81results about How to "Inhibition of catalytic activity" patented technology

The invention provides a method of producing a reactive silicon group-containing polyether oligomer which comprises reacting (a) a polyether oligomer having main chain of a polyether and, in each molecule, at least one unsaturated group represented by the general formula (1):(in the formula, R1 is a hydrocarbon group containing not more than 10 carbon atoms and R2 is a divalent organic group containing 1 to 20 carbon atoms and one or more species selected from the group consisting of hydrogen, oxygen and nitrogen atoms as a constituent atom) or the general formula (2):on a side chain or at a terminus with (b) a reactive silicon group-containing compound in the presence of (c) a group VIII transition metal catalyst to introduce the reactive silicon group into said polyether oligomer (a),wherein the reaction is carried out in the presence of (d) a sulfur compound.

Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.

The invention belongs to the field of fluorescence analysis technology, and specifically discloses a ratio fluorescence analysis method for detecting mercury ions based on silicon-doped carbon quantumdots and platinum-gold nano-particles. The ratio fluorescence analysis method for detecting the mercury ions specifically comprises that: the silicon-doped carbon quantum dot which can emit blue fluorescence and is prepared by using N-[Beta]-(aminoethyl)-[Gamma]-aminopropyl trimethoxysilane and citric acid as a silicon source and a carbon source separately is used as a reference fluorophore; andthe platinum-gold nano-particles catalyze the OPD to produce a DAP-responsive fluorophore which can emit orange-yellow fluorescence; meanwhile, since the DAP characteristic absorption spectrum mostlyoverlaps with the emission spectrum of the silicon-doped carbon quantum, the DAP can efficiently quench the silicon-doped carbon quantum dots. Meanwhile, the catalytic effect of the platinum-gold nano-particles can be specifically inhibited by using the metal-selective effect of the mercury ions; therefore, the detection of trace mercury ions using the double-emission ratio fluorescence analysis method is realized. The ratio fluorescence analysis method for detecting the mercury ions has the advantages such as simple operation, high sensitivity, quickness and convenience, and can be used for rapid detection of mercury ions, which has broad application prospects.

It is an object of the present invention to provide a method of producing a rutile titanium dioxide fine particle having a high ultraviolet protection property and high transparency for visible light. The present invention provides a method of producing a rutile titanium dioxide fine particle, comprising the steps of (1) treating titanium dioxide hydrate with at least one of a basic compound selected from the group consisting of hydroxides of alkali metal and hydroxides of alkaline-earth metal, and (2) treating the compound obtained by the step (1) with a carboxylic acid group-containing compound and an inorganic acid.

A process for the hydrotreating of fuels with co-production of hydrogen during operation of the process, which enables i.e. reduced need of make-up hydrogen in the hydrotreating stage. The hydrocarbon fuel introduced to the hydrotreatment stage is a fuel containing renewable organic material which generates carbon monoxide during operation of the process. The carbon monoxide is then converted to hydrogen in the recycle loop by a water gas shift stage.

The invention relates to a method of effectively producing 1, 3-propylene glycol by changing the membrane permeability, which adds nonionics to change the membrane permeability, effectively promotes the cell growth, and increases the concentration of 1, 3-propylene glycol which is the finished product of fermentation. The utility model has the technical process that as follows: adding the second-class germ culture into the fermentation culture; adding nonionics which can improve the membrane permeability to the fermentation culture; the nonionics reduce the resistance of the oxygen and nutrient substance from entering the cell, promote the cell growth, enhance the secreting of metabolite to the extra-cellular area, reduce the accumulation of metabolite in cell, and facilitate the elimination of inhibition of product and sub product, in particular the inhibition of cell growth and cell catalytic activity by 1, 3-propylene glycol. The concentration of the fermentation product--1, 3-propylene glycol is increased by 10 to 70 percent. With simple technical process and low production cost, the invention is easy to be industrially applied.

The invention provides a method for operating a reformed gas production apparatus with which it is possible to achieve a high reforming efficiency while preventing a drop in catalyst activity due to the deposition of carbon. The reformed gas production method uses a reforming catalyst to reform a fuel that contains a hydrocarbon having at least two carbon atoms to produce a reformed gas that includes methane, hydrogen, and carbon monoxide. With this method, a fluid that includes the fuel, at least one of steam and a carbon dioxide-containing gas, and an oxygen-containing gas, is supplied to a reforming reaction region, and with the thermal decomposition index temperature of the fuel, which is determined by the type and the concentration of the hydrocarbons having at least two carbon atoms that make up the fuel, serving as an upper limit temperature of the reforming reaction region, the fluid is brought into contact with the reforming catalyst to produce the reformed gas.

The invention provides a palladium / alkali metal compound supported catalyst and a preparation method and application thereof. The catalyst is composed of a supporter and an active component supported on the supporter. The supporter is active carbon. The active component comprises elemental palladium and an alkali metal compound. Based on the mass of the supporter active carbon, the supporting amount of the elemental palladium is 0.25-15.0wt%, and the theoretical supporting amount of alkali metal elements in the alkali metal compound is 0.01-5.0wt%. The catalyst can be applied to a catalytic hydrogenation reaction of a haloaromatic nitrocompound and / or an aromatic nitro compound. The catalyst is high in catalytic activity and easy to recycle and use indiscriminately, no dehalogenation inhibitor needs to be added when the catalyst is applied to the catalytic hydrogenation reaction of the haloaromatic nitrocompound, and the reaction conversion rate and the product selectivity are still excellent on the premise of keeping the high reaction speed.

This invention relates to a method for selecting PDE IV inhibitors which have a salutory therapeutic index, and to compounds having these properties.

A synthesis gas production apparatus (reformer) to be used for a synthesis gas production step in a GTL (gas-to-liquid) process is prevented from being contaminated by metal components. A method of suppressing metal contamination of a synthesis gas production apparatus operating for a GTL process that includes a synthesis gas production step of producing synthesis gas by causing natural gas and gas containing steam and / or carbon dioxide to react with each other for reforming in a synthesis gas production apparatus in which, at the time of separating and collecting a carbon dioxide contained in the synthesis gas produced in the synthesis gas production step and recycling the separated and collected carbon dioxide as source gas for the reforming reaction in the synthesis gas production step, a nickel concentration in the recycled carbon dioxide is not higher than 0.05 ppmv.

The invention discloses novel N-4-phenylsulfonamido--N'-1-desoxy-(2-desoxy-2-substituted-amino)-beta-D-glucopyransoylthiocarbamide compounds with the general formula disclosed in the specification, which have the activity of inhibiting carbonic anhydrase and further achieve the effect of resisting tumor metastasis and invasion. The compounds structurally have the three active segments sulfamine, substituted glucosamine and thiocarbamide, and the three active segments and Zn<2+> ions in the carbonic anhydrase form coordinate bonds, thereby inhibiting the catalytic activity of the enzyme and performing the function of resisting tumor metastasis and invasion. Thus, the compounds have application potential in the aspect of antitumor drugs. In the general formula, R is defined in the specification.

A catalyst body of the present invention includes: a porous carrier in which a large number of aggregate particles containing a main component of a nonoxide ceramic are bonded to one another while a large number of pores are disposed; and a catalyst layer carried on the porous carrier and containing a compound of an alkali metal, wherein the porous carrier has an oxide film unavoidably formed on a part of the surface of the aggregate particles, and an oxide film protective layer formed of a material which does not form low-melting glass with the alkali metal is further disposed between the oxide film and the catalyst layer in such a manner as to coat at least a part of the oxide film.

A process for the hydrotreating of fuels with co-production of hydrogen during operation of the process, which enables i.e. reduced need of make-up hydrogen in the hydrotreating stage. The hydrocarbon fuel introduced to the hydrotreatment stage is a fuel containing renewable organic material which generates carbon monoxide during operation of the process. The carbon monoxide is then converted to hydrogen in the recycle loop by a water gas shift stage.

The invention discloses a detection method for organophosphorus pesticides. The detection method comprises the following steps: fully mixing a test sample which may contain organophosphorus pesticides (such as thimet, omethoate and rogor) with gold-core platinum-shell nanoparticles and polyacrylic acid in a phosphate buffer solution so as to form a first mixed system; and then adding a sodium citrate buffer solution and the characteristic substrate of peroxidase, carrying out uniform mixing so as to obtain a second mixed system and determining the light absorption value of the obtained mixture in the range of visible-light wavebands so as to realize detection of the organophosphorus pesticides in the test sample. The invention also discloses a detection kit for the organophosphorus pesticides. The detection kit comprises the characteristic substrate of peroxidase, the gold-core platinum-shell nanoparticles, polyacrylic acid, auxiliary reagents and the like. The detection method for the organophosphorus pesticides in the invention is simple, convenient, rapid, low in cost, high in stability and applicable to detection of residual organophosphorus pesticides in environment samples, food samples and the like.

A polyester polymer comprising alkylene arylate units, said polymer having an It.V. of at least 0.72 dl / g, a vinyl ends concentration of at least 0.8 microequivalents per gram, an AA generation rate of less than 20 ppm are prepared by addition of a catalyst deactivator either late in the polycondensation or upon remelting of a solid polyester polymer.

The invention provides a method for increasing the concentration of 1, 3-propanediol in biological fermentation production, particularly relating to a method for adding an antibiotic, reducing transfer resistance when nutrition and metabolites enter or exit a cell, effectively promoting cell growth and increasing the concentration of the 1, 3-propanediol in the biological fermentation production. The technical process includes the steps that: a secondary seed culture solution is fed into a fermentation culture solution, meanwhile, the antibiotic which can improve cell permeability is added into the fermentation liquor, and the antibiotic is added to change the cell permeability so as to reduce the transfer resistance when the nutrition and the metabolites enter or exit the cell, thus improving the growth capability and the productivity of the thalli and increasing the concentration of the product, 1, 3-propanediol; furthermore, microbes are impelled to excrete the metabolites outside the cells, which decreases the accumulation of the metabolites in the cells, is favorable to eliminate the inhibition of products and by-products, especially reduces the inhibition of the 1, 3-propanediol to cell growth and cell catalytic activity, and at last, the concentration of the fermentation product, 1, 3-propanedio, is improved by 10 percent to 70 percent. The technical process is easy and simple, with low production cost.

The invention discloses a thermo-oxidative aging resistant glass fiber reinforced polypropylene material and a preparation method thereof. The material is composed of the following components: polypropylene, glass fibers, a metal deactivator, a silicone master batch, a compatilizer, an antioxidant, a light stabilizer, a nucleating agent and a lubricating agent. By utilizing the synergistic thermo-oxidative aging resistance between functional additives, aging catalysis of metal ions on the material matrix can be inhibited by matching with the metal deactivator, so that the thermo-oxidative aging resistance of the metallic insert material is obviously improved; the prepared reinforced polypropylene has long-term thermo-oxidative aging resistance, and the performance retention rate is more than 85% after thermo-oxidative aging of 150DEG C per 1500 hours; the catalytic aging influence of the metal ions on the polymer matrix can be eliminated aiming at injection materials with metal inserts, and the problems that the application environments of reinforced polypropylene products in the fields of automobiles, household appliances and electronic materials are limited and the long-term service performance is greatly reduced are solved.

Coating materials for coating the electrodes of a fuel cell are disclosed. In one embodiment, the coating materials comprise perfluoroalkanesulfonic acids having the general formula F3C—(CF2)n—SO3H, wherein n ranges from 8 to 17. In another embodiment, the coating materials comprise perfluoroalkanesulfonimides having the general formula CnF2n+1SO2NHO2SF2m+1Cm, wherein the sum of m and n ranges from 8 to 17. These long chain sulfonic acids and imides impart improved electrode performance and decrease polarization.

A catalyst body of the present invention includes: a porous carrier in which a large number of aggregate particles containing a main component of a nonoxide ceramic are bonded to one another while a large number of pores are disposed; and a catalyst layer carried on the porous carrier and containing a compound of an alkali metal, wherein the porous carrier has an oxide film unavoidably formed on a part of the surface of the aggregate particles, and an oxide film protective layer formed of a material which does not form low-melting glass with the alkali metal is further disposed between the oxide film and the catalyst layer in such a manner as to coat at least a part of the oxide film.

The invention discloses a glow-type chemiluminescence sensor constructed based on hydrogel and a preparation method and application thereof. The invention also discloses an analytical method for detecting organophosphorus pesticides by using the glow-type chemiluminescence sensor constructed based on hydrogel, which comprises the following steps: (1) preparing ABEI / CO<2+> / CS hydrogel; (2) preparing an MOF-Pt material; and (3) mixing an organophosphorus pesticide with acetylcholinesterase for reaction to obtain mixed solution, adding chlorinated acetylcholine solution, choline oxidase solutionand PBS buffer solution into the mixed solution for reaction to obtain a mixture, adding the MOF-Pt and the mixture into the hydrogel, and measuring the chemiluminescence intensity with a chemiluminescence imager. The analytical method does not need the aid of precise and expensive experimental instruments, has no strict and complex experimental operation process, greatly reduces the detection cost of organophosphorus pesticides, and has the advantages of high sensitivity, short detection time, long luminescent time, high-throughput detection and the like.

The invention relates to a blood ammonia (AMM) detection reagent and in particular relates to a high-stability single-reagent liquid-state blood ammonia (AMM) detection reagent. The reagent is mainly prepared from main substances including a buffering solution, LDH (Lactate Dehydrogenase), a heavy metal ion chelating agent, an ionic balance agent, a preservative, alpha-KG, NADH.NA2, a surfactant, a protecting agent and the like. According to the reagent, a single reagent of glutamate dehydrogenase two-point method and kinetic method is established; the utilization operation is effectively simplified and the stability of effective components of a product is guaranteed; the metal chelating agent is properly selected so that the inhibition, caused by the heavy metal ions, on the activity of an enzyme in the reagent is effectively removed; interference on the enzyme is not caused; the protecting agent is properly added so that the stability of the enzyme and the stability of key substrates in the reagent are effectively protected; the substances are added so that the stability of a single-reagent product provided by the invention is effectively guaranteed and the reagent is greatly convenient for utilization and popularization clinically.

The invention provides a photoresist and a preparation method and application thereof. The photoresist is prepared from, by weight, 40-80 parts of polyester acrylic resin, 2-10 parts of pigment, 6-12 parts of dye, 8-25 parts of reactive diluent, 2-8 parts of photoinitiator and 1-5 parts of dispersing agent. The photoresist has the advantages that the defects that an existing photoresist can not be used for printing and is extremely large in viscosity and the drying speed can not be precisely controlled are overcome, the photoresist has the advantages of being bright in color and luster, high in transparency, firm in adhesion force, high in curing speed, stable in performance, high in storage performance, excellent in weather resistance and corrosion resistance and the like, and the photoresist is suitable for the emerging industry of printing photoresists.

There is provided a steam reforming catalyst comprising a carrier and a catalyst supported thereon. The carrier contains a composite oxide containing Ce and Zr. The content of the Ce is not less than 1.0 mol and not more than 3.0 mol per 1 mol of the Zr. The catalyst contains Ni and Ti. The content of the Ni is not less than 70% and not more than 97% by mole, and the content of the Ti is not less than 3% and not more than 30% by mole, based on 100% by mole of the total of the Ni and Ti.

The use of a eosinophil secondary granules basic protein and any functional fragments thereof, and preferably, the use of Major Basic Protein (MBP) purified from eosinophils, as a natural heparanase inhibitor. Also, methods for the inhibition of the catalytic activity of heparanase using MBP, and to methods and compositions for the treatment of heparanase associated pathologic disorders. These methods and composition are particularly useful for the treatment of angiogenesis, tumor formation, tumor progression or tumor metastasis.

The invention discloses a detecting method for lead ions. The detecting method comprises the following steps: mixing a to-be-detected solution containing S2O3<2-> and Pb<2+> with dispersion liquid ofgolden core platinum shell nanoparticles; then adding a developing solution, then determining a light absorption value of an obtained mixed reaction system at ultraviolet-visible light spectrum, and realizing the detection of the Pb<2+> in the to-be-detected solution. According to the detecting method for the lead ions, provided by the invention, colorimetric detection of Pb<2+> can be realized, linear range is 50nmol / L to 2.0mu mol / L and the sensitivity can reach 6.7nmol / L; the detecting method has the advantages of simplicity, quickness, low cost, high stability and the like, and can well meet the demand of actual application.

The present invention discloses a heavy metal colorimetric detection method capable of adjusting the catalytic activity of manganous-manganic oxide based on oligonucleotide. According to the method, ato-be-detected sample liquid sample A1 of which the target heavy metal (mercury (II) or cadmium (II)) concentration is known is prepared; a blank reference solution sample A2 is prepared; the absorbance values of the sample A1 and the sample A2 at 450 nm are measured through a microplate spectrophotometer, and an absorbance difference value (deltaA ) is obtained; a target heavy metal concentration and absorbance variation quantity standard curve is drawn according to the absorbance difference value; the regression equation of a relation between target heavy metal concentration and absorbanceis established according to the standard curve; a to-be-detected solution (river water, lake water and tap water) sample C of which the target heavy metal concentration is unknown is prepared; and theabsorbance value of the sample C at 450 nm is measured through the microplate spectrophotometer, and the absorbance difference value of the sample C and the sample A2 is calculated, and the difference value is substituted into the linear regression equation, so that the concentration of a target heavy metal in the sample C is obtained. The method has the advantages of convenience in construction,high sensitivity, high specificity and the like.