The invention discloses a method for simultaneously measuring various endocrine disruptors in an environment water sample, and belongs to the field of environment detection. The method includes the steps of firstly, taking a water sample, taking supernate after conducting natural depositing or centrifuging, enriching the supernate through an activated solid-phase extraction small column by means of a solid-phase extraction device, and conducting centrifuging or vacuum drying on the extraction column after enriching; secondly, eluting the extraction column through an organic solvent, and conducting volume fixing through methyl alcohol after eluant is concentrated to prepare to-be-measured liquid; thirdly, establishing a quantifying method of target pollutants; fourthly, measuring the concentration of the endocrine disruptors in the water sample through the efficient liquid-phase chromatography-triple quadrupole mass spectrometry. The method is small in reagent consumption, low in cost and few in step, but can simultaneously quantitatively analyze the endocrine disruptors in the water body, several types to more than one dozen of types of traditional concerned endocrine disruptors are expanded into 103 types of endocrine disruptors, the analysis flux is greatly improved, the application range is expanded, and the potential high-risk endocrine disruptors in the environment water sample can be better recognized.