The invention discloses an anti-inflammation and allergy-relieving repair composition and a preparation method and an application thereof. The composition consists of a cactus extract, an oat bran extract, a sophorae flavescentis extract, an ophiopogon japonicus root extract, a peony root extract, a scutellaria baicalensis root extract, butanediol, pentanediol and water. The preparation method comprises the following steps: 1) preparing a sophorae flavescentis extract solution; 2) carrying out super-high pressure homogenization of the cactus extract, the oat bran extract, the ophiopogon japonicus root extract, the peony root extract, the scutellaria baicalensis root extract, butanediol and pentanediol to obtain a plant extract mixed solution; and 3) carrying out mixing, super-high pressurehomogenization and filtration of the plant extract mixed solution and the sophorae flavescentis extract solution. The anti-inflammation and allergy-relieving repair composition has anti-inflammatory,anti-allergic and analgesic effects, can enhance skin barrier function, enhances the skin self-protection ability, effectively repairs inflammatory skin, especially skins suffered from hormone-dependent dermatitis and cannot produce drug resistance, dependence and side effects after being used for a long time.