433 results about "Fluorobenzene" patented technology

The invention discloses a preparation method of 5-bromo-1,3-dichloro-2-fluorobenzene, which comprises the following steps: (1) simultaneously feeding ammonium salt and a sodium nitrite aqueous solution into a tubular reactor for tubular diazotization reaction so as to obtain a diazonium salt intermediate, wherein the ammonium salt is prepared through dissolving 3,5-dichloro-4-fluoroaniline in sulfuric acid; (2) dissolving cuprous bromide in hydrobromic acid, heating to 100-130 DEG C, dropwise adding the diazonium salt intermediate prepared in the step (1) for reaction, and after the complete reaction, performing after-treatment to obtain the 5-bromo-1,3-dichloro-2-fluorobenzene. According to the preparation method, the tubular diazotization reaction technology is adopted to prepare diazonium salt, so that the side reaction including diazonium salt coupling and decomposition and the like can be reduced, the diazotization reaction is enabled to be more stable, and the final yield is improved; in addition, the tubular diazotization reaction technology has a series of advantages of continuity in production, safety, short reaction time, energy saving and the like, and is relatively suitable for industrial production in the future.

The invention relates to technical field of a lithium ion battery, in particular to an electrolyte of a rapid-charging lithium ion battery. The electrolyte comprises a solvent, a lithium salt and an additive, wherein the solvent contains more than two mixtures of linear carbonic ester with a low boiling point, linear carboxylic ester, fluorobenzene and hydrofluoroether, and the additive comprises a first additive for negative electrode film forming, a second additive for improving the cycle performance of the battery and a third additive for improving the high-temperature performance of the battery. Compared with the prior art, the organic solvent and the three additives are used in a combination way to generate a synergistic effect, the rapid charging demand of a high-potential, high-compaction-density and more than 2C rapid-charging system battery with a voltage of 4.35V and negative electrode compaction density of over 1.6g / cm<3> can be met, and meanwhile, the electrolyte has favorable cycle performance and high- and low-temperature performance.

The invention provides a lithium-ion battery electrolyte, comprising a solvent and an additive, wherein the solvent comprises propyl propionate and two or three selected from a group consisting of vinyl carbonate, diethyl carbonate and propylene carbonate, and the additive comprises vinyl sulfate, fluoroethylene carbonate, adiponitrile, glycol bis(propionitrile) ether, 1,3-propanesultone and fluorobenzene. A lithium-ion battery prepared from the lithium-ion battery electrolyte has stable usability under the condition of 4.40 V or 4.45 V, has energy density of 750 Wh / L or above, cycle life of 800 times or above and a capacity retention ratio of 80% or above, so the service life of a novel high-voltage high-energy-density polymer lithium-ion battery is substantially improved.

The invention provides a lithium ion battery electrolyte and a secondary battery containing the lithium ion battery electrolyte, and relates to the technical field of electrochemistry. The lithium ion battery electrolyte contains a lithium salt, an organic solvent, 0.5-5% by weight of a film-forming additive, 1-15% by weight of a fluorobenzene compound, 0.01-0.5% of a wetting agent, and 0.01-2% of a stabilizer. The lithium ion secondary battery comprises a positive electrode material, a negative electrode material and an electrolyte, wherein the positive electrode material comprises, by mass, 85% of LiCoO2, 7.5% of polyvinylidene fluoride (PVDF) and 7.5% of conductive carbon black SP, and the negative electrode material comprises, by mass, 90% of high compactness graphite, 7% of polyvinylidene fluoride (PVDF) and 3% of conductive carbon black SP. According to the present invention, the battery capacity can be increased, the charge / discharge cycle performance can be improved, and the electrochemical window can be widened.

The invention discloses a synthesis method of synthesizing florfenicol. The synthesis method comprises the following steps: L-threo-(p-(methylsylfonyl) phenyl) serine ethyl ester which is used as raw material is processed by the protection by a protecting group, configurational transition, hydrolyzation, acetylation, re-protection, deoxidation, fluorination, and pre-hydrolyzation, so that the florfenicol is obtained, wherein, the protecting group R is one of benzoyl chloride, phthalic anhydride, cyanophenyl, and allyl compounds; the configurational transition is performed when sodium alcoholate or sodium methoxide exists. The raw material which is used in the method is a byproduct which is generated during the process of preparing thiamphenicol, is easy to get in the market, and is inexpensive; the technological operation is simple, the cost is low, the yield rate is high, and the synthesis method has industrialized value.

The invention relates to a functional additive for a lithium ion battery electrolyte, the lithium ion battery electrolyte and a lithium ion battery and belongs to the technical field of lithium ion batteries. The functional additive is prepared from the components in parts by weight as follows: 0.5-3 parts of vinylene carbonate, 0.1-2 parts of lithium difluoro(oxalato) borate, 0.1-2 parts of lithium difluoro phosphate, 3-5 parts of fluorobenzene and 0.1-1 part of methylene methanedisulfonate. The electrolyte comprises lithium salt, an organic solvent and the functional additive, wherein the mass percents of the components of the functional additive in the electrolyte are as follows: 0.5%-3% of vinylene carbonate, 0.1%-2% of lithium difluoro(oxalato) borate, 0.1%-2% of lithium difluoro phosphate, 3%-5% of fluorobenzene and 0.1%-1% of methylene methanedisulfonate. The invention further relates to the lithium ion battery using the electrolyte. The high-temperature cycle performance of the lithium ion battery is significantly enhanced.

The invention discloses a method for preparing ceritinib, belonging to the field of chemical pharmacy. The method comprises the following steps: by taking 3-bromine-4-methylphenol as an initial raw material, performing phenolic hydroxyl isopropylation, nitration, coupling and reduction reaction, obtaining a midbody 1, by further taking o-nitro fluorobenzene as another initial raw material, performing isosulfhydrylation, oxidation, reduction and pyrimidine, obtaining a midbody 2, performing coupling reduction on the midbody 1 and the midbody 1, obtaining ceritinib which is protected by BOC acid anhydride, and finally removing a t-butyloxycarboryl protecting group, and obtaining ceritinib. The method is simple and feasible to operate, relatively high in yield, small in pollution and applicable to industrial production.

The present invention concerns a process for preparing aseptic crystalline 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one palmitate ester (I) substantially free of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (II-a), 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3 -yl)-1-piperidinyl]ethyl]-6,7-dihydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one (II-b), and 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-ethyl]-6,7,8,9-tetrahydro-2-methyl-9-pentadecyl-4H-pyrido[1,2-a]pyrimidin-4-one (III), and having an average particle size ranging from 20 to 150 μm.

The invention relates to a preparation method for the two, four, six-three-chlorine fluorobenzene, belonging to fluorin chemical engineering technical field. The invention is characterized in that three and five-two chlorine and four fluorin are used as the materials, which are catalyzed and chlorinated with the chlorine under the action of a catalyst in order to make the two, four and six-three-chlorine fluorobenzene; the reaction temperature ranges from one hundred and fifty and two hundred and fifty DEG C; the catalyst is chosen from oxidation benzoyl, azobisisobutyronitrile, and crown ether; the dosage accounts for zero point zero three percent to one percent of the three and five-two-chlorine-four-nitrobenzene. The invention has the advantages that the defects of the preparation method in the prior art such as low yield, high reaction temperature and the rigorous equipment condition are overcome; the preparation method enables the reaction to be completed below two hundred and twenty DEG C; the reaction equipment and the corresponding matched auxiliary equipment has low cost; the material transformation rate and the yield are increased; the purity of the products can reach ninety-nine point eight percent; the materials of the invention can be chosen from the leftovers which can be seen commonly in chemical enterprises and the rectifying remaining, which can save the prior resources with good economic benefit, environmental benefits and social benefits.

The invention discloses a non-aqueous electrolyte solution for a high-voltage lithium ion secondary battery. The non-aqueous electrolyte solution comprises a non-aqueous solvent, a lithium salt dissolved in the non-aqueous solvent and additives, wherein the non-aqueous solvent comprises 1-15mass% of fluorobenzene in the electrolyte; and the additives comprise fluoroethylene carbonate (FEC) and a tri-nitrile material. Due to the non-aqueous electrolyte solution for the high-voltage lithium ion secondary battery, the high-voltage lithium ion secondary battery can obtain excellent cycling performance and high-temperature performance.

The invention discloses a method for measuring benzene and benzene series in printing ink. In the method, fluorobenzene is used as an internal standard substance, and the benzene and benzene series content of the printing ink is measured by headspace gas chromatography-mass spectrometry. The measuring method has the advantages of simple sample pretreatment, high automation degree of the whole operation, high measurement sensitivity and repeatability, capability of realizing measurement continuity, and suitability for simultaneous, quick and accurate detection of the benzene and benzene series content of batch printing ink. The invention provides a method and scientific evidences for analyzing and controlling the benzene and benzene series content of the printing ink.

The invention provides a novel method for synthesizing ezetimibe. The method uses fluorobenzene as an initial raw material to react with glutaric anhydride and 4(s)-4-phenyl oxazolidone in sequence under the action of a catalyst, and generates the ezetimibe via condensation, cyclization, deprotection, reduction and other conventional methods after carbonyl is protected by thiol. The method has the advantages of high yield and few side reactions, and is applicable to industrial production.

An electric double layer capacitor having a pair of polarized electrodes and an electrolytic solution capable of forming an electric double layer at the interface with the polarized electrodes, wherein the electrolytic solution is an organic electrolytic solution containing a fluorobenzene of the formula 1: wherein n is an integer of from 1 to 6.

The invention discloses a synthetic method of 4-(2,2-difluoro-1,3-benzodioxole-4-yl)pyrrole-3-nitrile. The method comprises the following steps of: preparing an intermediate 2,2-difluorobenz-1,3-dioxole through reacting catechol with dibromodifluoromethane, and preparing an intermediate 2-cyano-3-(2,2-difluorobenz-1,3-dioxole-4-yl)-2-acrylate. The fludioxonil prepared by the synthetic method provided by the invention has the purity of more than 99.0% and the total yield of more than 45.0%; the synthetic method has the advantages of cheap and easily available raw materials, simple process, high product yield in each step, good purity, low production cost, applicability to batch industrial production and the like.

The invention discloses a lithium ion battery electrolyte. The electrolyte comprises a non-aqueous organic solvent, a lithium salt, a film formation agent and additives, wherein four additives of fluorobenzonitrile, fluorobenzene, an oxalic acid and phosphoric acid lithium salt and a fluorotrioxophosphate lithium salt are simultaneously added into the lithium ion battery electrolyte, a synergistic effect will be generated by simultaneously using the additives, so that the ternary positive electrode material has advantages of excellent cycle property, high-temperature storage performance, low-temperature discharge performance, safety and the like under a high-voltage (4.3-4.5V) condition, and the problem that the cycle property, the high-temperature performance and the low-temperature performance of a high-voltage ternary battery electrolyte in the prior art cannot be simultaneously compatible is solved very well.

The invention discloses a cross-linkable fluorobenzene-containing end-capped liquid crystal conjugated polymer based on benzodithiophene and double thiophene-substituted difluorobenzothiadiazole and an application thereof to a solar cell. The polymer is characterized by being shown as a structural formula in the specifications. The conjugated polymer disclosed by the invention has liquid crystal characteristic, and can be used for inducing, adjusting and controlling the ordered structure of an active layer and increasing hole mobility; the terminal group of the polymer is functionalized by using a fluorobenzene-containing end-capping agent, so that uniform dispersion between the polymer and PCBM ([6,6]-phenyl-C61-butyric acid methyl ester) can be facilitated, the hole electron transmission rate of the active layer is increased, the device performance is enhanced effectively, and energy transformation efficiency is up to 7.6 percent; and due to the introduction of a cross-linkable unit, a cross-linked active layer material with a stable structure can be obtained, the stability of a device is enhanced, the service life of the device is prolonged, and the efficiency can still reach 7.3 percent 40 days later.

The invention provides a high-voltage lithium ion battery and electrolyte thereof. The electrolyte of the high-voltage lithium ion battery comprises non-aqueous organic solvent and lithium salt which is dissolved in the non-aqueous organic solvent. To calculate by the total mass of the solvent and additives of the high-voltage lithium ion battery, the non-aqueous organic solvent comprises the following components mass percentage: 35-53 percent of cyclic carbonate, 17-39 percent of chain carbonate and 15-30 percent of fluorobenzene (FB). The electrolyte of the high-voltage lithium ion battery additionally comprises at least one of the following additives by mass percentages: 0.5-10 percent of vinylene carbonate (VC), 3-15 percent of fluoroethylene carbonate (FEC) and 1-7 percent of 1, 3-propanesultone (PS). The high-voltage lithium ion battery comprises a positive plate, a negative plate, a diaphragm which is arranged between the positive plate and the negative plate close to each other, and electrolyte which is the electrolyte of the high-voltage lithium ion battery. Therefore, gas which is produced by the battery during high-temperature storage under high voltage can be reduced, the high-temperature storage performance and the safety performance of the battery are improved and the circulating performance of the battery under the high voltage is improved.

The invention relates to an ultrahigh-fluorine-substituted liquid crystal compound with a CF2O bridge bond, a synthetic method and application, in particular to 1-alkoxy-4-((difluoro(3,4,5-trifluoro-phenoxyl)methylene)-3,5-difluoro phenyl) ethyl)-2,3,5,6-tetrafluorobenzyl and a synthetic method. The compound can be used for preparing a mixed liquid crystal compound.

The present invention relates to two synthesis methods for preparing 2,3,4-trifluorobenzoic acid, in which 2,3,4-trifluoroaniline is used as raw material, the diazotization of amino group and nitrile grouping actino are used to obtain 2,3,4-trifluorobenzonitrile, processed with acid hydrolysis to obtain the invented product, in another mether, 2,3,4-trifluoroaniline processed by diazotization of amino group and bromization to obtain 1-bromo-2,3,4-trifluorobenzene, then reacted with metal magnesium to obtain Grignard reagent, and reacted with carbon dioxide and processed by acid hydrolysis so as to synthesize the invented product.

The invention discloses a method for testing the content of benzene and benzene series in a water base adhesive for tobaccos. The method comprises the following steps of: preparing internal standard matrix correction liquid, standard working solution and sample solution; performing static headspace gas chromatography and mass spectrometry analysis; drawing a standard curve, calculating a result and the like. The improved and optimized detection method has the advantages of simplicity and accuracy in operation, high sensitivity, high recycling rate, high repeatability and the like. In the method, fluorobenzene is used as an internal standard for internal standard quantitative detection, so that errors caused by a sample preparation process, different sample injection quantities or different instrument precision and the like can be reduced effectively; and under the adopted chromatographic condition, the separation degree of five target compounds and an internal standard chromatographic peak is high and higher linearity relevance is high; and the detection limit is 0.40 to 0.84mu g / kg, the quantitation limit is 21.32 to 2.79mu g / kg, the marking recovery rate is 95 to 101 percent, and the average relative standard deviation is 0.91 to 2.46 percent.

The invention discloses a preparation method of {[Cu(L)] (ClO4).0.25H2O} (1) (L=4-(3-(4H-1, 2, 4-triazole-4-yl)phenyl)-4H-1, 2, 4-triazole). The complex is prepared by using a hydrothermal method comprising the step of reacting Cu(ClO4)2 and L under a 100-DEG C hydrothermal condition. The invention further discloses application of a copper complex, namely {[Cu(L)] (ClO4).0.25H2O} (1) (L=4-(3-(4H-1, 2, 4-triazole-4-yl)phenyl)-4H-1, 2, 4-triazole) as a catalyst for coupled reaction of p-fluorophenylboronic acid.

A benzo[k]fluoranthene derivative represented by the following formula (1):wherein R1 to R12 are as defined in the specification. The benzo[k]fluoranthene derivative represented by the formula (1) reduces a driving voltage of an organic electroluminescence device and makes it possible to realize light emission with high efficiency and long lifetime.

The present invention provides a lithium secondary battery improved in safety from overcharge as well as cycle characteristics. A non-aqueous electrolytic solution is used for the lithium secondary battery. In the non-aqueous electrolytic solution, an electrolyte salt is dissolved in a non-aqueous solvent. The non-aqueous solvent comprises two or more cyclic carbonate compounds. The non-aqueous electrolytic solution further contains 1 to 10 wt. % of a cyclohexylbenzene compound having a halogenated benzene ring and 0.1 to 5 wt. % of a fluorobenzene compound.

Disclosed is a non-aqueous electrolyte composition for batteries, which is composed of a mixture of a fluorobenzene component and a carbonic acid ester component in which the volume ratio of the fluorobenzene component to the carbonic acid ester component ranges from 50:50 to 5:95. The non-aqueous electrolyte composition has a significant advantage over electrolyte compositions employing carbonic acid ester solvents only, in terms of low temperature performance, cell life, and high-temperature dischargeability.

The invention provides a method for preparing 2, 4, 5-trifluoro-phenylacetic-acid. The method adopts 1, 2, 4-trifluoro-benzene to react with polyformaldehyde and chlorinating agent to obtain 2, 4, 5-trifluoro-benzyl chloride, and adopts the 2, 4, 5-trifluoro-benzyl chloride to react with cyaniding agent in ionic liquid to obtain 2, 4, 5-trifluoro-benzyl cyanide, and then the 2, 4, 5-trifluoro-benzyl cyanide is hydrolyzed in acid or alkalic conditions to obtain the 2, 4, 5-trifluoro-phenylacetic-acid. The preparation method for preparing 2, 4, 5-trifluoro-phenylacetic-acid requires cheap and available materials, and has moderate reaction conditions, less three-wastes and better safety; industrialized production can be easily realized, the product purity is high, and quality is stable, thuscompletely meeting the using requirement of 2, 4, 5-trifluoro-phenylacetic-acid as a pharmaceutical intermediate.

The invention discloses a preparation method of a biphenyl triphosphane ligand and an application thereof in hydroformylation reaction. The prepared biphenyl triphosphane ligand has the structure shown as a formula (I) or formula (II) described in the specification. In the formula (I), aryl substituent Ar is benzene, p-methyl benzene, m-benzenyl trifluoride, p-benzenyl trifluoride, 3, 5-dibenzenyl trifluoride, 3, 5-difluorobenzene, 3, 5-dimethyl benzene, 3, 5-di-tert-butyl benzene, 3, 5-di-tert-butyl-4-metoxybenzene, p-metoxybenzene, p-dimethylamino benzene, 2-pyridine, p-fluorobenzene or 2, 3, 4, 5, 6-pentafluoro benzene; in the formula (II), R is in a cyclic phosphonate structure. The biphenyl triphosphane ligand disclosed by the invention can be used as a linear hydroformylation reaction catalyst, so that the selectivity and reaction rate of hydroformylation reaction can be remarkably improved. The biphenyl triphosphane ligand is low in cost and has a huge practical value.

The invention belongs to the technical field of nonaqueous electrolyte batteries and particularly relates to a nonaqueous electrolyte which comprises solvent, solute and additive. The solvent is composed of ethylene carbonate, propylene carbonate, diethyl carbonate, ethyl methyl carbonate and fluorobenzene compounds which are mono-fluorobenzen or di-fluorobenzene, wherein the content of the fluorobenzene compounds is 2%-40% by volume percent on the basis of the solvent. The additive is one of nitriles, vinyl acetate and vinylene carbonate, wherein the chemical formula of the nitriles is NC-R-CN, R refers to alkyl groups and contains 2-6 carbon atoms. Compared with the prior art, the nonaqueous electrolyte has the advantages that the cycle life of batteries can be prolonged, high-temperature storage performance of the batteries can be improved, and expansion of the batteries at high temperature is inhibited while overcharge safety performance of the batteries is well considered. In addition, the invention further discloses a lithium ion battery containing the nonaqueous electrolyte.

The invention relates to a drug combination of a multi-poly (ADP-ribose) polymerase (PARP) inhibitor, a method of treating or preventing HBV-related diseases by utilizing the drug combination, and the application of the drug combination. More specifically, the invention relates to a drug combination comprising 1-(ciprofloxacin formyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro benzoyl] piperazine, a method of treating or preventing HBV, liver cancer, liver cirrhosis and other HBV-related diseases by utilizing the drug combination, and the application of the drug combination.

The invention discloses a thermal-activation delayed fluorescence material with blue light emission wavelength. By using 4-fluorophenylacetonitrile as an electron acceptor unit, electron donors are connected to 2, 3, 5 and 6 sites of the central benzene ring to obtain the thermal-activation delayed fluorescence material. The thermal-activation delayed fluorescence material is the compound represented by the structural general formula (I), wherein R represents N-carbazolyl, N-phenothiazinyl or N-phenoxazinyl. Different electronegative functional groups are introduced into the 2, 3, 5 and 6 sites of the parent benzene ring of the 4-fluorophenylacetonitrile electron acceptor to perform chemical modification, thereby implementing blue light emission. The prepared fluorescent material has typical thermal-activation delayed fluorescence effects, can delay the fluorescence life by 10-60 microseconds, and is applicable to organic electroluminescent devices.

The invention discloses lithium ion battery flame-retardant electrolyte which comprises raw materials of an electrolyte lithium salt, an organic solvent and a flame-retardant additive, wherein the organic solvent is prepared from the following components in parts by volume: 15-40 parts of an organic basic solvent with a high dielectric constant, 5-45 parts of a low-vapor pressure solvent, 10-55 parts of a low-viscosity solvent and 2-35 parts of an indoor temperature ionic liquid; the anion of the indoor temperature ionic liquid is prepared from at least one ion of tetrafluoroborate, hexafluoroborate, trifluoromethanesulfonate, bi-trifluoro sulfonamide and trifluoroacetic acid; the cation of the indoor temperature ionic liquid is ammonium cation; the flame-retardant additive is at least one of fluoroproplylene carbonate, di-fluoroproplylene carbonate, trifluoroproplylene carbonate, fluorobenzene ether, fluoro ether and propyl-2,2,2-trifluoro-ethyl carbonate; the mass of the flame-retardant accounts for 1-20% of the total mass of the electrolyte. By adopting the lithium ion battery flame-retardant electrolyte, not only is the flame-retardant property of the electrolyte remarkably improved, but also the charge and discharge property of a battery is slightly affected.