502 results about "Reaction intermediate" patented technology

A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.

The invention relates to a method for preparing furfural compounds from biomass. The method specifically comprises the preparation of a solid acid catalyst and a reaction process of the solid acid catalyst. The method disclosed by the invention can also be applied to biomass derivatives. The method comprises the steps of adding biomass or biomass derivatives and the solid acid catalyst to a reactor, filling with protective gas, and adopting an organic solvent / saturated inorganic salt aqueous-solution two-phase reaction system, thereby obtaining furfural and 5-hydroxymethylfurfural in a high yield manner under mild conditions. The method has the advantages that after the reaction is completed, the produced furfural and 5-hydroxymethylfurfural are efficiently extracted into an upper-layer organic phase, the solid acid catalyst and an unreacted substrate are retained in a bottom-layer water phase, the furfural, the 5-hydroxymethylfurfural or a mixture of the furfural and the 5-hydroxymethylfurfural can be obtained through simple separation, and fine chemicals and liquid fuels can be prepared in a manner that the furfural, the 5-hydroxymethylfurfural or the mixture of the furfural and the 5-hydroxymethylfurfural serves as a reaction intermediate; and the used catalyst is pollution-free and can be recovered and reused, so that the method has good industrial application prospects.

The invention discloses a high-solid-content UV-curing aqueous urethane acrylate dispersion liquid and a preparation method thereof, wherein the method comprises the following steps of: firstly carrying out the monoesterfication reaction on the partial hydroxide group at the tail end of hyperbranched polyester and the anhydride group of dicarboxylic anhydride to obtain an intermediate I; carrying out the end capping reaction on an isocyanate group in diisocyanate and the hydroxide group in a hydroxyalkyl methacrylate monomer to obtain a reaction intermediate II; carrying out the reaction on the residual hydroxide group of the intermediate I and the residual isocyanate group of the reaction intermediate II to obtain a reaction intermediate III; and carrying out alkali neutralization, aqueous dispersion and reduced-pressure distillation on the reaction intermediate III to remove an organic solvent to obtain the UV-curing urethane acrylate aqueous dispersion liquid. The dispersion liquid has the characteristics of high solid content, relatively low viscosity, UV curability, good mechanical performance of a paint film and the like, conforms to the concept of environmental protection, can be applied to the fields of environment-friendly coatings, aqueous ink, aqueous adhesives, fabric coating agents and the like and has broad prospect.

The present invention provides a processes, having practical utility, for preparing 2-oxindoles, N-hydroxy-2-oxindoles, or mixtures thereof comprising: catalytically hydrogenating a 2-nitroarylmalonate diester to produce a 2-(N-hydroxyamino)arylmalonate diester, a 2-aminoarylmalonate diester, or mixtures thereof as a first reaction intermediate; cyclizing, by intramolecular aminolysis of one ester group, the first reaction intermediate to produce a N-hydroxy-2-oxindole-3-carboxylate ester, 2-oxindole-3-carboxylate ester, or mixtures thereof as a second reaction intermediate; and hydrolyzing and decarboxylating the remaining ester group of the second reaction intermediate to produce the N-hydroxy-2-oxindole, the 2-oxindole, or mixtures thereof, wherein the cyclization reaction and the hydrolysis and decarboxylation reaction are conducted in situ with the catalytic hydrogenation reaction without isolation of said reaction intermediates.

The invention discloses polysiloxane with UV (Ultraviolet) and moisture double curing groups and a preparation method thereof. The polysiloxane is prepared by the following steps: mixing hydroxyl silicone oil with a silane coupling agent containing amido and carrying out a reaction to generate an intermediate; and then, adding an acrylic monomer containing isocyanate into the reaction intermediate and mixing and reacting to obtain the polysiloxane. The modified polysiloxane synthetic method disclosed by the invention is simple and low in cost, has the characteristics of quick curing and high efficiency, avoids the defect that the dash area or the bottom layer cannot be cured, and has the characteristics of excellent performances and photocuring technology of the organosilicon material. The modified polysiloxane can be applied to the field of binders, film coatings and encapsulating materials.

The invention discloses a method for preparing a difluoromethoxy bridge type liquid crystal compound, which comprises the following steps: uniformly mixing a compound shown in a formula II and a compound shown in a formula III with alkali under the condition that a catalyst exists for reaction and obtaining a compound shown in a formula I after reaction. The method has the beneficial effects that a reaction substrate is changed into the compound shown in the formula II and a phenylo boric acid derivative shown in the formula III, the reaction steps are reduced, a reaction intermediate is simplified, the total reaction yield is greatly improved, and different group compounds can use the same intermediate formula I. The method is particularly suitable for preparing the difluoromethoxy bridge type liquid crystal compound. Formula II, formula III and formula I are shown in the instruction.

The present invention provides novel glutathione-dependent formaldehyde dehydrogenase that makes possible quantitative measurement of formaldehyde by cycling reaction, and a determination method of formaldehyde and biological components, such as creatinine, creatine, homocysteine and the like, which produces formaldehyde as a reaction intermediate. In addition, the present invention provides a reagent kit for the above-mentioned determination method. The present invention provides a novel determination method of a homocysteine using transferase utilizing homocysteine and other compound as a pair of substrates. Particularly, the present invention provides a determination method of homocysteine which includes bringing betaine-homocysteine methyltransferase and dimethylglycine oxidase into contact with a sample and measuring produced hydrogen peroxide or formaldehyde. Moreover, the present invention provides novel dimethylglycine oxidase stable to thiol compound, which is suitably used for the measurement. The present invention provides a reagent kit used for any of the above-mentioned determination methods of homocysteines.

The invention relates to a synthesis technique of tenofovir, and relates to the field of medicinal chemistry. Using natural (R)-lactate as the starting material, chiral R-1,2-propanediol is obtained through reduction, and then reacted with diethyl carbonate under the action of alkali to obtain the key reaction intermediate R-propylene carbonate ester. Use adenine and R-propylene carbonate to prepare R-9-(2-hydroxypropyl)adenine; Gained R-9-(2-hydroxypropyl)adenine and diethyl p-toluenesulfonyloxyphosphate Under the catalysis of magnesium tert-butoxide, the condensation reaction is carried out to obtain R-9[(diethylphosphorylmethoxy)propyl]purine; the obtained R-9[2-(diethylphosphorylmethoxy) Propyl]purine is hydrolyzed to obtain Tenofovir. The process has short reaction steps, short required reaction time, high quality yield and good product quality, and is suitable for industrialized production.

The present invention discloses a phosphorus-nitrogen co-reactive flame retardant used for polyurethane, a preparation method therefor and an application thereof. The method comprises: adding epoxy chloropropane and alcohol amine compound into an organic solvent; carrying out an ring-opening and ring-closing reactions in a reaction molar ratio; and filtering, and removing the solvent under reduced pressure, thereby obtaining a reaction intermediate glycidol alcohol amine which is viscous liquid at room temperature; and carrying out a reaction between DOPO and an epoxy group to form a reactive flame retardant with end groups as double hydroxyl groups and a DOPO flame retardant group. The flame retardant has a phosphorus-nitrogen co-reactive flame retardant effect, is environmentally-friendly,non-toxic, low in smoke, and can be used as a chain extender to apply to the preparation for a structural flame retardant polyurethane material, so that the preparation process is simple, and the flame-retardant effect is remarkable. The polyurethane material synthesized by using the flame retardant has good mechanical properties, an oxygen index increased to 27-29%, and a flame retardant grade up to UL94 V-0.

The invention provides hyper-branched waterborne polyurethane and a preparation method thereof, and relates to hyper-branched waterborne polyurethane obtained by the method and application thereof. The method comprises the following steps: 1) diisocyanate containing two isocyanate radicals reacts with organic acid containing one carboxyl group and two hydroxyl radicals, so as to obtain a reaction intermediate which contains two isocyanate groups and one carboxyl group on average and is called A1 for short; 2) the A1 reacts with a monomer containing one amino group and two (or more than two) hydroxyl radicals, so as to obtain a reaction intermediate which contains one isocyanate group, one carboxyl group and two (or more than two) hydroxyl radicals on average and is called A2 for short; and 3) the A2 is heated to enable the isocyanate group to react with the hydroxyl radicals, so as to obtain a hyper-branched waterborne polyurethane product containing hydrophilic carboxyl group structures, and then the product is separated and dried so as to obtain a hyper-branched waterborne polyurethane solid product in the shape of white powder. The obtained hyper-branched waterborne polyurethane simultaneously contains a large number of carboxyl groups and hydroxyl radicals, can be neutralized with alkaline matter and then dissolved in water, is suitable to be used as environment-friendly waterborne coatings, waterborne adhesives, phase compatibilizers, rheological additives, thixotropic agents, nucleating agents, active compound carriers or catalyst carriers and the like, and has wide application prospects.

The invention relates to a method for preparing compound palbociclib (shown as the formula I). A compound D (shown as the formula II) serves as a raw material, and a compound E (shown as the formula III) is obtained through a rearrangement reaction of alkenyl ether; then the compound E is subjected to t-butyloxycarboryl protection group removal under the acidic condition, and target product palbociclib is obtained; an R group in a compound D is selected from any one of a C1-C6 alkyl group, a C1-C6 halogenate alkyl group, C1-C6 hydroxyalkyl and a C1-C6 naphthenic base. The process procedure and operation steps are easy and convenient, prepared palbociclib is high in purity, and good popularization prospects are achieved.

The invention provides a hyperbranched polyurethane acrylate UV light-cured resin with a novel structure, and relates to an application of the resin. The resin has the following structure as shown in the specification. A preparation method of the resin comprises the steps: firstly carrying out a reaction of a diisocyanate monomer with a dihydric alcohol, and then carrying out a reaction with a single amino polyhydroxy monomer to prepare an ABn reaction intermediate having end groups with an isocyanate group and a plurality of hydroxyl groups; allowing the ABn reaction intermediate to undergo a self-polycondensation reaction, and preparing hyperbranched polyurethane (HPU-Xm) containing terminal hydroxyl groups; carrying out a reaction of the diisocyanate monomer with hydroxyalkyl acrylate, and thus obtaining a reaction intermediate C containing an isocyanate terminal group and an acrylic double bond terminal group; and carrying out a reaction of the reaction intermediate C with HPU-Xm, and obtaining the UV light curable hyperbranched polyurethane acrylate resin product averagely containing 2-32 double bonds. The product contains more terminal double bonds, can perform fast light curing, is suitably used as UV curable coatings, adhesives, rheological processing additives, active compounds and the like, and has wide application prospects.

The invention discloses a quinolinic compound showed in the formula A and pharmacy acceptable solvate, optical isomers or polymorphic substance and a reaction intermediate compound showed in the formula D; wherein, R1, R2 and R3 are respective and independent H, halogen or group showed in the formula H; wherein, the R is H, the halogen, alkyl of C1-C4 or alkoxide of C1-C4. The invention further discloses a preparation method thereof and application for preparing medicines for inhibiting HMG CoA reductase and treating hyperlipemia related diseases. Compared with the existing fuvastatin, rosuvastatin and pitavastatin in the prior art, the quinolinic compound of the invention can better inhibiting the activity of the HMG CoA reductase and can be used for treating hyperlipemia related diseases.

The present invention relates to a composite electrode material having a carbon base material and iron oxide particles mainly containing Fe3O4 and being supported on the carbon base material and the particles have a D90 of 50 nm or less. In the composite electrode material, since the particle size of the iron oxide particles mainly containing Fe3O4 serving as an active material is small, the electron conductivity of the composite electrode material is not considerably reduced even when being covered with a Fe(OH)2 layer as a reactive intermediate for an electrode reaction. Thus, when the composite electrode material is used, an iron negative electrode having sufficient electron conductivity and charge-discharge cycle characteristics is provided. A negative electrode including the composite electrode material is favorably used as a negative electrode for a metal-air battery.

The invention discloses a new synthesis method for a BCL-2 inhibitor Venetoclax. The synthesis method includes the steps that 2,4-difluoro methyl benzoate serves as a raw material, the 2,4-difluoro methyl benzoate and 5-hydroxy-7-azaindole are subjected to a condensation reaction, Ven-16 is obtained, and 4-substituted isomer and other impurities are removed through recrystallization; the product and N-Boc-piperazine are reacted and hydrolyzed, and Ven-18 is obtained; Ven-18 and Ven-21 are condensed, Boc of trifluoroacetic acid is removed, and Ven-20 is obtained; the product and Ven-7 are reacted, reaction intermediates in all the steps have the good crystal forms, purification can be carried out through crystal to achieve the center control requirements of the technology, and a final product Venetoclax can also be subjected to recrystallization to obtain the product Venetoclax, wherein the HPLC purity of the Venetoclax is larger than 99.5%, and the individual impurity of the Venetoclax is smaller than 0.1%; the Venetoclax has the industrialized application value.

The invention relates to a multiphase catalytic reaction device for testing in situ solid-state nuclear magnetic resonance, which is a magic angle spinning multiphase catalytic reactor in which an online solid-state nuclear magnetic resonance system, a quadrupole mass-spectrometer, a gas chromatograph and a laser-induced hyperpolarized 129Xe isotope probe are linked for use. The reactor can apply various solid-state nuclear magnetic resonance techniques to track and detect a catalyst structure, reaction intermediates and species with catalyst activity in the catalytic reaction process; reaction products are qualitatively and quantitatively analyzed by the quadrupole mass-spectrometer and the gas chromatograph, so that the performance of the catalyst is evaluated; simultaneously, laser-induced hyperpolarized 129Xe isotope is used as a probe molecule to study the change of the catalyst structure, adsorption positions and diffusion behaviors of various species in the reaction process and the like. In-situ tracking in the catalytic reaction process and the mechanism of the catalytic reaction can be systematically studied through the various techniques.

The invention which provides a ceftezole sodium powder injection and a synthesis method for the powder injection consists of more stable ceftezole sodium crystals; in the method, tetrazoleacetic acid, N, N'- dicyclohexylcarbodiimide and 7-amino cefgadoleic acid with the proportion of 1.4 to 1.7:1 to 1.3:1 make reactions in dimethyl sulfoxide; ceftezole is prepared by causing a react intermediate to react with thiadiazole thiol of 1.1 to 1.3 times; the ceftezole sodium is prepared in sodium bicarbonate water solution after acetone is re-crystallized. The method is easy in operation and has the total yield of 55.5 percent.

Provided according to embodiments of the invention are resin coated particulates for use in oil and gas subterranean extractions. The resin coated particulates comprise a particulate substrate and a resin coating. The resin coating comprises a particulate substrate and a resin coating including epoxy-functional compounds and an aqueous dispersion of an amine functional microgel wherein the amine functional microgel is formed by reacting a chemical excess of a polyfunctional epoxide compound with an amine salt to form a polyfunctional epoxide amine salt reaction intermediate product, and condensing at least some of the unreacted epoxide groups of the polyfunctional epoxide amine salt reaction intermediate product with a polyamine. Methods of treating a subterranean fracture are also provided.

The invention belongs to the technical field of agricultural fertilizers, and in particular relates to an organic water-soluble foliar fertilizer and a preparation method thereof. The organic water-soluble foliar fertilizer is characterized by being prepared from the following raw materials in part by mass: 1 to 40 parts of protein hydrolyzate, 0.5 to 5 parts of organic trace element, 0.1 to 2 parts of photosynthetic reaction intermediate, 0.1 to 5 parts of plant natural penetration promoting component and 0.1 to 5 parts of preservative. The preparation method of the organic water-soluble foliar fertilizer comprises the following step of: fully mixing the protein hydrolyzate, the organic trace element, the photosynthetic reaction intermediate, the plant natural penetration promoting component and the preservative in the using amount of the components determined according to a formula to obtain the organic water-soluble foliar fertilizer. The organic water-soluble foliar fertilizer can improve the immunity of crops, promote the robustness of the crops, enhance disease resistance and achieve the effect of improving yield and quality; and the product is used in the fields of vegetables, fruits, flowers, tea, lawns and the like, and can improve the yield by 11.2 to 30.7 percent compared with a control group.

The invention relates to a preparation process of lavo-ofloxacin and ofloxacin which are anti-infectious medicaments, belonging to the synthetic process with tetrafluorobenzoic aid as raw material. The preparation method is characterized in that (2, 3, 4, 5-phenyl tetrafluoride formyl) ethyl acetate and DMFA react for 1.0-1.5h in toluene at 50-55 DEG C with the existence of acylating catalyst; the reaction product is washed by water, and an aqueous layer is separated; at 30-35 DEG C, L-amino propanol is dripped in an oil layer to carry out replacement reaction for 1.5-2.0h; toluene is decompressed, recovered and dried proper quantity of DMF is added to the oil layer for diluting; the diluted oil layer is dripped into back-flow DMF with the existence of anhydrous potassium fluoride to carry out back-flow reaction for 6h; DMF is recovered, water is added for centrifugation, acid is added to the obtained solid to be hydrolyzed to prepare lavo-perfluorocarboxylic acid, the lavo-perfluorocarboxylic acid reacts with N-methyl piperazine in DMSO at 90-110 DEG C by taking triethylamine as an acid-binding agent, and the lavo-ofloxacin is obtained after the fine purification of the product of reaction. The process improves the reaction condition of (2, 3, 4, 5-phenyl tetrafluoride formyl) ethyl acetate and DMFA, lowers the reaction temperature, shortens the reaction time and improves the reaction yield of lavo-fluoro ester serving as a reaction intermediate by 20 percent.

A reactor for forming a reactive intermediate from a precursor for the deposition of a low dielectric constant polymer film via transport polymerization is disclosed. The reactor includes an inlet for admitting a flow of the precursor into the reactor, an interior for converting the precursor to the reactive intermediate, an outlet for admitting a flow of the reactive intermediate out of the interior, and at least one of an energy source and an oxidant source associated with the outlet for decomposing residues in the outlet.

The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermediates and / or products are produced in the same step by different chemical reactions.

The present invention belongs to the technical field of medicine, and relates to a tenofovir disoproxil fumarate synthesis method, wherein (R)-1,2-propanediol and carbonate are adopted as raw materials, and condensation, etherification, hydrolysis, esterification salification and other steps are performed to prepare the finished product. According to the present invention, the process improving and the reaction intermediate treatment are performed so as to easily achieve the reactions in the subsequent steps and the separation and purification, improve the yield and the corresponding purity of the target product, and obtain the tenofovir disoproxil fumarate meeting the medical standard.

The invention discloses an in-situ capture heterogeneous catalytic reaction intermediate product device and a use method thereof. The device comprises a reaction gas control system, an in-situ infrared pool system and an analyzing and testing system. The device can be used for carrying out a temperature-variable heterogeneous catalytic reaction at low pressure (smaller than or equal to 1.0 MPa), a catalyst active species, the reaction intermediate product, a reaction product and the like in the catalytic reaction can be monitored and tracked in real time, the changes, such as the influence of matching of raw material gas, reaction temperature, reaction pressure and the like on the catalytic reaction, of the reaction process along with various catalytic reaction conditions can be observed online, reactants, an intermedium and the product in the catalytic reaction process can be subjected to qualitative and quantitative analysis through an in-situ infrared instrument, a gaschromatograph and the mass-spectrography, especially the intermedium and the product with low content (ppm grade) can be monitored online, and therefore the performance of catalysts can be compared, and the heterogeneous catalytic reaction mechanism can be studied. Compared with the prior art, data is precise, operation is easy, and the device has great significance on heterogeneous catalytic reaction mechanism study.