399 results about "Ofloxacin" patented technology

The invention provides an ophthalmic, otic or nasal pharmaceutical composition, comprising levofloxacin or the pharmaceutical acceptable salts thereof and loteprednol etabonate, wherein the weight ratio of loteprednol etabonate to levofloxacin is 1:0.2-5. The use of ophthalmic, otic or nasal pharmaceutical composition of the invention in preparation of the medication for treatment of conjunctivitis, keratitis, blepharitis, dacrycystitis, hordeolum, corneal ulcer and ocular infection accompanied with ophthalmitis and even inflammation of the surrounding tissues, to prevent increase of bacterial infection risks and the tissue inflammation of the infected area after the ophthalmic surgeries or ocular injuries, to treat or alleviate the bacterial infection in combination with the tissue inflammation of the infected area, or to treat tympanitis, otitis externa and infective rhinitis.

The invention discloses water, ethanol and ethanol aqueous extracts of traditional Chinese medicine pithecellobium clypearia and application of corresponding petroleum ether, ethyl acetate, normal butanol and a water extractants in preparation of medicines for treating methicillin-resistant staphylococcus aureus (MRSA) and antibiotics anti-MRSA sensitization medicines. Meanwhile, the invention further discloses a preparation method of the extracts or extractants. Experimental results show that water, 10% ethanol, 30% ethanol, 60% ethanol, 95% ethanol extracts of pithecellobium clypearia and corresponding ethyl acetate, normal butanol and water extractants have stronger anti-MRSA effect, wherein the activity of the ethyl acetate extracting part of the 60% ethanol extract of pithecellobium clypearia is the strongest, and the ethyl acetate extracting part of the 60% ethanol extract of pithecellobium clypearia has sensitization effect on erythrocin, ceftriaxone sodium, levofloxacin for treating MRSA.

The invention discloses a solid phase extraction and HPLC-fluorescence detection method for fluoroquinolones antibiotics. The method comprises the following steps of passing a pretreated water sample through an activated solid phase extraction column; eluting the solid phase extraction column with a Na2EDTA aqueous solution; then vacuumizing; and finally, eluting the water sample for three times by a concentrated ammonia methanol solution with a concentrated ammonia volume percent concentration of 6 percent by 0.5-2mL each time. An obtained eluent is blow-dried to 0.1-0.4mL in air flow, water is added to reach a constant column of 1.0mL so as to obtain a test sample, and then HPLC-fluorescence detection is carried out. By adopting the solid phase extraction-HPLC-fluorescence detection technology and utilizing a conventional analytical instrument, the method can simultaneously measure the contents of four typical fluoroquinolones antibiotics of ofloxacin, norfloxacin, ciprofloxacin and enrofloxacin in the water sample. The method has simple operation and low cost and can be applied to the measurement of the ultratrace of four typical fluoroquinolones antibiotics in waste water and surface water.

The invention relates to a preparation process of lavo-ofloxacin and ofloxacin which are anti-infectious medicaments, belonging to the synthetic process with tetrafluorobenzoic aid as raw material. The preparation method is characterized in that (2, 3, 4, 5-phenyl tetrafluoride formyl) ethyl acetate and DMFA react for 1.0-1.5h in toluene at 50-55 DEG C with the existence of acylating catalyst; the reaction product is washed by water, and an aqueous layer is separated; at 30-35 DEG C, L-amino propanol is dripped in an oil layer to carry out replacement reaction for 1.5-2.0h; toluene is decompressed, recovered and dried proper quantity of DMF is added to the oil layer for diluting; the diluted oil layer is dripped into back-flow DMF with the existence of anhydrous potassium fluoride to carry out back-flow reaction for 6h; DMF is recovered, water is added for centrifugation, acid is added to the obtained solid to be hydrolyzed to prepare lavo-perfluorocarboxylic acid, the lavo-perfluorocarboxylic acid reacts with N-methyl piperazine in DMSO at 90-110 DEG C by taking triethylamine as an acid-binding agent, and the lavo-ofloxacin is obtained after the fine purification of the product of reaction. The process improves the reaction condition of (2, 3, 4, 5-phenyl tetrafluoride formyl) ethyl acetate and DMFA, lowers the reaction temperature, shortens the reaction time and improves the reaction yield of lavo-fluoro ester serving as a reaction intermediate by 20 percent.

The invention relates to a kind of compound collagen protein gutta, which is the mixture of collagen protein and antibiotics. For every 100ml compound collagen gutta, there is 10-500mg collagen protein which is extracted from the tendon, 100-600mg antibiotics which include one or two kinds of the following antibiotics: ofloxacin, alficetin, tenebrimycin, while the rest is the iso-osmia, which is 5% amylaceum solution. The product has three main functions: resist bacteria and inflammation; help to keep the eyeball moist, promote the agglutination and relieve the asthenopia; be used in the treatment of the damage to the cornea, keratohelcosis, keratitis punctata, slight chemical injury to cornea as well as the thermal damage to the cornea; prevent the ophthalmia and relieve the asthenopia; prevent the cohesive property of the collagen from being diluted so as to extend the effective time of the gutta; resist the bacteria as well as promote the agglutination.

The invention relates to the technical field of environment detection and is suitable for measuring erythrocin, chloramphenicol, sulfamethoxazole, sulfadiazine, roxithromycin, cefotiam, pyridazol, norfloxacin, ofloxacin, tetracycline and doxycycline in sewage, surface water and bottom mud. After being sampled, a water sample and a mud sample are pretreated and detected through ultra-high performance liquid chromatography-triple quadrupole mass spectrometry, and qualitative diagnosis is conducted through the characteristic ion pair (m/z) of a target compound, a standard curve is drawn accordingto the response value and the corresponding concentration, and the external standard method is used in quantification, so that the contents of various antibiotics in the sample are obtained. The method is accurate, sensitive and simple, and is suitable for measuring the contents of 11 typical antibiotics in the sewage, the surface water and the mud at the same time.

The invention discloses a method for preparing ofloxacin. The invention aims to provide a method for preparing ofloxacin, which has short production period, less pollution, high raw material utilization rate, yield and purity, and simple and convenient operation. The method comprises the following steps: preparing 9,10-difluoro-2,3-dihydro-3-methyl-7-O-7H-pyridino[1,2,2-de]-[1,4]- benzoxazinyl-6-carboxylic acid by tetrafluorobenzoyl chloride as a raw material through a compounding method; and reacting with alkali in an organic solvent to obtain the ofloxacin. The invention has the advantages that the tetrafluorobenzoyl chloride reacts with 3-(2-R1-2-R2-4- methylimidazole alkyl) acrylic ester, the product is directly hydrolyzed during post processing and then is carried out the ring close;the reaction step is reduced, the reaction time is shortened, and the yield is as high as 85-90 percent. Organic or inorganic alkali is added in preparation, thereby reducing the feed content of methyl piperazine, reducing the reaction cost and having high yield.

The invention relates to a preparation method of a magnetic microspheres-based levofloxacin surface imprinted material. The preparation process mainly comprises three steps: preparation of magnetic microspheres; coating of the magnetic microspheres with a molecularly imprinted material; and elution of template molecules. A synthetic method provided by the invention is simple. The prepared magnetic microspheres-based surface molecularly imprinted material has specific recognition function, high adsorption capacity and rapid adsorption ability of levofloxacin and has chiral resolution function of ofloxacin, has good magnetic response and high mechanical strength, can be used as an absorption filler or a coating material, also can be used in preparation of a molecular imprinting sensor and a chip, and is of great significance for researches on specific recognition, chiral resolution and highly sensitive detection of floxacin drugs.

The invention discloses a preparation method for ofloxacin. The prior method uses an organic solvent with higher boiling point and larger polarity, so unit consumption and energy consumption of raw materials are increased and heavy odor is caused; and the prior method adopts other alkaline matters except the reaction raw materials as acid-bonding agents, so solid waste is increased and salt and organic matters in discharged waste water are increased. The preparation method mixes difluorocarboxylic acid, N-methyl piperazine and a catalyst in a reaction solvent for piperazine condensation reaction, obtains a crude product of the ofloxacin after complete reaction and post treatment, and converts the crude product of the ofloxacin into the finished product of the ofloxacin through primary purification treatment; and the reaction solvent is water or a water solution of the N-methyl piperazine. The method takes the water as the reaction solvent and the N-methyl piperazine as the acid-bonding agent, and does not use any other organic solvent and acid-bonding agent to prepare the ofloxacin with good quality and high yield.

Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.

The invention discloses a medicine-carrying system of a vitamin E-modified silicon-base hydrogel contact lens as well as a preparation method and application of the medicine-carrying system. The preparation method comprises the following steps: (1) synthesizing an organosilicone prepolymer of a methacrylate terminal group through hydroxyl modification of the methacrylate terminal group, mixing reaction monomers, putting a mixture into a mold, and carrying out curing by virtue of a one-time mold pressing method, so as to obtain a silicon-base hydrogel contact lens; (2) soaking the prepared silicon-base hydrogel contact lens into a mixed solution of vitamin E and ethanol for modification, so as to obtain a vitamin E-modified silicon-base hydrogel contact lens; and (3) loading ofloxacin of different concentrations with the silicon-base hydrogel contact lens before being modified by vitamin E and the vitamin E-modified silicon-base hydrogel contact lens. The prepared medicine-carrying system of the vitamin E-modified silicon-base hydrogel contact lens is good in biocompatibility, high in light transmittance and relatively good in mechanical property and is capable of prolonging the drug release time.

The invention relates to a slow release micro-pellet preparation containing Levofloxacin, its preparation process and therapeutic use, wherein the micro-pellet preparation contains 0-40% of conventional medicinal particles and 60-100% of slow release medicinal micro-pellet, the micro-pellet contains medicinal core including Levofloxacin, and slow release coating layer whose content being 4-100% of the pellet core.

The invention discloses levofloxacin hydrochloride sustained-release eye drops which are ophthalmic preparations prepared by using levofloxacin hydrochloride as a pharmacodynamic raw material, matching with sodium hyaluronate to play a role of a thickener, and then matching with a metal ion complexing agent pharmaceutically acceptable to local parts of eyes, an osmotic pressure regulator and a pH regulator, wherein per 100 parts by weight of a finished product preparation contains 0.30-1.00 part by weight of levofloxacin hydrochloride and 0.1-1.00 part by weight of sodium hyaluronate. The medicine liquid provided by the invention has high viscosity, prolongs the time of medicine staying in the eyes, improves the absorption of the medicine, and improves the bioavailability of the eye drops; no preservative is added to the eye drops provided by the invention, so as to improve the biological safety of the eye drops.

The invention discloses a levofloxacin hydrochloride tablet and a preparation method of the levofloxacin hydrochloride tablet. The preparation is prepared by blending and tabletting medicine-containing particles, citric acidenteric particles and a lubricant, wherein the citric acidenteric particles is prepared by dissolving the citric acid and the polyvinyl acetatephthalic acid ester in ethyl alcohol. According to the invention, the citric acid is wrapped in an enteric material and is not dissolved in the stomach, the citric acid is dissolved and released in the intestines, so that the alkalinity of the intestinal juice is reduced, the levofloxacin hydrochloride is enabled not to be separated out, and therefore, the bioavailability of the medicine is improved.

The invention provides a preparation method of high-purity Levofloxacin semihydrate, which belongs to the technical field of the medicine synthesis, and solves the problems of the present preparation method that the prepared Levofloxacin semihydrate is difficult to recycle and has low purity and the used organic solvent is difficult to degrade. The preparation method comprises the following steps: a. preparing Levofloxacin salt; b. preparing Levofloxacin crude product II; c. preparing Levofloxacin semihydrate. The Levofloxacin semihydrate prepared by the preparation method has the advantages of high purity, good quality and appearance, high titration content, high recycling rate, low cost and good environmental-protection performance.

The invention provides a method for preparing levofloxacin hydrochloride sodium chloride injection. By researching a liquid medicine preparation method, medicinal charcoal pretreatment and a terminal sterilization process, product quality is ensured by the aid of technologies of a concentrated solution and diluted solution method, charcoal slurry preparation from medicinal charcoal, water bath sterilization and the like, production is facilitated, obtained finished products have higher stability, so that the storage life of the finished products can be prolonged, and clinical use effects are better.