845 results about "Ceramide" patented technology

Disclosed are multilayered liposomes for transdermal absorption and a method of preparing the liposomes. The multilayered liposomes are prepared using a mixture of oil-phase components comprising squalane, sterols, ceramides, neutral lipids or oils, fatty acids and lecithins, is 200 to 5000 nm in particle size, and is capable of entrapping a physiologically active substance. The multilayered liposomes entrap a larger amount of a physiologically active substance and are structurally stable when encapsulating the physiologically active substance, compared to unilamellar liposomes. Also, they are prepared by a simple and cost-effective process not using a high-pressure homogenizer but using a general homo mixer. Further, since the multilayered liposomes are prepared in a larger size than the intercellular spaces in the stratum corneum, they overcome the tension of surrounding cells when passing through the intercellular spaces and are thus able to penetrate into the dermal layer, compared to nano-sized unilamellar liposomes. Thus, the multilayered liposomes are useful for enhancing the transdermal absorption of physiologically active substances.

The invention is directed to methods of modulating an immune response in an animal, comprising administering a composition comprising one or more soluble CD1d complexes, in particular non-specific soluble CD1d complexes. Soluble CD1d complexes comprise a soluble CD1d polypeptide, a β2-microglobulin polypeptide, and a ceramide-like glycolipid antigen bound to the CD1d antigen binding groove, and in certain embodiments, an immunogen. The administration of compositions of the present invention affects the activity of CD1d-restricted NKT cells, and in particular, allows for multiple administrations without causing CD1d-restricted NKT cell anergy.

Disclosed is a topical skin care composition that includes water, silymarin, hydrolyzed algin, palmitoyl tripeptide 8, ceramide 2, pomegranate extract comprising pomegranate sterols, glycerin, disodium EDTA, caprylic / capric triglyceride, shea butter, C12-15 alcohols benzoate, dimethicone, glyceryl stearate and PEG 100 stearate, cetyl alcohol, stearyl alcohol, stearic acid, butylene glycol, caprylyl glycol, and (s) a mixture of acrylamide / sodium acryloyldimethyl taurate copolymer, isohexadecane, and polysorbate 80.

Glycosylceramide analogues are disclosed in which the ceramide moiety and optionally the carbohydrate moiety are modified or replaced. These analogues are useful as immunomodulators, antitumor agents, and as other pharmaceutical agents.

Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

The invention is a cosmetic or dermatological preparation comprising taurine and at least one substance selected from the group consisting of phytosterols, ceramides, long-chain fatty acids, and cholesterol. The invention also includes a method of strengthening the skin barrier comprising applying to the skin a preparation comprising taurine and at least one substance selected from the group consisting of phytosterols, ceramides, long-chain fatty acids, and cholesterol. The invention also includes methods of moisturizing the skin, improving the microtopography of the skin, improving the elasticity of the skin, treating or preventing functional disorders of skin appendages, treating or preventing the symptoms of skin ageing, and treating or preventing the harmful effects of ultraviolet radiation on the skin comprising applying the preparation.

Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

Skin protectant compositions that are free of cholesterol and suitable for topical application to skin of a mammal. In a preferred embodiment, these skin protectant compositions comprise a ceramide; a squalane; a phytosterol-containing liposome; a phospholipid-containing ingredient; at least one triglyceride; and at least one dermatologically acceptable excipient. These compositions are capable of restoring or repairing a skin lipid barrier of a mammal, and treating skin conditions associated therewith.

A lip balm product having a synthetic ceramide, an anti-irritant compound, sodium hyaluronate, cosmetic wax, boswellic acids and / or esters and / or salts thereof, extract of the Portuluca pilosa plant, matrikin-mimetic peptide, dehydrated microspheres of marine collagen and glycosaminoglycans, and mica along with optional lip balm formulation acceptable carriers and / or solvents. Where desired, the lip balm may further contain medicinal agents suitable for the treatment of various conditions of the lip.

The present disclosure relates to nutritional compositions comprising a neurologic component, wherein, the neurologic component may promote brain and nervous system development and further provide neurological protection and repair. The neurologic component may include phosphatidylethanolamine, sphingomyelin, cytidine diphosphate-choline, ceramide, uridine, at least one ganglioside, and mixtures thereof. The disclosure further relates to methods of promoting brain and nervous system health by providing said nutritional compositions to target subjects, which includes pediatric subjects.

The invention discloses a cosmetic and a preparation method thereof. The cosmetic is prepared from five components of A, B, C, D and E. The cosmetic is composed of thirty raw materials including deionized water, hydroxyethyl cellulose, allantoin, carbopol U20, propanediol, 1,3-butanediol, sodium hyaluronate, an aloe vera extract, a natto extract, asiaticoside, vitamin C, bisabolol, an amino acid humectant, D-panthenol, VC ethyl ether, nicotinamide, glabridin, tranexamic acid, ceramide, algal polysaccharide, glucan, dipotassium glycyrrhizinate, an epidermal growth factor (EGF), triethanolamine, isothiazolinone, essence, squalane, jojoba oil, vitamin E oil and crystal sparkling pearl powder. The cosmetic has the functions of making skins fine and smooth, brightening the skins, repairing sensitive skins, controlling oil, toning skins and modifying skin blemishes, has no side effect or no dependence, and does not threaten health of a human body.

The invention relates to the use of a composition containing, preferably in a physiologically acceptable medium comprising an aqueous phase, at least one oxidation-sensitive hydrophilic active principle selected from the group consisting of ascorbic acid and its derivatives and at least one non-crosslinked N-vinylimidazole polymer or copolymer, the active principle and the polymer or copolymer both being present in the aqueous phase, for promoting the synthesis of epidermal ceramides and / or for improving the barrier function of the skin, among other uses.

A coenzyme Q10 and ceramide-containing preliposome, and pharmaceutical preparations and cosmetics containing the same. The preliposome can further comprise other lipid components. A granular and lyophilized solid-preparation is produced by lyophilization or spray drying. Then, the coenzyme Q10-containing proliposome is obtained by adding water in the said solid-preparation and shaking. Transdermal absorption of coenzyme is improved together with the effect of coenzyme Q10 in cosmetics and the stability of coenzyme Q10 and liposome, which facilitate the formulation of cosmetics.

The invention discloses a compound traditional Chinese medicine extract and application thereof to a whitening, moisturizing and anti-aging skin care product. The compound traditional Chinese medicine extract is prepared from the following raw material medicines in parts by mass: 10-50 parts of selaginella, 10-50 parts of peach blossom, 10-50 parts of bletilla and 10-50 parts of pseudo-ginseng. The compound traditional Chinese medicine extract which is prepared from the raw materials has an effect of suppressing tyrosinase and proliferation of melanocyte, has a superior whitening effect, has an effect of proliferating and promoting fibroblast and has an excellent effect of promoting generation of ceramide. The whitening, moisturizing and anti-aging skin care product which is obtained by applying the compound traditional Chinese medicine extract to preparing the whitening, moisturizing and anti-aging skin care product has a durable natural whitening effect and can be used for improvingmetabolism and moisturizing effects of skin.

The invention discloses a moisturizing repair composition containing ceramide and phytosterol and a preparation method thereof and belongs to the field of cosmetics. The moisturizing repair composition is prepared from the following components in percent by mass: 0.01-5% of ceramide, 0.1-0.5% of phytosterol, 0.1-10% of shea butter, 0.5-10% of hydroxyethylurea, 0.1-6% of ammonium lactate, 1-30% ofa polyhydric alcohol moisturizing agent, 1-5% of an emulsifier, 1-20% of skin moistening grease, a proper amount of a thickener, essence and a preservative and the balance water, totaling 100%. The composition is an emulsified body which contains ceramide as the primary natural moisturizing factor of human skin and phytosterol and shea butter originated from plants, so that the composition has good moisturizing and repairing action, can keep the skin moisten and flexible and smooth, and can resist damage of outside severe climate environment to the skin.

Composition which, in a preferred embodiment, contains, in a cosmetically acceptable medium, at least one monosaccharide and / or disaccharide, at least one α-hydroxy acid, and at least one ceramide compound. Uses include topical application for the treatment of keratinous substances, in particular keratinous fibres, especially the hair.

The invention discloses a composite moisturizing agent characterized in comprising, by weight, 30-50% of glycerol, 15-30% of water, 12-15% of sodium lactate, 12-15% of PCA sodium, 3-10% of allantoin, 2-5% of beta-glucan, 0.5-2.5% of polyquaternium-51, and 0-1% of sodium hyaluronate. The composite moisturizing agent composition provided by the invention has a far better effect against skin water loss than those of independent applications of single components in the composition. The composition provided by the invention has a far better effect for skin elasticity than those of independent applications of single samples. Therefore, the components provide a synergetic effect. When the composition is compounded, skin moisture retention can be improved. Also, the composition provided by the invention has a far better effect in improving skin moisture retention than reference samples such as polyethylene glycol, ceramide, collagen, and chitin. Therefore, the composite moisturizing agent provided by the invention is a high-efficiency moisturizing agent.

The invention discloses a method for preparing a brown rice enzyme yogurt. The preparation method mainly comprises the steps of pretreatment of raw materials, homogenization, sterilization, cooling, addition of brown rice enzyme and a ferment, fermentation, cooling, filling and refrigeration. The addition of the brown rice enzyme and the ferment is as follows: 3-7 parts by weight of the brown rice enzyme and 4-6 parts by weight of the ferment are added in 100 parts by weight of mixed solution after the treatment for carrying out inoculation; and the ferment is mixed culture solution of streptococcus thermophilus and lactobacillus bulgaricus. The brown rice enzyme is formed by fermenting brown rice, dozens of types of new enzyme can be derived when having the nutrition of the brown rice, and the brown rice enzyme yogurt is further rich in gamma-aminobutyric acid, glutathione, gamma-oryzanol, ceramide, lipopolysaccharides from rice bran, minerals and other nutritional components. The brown rice enzyme yogurt mixes the dual functions of the brown rice enzyme and the yogurt, is easy to be absorbed by human body and can improve the immunity of the human body and activate cells, thereby being the beneficial complement to modern dietary nutrition.

Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

The invention discloses a preparation process and application of compound ceramide liposome. The preparation process disclosed by the invention comprises the following steps of uniformly mixing 10-60% by weight of glycerinum, 0.1-0.5% by weight of cholesterol, 0.1-0.5% by weight of salicyloyl Phytosphingosine, 0.1-0.5% by weight of ceramide VI, 0.1-0.6% by weight of ceramide IIIB, 0.5-3% by weight of hydrogenated phospholipid, 1-5% by weight of octyldodecanol, and 1-20% by weight of dipropylene glycol at 70-90 DEG C, adding 5-50% by weight of water into the mixed solution, uniformly stirring, and processing through a high-pressure homogenizer so as to obtain the transparent compound ceramide liposome, wherein the high-pressure homogenizing pressure is 600-1000 bar; and the cycle number is 2-5. The compound ceramide liposome disclosed by the invention is high in stability and good in water dispersibility and biocompatibility, and can be freely matched with cosmetic formulae at normal temperature; and the preparation method is simple, controllable and good in repeatability.

The invention particularly discloses a composition for promoting opening of skin aquaporin, which is mainly proportionally prepared from deionized water, glycerol, carbomer, xanthan gum, lycine, trehalose, inositol, taurine, lauryl mammary gland sodium lactate, monomethyl-monosilane triol, oxyproline, aspartic acid, yeast amino acid, polyglutamic acid, sodium hyaluronate, dipotassium glycyrrhetate, purslane extracting solution, licorice extract, ceramide, phytosphingosine, cholesterol, oligopeptide-1, polyquaternary amine salt-14 and the like. The composition has the function of promoting opening of skin aquaporin, has better water replenishing and locking effect, and effectively prevents and resists the phenomena of dry skin mucosa and skin aging.

A semitransparent cosmetic consisting of an O / W emulsion which comprises (a) a ceramide, (b) an oil component, (c) a nonionic surfactant, and (d) water and has a mean particle diameter of 100 to 300 nm; a semitransparent cosmetic as described above wherein the component (c) is polyoxyethylene hydrogenated castor oil; and a semitransparent cosmetic as described above wherein the mass ratio of the total amount of the components (a) and (b) to the amount of the component (c) lies between 3:1 and 1.2:1. The ceramide-containing O / W emulsion cosmetics are excellent in long-term stability and have beautiful appearances and a sense of luxuriousness.

A method of selecting a skin cleanser can include measuring the levels of particular ceramides on the skin both before and after product application and testing for a change in ceramide levels.

The invention discloses a skin care composition, wherein the composition mainly comprises the following materials according to parts by weight: 0.1-5 parts of L-fucose, 0.05-5 parts of coenzyme Q10, 0.1-5 parts of hyaluronic acid, 0.05-2 parts of ceramide, and 1-25 parts of mPEG. The skin care composition can be prepared into any common skin care preparation. In addition, the invention further discloses application of the composition in preparation of the skin care composition having the functions of preventing aging and skin inflammation and moisturizing.

The invention provides a cosmetic or pharmaceutical product capable of recovering and maintaining the shielding function and the moisture-preserving function of the skin, in particular to a ceramide production accelerant or humectant using plants or extractives thereof, such as motherwort and yam as active components.

A vesicle dispersion comprising (A) sucrose fatty acid ester, (B) a sphingosine and / or its derivative, and (C) an aqueous component and a cosmetic composition comprising the vesicle dispersion are disclosed. The vesicle dispersion can stably contain sphingosines such as a ceramide, excelling in a moisturizing effect of the skin, and the cosmetic composition comprising the vesicle dispersion exhibits an excellent moisturizing effect, storage stability, and the like.

We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.

The invention discloses a skin care product having anti-wrinkle firming and beauty-maintaining moisturizing effects. The skin care product is prepared from the following the following raw materials in certain proportions: ceramide 1, tripeptide-3, kirilow rhodiola root extract, asiatic pennywort herb extract, punica granatum fruit extract, hyaluronic acid, rosebud extract, lavender oil, soybean peptides, hamamelis virginiana extract and vitamin C. The raw materials of the skin care product having the anti-wrinkle firming and beauty-maintaining moisturizing effects are natural plants and Chinese herbs and no additives such as essence, pigment, mineral oil and preservative are added; the use of the skin care product brings about remarkable anti-wrinkle and moisturizing effects; the skin care product has good wrinkle removing capability and moisturizing effect, and strong moisture increasing capability and continuous moisture maintaining effect. Human body irritation and patch testing research results indicate that the skin care product has no irritation and untoward effects on a human body; the skin care product is capable of maintaining moisture, nourishing skin, preventing rough skin and skin aging, and keeping the skin bright and elastic, and has the anti-wrinkle firming and beauty-maintaining moisturizing effects.