The invention discloses a water-insoluble
medicine sustained-release pellet, a sustained-release
orally disintegrating tablet thereof and a preparation method thereof. The water-insoluble
medicine sustained-release pellet comprises a hollow pellet core, a
medicine layer, an
insulation layer and a sustained-release layer, wherein the sustained-release layer comprises the following ingredients: 54 to 88 percent of sustained-release materials, 2 to 30 percent of antitackiness agents and 1 to 30 percent of pore-foaming agents, wherein the percentage is the
mass percentage in the sustained-release layer, wherein the sustained-release materials are one kind or several kinds of materials selected from
ethyl acrylate and
methyl methacrylate copolymers,
polyvinyl acetate and
ethyl cellulose. Through regulating the
coating combinations and filling auxiliary materials to be pressed into orally disintegrating tablets, the medicine can be slowly released for more than 8 to 13 hours, so the stable blood medicine concentration can be maintained, the
side effect is reduced, the medicine taking times can be reduced, and the medicine taking is convenient. The invention conforms to zero-grade release, has the advantages of high final accumulated medicine release amount, high
efficacy, strong selectivity, good mouth feeling, simple production steps and high efficiency, and can be applied to large-scale production.