The invention relates to a preparation method of a temperature and CO2 double-responsive block
copolymer nano
micelle. The preparation method disclosed by the invention comprises the following steps of initiating
caprolactone ring-opening
polymerization by utilizing
pyrene methanol under the protection of
inert gas, then, carrying out
esterification reaction by utilizing terminal hydroxyl of
polycaprolactone and terminal carboxyl of a reversible addition-fragmentation
chain transfer polymeric
chain transfer agent, thereby obtaining a reversible addition-fragmentation
chain transfer polymerized macromolecular chain
transfer agent; and carrying out reversible addition-fragmentation chain transfer
polymerization of N-isopropylacrylamide and an N,N-dimethylacrylic acid dimethylamino
ethyl ester monomer by taking azodiisobutyronitrile as the initiator under the protection of
inert gas so as to obtain Py-PCL-b-(NIPAM-coDMAEMA) block
copolymer, dissolving the Py-PCL-b-(NIPAM-coDMAEMA) block
copolymer in water, thereby obtaining a steady temperature and CO2 responsive nano-
micelle. The temperature and CO2 double-responsive block copolymer nano-
micelle disclosed by the invention has biodegradability,
biocompatibility and bioactivity simultaneously; the steady nano micelle self-assembled in water has temperature and CO2 double-responsive characteristic; the preparation method disclosed by the invention has wide application prospect in the fields, such as
drug-
controlled release carriers, biological intelligent switches,
soft tissue engineering bracket materials and biological sensors; the preparation method disclosed by the invention is simple and practicable and has good popularization and application values; all the raw materials can be industrially produced.