127 results about "Electrochemical detector" patented technology

A glucose sensor in the form of a skin patch 2 has a microneedle 4 which painlessly penetrates the skin to draw out interstitial fluid. The interstitial fluid passes to a common entrance port 7. A series of microchannels 8 is provided on the skin patch. The fluid drawn onto the patch is selectively switched between a number of microchannels 8 by means of electro-osmotic pumps 10 and hydrophobic gates 12. Each microchannel 8 has an electrochemical detector 11 for sensing gluocse concentration. Also disclosed is a monlithic device with an integrated lance 83.

A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities, heaters, electrochemical detectors, sensors for temperature, pH, fluid flow, and other useful components. The device may be fabricated from a plastic substrate such as, for example, a substantially saturated norbornene based polymer. The components are integrated into the device by adhering an electrically conductive film to the substrate. The film may be made of metal or an electrically conducting ink and is applied to the device through metal deposition, printing, or other methods for applying films. Methods for reducing bubble formation during electrokinetic separation and methods for heating material in a microfluidic device are also disclosed.

A microfabricated capillary electrophoresis chip which includes an integral thin film electrochemical detector for detecting molecules separated in the capillary.

A glucose sensor suitable for measuring glucose levels in human saliva is provided. Systems containing the glucose sensor and methods for making and using the sensor are also provided. The glucose sensor is highly sensitive and can detect glucose levels at least down to 5 ppm. Fabrication of the sensor involves depositing single-walled carbon nanotubes onto the surface of a working electrode in a 3 electrode electrochemical detector and functionalizing the nanotubes by depositing layers of polymers, metallic nanoparticles, and glucose oxidase enzyme onto the nanotubes. The sensor can be used as a disposable, single-use device or as part of an analytical system, such as a microfluidics system, for the analysis of multiple analytes. The sensor enables the diagnosis and monitoring of diabetes to be performed without pain or the need for finger pricks in a home or clinical setting.

The invention provides a preparation method and the application of an electrochemical micro-fluidic sensing chip. The preparation method comprises the following steps: directly coating an improved glass solution on a commercial standard printed electrode; and performing vacuum plasma treatment on a PDMS (Polydimethylsiloxane) chip with pre-designed pipelines and the printed electrode coated with the glass solution together, and directly bonding the PDMS chip on the commercial standard printed electrode to form a novel electrochemical microfluidic sensing platform. A sensor provided by the invention can perform ultrasensitive detection on various sample analytes in a biological fluid sample, taking the detection of a prostate cancer marker PSA (Prostate-specific Antigen) in human serum as an example, a coulomb amperometry is used for detection, and a result shows that the detection sensitivity can reach 0.84 pg / mL which is improved by two magnitudes than the standardized clinical testing requirement of 0.1 ng / mL, so that the sensor has superhigh detection sensitivity and accuracy, which are higher than those of other electrochemical detection devices, is convenient in operation, and can integrates sample processing, separation and the like on one micro electrochemical microfluidic sensing chip.

On a conventional T-shaped glass chip, a permanent magnet is utilized to fix and decorate a nanometer magnetic bead of a DNA probe in a separation channel of a chip; the rapid, sensitive, high-specific, high-stability, low-cost separation detection on the DNA is realized by utilizing electric drive sampling and combining a laser induced fluorescence detector or an electrochemical detector, thus solving the defects that the time of separating and detecting the DNA by utilizing a microfluidic chip is long, the separation effect is poor, the sensitivity is low, the specific is poor and the stability is poor and the like; the interface manufacturing is avoided by an electric sampling manner; the influence of dead volume is removed; and the sample use amount is reduced in a narrower and uniform micro pipeline, and meanwhile the lower detection limit is ensured.

The invention discloses a portable ractopamine molecular imprinted silk-screen printed electrochemical sensor, and belongs to the technical field of fast detection. 60-100 [mu]L of an electric conductance solution contains a to-be-detected sample is dropwise added to the surface of a ractopamine molecular imprinted silk-screen printed electrode, the standing adsorption time is 50-200 s, then the ractopamine molecular imprinted silk-screen printed electrode is horizontally inserted into a clamping slot of a portable electrochemical detector, a current peak value during scanning is recorded, calculation is performed according to a standard curve between the ractopamine concentration and the current peak value I([mu]A)=-14.944logC([mu]M)+0.2641 (R<2>=0.9923); and finally, the detected concentration of ractopamine in the sample is displayed on an LED screen. The sensor has the advantages of high precision, high stability and high repeatability.

The invention discloses a quantitative polymerase chain reaction (PCR) microfluidic chip integrated device for an integrated electrochemical detection technology. The PCR microfluidic chip integrated device comprises a fixed foundation, thermostats, a PCR microfluidic chip, and an electrochemical detector, and is characterized in that: three independent thermostats, namely a low-temperature annealing thermostat, an appropriate-temperature extending thermostat, and a high-temperature denaturation thermostat are sequentially manufactured on the fixed foundation in parallel; PCR reaction in the PCR microfluidic chip can be finished in a low-temperature annealing area, an appropriate-temperature extending area and a high-temperature denaturation area; and the electrochemical detector for quantitative detection of PCR reactant is arranged in a deoxyribonucleic acid (DNA) amplification reaction tube. The quantitative PCR microfluidic chip device is suitable for various gene diagnosis and detection and laboratories. The device platform integrates temperature control, PCR reaction and detection, and is high in miniaturization degree.

The invention provides simultaneous, rapid and continuous detection of multiple proteins, nucleic acids or pathogens by using a nanometer probe, paramagnetic micro-nano-particles and a microfluidic chip. According to the present invention, a monoclonal antibody or complementary nucleic acid sequence modified nanometer probe and antibody or nucleic acid modified magnetic micro-nano particle are used as detection reagents, a multi-channel microfluidic chip is used as a detection reaction cell, the antibody or nucleic acid modified magnetic micro-nano particle are immobilized on the bottom portion of the reaction cell by using a magnetic field to form a rewritable detection substrate, and an ultraviolet visible spectrophotometer, a fluorescence detector or an electrochemical detector is used as a signal acquisition device, such that the simultaneous and rapid detection of multiple proteins, nucleic acids or pathogens can be achieved; and based on the rewritability of the nanometer immune substrate and the anti-adhesion property of the chip material, the detector can achieve the continuous testing of different samples so as to substantially improve the detection automation and the sample treatment ability, and has wide application values in the fields of disease diagnosis, infectious disease monitoring, food hygiene and safety monitoring, and the like.

The invention relates to a poisonous and harmful gas detection chip and a preparation method thereof. For a chip detection system, a reaction microchannel, a fluid microchannel, an electrode microchannel and a microfluid driving region are processed on a microfluidic chip, so that the integration of a plurality of functional units is realized. An electrochemical oxidation / reduction reaction of poisonous and harmful gas is performed on the surface of an electrode slice embedded in the reaction microchannel; electrolysis is carried out to generate the change of an electrochemical signal; and an electrochemical detector obtains the type and concentration information of the analysed gas by analysing the change of the electrochemical signal.

The invention discloses a trace Na ion quickly determining method, applied to water quality analysis and monitoring. Under the action of peristaltic pump, one path of ultrapure water enters pipeline meeting through carrying liquor pump line, flow path and bypass pipeline, the other path fully alkalizes through the alkali liquor flow path to enter the pipeline meeting, the ultrapure water joins the alkali liquor to fully alkalize in the reacting coiled pipe and then enters current electrochemical detector, the blank signal value of the electrode potential signal produced between Na selective electrode and reference electrode is displayed by the Na ion processor and the recorder records the base line of the blank value; a water sample to be measured enters quantitative sampling ring through the lead-in pipe in the sampling position of the filling valve, when the filling valve switches filling position, the filled water sample stuff is uniformly alkalized to enter the current electrochemical detector, the electrode potential signal produced between the Na selective electrode and reference electrode is displayed by the Na ion processor and output to the recorder, which records the real testing curve.

A conductive oxide solid formed through an electrochemical process. The resulting solid predominantly contains oxides of the highest oxidation state. Additionally, the solid can be thick, uniform, stable across a wide range of acidity and temperature, fully hydrated, and conductive with a very low redox potential. A preferred embodiment is an iridium solid formed at high temperature in molten carbonate, said solid containing intercalated lithium. The solid has application as an electrode with reduced drift. An electrochemical acidity sensor is disclosed which pairs an electrode bearing the solid with a reference electrode. Additionally, sensor apparatuses for measuring carbon dioxide and other materials as well as methods for measuring materials using an embedded acidity sensor are disclosed.

The invention discloses a method for determination of low-concentration H2S in air. The method comprises that air is collected by an air sampler; H2S in the air is absorbed by a NaOH-EDTA mixed solution having a certain concentration so that the H2S is quantificationally transformed into S ions; an S ion concentration of the absorption solution subjected to high-purity nitrogen or argon preblowing is determined by an ion chromatograph (as an electrochemical detector); and the S ion concentration is further converted into H2S content of the air. The method has the advantages of high sensitivity, accurate result, good repeatability, simple experiment steps, fast analysis speed, no reagent pollution and reagent safety, and can be used for determination of a H2S concentration of indoor and outdoor air.

The invention discloses an analyzing device and method of enzyme inhibitor in the solution, which consists of electrode test piece and electrochemical detector, wherein the electrode test piece only provides one-time analysis for user. The invention can also be used to test the pesticide residues in the vegetable and fruit.

An electrochemical detector integrated on a capillary electrophoresis chip according to the present invention includes: a first substrate having a microchannel; a second substrate adapted to mate with the first substrate and having at least one peripheral electrode for conducting electrophoresis of a sample injected along the microchannel of the first substrate, in which a separation channel is formed along the microchannel by bonding the first substrate with the second substrate; a first electrode, made of indium tin oxide (ITO), formed on the first substrate to be positioned over the separation channel; and a second electrode, made of indium tin oxide (ITO), formed on the second substrate to be positioned under the separation channel, and spaced apart from the first electrode at a predetermined interval, wherein the first electrode and the second electrode constitute a detector to measure electrical characteristics of the sample passing along the separation channel. According to the present invention, since the specific characteristics of a sample can be evaluated by measuring the electrical or genetic characteristics of the sample flowing along the microchannel formed in a chip using a detector, a chip for a micro-analysis system having a simple structure can be realized.

An electrochemical detector including side channels associated with a separation channel of a sample component separation apparatus is provided. The side channels of the detector, in one configuration, provide a sheath-flow for an analyte exiting the separation channel which directs the analyte to the electrically developed electrochemical detector.

The present invention provides a pressurized capillary electrochromatography electrochemical detection device comprising a liquid storage tank of mobile phase, a high pressure pump used for carrying the mobile phase and providing liquid to a separation capillary electroosmotic chromatography connected to a detection cell through a microflow controller in which a sample can be input, a high voltage power supply which both ends are applied respectively to a liquid intake terminal of the capillary electrochromatography and a detection cell connected to an electrochemical detector which output terminal signals are connected to a computer through a signal gathering analysis meter. By combining the capillary electrochromatography separation technology and the electrochemical detection technology, the present invention is capable of separating, quickly and efficiently, and detecting, with a high sensitivity, species having electrochemical activity.

The invention belongs to technique field of electrochemistry sensor, specially a polymethyl methacryate and carbon nanometer tube composite material electrode and preparing method. The electrode adopts polymethyl methacryate and carbon nanometer tube composite material, the preparing method includes: prepolymer solution composed by the azobisisobutyronitrile and polymethyl methacryate is mixed evenly with carbon nanometer tube and filled in the electrode tube, then heated to aggregation, the carbon nanometer tube and polymethyl methacryate prepolymer solution are solidified to obtain electrode; the composite material filling end of the electrode is made to be disc shape, the metal wire and another end of the electrode tube is fixed by admixture to obtain electrode needed. The electrode is easy to produce, cost is low, and can be batch processed, it is an electrochemistry sensor with high-sensitivity, and can be used in capillary tiselius, microflow chip, flow injection analysis system, liquid chromatography, and possesses perfect foreground in filed of environmental monitoring, clinical diagnosis and food analysis.

The invention discloses a method for detecting amino acid contained in table vinegar. The method for detecting amino acid contained in table vinegar comprises the steps of: (1) distilling and extracting steam for a to-be-detected sample of table vinegar; (2) extracting and purifying an extractive in the step (1) by using a solid phase extraction column; (3) detecting a purified product of the step (2) by utilizing an ion chromatography-electrochemical detector, thereby obtaining the chromatogram map of the amino acid contained in the test sample of the table vinegar; (4) preparing 18 amino acid standard solutions, and carrying out ion chromatography analysis to obtain a chromatogram map of the 18 amino acid standard solutions; and (5) comparing the chromatogram maps respectively obtained in the step (3) and the step (4), thereby obtaining the types of amino acid contained in the test sample of table vinegar. The method for detecting amino acid contained in table vinegar provided by the invention has the advantages that an efficient, accurate and flexible analysis method for detecting 18 amino acid in the table vinegar by combining extraction with a distillation method, purification with a strong cation solid phase extraction column (SCX, strong cation exchanger) and an ion chromatography-electrochemical detector is established.

The present invention relates to offer an apparatus and a method for an integral electrochemical biosensor combining designs of blood sampling, continuous and multiply testing, multi-channel detecting and adjustable working voltage; furthermore several physiologic parameters can be obtained simultaneously in an identical testing. The invention provides convenience for users and improves the practicability. Said integral electrochemical biosensor comprises: at least a sampling device configured to supply a sample carrying room, which is in vacuum or a state of relative negative pressure by an applied force with a pressure difference to make inactive humor at a relative high pressure injecting into said sample carrying room; a plurality of electrode sets comprising a compared electrode, an assisting electrode and an operating electrode, on which chemical and / or physical reactions between said inactive humor and chemicals bring out after said inactive humor injecting into said sample carrying room; a multi-channel electrochemical detector configured to provide several choices of operating voltage for said operating electrodes; a logic and data device configured to grab and calculate data of result from said physical or / and chemical reactions; a signal displaying device configured to explicitly show physiological parameter values of said inactive humor and corresponding concentration of said physiological parameters.

This invention discloses a method for rapidly detecting E. coli concentration in water body. The method comprises: utilizing IrO2 / Pd decorative electrode as the electrochemical detector for flow injection-Ampere analysis, adding inducer isopropyl beta-D-thiogalactoside (IPTG), penetrant polymixin B nonapeptide and lysozyme into E. coli solution, releasing beta-D-galactosidase from E. coli cells induced by IPTG and catalytically hydrolyzing substrate 4-aminophenol-beta-D-galactopyranose in E. coli solution to obtain 4-aminophenol. Since the E. coli concentration in E. coli solution is in linear relationship with the amount of 4-aminophenol, rapidly detecting the amount of 4-aminophenol can realize rapid detection of E. coli concentration. The method has such advantages as short detection time, easy operation and high detection accuracy.

A method for measuring the component and calorific value of goal gas. The method includes measuring a volume concentration of H2 (TH2) using a thermal conductivity detector (TCD), measuring a volume concentration of O2 using an electrochemical detector (ECD), measuring volume concentrations of CO, CO2, CH4, and CnHm in the coal gas, revising an interference of CH4 in CnHm, revising a measured volume concentration of H2, and calculating the calorific value of the coal gas.

The invention provides a method and a system for electro chemical analysis of an antioxidant in cosmetics. The method for electro chemical analysis of the antioxidant in cosmetics comprises the following steps: performing pretreatment on a cosmetic sample in advance; and detecting the cosmetic sample by an electrochemical detector, and accurately detecting an antioxidant component under a complexbackground of the cosmetics.

The invention discloses a high precision portable electrochemical detection terminal. In the prior art, the conventional electrochemical detector has the disadvantages of complicated structure, bad interference resistant performance, bade stability, and low detection precision, and the provided detection terminal solves the problems mentioned above. The detection terminal is characterized by comprising a forward voltage follower circuit, a RE electrode and CE electrode based on the forward voltage follower circuit, a current / voltage conversion circuit, a WE electrode based on the current / voltage conversion circuit, and a three-circle opposite vertex intersected negative feedback amplifier, which is connected to the current / voltage conversion circuit. The provided detection terminal has the advantages of simple circuit, good circuit stability, strong interference resistant property, low energy consumption, and high testing precision, and thus is suitable for promotion and application.

An analytical device including a sensor, an analytical circuit, and a power source. The power source includes an optical coupler formed of a light source and a photovoltaic cell for producing an electromotive force in response to light from the light source. The optical coupler is configured to provide the electromotive force to the analytical circuit. The power source may be configured for separation between the power supply and the resulting electromotive force supplied to the analytical circuit. Various aspects of the invention are directed to providing a power source for one or more components of an electrochemical detector. A method of providing power to an analytical instrument is also disclosed.

The invention discloses an electrochemical blood detection method and device for reducing blood red cell interference, and the method comprises the following steps: blood and anti red cell antibody beads are reacted, blood red cells are bonded with the anti red cell antibody beads to obtain red cell beads; the anti red cell antibody beads are anti red cell antibodies combined with nano magnetic beads; 2) the blood red cell beads are absorbed by a magnetic material to exclude the blood red cell interference in subsequent blood electrochemical detection process; and 3) magnetic material adsorption blood is routinely electrochemically detected. The device is an electrochemical biosensor test paper or / and an electrochemical detector. The beneficial effects are that through the detection method, during electrochemical blood detection, the influence of large volume of red blood cells on the measurement is eliminated, and the accuracy of detection results is ensured.

The invention relates to the technical field of detection, in particular to a handheld suction type electrochemical detection device capable of processing a sample automatically. The handheld suction type electrochemical detection device comprises a handheld electrochemical detector, and the handheld electrochemical detector comprises a sampling mechanism and an electrochemical monitoring mechanism; the sampling mechanism comprises a sampling sucker and a liquid transferring device, and the sampling sucker comprises a reagent tank or a filter core; the electrochemical detection mechanism comprises an electrode and an electrochemical control device, and the electrode is arranged in the sampling sucker; the liquid transferring device and the electrochemical control device are integrated into a handheld shell; a connector is fixed to the shell, the connector is detachably connected with the sampling sucker, an electrode interface is fixed in the connector, and the electrode interface is connected with a detection port of the electrochemical control device; when the sampling sucker is connected with the connector, the electrode is connected with the electrode interface. By means of the sampling mechanism, the sample can be sucked in and exhausted out to be prepared, filtered and the like; thus, automatic treatment of the sample is achieved; by means of the electrochemical monitoring device, the sample can be electrochemically detected.