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Preparation process and application of compound ceramide liposome

A technology of ceramide lipid and ceramide, which is applied in the preparation process and application field of compound ceramide liposome, can solve the problems of poor stability and water dispersibility of ceramide emulsion, difficulty in direct application of cosmetics, etc., and achieves a simple and reliable preparation method control, good water dispersion and high stability

Inactive Publication Date: 2015-04-29
MEIJIALE SHANGHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the stability and water dispersibility of the ceramide emulsions generally prepared at present are poor, and it is difficult to be directly applied to cosmetics and other problems.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation technology of compound ceramide liposome, its technological process is: take by weighing 50g glycerol, 0.2g cholesterol, 0.2g salicyl phytosphingosine, 0.2g ceramide VI, 0.2g ceramide IIIB, 1g hydrogenated phospholipid 90H, 2g octyldodecanol, 5g dipropylene glycol, stirred at 70°C to form a transparent solution, added 41.2g of water and stirred evenly, and circulated the mixed solution through a high-pressure homogenizer under a pressure of 600bar for 5 Once, transparent composite ceramide liposomes were obtained, and the particle size of the composite ceramide liposomes was measured by a laser particle size analyzer to be about 450nm.

[0026] Composite ceramide liposomes obtained in the aforementioned process can be freely matched with cosmetic formulations under normal temperature conditions to obtain better application effects.

Embodiment 2

[0027] Embodiment 2: the preparation technology of compound ceramide liposome, its technological process is: take by weighing 60g glycerol, 0.5g cholesterol, 0.5g salicyl phytosphingosine, 0.5g ceramide VI, 0.5g ceramide IIIB, 3g hydrogenated phospholipid 75H, 5g octyldodecanol, 15g dipropylene glycol, stir at 80°C to form a transparent solution, add 15g water and stir evenly, and circulate the mixed solution through a high-pressure homogenizer under 800bar pressure for 3 times , to obtain transparent composite ceramide liposomes, the composite ceramide liposomes measured by laser particle size analyzer, its particle size is about 430nm. The complex ceramide liposome obtained by this scheme can be freely intermixed with cosmetics. For the cosmetics mentioned here, it can adopt any type of cosmetics available in the market, and only need to add part of the complex ceramide prepared in this case. Liposomes.

Embodiment 3

[0028] Embodiment 3: the preparation technology of compound ceramide liposome, its technological process is: take by weighing 30g glycerol, 0.5g cholesterol, 0.5g salicyl phytosphingosine, 0.5g ceramide VI, 0.5g ceramide IIIB, 3g hydrogenated phospholipid 95H, 5g octyldodecanol, 20g dipropylene glycol, stir at 90°C to form a transparent solution, add 40g water and stir evenly, and circulate the mixture twice through a high-pressure homogenizer under 1000bar pressure , to obtain transparent composite ceramide liposomes, the composite ceramide liposomes measured by laser particle size analyzer, its particle size is about 350nm.

[0029] The compound ceramide liposome of this project has high stability, good water dispersibility, and good biocompatibility, and can be freely mixed with cosmetic formulas under normal temperature conditions; the preparation method is simple and controllable, and has good repeatability.

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Abstract

The invention discloses a preparation process and application of compound ceramide liposome. The preparation process disclosed by the invention comprises the following steps of uniformly mixing 10-60% by weight of glycerinum, 0.1-0.5% by weight of cholesterol, 0.1-0.5% by weight of salicyloyl Phytosphingosine, 0.1-0.5% by weight of ceramide VI, 0.1-0.6% by weight of ceramide IIIB, 0.5-3% by weight of hydrogenated phospholipid, 1-5% by weight of octyldodecanol, and 1-20% by weight of dipropylene glycol at 70-90 DEG C, adding 5-50% by weight of water into the mixed solution, uniformly stirring, and processing through a high-pressure homogenizer so as to obtain the transparent compound ceramide liposome, wherein the high-pressure homogenizing pressure is 600-1000 bar; and the cycle number is 2-5. The compound ceramide liposome disclosed by the invention is high in stability and good in water dispersibility and biocompatibility, and can be freely matched with cosmetic formulae at normal temperature; and the preparation method is simple, controllable and good in repeatability.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a preparation process and application of a composite ceramide liposome. Background technique [0002] Ceramides, also known as sphingolipids, are lipids present in the skin and play an important role in the formation of the stratum corneum of the epidermis. It is similar to the material structure that makes up the stratum corneum of the skin, and can quickly penetrate into the skin and combine with the water in the stratum corneum to form a network structure to lock in moisture. Studies in recent years have shown that when the skin is dry, desquamated, and cracked, and its barrier function is significantly reduced, supplementing the skin with ceramide can quickly restore moisturizing and barrier function. [0003] As the age increases and enters the old age, the ceramides in the human skin will gradually decrease. The appearance of skin abnormalities such as dry skin and rough skin is a...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/68A61Q19/00A61Q19/08
Inventor 张文源
Owner MEIJIALE SHANGHAI BIOTECH CO LTD
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