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169results about "Saccharide libraries" patented technology
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Methods and products related to the improved analysis of carbohydrates
The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation / altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
Owner:MOMENTA PHARMA +2
Multiplexed measurement of membrane protein populations
Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound and separation and detection. For oligonucleotides, the eTag reporters are synthesized at the end of the oligonucleotide by using phosphite or phosphate chemistry, whereby mass-modifying regions, charge-modifying regions and detectable regions are added sequentially to produce the eTag labeled reporters. By using small building blocks and varying their combination large numbers of different eTag reporters can be readily produced attached to a binding compound specific for the target compound of interest for identification. Protocols are used that release the eTag reporter when the target compound is present in the sample.
Owner:MONOGRAM BIOSCIENCES
Microprocessor-controlled microfluidic platform for pathogen, toxin, biomarker, and chemical detection with removable updatable sensor array for food and water safety, medical, and laboratory applications
InactiveUS20130217598A1Rich abilityConvenient statisticsBioreactor/fermenter combinationsPeptide librariesSensor arrayDisease monitoring
The invention provides a platform technology with rich ability to flexibly perform, create, deploy, maintain, and update a wide range of panels, assay, array, and / or sequence of tests for a wide range of substances and pathogens. The invention provides a unifying framework for widely-ranging miniature sensor implementation, fluidic / gas interfacing, electrical interfaces and optical interfaces, and further by collocating, allowing the integration a large number highly-selective sensors and chemical sensors—together as needed with appropriately selected supplemental sensors (for example temperature, pH, selective ions, etc.), into a common readily-manufacturable framework. The diverse sensor arrays give rise to statistical enhancing through novel statistical processing approaches. The invention is deployable and useable in a wide range of situations previously unavailable, and addresses many otherwise problematic aspects of field testing for food safety, water safety, epidemic outbreaks, routine diagnosis, and disease monitoring.
Owner:NRI R&D PATENT LICENSING LLC
Microdevices having a preferential axis of magnetization and uses thereof
Owner:CAPITALBIO CORP +2
Microarrays and their manufacture by slicing
InactiveUS7179638B2Inexpensive and sufficiently standardizedQuality assuranceBioreactor/fermenter combinationsCompound screeningFiberMaterials science
Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that may be glued to a backing.
Owner:LARGE SCALE PROTEOMICS
Automatic variable-speed transmission
InactiveUS6869379B2Compact structureSimple structurePeptide librariesNucleotide librariesPower flowEngineering
An automatic variable-speed transmission for setting up a plurality of gear steps with an input shaft, an output shaft and two transmission units which form two parallel branches. One branch has a multi-step transmission and the other a summing transmission with a friction clutch for starting and for central synchronization, the friction clutch having a first friction element and a second friction element, one of the friction elements being connectable to various transmission elements by means of at least one shift element, with at least one first power command range for gear-step changes between low gear steps and at least one second power command range for at least the gear change into the highest gear step and for the highest gear step. In this case, the at least one shift element connects the one friction element to transmission elements such that there is reduced reactive-power flow in any operating mode.
Owner:GETRAG INNOVATIONS
Microdevices having a preferential axis of magnetization and uses thereof
This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
Owner:AVIVA BIOSCI
Focused libraries of genetic packages
Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.
Owner:DYAX CORP
Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon
ActiveUS20130172207A1Enhance plasmonic near-infrared fluorescenceEnhanced fluorescence emissionPeptide librariesNucleotide librariesAssayGold film
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Self-addressable self-assembling microelectronic integrated systems, component devices, mechanisms, methods, and procedures for molecular biological analysis and diagnostics
InactiveUS20070178516A1High sensitivityStrong specificityPeptide librariesSequential/parallel process reactionsSelf assemblingElectron
A method for electronically stabilizing hybridization of nucleic acids bound at a test site of a microelectronic device is described. First and second negatively charged nucleic acids are provided, the second nucleic acid being bound to the test site. A zwitterionic buffer having a conductance of less than 100 mS / cm is applied to the microelectronic device. A current is applied to the test site to positively bias the test site, such that the first negatively charged nucleic acid is transported to the positively biased test site having the bound the second negatively charged nucleic acid. At the test site, the first and second negatively charged nucleic acids hybridize. The zwitterionic buffer acquires a net positive charge under influence of the current, such that the positively charged zwitterionic buffer stabilizes the hybridization by reducing the repulsion between the first and second negatively charged nucleic acids
Owner:GAMIDA FOR LIFE
Detection of Cancer through Breath Comprising a Sensor Array Comprising Capped Conductive Nanoparticles
ActiveUS20110269632A1High sensitivityGood curative effectPeptide librariesNucleotide librariesSensor arrayNanoparticle
Sensor array for detecting biomarkers for cancer in breath samples. The sensor array is based on 2D films or 3D assemblies of conductive nanoparticles capped with an organic coating wherein the nanoparticles are characterized by a narrow size distribution. Methods of use of the sensor array for discriminating between patterns of volatile organic compounds from healthy individuals and patients with various types of cancer are disclosed.
Owner:TECHNION RES & DEV FOUND LTD
Functionalized polydiacetylene sensors
ActiveUS20110059867A1Improve conductivityPeptide librariesPeptide/protein ingredientsAnalyteCoupling
A microarray includes a solid substrate having a surface, the surface having a plurality of binding spots and a plurality of reaction moieties bound to the binding spots. A reaction moiety includes a plurality of polyacetylene monomers, the polyacetylene monomers having a first coupling region and a second coupling region, the first coupling region having a first functional group operable to bind to the binding spot and the second coupling region comprising a second functional group operable to bind to an accessory molecule; and an accessory molecule having a binding region and an analyte reaction region, the analyte reaction region operable to selectively bind to the target analyte, and the binding region operable to bind to the second coupling region of the polyacetylene monomer. Upon binding a target analyte with the reaction moiety, a color change from the polyacetylene monomer occurs and the reaction moiety produces fluorescence.
Owner:RGT UNIV OF MICHIGAN
Chemical array reading
InactiveUS7269518B2Reduce misunderstandingEasy to implementBioreactor/fermenter combinationsMaterial nanotechnologyParallel computingComputer program
A method in which a chemical array is read on an array reader and the results saved in a memory linked with a performance characteristic of the array reader. Alternatively or additionally results from reading an array and a linked performance characteristic of a reader which performed the reading are retrieved from a memory. Computer program products and apparatus are also provided.
Owner:AGILENT TECH INC
Atmospheric control in reaction chambers
Apparatus and methods are disclosed for controlling atmospheric characteristics inside a chamber. An apparatus comprises a mechanism for diffusively introducing pressurized gas into the apparatus, an outlet element in fluid communication with the mechanism, and a chamber in fluid communication with the outlet element. The outlet element and the chamber are disposed such that gas flow therethrough is substantially uniform. The chamber comprises a gas outlet and the outlet element comprises a plurality of openings. The apparatus may be employed in the manufacture of biopolymers on the surface of a support such as an array of biopolymer features on the support.
Owner:AGILENT TECH INC
Novel carbohydrate compositions and a process of preparing same
The present invention is directed to novel methods to produce carbohydrate polymers and oligomers especially for pharmaceutical and food industries. The invention is directed to methods to remodel monosaccharides, and / or oligosaccharides and / or polysaccharides by a different monosaccharide, oligosaccharide or polysaccharide and optionally by further alcohol substances, under condensing conditions, preferably in acid catalysed reactions.
Owner:GLYKOS FINLAND
Apparatus and methods for the automated synthesis of oligosaccharides
InactiveUS7160517B2Sequential/parallel process reactionsExhaust apparatusCombined methodCombinatorial chemistry
One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.
Owner:MASSACHUSETTS INST OF TECH
Microarray channel devices produced by a block mold process
InactiveUS20030203366A1Improve bindingIncrease surface areaBioreactor/fermenter combinationsPeptide librariesBiologic AssaysAssay
Microarrays are made from sections of a molded block having many channels. These channels, which are formed by casting and / or embedding a rod in a moldable solid, are used to immobilize biological and chemical binding components after rod removal. The microarrays can be used in general biological assays, clinical evaluations and chemical library analyses.
Owner:LARGE SCALE PROFEOMICS
Alpha-selective sialyl phosphate donors for preparation of sialosides and sialoside arrays for influenza virus detection
ActiveUS8507660B2Esterified saccharide compoundsSaccharide with carbocyclic radicalsHemagglutininCancer cell
Owner:ACAD SINIC
Method for purifying proteins
The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.
Owner:BIO RAD LAB INC
Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
InactiveUS20100061990A1Immunoglobulins against blood coagulation factorsSaccharide librariesHemagglutininSyndecan binding
The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.
Owner:MASSACHUSETTS INST OF TECH
Optically encoded particles, system and high-throughput screening
ActiveUS20070148695A1Amenable to in vivo diagnosticsBioreactor/fermenter combinationsPeptide librariesPorosityAnalyte
The invention concerns a particle having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.
Owner:RGT UNIV OF CALIFORNIA
Method and apparatus for chemical and biochemical reactions using photo-generated reagents
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. Specifically, the method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
Owner:RGT UNIV OF MICHIGAN
Detection, prevention and treatment of ovarian cancer
InactiveUS20070265170A1Highly reproducible resultImprove signal-to-noise ratioSugar derivativesSaccharide librariesPhysiologyMammal
The invention provides compositions and arrays of glycans for detecting, treating and monitoring ovarian cancer in a human or other mammal.
Owner:THE SCRIPPS RES INST +1
Apparatus for screening compound libraries
InactiveUS6387257B1Component separationIon-exchanger regenerationChemical compoundMass Spectrometry-Mass Spectrometry
Disclosed are apparatus for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. The apparatus of this invention also permit a compound library to be rapidly screened to determine if any member of the library has a higher affinity for the target receptor relative to a pre-selected indicator compound.
Owner:HINDSGAUL OLE +1
Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
InactiveUS20060188966A1Difficult to controlModerate yieldSurgical adhesivesSaccharide librariesP. multocidaSugar
The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin / heparosan synthases from Pasteurella multocida, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure.
Owner:THE BOARD OF RGT UNIV OF OKLAHOMA
Neoglycorandomization and digitoxin analogs
ActiveUS20090075842A1Enhance desirable propertyEliminate side effectsBiocideSugar derivativesATPaseSide effect
The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use a universal chemical glycosylation method that employs reducing sugars and requires no protection or activation. In a preferred embodiment, the invention provides a library of neoglycoside digitoxin analogs that includes compounds with significantly enhanced cytotoxic potency toward human cancer cells and tumor-specificity, but are less potent Na+ / K+-ATPase inhibitors in a human cell line than digitoxin.
Owner:WISCONSIN ALUMNI RES FOUND
Microarray having a base cleavable sulfonyl linker
ActiveUS7541314B2Bioreactor/fermenter combinationsSequential/parallel process reactionsNucleotideBiochemistry
The present invention provides a microarray having base cleavable, sulfonyl-containing linkers and a process to make the microarray. Oligonucleotides of any sequence may be synthesized on the microarray having the cleavable linker. The oligonucleotides may be cleaved and recovered as a pool of oligonucleotides having a three prime phosphate moiety. Specifically, the microarray is an electrode containing microarray, and the oligonucleotides are electrochemically synthesized.
Owner:CUSTOMARRAY
Sparse matrix system and method for identification of specific ligands or targets
InactiveUS20090298707A1Highly effective toolsManageable sizePeptide librariesPeptide/protein ingredientsSolubilityBiological property
In certain embodiments, this invention pertains to the creation of “Sparse Matrix” libraries of compounds. The sparse matrix libraries of this invention typically span an n-dimensional parameter (property) space at extremely sparse intervals and thereby provide a relatively small library of compounds (e.g., a library of about 200 or fewer compounds) that can be used to quickly and efficiently screen the compound parameter space for one or more desired physical, chemical, or biological properties (e.g., binding specificity, binding avidity, γtoxicity, solubility, mobility, cell permeability, serum half-life, biocompatibility, etc.).
Owner:C3 JIAN +1
Detection of cancer through breath comprising a sensor array comprising capped conductive nanoparticles
ActiveUS9696311B2High sensitivityGood curative effectPeptide librariesNucleotide librariesSensor arrayMedicine
Owner:TECHNION RES & DEV FOUND LTD
Arrays with cleavable linkers
InactiveUS20070213297A1Treating and preventing HIV infectionAntibacterial agentsBiocideGlycanTest sample
Owner:THE SCRIPPS RES INST
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