytoplasmic signaling domain from the T cell receptor, and / or costimulatory molecule(s).

The invention provides cell-adherent polymeric coatings for articles having a nanofibrillar structure. The coatings include a synthetic, non-biodegradable polymer having at least one pendent amine group, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long term culturing of cells using the polymer coated nanofibrillar structures. The polymer coated nanofibrillar structures of the invention have been found to be particularly useful for the growth and differentiation of cells, including neural precursors.

The invention discloses traditional Chinese medicine organic fertilizer. The traditional Chinese medicine organic fertilizer comprises sweet wormwood herb, green Chinese onion, sophora flavescens, yellow soybean, salvia miltiorrhiza, perilla stem, castor root or castor leaf, salvinia natans, onion, peach leaf, camphor, tripterygium wilfordii, agaric, pine needle, plantain seed, lime, honeysuckle, frankincense, Chinaberry bark, Chinese yam, potash, carrot leaf, radish leaf, poria cocos, pyrethrum, belvedere fruit, pseudo-ginseng, negundo chastetree fruit, mulberry leaf, hot pepper leaf, ginger leaf, phoenix tree flower, tobacco, pepper and suberect spatholobus stem. The fertilizer can improve the soil structure, so that the soil is abundant in organic matters and soil hardening caused by excessive using amount of chemical fertilizer is avoided; a good effect of increasing yield is achieved; the fertilizer can expel, kill and prevent insects, reduces the using amount of pesticide or does not use the pesticide, contributes to environmental protection, and reduces the pesticide residue of agricultural products or has no pesticide residue in the agricultural products; the fertilizer can inhibit generation and growth of harmful germs and reduce the number of the harmful germs so as to reduce the morbidity of crops and solve the problem of continuous cropping; and the cost is low.

Atherosclerotic plaque and blood vessels may be stabilized by directing vibrational energy, typically ultrasonic energy, into the adjacent blood vessel wall. Application of the vibrational energy, optionally in combination with growth factors, growth factor genes, or other substances which enhance growth stability of a fibrotic cap over the plaque, will reduce the risk of rupture of unstable plaque and inhibit the conversion of stable plaque into unstable plaque.

The invention provides a general aviation flight monitoring airborne system based on an ADS-B (Automatic Dependent Surveillance-Broadcast). The system comprises an airborne ADS-B transceiver based on UAT (Ultra Aperture Terminal)\1090ES (Echo Sounding), a message processor based on the ADS-B and an airborne CDTI (Cockpit Display of Traffic Information) based on the ADS-B. The system provided by the invention has an ADS-B OUT / IN function and can be used for coding information input by an airborne FMS (flight management system), a GNSS (Global Navigation Satellite System), a barometric altimeter and a pilot, generating a message and broadcasting the message; and the system can receive flight status ADS-B messages of other airplanes and ground monitoring messages and separate UAT signals from 1090ES signals by virtue of a UAT data chain and a 1090ES data chain. The system provided by the invention can be used for respectively verifying, storing and parsing the flight status of the other airplanes\ground monitoring messages, messages of a local airplane, heartbeat messages of a host, graphical display navigation information, traffic information of the local airplane and traffic information of the other airplanes within a certain range of the local airplane.

The invention relates to preparation method and application method of a grape special fertilizer, wherein the preparation method comprises the following steps: preparing an I-type fertilizer by taking the following ingredients in parts by weight: 30-40 parts of urea, 20-30 parts ammonium phosphate, 15-30 parts of potassium sulphate, 1-3 parts of humic acid, 1-3 parts of excrement, 1-5 parts of synergist, 0.1-1.0 part of ferrous sulphate, 0.1-0.8 part of zinc sulfate, 0.1-0.6 part of manganese sulphate, 0.1-0.6 part of borax, 0.1-0.4 part of copper sulfate, 3-7 parts of plaster and 3-13 parts of bentonite; preparing an II-type fertilizer by taking the following ingredients in parts by weight: 7-15 parts of urea, 25-35 parts ammonium phosphate, 35-45 parts of potassium sulphate, 1-3 parts of humic acid, 1-5 parts of excrement, 2-5 parts of synergist, 0.1-1.0 part of ferrous sulphate, 0.1-0.8 part of zinc sulfate, 0.1-0.6 part of manganese sulphate, 0.1-0.6 part of borax, 0.1-0.4 part of copper sulfate, 3-7 parts of plaster and 3-13 parts of bentonite; and blending, spraying, pelleting and drying at lower temperature to obtain the product. The application method of the fertilizer comprises the following steps: taking an organic fertilizer and the II-type fertilizer as a base fertilizer; applying the I-type fertilizer before blossom, applying the II-type fertilizer in the young fruit development period, and meanwhile, respectively spraying monopotassium phosphate and rare earth mixed liquid once on the leaf surfaces; and spraying calcium nitrate or calcium acetate to enhance the storage resistance property before picking.

The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally configured for growth of cells in an anatomically correct adult phenotype in vitro. In particular, described herein are nanotextured substrates which are structurally configured for the anisotropic organization, maturation, and growth of in vitro-differentiated muscle cells, such as cardiomyocytes, and methods for the production and use thereof in varying sizes, nanotextures and substrate rigidities. In vitro-differentiated cardiomyocytes grown on the nanotextured substrates described herein are better-differentiated and more closely mimic adult cardiac tissue than the same cells grown on a non-textured substrate of the same composition. The nanotextured substrate / cell constructs provide a platform for screening to predict the effect of test agents or drugs on, for example, human cardiac tissue, including patient-derived tissue, or for the identification of agents that effect various cardiac functional parameters.

Vaccines that target one or more antigens to a cell surface receptor improve the antigen-specific humoral and cellular immune response. Antigen(s) linked to a domain that binds to a cell surface receptor are internalized, carrying antigen(s) into an intracellular compartment where the antigen(s) are digested into peptides and loaded onto MHC molecules. T cells specific for the peptide antigens are activated, leading to an enhanced immune response. The vaccine may comprise antigen(s) linked to a domain that binds at least one receptor or a DNA plasmid encoding antigen(s) linked to a domain that binds at least one receptor. A preferred embodiment of the invention targets HIV-1 env antigen to the CD40 receptor, resulting in delivery of antigen to CD40 positive cells, and selective activation of the CD40 receptor on cells presenting HIV-1 env antigens to T cells.

The invention relates to a process for producing organic fertilizers, in particular to a process for producing composts by employing the method of compost fermentation, wherein the process comprises: selecting filthy mud as main fermenting raw materials, adding a conditioner in the filthy mud to adjust the carbon nitrogen ratio between 15 and 30, then adding catalytic bacteria, finally performing compost fermentation, wherein the conditioner is capable of employing castoffs as animal wastes, sawdust, wooden meals, traditional Chinese medicine dregs, straws, leave and the like and the castoffs have rich organic contents. The nutrition composition of organic base material which are fermented is more reasonable via controlling carbon nitrogen ratio in the invention, and the invention uses filthy mud which urgently needs to be handled to replace the conventional night soils and straws to be main raw materials of the composts, changes waste into valuable, and has certain effect for improving urban environment.

The invention concern the use of a virus for the preparation of a medicament for the vaccination or treatment of a neonatal or prenatal animal, including a human, wherein the virus is capable of infecting the cells of the neonatal or prenatal animal, including a human, but not capable of being replicated to infectious progeny virus in the neonatal or prenatal animal, including a human. The virus is preferably a Modified Vaccinia Virus Ankara. In particular, the invention concerns the vaccination of neonates against infections with viruses belonging to the same virus group than the virus used for vaccination. Moreover, the invention concerns the vaccination of neonates against antigens selected from foreign antigens and tumour antigens, wherein the tumour antigen and / or the foreign antigen are different from the antigens associated with the virus. The invention further concerns the use of viruses as defined above to increase the level of factors which activate dendritic cells or their precursor cells and / or to increase the number of dendritic cells or their precursor cells and / or to increase the production and / or cellular content of an interferon (IFN) or IL-12.

Compositions and methods for improving the nutritional and physiological status of a woman and her child during all stages of pregnancy are provided herein. This includes pre-conceptional women, pregnant women, and post-natal women (both lactating and non-lactating mothers). The compositions are particularly useful for the neurological, visual, and cognitive development of an embryo, fetus, or infant and the nutritional and physiological well-being of the mother, fetus, and infant. The compositions contain one or more folates, such as a reduced folate and / or folic acid, and one or more essential fatty acids (EFA), such as an omega-3 and / or omega-6 fatty acid. The addition of the essential fatty acid improves upon the folate containing nutritional preparations described in the prior art. The one or more folates and essential fatty acid may be administered together or in separate dosage units. The one or more folates may be selected from folic acid / folate, one or more reduced folates, or a combination of folic acid / folate and one or more reduced folates. The reduced folate is preferably 5-methyltetrahydrofolate, and most preferably 5-methyl-(6S)-tetrahydrofolic acid. The essential fatty acid is preferably an omega-3 fatty acid, and is preferably docosahexenoic acid (DHA) derived from a vegetarian or non-fish source. The compositions may optionally contain other vitamins, minerals, and ingredients, such as, emollient laxatives—all defined herein as “optional or other ingredients”.

The invention belongs to the technical field of manufacture engineering, relates to a manufacture technology method of a high-performance composite material pipe mold element, and particularly relates to a method for forming a composite material pipe mold element by pressurizing air bags with assistance of resin film transfer. According to the invention, a dry state fiber fabric and a thermoset resin adhesive film act as a base of a material, so that the method has the multiple advantages of reducing the manufacture cost obviously, improving the production efficiency effectively, expanding the application range of the manufacture technology extremely and the like. Compared with the traditional prepreg-autoclave technology, the fiber / adhesive film pre-dipping process is saved, so that on one hand, the using of a pre-dipping machine is prevented, and the cost of production equipment is reduced obviously, and on the other hand, the reduction of manufacture links improves the production efficiency effectively; additionally, most importantly, as for manufacture of pipe mold elements with the dry state fiber structure incapable of being treated by the pre-dipping mode, such as fiber 2.5D / 3D braided structure, the technology provided by the invention can also be used, and the technology application range is expanded extremely.

An aqueous elastomer dispersion includes a dispersed phase and an aqueous phase. The dispersed phase includes an elastomer including curable aliphatic conjugated-diene elastomers, such as polyisoprene, and a minor amount of at least one additive. The aqueous phase includes water and other optional components in either a soluble state or a dispersion state. The aqueous elastomer dispersion may be prepared by dissolving an elastomer, such as rubber, and additives in a solvent mixture and then converting the resulting solution into an aqueous emulsion. The aqueous emulsion is concentrated and the solvent is stripped from it to yield a dilute latex. The dilute latex that is obtained is concentrated again. Articles made from the aqueous elastomer dispersion include medical gloves, condoms, probe covers, dental dams, finger cots, catheters and the like.

The invention relates to a well drilling method of a through tubing of a gas lift under-balanced coiled tubing, which is applied in the technical field of petroleum well drilling. The through tubing operation way of the coiled tubing is adopted for carrying out under-balanced well drilling or low-pressure well drilling on target well sections at the lower part in a shaft with a drilled upper borehole, wherein the target well sections are a vertical well, a directional well or a horizontal well. The method has the following effects: the adoption of the through tubing operation of the coiled tubing can form three circulation channels by utilizing the coiled tubing, an oil tube and a sleeve, and a matching pipe column has good universality, does not need a special drilling column or an inner tube and does not need to use a rotary blowout preventer and other special equipment; a gas injection channel and a slurry injection channel are independent mutually, thereby being capable of more conveniently controlling the well bottom pressure and the under-pressure value and using an underground power drilling tool and a slurry pulse measurement system which are applicable to slurry well drilling to carry out well drilling operation and trajectory control; and the method does not need to be connected with a single and can keep the continuous circulation during the tripping process and the drilling process, and realize the full-process controllable under-balanced well drilling operation and the full-process controllable low-pressure well drilling operation.

The invention relates to a formulation technology of the compound feed for carps. The compound feed is prepared from the following raw materials in percentage by weight: 20-30 percent of soybean meal CP 46%, 18-23 percent of cottonseed meal CP 45 %, 12-18 percent of rapeseed cake, 4-10 percent of imported fish meal, 13-20 percent of wheat, 4-9 percent of rice bran, 2-10 percent of maize gluten feed, 1.6-3 percent of soybean oil, 1-2 percent of calcium biphosphate, 0.1-0.3 percent of salt, 0.15-0.3 percent of choline chloride 50% of content and 0.7-1.3 percent of carp premix compound, and the sum of the components is 100 percent. The compound feed for carps, which is prepared by the formulation of the compound feed for carps, enables carps to grow rapidly and have high single birth and strong disease resistance and has low bait factor, decreased culture cost and obvious economic benefits.

The artificial inoculation and controlled fermentation process of producing traditional bean jam belongs to the field of improved and industrialized production process of traditional food. The production process of bean jam has artificial inoculation to prepare yeast, temperature control in the fermentation stage, addition of saccharomycete and lactic acid bacillus in proper fermentation stage, and simulation of natural fermentation process to promote the bean jam mature. The said production process has shorted period less than 50 days while maintaining the flavor of the traditional fermented bean jam unchanged basically.

A cell population cultured ex-vivo in a culture medium under conditions permitting cells of the cell population to proliferate and, at the same time, reducing a capacity of the cells in utilizing cooper, the cells are hence expanded yet not further differentiated as compared to ex-vivo seeded cells from which the cell population developed.

The invention discloses an intrusion detection method based on an incremental GHSOM (Growing Hierarchical Self-organizing Maps) neural network, and belongs to the technical field of network information safety. The method comprises the following steps: 1), acquiring network data online and inputting the network data to an intrusion detection module; 2), calculating a triumph nerve cell t capable of detecting a current vector quantity x by the intrusion detection module; 3), using t to detect x if t is a covering nerve cell and is of the same kind with t; otherwise, putting an unknown attack type tag on x and adding x into an incremental training set; 4), when t meets the expanding conditions, expanding a virtual nerve cell t' from the lower part of t and then expanding a new SOM (Self-organizing Maps) from t', and using an incremental training set It corresponding to t to carry out training; 5), searching a mature father nerve cell of a newly expanded SOM subnet, and if the mature father nerve cell exceeds the conditions for deleting an immature subnet, then training the immature neural network expanded dynamically again; and 6), judging the occurrence of the intrusion according to a detected result output by the intrusion detection module. The intrusion detection method can be used for timely detecting various intrusion behaviors, in particular to the newly emerging intrusion behaviors.

A method for encouraging maturation and growth of a plant includes a provision of at least one stroboscopic lamp disposed adjacent the plant. The stroboscopic lamp is cycled through at least one on-period and at least one off-period for a predetermined cycling time. The plant is exposed to strobed high-intensity light during the at least one on-period, and not exposed to strobed high-intensity light during the at least one off-period. A maturation rate and the growth of the plant are thereby encouraged. A related system includes the at least one stroboscopic lamp and a controller for controlling the stroboscopic lamp according to the method, for encouraging maturation and growth of the plant.

A medical lead includes a pitted, grooved or threaded electrode array tip and a flexible tube or sheath encompassing the electrode array located near the lead tip. In some embodiments, the electrode array adheres to tissue, the tube or sheath adheres to the electrode array at the distal end of the electrode array or the tube or sheath adheres to tissue at the proximal end of the tube or sheath. Embodiments of the tube or sheath may be made from biodegradable material and can include electrode windows spaced along the tube or sheath corresponding to placement of electrode contacts of the electrode array.

The invention relates inter alia to a method for inducing a long-term protection in an animal against foreign antigens and tumor antigens comprising the step of administering to the animal at least one factor selected from type I interferons and Flt-3, and to a method for inducing a long-term increase of the number of dendritic cells in an animal comprising the step of administering to the animal a factor selected from type I interferon and Flt-3 and to a method of inducing or enhancing the maturation and / or for the activation of the immune system of an animal comprising the step of administering to the animal a factor selected from type I interferon and Flt-3.