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8641results about "Sludge treatment" patented technology
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Apparatus for manipulating droplets by electrowetting-based techniques
InactiveUS6911132B2Improve controllabilityImprove accuracyBurnersElectrostatic separatorsElectricityControl manner
An apparatus is provided for manipulating droplets. The apparatus is a single-sided electrode design in which all conductive elements are contained on one surface on which droplets are manipulated. An additional surface can be provided parallel with the first surface for the purpose of containing the droplets to be manipulated. Droplets are manipulated by performing electrowetting-based techniques in which electrodes contained on or embedded in the first surface are sequentially energized and de-energized in a controlled manner. The apparatus enables a number of droplet manipulation processes, including merging and mixing two droplets together, splitting a droplet into two or more droplets, sampling a continuous liquid flow by forming from the flow individually controllable droplets, and iterative binary or digital mixing of droplets to obtain a desired mixing ratio.
Owner:DUKE UNIV
Non-planar microstructures for manipulation of fluid samples
This invention comprises an apparatus and method for the manipulation of materials, including particles, cells, macromolecules, such as proteins, nucleic acids and other moieties, in fluid samples. The apparatus comprises an enclosed chamber on a chip having an internal microstructure with surface area substantially greater than the facial surface area of the internal structure. Generally the internal microstructure comprises a continuous network of channels, each of which has a depth substantially greater than its width. The network may comprise a single channel, a single channel with multiple branches, multiple channels, multiple channels with multiple branches, and any combination thereof. The internal structure may present an inert, non-reactive surface, or be coated with a reactive ligand, or be electrically conductive and optionally be coated with an electrical insulator. Discrete portions of the internal structure may differ in structural and surface properties. Multiple chips may be linked together to create a multiplexed array of chambers, optionally linked to other analytical devices.
Owner:CEPHEID INC
Electrophoretic displays containing magnetic particles
InactiveUS6870661B2Easy to fallImprove stabilitySludge treatmentStatic indicating devicesElectrophoresisDisplay device
Owner:E INK CORPORATION
Capillary electroflow apparatus and method
The present invention concerns an apparatus for conducting a microfluidic process. The apparatus comprises integral first and second plates. The first plate comprises an array of sample receiving elements for receiving a plurality of samples from an array of sample containers and dispensing the samples. The second plate comprises a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. Also disclosed is a method for processing an array of samples. At least a portion of each sample in an array of sample wells is simultaneously transferred to a corresponding array of microfluidic networks of cavity structures and channels by means of a corresponding array of sample receiving elements that is in integral fluid communication with the array of microfluidic networks. The samples are then processed. Also disclosed is a device for conducting a microfluidic process wherein the device comprising a planar substrate having a planar array of microfluidic networks of cavity structures and channels for conducting a microfluidic process. A plurality of such devices may be present on a continuous sheet. The invention further includes kits for carrying out microfluidic processes comprising an apparatus as described above.
Owner:ACLARA BIOSCIENCES INC
Apparatus and method for transferring liquids
InactiveUS6284113B1Sequential/parallel process reactionsSludge treatmentElectricityMechanical engineering
The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.
Owner:MONOGRAM BIOSCIENCES
Acrylic microchannels and their use in electrophoretic applications
Microchannels having at least an acrylic inner surface and methods of their use in electrophoretic applications are provided. The subject microchannels may be in the form of a variety of configurations suitable for holding an electrophoretic medium. The subject microchannels give rise to substantially reduced EOF and / or adsorption as compared to fused silica under conditions of electrophoresis and find use in a variety of electrophoretic applications in which charged entities are moved through a medium under the influence of the an applied electric field.
Owner:MONOGRAM BIOSCIENCES
Small object moving on printed circuit board
A printed circuit board based digital or droplet microfluidic system and method for producing such microfluidic system are disclosed. The digital microfluidic device comprises a printed circuit board having a substrate and a plurality of electrode pads disposed on the top surface of the substrate in a rectangular array. A via extends from each electrode pad through the substrate to other locations on the substrate . A dielectric layer is disposed on the electrode pads. Droplets may be manipulated using electrowetting principles and others by applying a voltage to the desired electrodes. Each electrode pad can be controlled directly and independently from the other electrode pads to modify the surface wettability of the dielectric layer in the vicinity of the electrode pad by applying a voltage to the desired electrode pad(s). In this way, droplets may be formed, moved, mixed, and / or divided or other small objects manipulated while in air or immersed in a liquid on the dielectric surface.
Owner:RGT UNIV OF CALIFORNIA
Microfluidic devices and methods of use
InactiveUS20020127736A1Lessening oscillation in velocityReduce oscillation amplitudeSludge treatmentFixed microstructural devicesElastomerThin membrane
A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.
Owner:CALIFORNIA INST OF TECH
Construction of electrophoretic displays
An electrophoretic display (100) comprises a front light-transmissive substrate (112), a rear substrate (116) spaced from the front substrate (112) so as to leave a cavity, and an electrophoretic medium (102) in the cavity, the electrophoretic medium (102) comprising a liquid external phase (120) and a plurality of capsules (104) suspended in the liquid external phase (120), each of the capsules comprising a capsule wall, a suspending fluid (106) held within the capsule wall and at least one electrically charged particle (108, 110) suspended in the suspending fluid (106).
Owner:E INK CORPORATION
Droplet-based particle sorting
InactiveUS20080053205A1Large facilityEasy to testSludge treatmentVolume/mass flow measurementChemical physicsParticle sorting
Owner:ADVANCED LIQUID LOGIC
Microfluidic chip having integrated electrodes
InactiveUS6939451B2Reduces the formation of air bubblesSludge treatmentFixed microstructural devicesElectrochemical detectorNorbornene
A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities, heaters, electrochemical detectors, sensors for temperature, pH, fluid flow, and other useful components. The device may be fabricated from a plastic substrate such as, for example, a substantially saturated norbornene based polymer. The components are integrated into the device by adhering an electrically conductive film to the substrate. The film may be made of metal or an electrically conducting ink and is applied to the device through metal deposition, printing, or other methods for applying films. Methods for reducing bubble formation during electrokinetic separation and methods for heating material in a microfluidic device are also disclosed.
Owner:MONOGRAM BIOSCIENCES
Systems and methods for optical actuation of microfluidics based on opto-electrowetting
InactiveUS6958132B2Improve performanceSludge treatmentMaterial analysis by electric/magnetic meansElectricityMicrofluidics
Owner:RGT UNIV OF CALIFORNIA
Miniature support for thin films containing single channels or nanopores and methods for using same
Single-channel thin film devices and methods for using the same are provided. The subject devices comprise cis and trans chambers connected by an electrical communication means. At the cis end of the electrical communication means is a horizontal conical aperture sealed with a thin film that includes a single nanopore or channel. The devices further include a means for applying an electric field between the cis and trans chambers. The subject devices find use in applications in which the ionic current through a nanopore or channel is monitored where such applications include the characterization of naturally occurring ion channels, the characterization of polymeric compounds, and the like.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
A device for generating droplets includes a substrate comprising a reservoir site configured to hold a liquid and including a first electrode, a droplet creation site including a second electrode, and droplet separation site disposed between the reservoir site and the droplet creation site and containing an electrode. The device includes control circuitry operatively coupled to the first, second, and third electrodes. The control circuitry is configured to measure the fluid volume on the electrodes and independently adjust an applied voltage to increase / decrease the quantity of fluid. The device can move fluid onto the creation site or back onto to the reservoir site. When the fluid volume is at the desired value or range, a driving voltage is delivered to the first and second electrodes to form a new droplet. The device may generate droplets having a uniform or user-defined size smaller than the electrode.
Owner:RGT UNIV OF CALIFORNIA
Inline-injection microdevice and microfabricated integrated DNA analysis system using same
InactiveUS20090035770A1Sludge treatmentVolume/mass flow measurementCapillary electrophoresisElectrophoresis
Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including affinity-based capture matrixes inline with separation channels are provided. The affinity-based capture matrixes provide inline sample plug formation and injection into a capillary electrophoresis channel. Also provided are methods and apparatuses for a microbead-based inline injection system for DNA sequencing.
Owner:RGT UNIV OF CALIFORNIA
Droplet-based nucleic acid amplification device, system, and method
InactiveUS20080038810A1Reduces and eliminates build-upImprove efficiencyElectrostatic separatorsSludge treatmentTemperature controlBiology
The present invention relates to a droplet-based nucleic acid amplification device, system, and method. According to one embodiment, a droplet microactuator is provided and includes: (a) a substrate comprising electrodes for conducting droplet operations; and (b) one or more temperature control means arranged in proximity with one or more of the electrodes for heating and / or cooling a region of the droplet microactuator and arranged such that a droplet can be transported on the electrodes into the region for heating.
Owner:DUKE UNIV +1
Electrophoretic media containing specularly reflective particles
ActiveUS20040094422A1Good flexibilityImprove uniformitySludge treatmentStatic indicating devicesElectrophoresisSpecular reflection
An electrophoretic medium (100) comprises at least one type of particle (108) suspended in a suspending fluid (106) and capable of moving therethrough on application of an electric field to the medium, the particles (108) including at least one electrophoretically mobile specularly reflective particle.
Owner:E INK CORPORATION
Electrophoretic media containing specularly reflective particles
ActiveUS7312916B2Improve reflectivityReduces backplane scatteringSludge treatmentStatic indicating devicesElectrophoresisSpecular reflection
An electrophoretic medium (100) comprises at least one type of particle (108) suspended in a suspending fluid (106) and capable of moving therethrough on application of an electric field to the medium, the particles (108) including at least one electrophoretically mobile specularly reflective particle.
Owner:E INK CORPORATION
Electrode addressing method
InactiveUS20090192044A1Reduce in quantitySimplify line selection meanElectrostatic separatorsSludge treatmentElectrode arrayEngineering
A device for addressing an electrode array of 2n lines of an electro-fluidic device, each line having N electrodes (n≦N). The device includes, on each line, n selection electrodes, all of the line selection electrodes being connected to 2n line selection conductors, 2n−1 line selection electrodes of 2n−1 lines being connected to each line selection conductor, and selection devices for selecting one or more line selection conductors.
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Methods and systems for control of microfluidic devices
InactiveUS7010391B2Easy programmingSludge treatmentFixed microstructural devicesControl systemLow voltage
Owner:HANDYLAB
Method and Apparatus Using Electric Field for Improved Biological Assays
ActiveUS20090032401A1Avoid corrosionIncrease electric fieldElectrostatic separatorsSludge treatmentPresent methodEngineering
Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which is controllable to provide a positive charge and a negative charge to a given electrode. By controlled use of the electric field charged species in a fluid in a fluid channel are directed into or out of the well by an electric field between the electrodes. The present method involves the transport of fluids, as in a microfluidic device, and the electric field-induced movement of reactive species according to various assay procedures, such as DNA sequencing, synthesis or the like.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Methods for manipulating droplets by electrowetting-based techniques
InactiveUS20060054503A1Improve controllabilityImprove accuracySludge treatmentShaking/oscillating/vibrating mixersElectricityEngineering
Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.
Owner:DUKE UNIV
Liquid transfer device
InactiveUS20090321262A1Reduce in quantityEasy to controlSludge treatmentTransportation and packagingSpherical shapedEngineering
Provided is a liquid transfer device which controls electrically liquid position. The surface of the liquid transfer device is provided with unevenness in order to solve a problem of having a large number of electrodes for controlling voltage. The number of electrodes for controlling voltage can be halved by utilization of restoring force of liquid to a spherical shape by surface tension, in addition to electrical force.
Owner:HITACHI HIGH-TECH CORP
Electrophoretic particles and processes for the production thereof
In electrophoretic media, it is advantageous to use pigment particles having about 1 to 15 percent by weight of a polymer chemically bonded to, or cross-linked around, the pigment particles. The polymer desirably has a branched chain structure with side chains extending from a main chain. Charged or chargeable groups can be incorporated into the polymer or can be bonded to the particles separately from the polymer. The polymer-coated particles can be prepared by first attaching a polymerizable or polymerization-initiating group to the particle and then reacting the particle with one or more polymerizable monomers or oligomers.
Owner:E INK CORPORATION
Universal sample preparation system and use in an integrated analysis system
ActiveUS20110005932A1Optical radiation measurementSludge treatmentSample purificationCapillary Tubing
The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and / or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
Owner:INTEGENX
Systems and Methods for Controlling the Position of a Charged Polymer Inside a Nanopore
Techniques for controlling the position of a charged polymer inside a nanopore are provided. For example, one technique includes using electrostatic control to position a linear charged polymer inside a nanopore, and creating an electrostatic potential well inside the nanopore, wherein the electrostatic potential well controls a position of the linear charged polymer inside the nanopore.
Owner:GLOBALFOUNDRIES US INC
Microfluidic devices for methods development
InactiveUS6880576B2Material nanotechnologySludge treatmentChromatographic separationFlow resistivity
Microfluidic devices with multiple fluid process regions for subjecting similar samples to different process conditions in parallel are provided. One or more common fluid inputs may be provided to minimize the number of external fluid supply components. Solid materials such as chromatographic separation media or catalyst media is preferably provided in each fluid process region. Solid materials may be supplied to the devices in the form of slurry, with particles retained by porous elements or frits. Different fluid process regions may having different effective lengths, different solid material types or amounts, or may receive different ratios of common fluids supplied to the device. The flow resistances of dissimilar fluid process regions may be balanced passively with the addition of impedance elements in series with each fluid process region.
Owner:AGILENT TECH INC
Electrochemical device for moving particles covered with protein
InactiveUS6972080B1Efficient disposalElectrostatic separatorsSludge treatmentBlood componentElectrolysis
An electrochemical device for moving particles covered with a protein is provided. The device includes at least two electrodes that are in contact with a liquid containing the protein-covered particles and a circuit that generates a potential difference in a range that does not cause electrolysis of the liquid between the electrodes. The particles are moved by electrophoresis in the direction of the arrangement of the electrodes. The invention provided herein has numerous applications, including use in a microorganism concentration condensing device, a blood component induction device, and / or a blood component induction method, and / or an electric appliance that decreases the concentration of microorganisms present on the surface of a heat exchanger.
Owner:PANASONIC CORP
Microfluidic devices with thick-film electrochemical detection
InactiveUS6878255B1Reduce usageCost advantageSludge treatmentVolume/mass flow measurementAnalyteMicrofluidic channel
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic channel, and at least one thick-film electrode in fluidic connection with the outlet end of the microfluidic channel. The present invention includes an integrated on-chip combination reaction, separation and thick-film electrochemical detection microsystem, for use in detection of a wide range of analytes, and methods for the use thereof.
Owner:ARROWHEAD CENT
Sample Processing Droplet Actuator, System and Method
InactiveUS20080230386A1Easy to useFacilitates of propertySequential/parallel process reactionsSludge treatmentInterior spaceEngineering
Sample processing droplet actuators, systems and methods are provided. According to one embodiment, a stamping device including a droplet microactuator is provided and includes: (a) a first plate including a path or network of control electrodes for transporting droplets on a surface thereof; (b) a second plate mounted in a substantially parallel orientation with respect to the first plate providing an interior volume between the plates, the second plate including one or more stamping ports for transporting some portion or all of a droplet from the interior volume to an exterior location; (c) a port for introducing fluid into the interior volume between the plates; and (d) a path or network of reference electrodes corresponding to the path or network of control electrodes. Associated systems and methods including the stamping device are also provided.
Owner:ADVANCED LIQUID LOGIC +1
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