This invention discloses a method for manufacturing an insecticidal organic fertilizer. The fertilizer is composed of human or animal excrement, straw powder, tree leaves, wine lees, drug residues, sawdust, edible fungi residues, furfural residues, lime powder, fermentation agent, phosphorus- and potassium-leaching bacteria, tobacco powder, Ricinus communis leaf powder, Zanthoxylum cake powder, Datura and Strychnos nuxvomica. The fertilizer has such advantages as wide raw material resources, low cost, convenient usage, abundant nutrition, low fertilizer application amount, high efficiency, no toxicity, no pollution and no residues.