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42results about How to "Growing population" patented technology
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Methods and Systems For Distribution of a Mobile Wallet for a Mobile Device
InactiveUS20080126145A1Financial transaction facilitatedPromote disseminationFinanceTelephonic communicationPaymentWireless mobile devices
Methods and systems for distributing a mobile device application for use in making and receiving payments utilizing a mobile device such as a mobile telephone (cellphone) or wireless connected personal digital assistant (PDA). A downloadable mobile device application, when installed on a compatible mobile device, is operative for communicating with a mobile financial transaction system (MFTS) that facilitates the making and receiving of payments via wireless mobile devices. The downloadable mobile device application is provided via a download system that downloads the application to mobile devices according to download procedures appropriate for a particular type of mobile device. When a payment is made to a payee having a mobile device, system communicates a message to the payee's mobile device that informs that a payment has been made and instructs the payee about the downloadable mobile device application. If the mobile device user / payee downloads and installs the mobile device application on his or her mobile device and provides enrollment information, interaction between the MFTS and the mobile device user / payee is permitted, and payment is provided to the mobile device user as user / payee.
Owner:QUALCOMM INC
Methods and systems for distribution of a mobile wallet for a mobile device
InactiveUS8489067B2Promote disseminationGrowing populationFinanceTelephonic communicationPaymentWireless mobile devices
Owner:QUALCOMM INC
Coatings containing polycationic peptides for cardiovascular therapy
InactiveUS7217426B1Growing populationSurgeryPharmaceutical non-active ingredientsMedical deviceBiomedical engineering
Owner:ABBOTT CARDIOVASCULAR
Methods to mobilize progenitor/stem cells
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formulaZ-linker-Z′ (1)or pharmaceutically acceptable salt thereofwherein Z is of the formulawherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1–20 atoms,Z′ is of the formula—Ar(Y)j;wherein Ar is an aromatic or heteroaromatic moiety, and each Y is independently a non-interfering substituent and j is 0–3; and“linker” represents a bond, alkylene (1–6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
Owner:GENZYME CORP
Methods to mobilize progenitor/stem cells
Certain nitrogen-containing compounds that bind the chemokine receptor CXCR4 are able to mobilize progenitor and / or stem cells into the peripheral blood to permit harvesting them for stem cell transplantation.
Owner:GENZYME CORP
Method for chondrocyte expansion with phenotype retention
The present invention provides a method that maintains chondrocyte phenotype during serial expansion by culturing a population of chondrocytes in a defined serum-free culture medium containing cytokines and on a substrate that is modified by covalent attachment of hyaluronic acid. The underlying principle is to maintain native chondrocyte phenotype by growing the dissociated chondrocytes on a substrate modified by covalent attachment of hyaluronic acid to retain native chondrocyte morphology and function. Chondrocyte expanded in this manner can be used in various medical applications to repair cartilaginous tissues that have been injured by trauma or disease. This substratum provides a microenvironment that more closely mimics that of native articular cartilage, thereby promoting chondrogenesis in a predictable manner.
Owner:ZIMMER INC +1
Methods and compositions for modulating the mobilization of stem cells
InactiveUS20070190023A1Enhance mobilizationPrevent egressBiocidePeptide/protein ingredientsDiseaseCXCR4
Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells from the bone marrow to the peripheral blood are disclosed. In particular, the invention relates to the use of adrenergic agonists that act in concert with a mobilization compound or agent. The mobilization agent(s) may act to decrease the expression or function of the chemokine, CXCL12, or may act to block or antagonize CXCR4. The invention also relates to methods of using these compounds or agents for enhancing the mobilization of hematopoietic stem cells when harvesting of the stem cells is necessary for the treatment of diseases, disabilities or conditions whereby transplantation of such cells would be beneficial in ameliorating the symptoms associated with such diseases, disabilities or conditions. Methods of screening for novel agents and pharmaceutical compositions comprising these agents are also disclosed.
Owner:MT SINAI SCHOOL OF MEDICINE
Methods to mobilize progenitor/stem cells
ActiveUS20050043367A1Expand the populationIncrease productionAntibacterial agentsBiocideProgenitorAryl
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formulaZ-linker-Z′ (1)or pharmaceutically acceptable salt thereof wherein Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ is of the formula—Ar(Y)j;wherein Ar is an aromatic or heteroaromatic moiety, and each Y is independently a non-interfering substituent and j is 0-3; and “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
Owner:GENZYME CORP
Methods and devices for laser desorption chemical ionization
InactiveUS6838663B2Growing populationSamples introduction/extractionMaterial analysis by optical meansDesorptionGas phase
The subject invention pertains to a methods and devices for ionizing a sample material. The subject invention also relates to an ionization source and to a method of sampling gas-phase ions from a sample. An ionization source in accordance with the subject invention can be used in conjunction with mass spectrometry or other sampling techniques. The subject invention can utilize a means for desorbing gas-phase ions and neutral molecules from a sample and a means to generate reagent ions where the reagent ions ionize the desorbed neutral molecules so as to increase the population of gas-phase ions. The subject invention can incorporate laser radiation for desorbing gas-phase ions and neutral molecules from a sample. In a specific embodiment, the subject invention provides an ionization source that uses a pulsed laser for desorption, so as to produce a population of desorbed neutral molecules from a sample, as well as a number of gas-phase sample ions. In a further specific embodiment, the pulsed laser radiation can be adjusted such that neutral molecules are desorbed without the production of gas-phase sample ions by the laser radiation.
Owner:FLORIDA UNIV OF A FLORIDA
EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
InactiveUS20050054097A1Reduce capacityGrowing populationBiocideHepatocytesPopulationMolecular biology
Ex-vivo methods of expanding hematopoietic stem cells of hematopoietic mononuclear cells that comprise a major fraction of hematopoietic committed cells and a minor fraction of hematopoietic stem and progenitor cells, expanded populations of hematopoietic stem cells obtained thereby and their uses are disclosed.
Owner:GAMIDA CELL
Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
InactiveUS20040076603A1Inhibition of differentiationGrowing populationPeptide/protein ingredientsCulture processPopulationMolecular biology
Owner:GAMIDA CELL
Polycationic peptides for cardiovascular therapy
Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coating includes polycationic peptides, for example R7.
Owner:ABBOTT CARDIOVASCULAR
Mobilization of hematopoietic stem cells
ActiveUS8383124B2Effective levelingGrowing populationBiocidePeptide/protein ingredientsHematopoietic progenitor cellsBone marrow
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and / or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
InactiveUS7344881B2Inhibition of differentiationGrowing populationCulture processMammal material medical ingredientsProgenitor cellEx vivo
Ex vivo and in vivo methods of expanding a population of stem and / or progenitor cells, while at the same time reversibly inhibiting differentiation of the stem and / or progenitor cells by providing the stem and / or progenitor cells with an effective amount of at least one copper chelate, so as to maintain a free copper concentration available to said cells substantially unchanged, to thereby expand the population of said stem and / or progenitor cells, while at the same time reversibly inhibit differentiation of said stem and / or progenitor cells.
Owner:GAMIDA CELL
Mobilization of hematopoietic stem cells
ActiveUS20130202553A1Effective levelingGrowing populationBiocidePeptide/protein ingredientsHematopoietic Stem Cell MobilizationSurgery
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and / or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
Methods and compositions for modulating the mobilization of stem cells
InactiveUS7939057B2Enhance mobilizationPrevent egressBiocidePeptide/protein ingredientsDiseaseAdrenergic receptor agonists
Owner:MT SINAI SCHOOL OF MEDICINE
Piezoelectricity modulated release rate of drug from a coating
InactiveUS8241653B1Low release rateExpand the populationSurgeryCatheterControlled releaseActive agent
Provided herein is a method of controlling release rate of a bioactive agent from an implantable medical device comprising a coating, a coating on the implantable device and a method of making the coating.
Owner:ABBOTT CARDIOVASCULAR
Use of computationally derived protein structures of genetic polymorphisms in pharmacogenomics and clinical applications
InactiveUS20060141480A1Expand the populationReduce adverse side effectsMicrobiological testing/measurementBiological testingComputer basedMolecular biology
Provided herein are computer-based methods for generating and using three-dimensional (3-D) structural models of target molecules and databases containing the models. The targets can be protein structural variants derived from genes containing polymorphisms. The models are generated using molecular modeling techniques and are used in structure-based drug design studies for identifying drugs that bind to particular structural variants in structure-based drug design studies, to design allele-specific drugs and population-specific drugs and for predicting clinical responses in patients. Computer-based methods for predicting drug resistance or sensitivity via computational phenotyping are also provided. Databases containing protein structural variant models are also provided.
Owner:SAPIENT DISCOVERY
Methods to mobilize progenitor/stem cells
InactiveUS20060223180A1Growing populationIncrease productionAntibacterial agentsBiocideProgenitorOxygen
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and / or may be fused to an additional ring system; or Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
Owner:GENZYME CORP
Modified fc fusion proteins
InactiveUS20160024179A1Expand the populationLong half-lifeImmunoglobulin superfamilyPeptide/protein ingredientsDiseaseOligosaccharide
Preparations of modified Fc fusion peptides that exhibit metabolically complete or near-complete oligosaccharide structures are provided. Also provided are methods for preparation of the modified Fc fusion peptides. These preparations exhibit enhanced serum half-life and are useful for treatment of a variety of diseases.
Owner:PYRANOSE BIOTHERAPEUTICS
Mobilization of hematopoietic stem cells
ActiveUS20110020274A1Reduce in quantityImproved cancer therapyBiocidePeptide/protein ingredientsHematopoietic progenitor cellsBone marrow
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and / or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
Methods for use of a sensitive layer for hydrogen sulphide detection with saw/baw devices
InactiveUS20090280031A1Expand the populationHigh site densityMaterial analysis using sonic/ultrasonic/infrasonic wavesMaterial analysis by electric/magnetic meansPiezoelectric quartzVolumetric Mass Density
Methods can be adapted for design of a sensitive monolayer for detection of hydrogen sulphide at room temperature with SAW / BAW devices. The sensitive monolayer can be synthesized based on chemical compounds, which belongs to a class of thiacalix[n]arenas, mercapto halides, mercapto alcohols and chloromethylated thiacalix[n]arenas. The sensitive monolayer can be directly immobilized or anchored at the surface of a piezoelectric quartz substrate in a covalently bonded manner by means of direct printing process. The piezoelectric quartz substrate can be activated in basic medium or in acid medium before the immobilization of the sensitive monolayer in order to increase the population of OH groups. Thus, the synthesized sensitive monolayer exhibits a high site density, fast response and long-term stability for H2S sensing.
Owner:HONEYWELL INT INC
Methods for increasing blood flow and/or promoting tissue regeneration
Methods for increasing blood flow and / or regenerating tissue using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′) wherein Z is a cyclic polyamine containing 9-32 ring members of which 2-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and / or may be fused to an additional ring system; or Z is of the formula (I) wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms; Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n-X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; or Z is of the formula —Ar(Y)j; wherein Ar is an aromatic or heteroaromatic moiety, and each Y is independently a non-interfering substituent and j is 0-3; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
Owner:GENZYME CORP
TGF-alpha polypeptides, functional fragments and methods of use therefor
InactiveUS7329645B2Expand the populationGrowing populationBiocideNervous disorderPrecursor cellBiology
Disclosed are TGF-α polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.
Owner:APPLIED PROTEIN SCI
TGF-Alpha POLYPEPTIDES, FUNCTIONAL FRAGMENTS AND METHODS OF USE THEREFOR
InactiveUS20080242611A1Growing populationExpand the populationPeptide/protein ingredientsDepsipeptidesBlood Vessel TissuePrecursor cell
Owner:TWARDZIK DANIEL R +3
Use of computationally derived protein structures of genetic polymorphisms in pharmacogenomics for drug design and clinical applications
InactiveUS20060217894A1Expand the populationReduce adverse side effectsMolecular designProteomicsGenomicsProtein structure
Provided herein are computer-based methods for generating and using three-dimensional (3-D) structural models of target molecules and databases containing the models. The targets can be protein structural variants derived from genes containing polymorphisms. The models are generated using molecular modeling techniques and are used in structure-based drug design studies for identifying drugs that bind to particular structural variants in structure-based drug design studies, for designing allele-specific drugs and population-specific drugs and for predicting clinical responses in patients. Computer-based methods for predicting drug resistance or sensitivity via computational phenotyping are also provided. Databases containing protein structural variant models are also provided.
Owner:QUEST DIAGNOSTICS INVESTMENTS INC +2
Application of porous materials for bacterial quorum sensing inhibition/disruption
InactiveUS20170251674A1Eliminate and reduce productionReducing negative consequenceAntibacterial agentsBiocideSignalling moleculesActivated carbon
This application relates to the modulation of the flora of bacteria in an environment by inhibiting the quorum sensing of a specific bacteria in said environment by administering an effective amount of a quorum sensing control composition comprising at least one quorum sensing control agent, which is an adsorbent / catalytic inhibitor for a QS signal molecule, such as, N-acyl homoserine lactones (AHL), pseudomonas quinolone signal (PQS), and autoinducer-1 (AI-1), autoinducer-2 (AI-2) type of quorum sensing molecules. Quorum sensing control agents include a sorbent material, sorbent mineral or non-porous mineral such as, for example, phyllosilicate clays, silica, calcite, zeolites, diatomaceous earth, smectite, activated carbon, a nanoparticle or a combination of any of the foregoing. Methods include inhibiting the spoilage of food stuffs and preventing vibriosis in fish or shell fish.
Owner:OIL DRI OF AMERICA
Methods to mobilize progenitor/stem cells
InactiveUS20060193826A1Growing populationIncrease productionAntibacterial agentsBiocideProgenitorOxygen
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and / or may be fused to an additional ring system; or Z is of the formula N wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
Owner:GENZYME CORP
P27 and p21 in gene therapies
InactiveUS7462483B2Reduced activityReduce the amount requiredAntibody mimetics/scaffoldsGenetic material ingredientsProgenitorEmbryo
The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21cip1 / waf1 and / or p27, cyclin dependent kinase inhibitors. In the absence of p27 activity, progenitor cells move into the cell cycle and proliferate; whereas in the absence of p21 activity, stem cells move into the cell cycle and proliferate without losing their pluripotentiality (i.e., their ability to differentiate into the various cell lines found in the blood stream). Any type of stem cell or progenitor cell, or precursor thereof, including, but not limited to, hematopoietic, gastrointestinal, lung, neural, skin, muscle, cardiac muscle, renal, mesenchymal, embryonic, fetal, or liver cell may be used in accordance with the invention. The present invention provides a method of expanding a cell population, cells with decreased p27 and / or p21 activity, transgenic animals with a disrupted p27 and / or p21 gene, pharmaceutical compositions comprising the cells of the invention, and methods of using these cells in gene therapy (e.g., stem cell gene therapy) and bone marrow transplantation.
Owner:THE GENERAL HOSPITAL CORP
Methods to alter the tumor microenvironment for effective cancer immunotherapy
InactiveUS20180221475A1Growing populationEasy to demonstrateViral antigen ingredientsAntibody ingredientsRegulatory T cellTumor microenvironment
Methods and compositions for altering the microenvironment of a tumor are provided. The methods comprise reducing the population of tumor-residing immune suppressive regulatory T-cells, increasing the population of tumor lysing T-cells (such as CD8+ T-cells) and improving the efficacy of cancer immunotherapy. The compositions comprise the use of cationic lipids optionally combined with autologous antigens, non-autologous antigens, or tumor-associated antigens.
Owner:PDS BIOTECH
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