138results about How to "Prevent egress" patented technology

A fluid storage and dispensing system comprising a vessel for holding a fluid at a desired pressure. The vessel has a pressure regulator associated with a port of the vessel, and set at a predetermined pressure. A dispensing assembly, e.g, including a flow control means such as a valve, is arranged in gas / vapor flow communication with the regulator, whereby the opening of the valve effects dispensing of gas / vapor from the vessel. The fluid in the vessel may be constituted by a liquid which is confined in the vessel at a pressure in excess of its liquefaction pressure at prevailing temperature conditions, e.g., ambient (room) temperature. A phase separator such as a gas / vapor-permeable liquid-impermeable membrane, may be associated with the regulator, as a barrier to flow of liquid into the regulator, when the contained fluid in the vessel is in a liquid state.

Roll caster (11) produces thin steel strip (12) formed on casting surfaces (22A) of casting roll (22) that passes through first enclosure (37) adjacent casting roll surfaces (22A) and, optionally, thereafter second enclosure (61). Enclosure (37) and / or enclosure (61) may be fitted with spray nozzles (71,72) and / or (67, 68) operable to spray fine water mist adjacent strip (12) to produce hydrogen gas in enclosure (37) while tending to avoid liquid water contact with steel strip (12) and casting surfaces (22A). If hydrogen gas is produced only in enclosure (61), the two enclosures (37, 61) are interconnected so that gas can flow from enclosure (61) to enclosure (37). Enclosure (37) and, if present, enclosure (61) are sealed to maintain positive pressure and oxygen levels less than the surrounding atmosphere, and with the presence of hydrogen gas, reduce formation of scale on the strip in enclosure (37) and, if present, enclosure (61).

Embodiments of the present invention provide a device, system and method for providing high flow therapy interfaces for use in the treatment of respiratory conditions and in assisted respirations. In an embodiment of the invention, a nasal cannula for delivery of respiratory gases can include at least one nasal insert and at least one flange coupled to the at least one nasal insert where the at least one flange is configured to partially impede the egress of respiratory gasses delivered to an upper airway of a patient is provided. In another embodiment, a flange has a shape selected from the group consisting of a slotted, vented or slitted design and configured to partially impede the egress of respiratory gasses. In yet another embodiment, an oral interface for delivery of high flow therapy to the upper airway of a patient can include a gas diffuser that includes a terminus housing having a plurality of holes to allow the delivery of respiratory gases. In yet another embodiment, a high flow therapy interface includes at least one nasal cannula and at least one oral interface in fluid communication with the at least one nasal cannula, the oral interface can include at least one port for delivery of respiratory gases to the mouth of a patient.

A seal is provided for effectively inhibiting the egress of fluids from the working channel of an endoscope when an elongate device having a region with a non-circular cross-sectional shape is disposed therein. The seal has a body portion with a proximal end adapted for insertion of the elongate device, a distal end adapted for connection to the proximal end of the endoscope, and a wall defining a lumen adapted to receive the elongate device and to provide access to the working channel of the endoscope. The seal includes a sealing element for sealing the region of the elongate device with a non-circular cross-sectional shape. The sealing element conforms to the profile of the non-circular region.

An endoscope seal that effectively inhibits the egress of fluids from the working channel of an endoscope when an elongate device having a non-circular shaft is disposed therein. The endoscope seal includes a body portion having a proximal end adapted for insertion of an elongate device such as a rapid exchange biliary catheter, a distal end adapted for connection to the proximal end of an endoscope, a lumen extending therethrough which is adapted to receive the elongate device and to provide access to the working channel of the endoscope, and a means for conforming to the non-circular shaft of the elongate device to inhibit the flow of fluid from the working channel of the endoscope. The conforming means may, for example, comprise one or more protrusions extending radially inward in the lumen of the body portion, a sealing material such as a surgical foam that is disposed in the lumen of the body portion, or a sealing mandrel. Whether a single protrusion, a plurality of protrusions, a sealing material or a sealing mandrel is utilized, the present invention provides endoscope seals that readily seal about elongate devices having either circular or non-circular profiles.

An intracorporeal space filling device and a delivery system and method for using the device is disclosed. The space filling device is preferably configured for percutaneous delivery from a peripheral conduit of a patient. The space filling device has an elongated tubular or interconnected bead structure which may have a transmutable material disposed within it. The transmutable material can be altered from a non-rigid state to a rigid state by the application of various types of energy or by other suitable means. The space filling device can be positioned by a delivery system and detached from the delivery system after desired positioning is achieved.

The present invention provides a device / kit and methods of use thereof in rapid detection of target molecule binding to a cognate binding partner. The methods, inter-alia, make use of a device comprising channels or reservoirs, which are linked to nanochannels, whereby upon application of the cognate binding partner to the nanochannel comprising the target molecule under flow, a detectable change in conductance, capacitance or fluorescence or surface potential occurs.

A catheter comprising an inner tube having a distal end, a first lumen and a first delivery opening communicating with the first lumen for delivery of fluid to a patient and a second outer tube having a distal end, a second lumen and a first withdrawal opening communicating with the second lumen to withdraw fluid from the patient. The inner tube is positioned within the outer tube and the inner and outer tubes are relatively movable between a first and second position. In the first position, the distal end of the inner tube is spaced a first distance from the distal end of the outer tube to enable withdrawal of fluid and in the second position the withdrawal opening is blocked to prevent withdrawal of fluid from the patient.

Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells from the bone marrow to the peripheral blood are disclosed. In particular, the invention relates to the use of adrenergic agonists that act in concert with a mobilization compound or agent. The mobilization agent(s) may act to decrease the expression or function of the chemokine, CXCL12, or may act to block or antagonize CXCR4. The invention also relates to methods of using these compounds or agents for enhancing the mobilization of hematopoietic stem cells when harvesting of the stem cells is necessary for the treatment of diseases, disabilities or conditions whereby transplantation of such cells would be beneficial in ameliorating the symptoms associated with such diseases, disabilities or conditions. Methods of screening for novel agents and pharmaceutical compositions comprising these agents are also disclosed.

A two-stage, tandem, replaceable filter cartridge assembly includes an outer filter cartridge having a cylindrical shape and defining an axial bore therein, and an inner filter cartridge, also having a cylindrical shape which is received within the axial bore of the outer filter cartridge. The inner filter cartridge may be collapsible so that it can be easily inserted inside the axial bore of the outer filter cartridge, and is expandable so that in normal applications, it rests up against the inner surface of the outer filter cartridge's core, if such is included, or filter medium. One or both of the filter media of the inner and outer cartridges may be formed from an antimicrobial material. In a second embodiment, each of the inner and outer filter cartridges has top and bottom end caps which respectively are structured to mate with one another to form seals therebetween to prevent or minimize the egress of water between the mating top and bottom end caps.

A bi-layer bond coating for use on metal alloy components exposed to hostile thermal and chemical environment, such as a gas turbine engine, and the method for applying such coatings. The preferred coatings include a bi-layer bond coat applied to the metal substrate using high velocity oxy-fuel (HVOF) thermal spraying. Bi-layer bond coatings in accordance with the invention consist of a dense first inner layer (such as iron, nickel or cobalt-based alloys) that provides oxidation protection to the metal substrate, and a second outer layer having controlled porosity that tends to promote roughness, mechanical compliance, and promotes adherence of the thermal barrier coating (TBC). Preferably, the outer, less dense layer of the bi-layer bond coat is formed from a mixture of metallic powder and polyester to adjust and control the porosity, but without sacrificing mechanical compliance.

The present invention relates to the implantation of one or more prosthetic valve(s) in the pulmonary vein(s) of a subject as a means of decreasing or preventing an increase in pulmonary venous pressure. The present invention accordingly provides for novel treatment strategies for the treatment of medical disorders associated with elevated pulmonary venous pressure, including congestive heart failure, as well as for prosthetic pulmonary vein valves and their delivery systems. Expandable as well as fixed-dimension non-expandable pulmonary vein prosthetic valves for implantation by a variety of surgical and percutaneous procedures are also described.

An apparatus (10) for detecting the occurrence of partial discharge in electrical equipment, such as high voltage transformers. The apparatus comprises a detecting means including an ultrasonic transducer (11) mounted at one end of an electrically insulating elongate rod (13). The ultrasonic transducer (11) is adapted to detect ultrasonic pulses or waves generated by the occurrence of a partial discharge in the electrical equipment. A radio frequency (RF) transducer (17) is also utilized to detect radio frequency (RF) pulses or waves also generated by the partial discharge. The rod (13) can be mounted in the wall of the electrical equipment and so provide a mechanism for adjusting the position of the detecting means within the electrical equipment. The apparatus is also removable from the electrical equipment and re-locatable to other equipment.

A micro-electromechanical liquid ejection device includes a substrate that incorporates drive circuitry. Nozzle chamber walls are positioned on the substrate to define a nozzle chamber. The nozzle chamber walls include a roof wall that defines an ejection port in fluid communication with the nozzle chamber. The substrate defines an inlet passage through the substrate and into the nozzle chamber. An elongate drive member is fast with the substrate at a fixed end and incorporates an electrical circuit that is in electrical contact with the drive circuitry to receive an electrical signal from the drive circuitry. The drive member is configured so that a free end is displaced relative to the substrate on receipt of the electrical signal. A motion-transmitting member is fast with the free end of the drive member so that the motion-transmitting member is displaced together with the free end. An elongate liquid displacement member is fast at one end with the motion-transmitting member and extends into the nozzle chamber to be displaced together with the motion-transmitting member to eject liquid from the ejection port.

A device for closing an aperture in a vessel wall comprising a covering member having a longitudinal axis and positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture and having a first opening. A first retainer is positionable external of the vessel. A flexible connecting member operatively connects the covering member and the first retainer, wherein the first opening of the covering member is configured to restrict movement of the connecting member.

An apparatus for creating microbubbles of gas in a liquid, and for using such created microbubbles to purify said liquid of undesirable materials therein. A vertical pipe member is adapted to receive a liquid-gas mixture having gas bubbles of relatively large diameter therein. A series of horizontally-extending apertures are provided to permit the pipe member to expel such liquid-gas mixture radially outwardly from such pipe member. A plug means is provided in a lowermost distal end of the pipe member, so that such liquid-gas mixture is only expelled horizontally outwardly. The expelled liquid-gas mixture may contact the sides of a containment vessel. A baffle may further be provided in such containment vessel. In a refinement of the invention, a specific relationship is further specified between the exit area of the apertures and the interior cross-sectional area of the pipe member, in order to most suitably convert the gas bubbles in such liquid-gas mixture to microbubbles of a desired small size when expelled under pressure from such pipe member via such apertures. A limitation on the aperture maximum dimension, as a function of the pipe interior cross-sectional area and outer circumference, is also disclosed. A method of converting gas bubbles in such liquid-gas mixture to gas microbubbles, and for exposing such gas microbubbles to material entrained in such liquid-gas mixture so as to permit such gas microbubbles to physically or chemically react with such materials, is further disclosed.

A filter assembly for a plate heat exchanger comprising inlet and outlet ports for passage of a working medium and a cooling or heating fluid, respectively, wherein the filter assembly is dimensioned to fit into the inlet or outlet ports, wherein the filter assembly comprises a proximal flange and a distal flange and at least one filter tube attached at respective ends to the proximal flange and the distal flange, respectively, wherein the at least one filter tube is adapted to receive an elongated filter element and further comprises a plurality of inlet holes arranged on a circumferential surface thereof, and wherein the distal flange comprises at least one through-going outlet aperture in fluid communication with the interior of the at least one filter tube.

The present invention provides a method for the real-time continuous monitoring of a change or density and / or viscosity within a test sample. Such methods can be used to determine the occurrence of a chemical reaction within a test sample where the same causes and increase or decrease in the density and / or viscosity of the sample due to, for example, a gelation, precipitation or coagulation occurring within the test sample. There is further provided a multi-resonator apparatus for use in measuring the density and / or viscosity of a test sample in which the multi-beam resonator is immersed.

A package having two separate, sealed compartments. The compartments are connected at their distal ends with a fold-seal arrangement so that the compartments may be collapsed or folded in billfold fashion. The proximate ends are constructed with a sticky tab, which sticky tab is disposed on a tear-away area. The sticky tab functions to hold the compartments together in folded position. Each compartment is sealed to prevent the egress of dirt or moisture. One compartment is adapted to house a dry, absorbent tissue or wipe. The second compartment will contain a pre-moistened tissue or wipe.

A molluscan bivalve cage system includes a cage formed of a mesh material of sufficient porosity to allow entry of molluscan bivalves. A fixed buoyant mechanism is secured to an upper surface of the cage and an anchor counterweight mechanism maintains the bivalve cage in a relatively stable position within a marine environment. An adjustable stirrup mechanism adjusts the height of the bivalve cage above the bed of a marine environment during various stages of growth of the molluscan bivalves.

A well system includes a local control unit configured to communicably couple to a well shut-in assembly at a well site, the well shut-in assembly operable to shut-in a wellbore based on a command from the local control unit; and a remote control unit configured to wirelessly communicate a line-of-sight airborne wireless signal, at a location remote from the local control unit and the well site, to initiate the command from the local control unit to the well shut-in assembly.

Methods and compositions for modulating the mobilization of stem cells, particularly for promoting or increasing the mobilization of hematopoietic stem cells from the bone marrow to the peripheral blood are disclosed. In particular, the invention relates to the use of adrenergic agonists that act in concert with a mobilization compound or agent. The mobilization agent(s) may act to decrease the expression or function of the chemokine, CXCL12, or may act to block or antagonize CXCR4. The invention also relates to methods of using these compounds or agents for enhancing the mobilization of hematopoietic stem cells when harvesting of the stem cells is necessary for the treatment of diseases, disabilities or conditions whereby transplantation of such cells would be beneficial in ameliorating the symptoms associated with such diseases, disabilities or conditions. Methods of screening for novel agents and pharmaceutical compositions comprising these agents are also disclosed.