6275results about How to "High reaction yield" patented technology

Processes for the conversion of hydrocarbons boiling in the temperature range of from about 80° F. to about 1000° F. to diesel boiling range hydrocarbons, and processes for increasing the cetane number and amount of n-C17 hydrocarbon products in such processes. Diesel boiling range hydrocarbons may be produced by contacting a hydrocarbon boiling in the above-mentioned boiling range with a triglyceride-containing compound to form a mixture, and then contacting the mixture with a hydrotreating catalyst under suitable reaction conditions.

An objective of the present invention is to provide methods for efficiently producing (S)-1-(3,4-dimethoxyphenyl)-2-propanol at a high optical purity. Another objective is to provide novel reductases which reduce 3,4-dimethoxyphenylacetone, using NADPH as a coenzyme, to produce (S)-1-(3,4-dimethoxyphenyl)-2-propanol with a high optical purity.The inventors found that a 3,4-dimethoxyphenylacetone-reducing enzyme present in Torulaspora delbrueckii is a novel carbonyl reductase that reduces various carbonyls. This novel enzyme reduces 3,4-dimethoxyphenylacetone in a reduction reaction to produce (S)-1-(3,4-dimethoxyphenyl)-2-propanol with a high optical purity and at a high yield. Furthermore, the inventors isolated a DNA that encodes the present enzyme, and generated a recombinant bacterium which highly expresses the present enzyme. Thus, the present inventors established a simple and highly economical method of obtaining optically active alcohols with a high optical purity and at a high yield.

The invention provides a method of producing a reactive silicon group-containing polyether oligomer which comprises reacting (a) a polyether oligomer having main chain of a polyether and, in each molecule, at least one unsaturated group represented by the general formula (1):(in the formula, R1 is a hydrocarbon group containing not more than 10 carbon atoms and R2 is a divalent organic group containing 1 to 20 carbon atoms and one or more species selected from the group consisting of hydrogen, oxygen and nitrogen atoms as a constituent atom) or the general formula (2):on a side chain or at a terminus with (b) a reactive silicon group-containing compound in the presence of (c) a group VIII transition metal catalyst to introduce the reactive silicon group into said polyether oligomer (a),wherein the reaction is carried out in the presence of (d) a sulfur compound.

The invention discloses a preparation method of 1-(4-(4-(1H-1,2,4-triazolyl-1-yl)phenoxy)phenyl)-1H-1,2,4-triazole. The organic compound is prepared by heating 4,4'-dibromodiphenyl ether, triazole, potassium carbonate and copper oxide by a one-pot process. The preparation method has the characteristics of simple technological operation, low production cost and low environmental pollution, and is suitable for large-scale industrial production. The invention also discloses application of the 1-(4-(4-(1H-1,2,4-triazolyl-1-yl)phenoxy)phenyl)-1H-1,2,4-triazole in photoelectric materials.

The invention belongs to the field of medicinal chemistry, and discloses pyrimidine compounds containing semicarbazide and terminal alkyne structural units, and preparation methods and applications of the pyrimidine compounds in preparation of antitumor drugs by taking lysine specific demethylase 1 (hereafter referred to as LSD1) as a target. A pyrimidine active fragment is built by adopting a three-component one-pot method, and then the target compounds are prepared by substitution, chlorination and ammonification reaction. The general formulas of the compounds are as shown in the formula I in the specification. An in vitro anti-tumor activity experiment and an LSD1 inhibition activity experiment prove that the compounds have obvious inhibiting and killing action on a plurality of tumor cells by inhibiting the activity of the LSD1, can be used as lead compounds for further development, and are applied to preparation of the antitumor drugs.

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

The present invention relates to a new process for effectively converting the chirality of 4- or 5-position carbon of a 1,4-lactone- or 1,5-lactone sugar compound which comprises reacting the lactone compound with secondary amine and sulfonyl group-containing compound. The compound of which chirality is converted according to the present invention can be advantageously used for preparing such expensive rare sugar compounds as L-ribose, D-talose, etc.

The invention provides a method of a racemoid aldehyde group-ubstituted small cyclic amine compound, a high efficiency high enantio-selectivity synthesized chiral aldehyde group-substituted small cyclic amine compound and the synthesis of 3-substituted lactam compound with certain optical activity. Compared with the existing method, the method has wide adaptive substrate, and the catalyst is easily acquired, the reaction condition is mild, the operation is simple and convenient and the reaction efficiency is high. No adding of any metal salt compound is required, thus facilitating the production and the processing of the medicine.

The invention relates to a preparation process of herbicide dicamba, in particular to a supercritical preparation process. The preparation process of the herbicide dicamba comprises the following steps of: preparing 2,5-dichlorophenol into corresponding sodium phenolate, and then completing carboxylation reaction under a supercritical condition to obtain 3,6-dichlorosalicylic acid; and then completing O-methylation to prepare a product of 3,6-dichloro-2-methoxy salicylic acid, i.e. the dicamba, by taking dimethyl carbonate as a reagent. The invention changes the heterogeneous gas-solid reaction of the traditional process into homogeneous reaction under the supercritical condition, carries out the O-methylation reaction by using the dimethyl carbonate and has the advantages of high reaction yield, good product quality, reduced environmental pollution, lowered energy consumption, and the like.

The invention provides a preparation method of methylene diphenyl diisocyanate. The method comprises the following steps: performing a salt forming reaction on m-xylylenediamine and hydrogen chloride gas to obtain m-xylylenediamine hydrochloride; mixing the m-xylylenediamine hydrochloride, an organic phosphorus compound and solid phosgene for reaction to obtain methylene diphenyl diisocyanate. In a process of preparing methylene diphenyl diisocyanate, according to the application, an organic phosphorus compound additive is introduced, so that the reaction of m-xylylenediamine hydrochloride is promoted, therefore, the reaction rate and the effective conversion rate are improved.

The invention discloses a porous carbon-loaded composite material catalyst as well as a preparation method and application thereof. The catalyst consists of a carrier, an active component and a carbon quantum dot, wherein the active component and the carbon quantum dot are loaded on the carrier; the size of the carbon quantum dot is not more than 10 nm; the carrier is porous activated carbon; the active component is one of or a combination of several of platinum, palladium, iridium, ruthenium and rhodium; based on the mass of the carrier, the loading quantity of various metals in the active component is shown as follows: the platinum is 0-10.0 percent by weight, the palladium is 0-10.0 percent by weight, the iridium is 0-10.0 percent by weight, the ruthenium is 0-10.0 percent by weight, and the rhodium is 0-5.0 percent by weight; the loading quantity of the platinum, the rhodium and the palladium is not 0; the total loading quantity of the active component is more than 0.5 percent by weight and is not more than 20 percent by weight; based on the mass of the carrier, the loading quantity of the carbon quantum dot is not more than 15.0 percent by weight. The invention further provides application of the porous carbon-loaded composite material catalyst to the reaction of synthesis of chloroaniline by selective catalytic hydrogenation of chloro-nitrobenzene. The catalyst has the characteristics of being high in conversion rate, high in catalytic activity and high in stability.