91 results about "Infectious Rhinitis" patented technology

The present invention provides a combination of medicines for eyes or ears and nose, which comprises levofloxacin and loteprednol carbon ester; wherein, the weight ratio of the loteprednol carbon ester to the levofloxacin is between 1 to 0.2 and 1 to 5. The combination of medicine for eyes or ears and nose of the present invention is used for curing conjunctivitis, keratitis, blepharitis, dacryocystitis, hordeolum, corneal ulcer and eye infection with inflammation of eyes or even inflammation of tissue around eyes. The combination is also used for preventing bacterial infection risk after ophthalmology operation or eye injury and inflammation of the infected region, or the combination is used for curing or alleviating bacterial infection and tissue inflammation of the infected region after ophthalmology operation or eye injury, or cure tympanitis, otitis externa and infectious rhinitis.

The invention relates to a traditional Chinese medicine granule which has the effects of stopping cough and calming asthma, including four medicines of ephedra herb, bitter apricot seed, gypsum and liquoric root. The invention is mainly applicable to poultry infectious bronchitis, infectious laryngotracheitis, chronic respiratory disease, infectious rhinitis and other diseases. The formula of the invention has the effects of clearing heat, removing toxicity, stopping cough and calming asthma. The medicine can be prepared into the soluable granule by the combination of the special physiological structure of short reproductive tracts of birds which can not digest the wood fiber, the invention can be dissolved rapidly in fodder drinking water, and the invention can achieve the purpose of rapid onset of action after the drinking water is absorbed by sick chickens.

The invention provides a preparation method of a chicken infectious rhinitis and mycoplasma gallisepticum bivalent lipid inactivated vaccine, belonging to the technical field of biological products for animals. The preparation method is implemented by the following steps of: preparing a type A haemophilus paragallinarum inactivated antigen bacterial liquid, a type C haemophilus paragallinarum inactivated antigen bacterial liquid and a mycoplasma gallisepticum antigen liquid; uniformly mixing the type A haemophilus paragallinarum inactivated antigen bacterial liquid with the type C haemophilus paragallinarum inactivated antigen bacterial liquid in the volume ratio of 1:1 to obtain a mixed haemophilus paragallinarum inactivated antigen bacterial liquid; uniformly mixing the mixed haemophilus paragallinarum inactivated antigen bacterial liquid with the mycoplasma gallisepticum antigen liquid in the ratio of 1:1-1:1.5, pouring into an emulsifying tank and stirring; slowly adding poplar bark lipid till the final volume percentage concentration of the poplar bark lipid in the mixture is 2.0-3.8 percent; and continually stirring and emulsifying for 30-60 minutes. The vaccine has the advantages of easiness for absorbing, no toxic or side effect, short immunogenic time, long immune duration, good immune effect and capability of effectively preventing chicken infectious rhinitis and mycoplasma gallisepticum.

The invention discloses chicken feed for preventing and treating the chicken infectious rhinitis and a preparation method thereof.The feed is prepared from, by weight, 35-49 parts of corn, 21-38 parts of wheat, 10-17 parts of dasheen, 17-29 parts of Chinese yam, 5-15 parts of water caltrop starch, 5-11 parts of grape seeds, 1-3 parts of table salt, 2-4 parts of olive oil, 0.1-0.3 part of trace element premix, 0.1-0.3 part of vitamin premix and 4-10 parts of feed additive.The chicken feed has the advantages that the chicken infectious rhinitis can be effectively prevented, the chicken disease resistance can be improved, all the raw materials are natural products and matched with one another for combined action, and the chicken feed is high in safety, free of medicine residues and toxic and side effects and the like.

The invention provides a preparation method of a chicken infectious rhinitis lipid inactivated vaccine, belonging to the technical field of biological products for animals. The preparation method is implemented by the following steps of: preparing a type A haemophilus paragallinarum inactivated antigen bacterial liquid and a type C haemophilus paragallinarum inactivated antigen bacterial liquid; uniformly mixing the type A haemophilus paragallinarum inactivated antigen bacterial liquid with the type C haemophilus paragallinarum inactivated antigen bacterial liquid in the volume ratio of 1:1, and pouring into an emulsifying tank; stirring with a mixer; slowly adding poplar bark lipid at a low speed till the final volume percentage concentration of the poplar bark lipid in the mixture is 2.0-3.8 percent; and continually stirring and emulsifying for 30-60 minutes to obtain the vaccine, wherein the final bacterium content of a type A strain and the final bacterium content of a type C strain in the vaccine are 1,000,000,000 cfu / ml. The vaccine has the advantages of easiness for absorbing, no toxic or side effect, short immunogenic time, long immune duration, good immune effect and capability of effectively preventing chicken infectious rhinitis and mycoplasma gallisepticum.

The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious rhinitis.

The invention provides an ophthalmic or otic and nasal pharmaceutical composition, which comprises lavo-ofloxacin and salts thereof and difluprednate, wherein the weight ratio of the difluprednate to the lavo-ofloxacin is 1:1-1:10. The ophthalmic or otic and nasal medicament composition is applied to treating conjunctivitis, keratitis, eyelid inflammation, dacryocystitis, hordeolum, corneal ulcer and eye infections with inflammations of eyes or surrounding tissues, or preventing increased risk of bacterial infections and tissue inflammations of infected parts after ophthalmic surgeries or eye injuries, or treating or relieving the bacterial infections combined with tissue inflammations of the infected parts after the ophthalmic surgeries, or treating otitis media, otitis externa and infectious rhinitis.

The invention relates to a traditional Chinese medicine composition capable of relieving exterior syndrome and dissipating cold, dredging nasal orifices, and expelling the wind and relieving pain. The traditional Chinese medicine composition comprises the ten medicinal materials of flos magnoliae liliflorae, cocklebur fruit, schizonepeta, divaricate saposhnikovia root, houttuynia cordata, radix angelicae, ligusticum wallichii, scutellaria baicalensis, fructus forsythiae and honeysuckle, and is used for treatment in the high-incidence season of the infectious coryza of chicken. The traditional Chinese medicine composition disclosed by the invention is reasonable in prescription, without toxic and side effects, easily-available in raw materials, low in cost, and convenient to use, as well as has the advantages of being wide in application range, high in bioavailability, good in treatment effect, and without recurrence.

The invention relates to a Chinese herbal oral liquid for treating chicken infective rhinitis. The Chinese herbal oral liquid is prepared from the following raw materials, by weight, 4-6 parts of biod magnolia flower bud, 3-5 parts of siberian cocklebur fruit, 4-6 parts of divaricate saposhnikovia, 4-6 parts of angelica archang lica, 1-3 parts of szechwan lovage rhizome, 0.1-0.3 part of manchurian wildginger herb, and 1-2 parts of licorice root. The preparation method for the oral liquid comprises: weighing biod magnolia flower bud, siberian cocklebur fruit, divaricate saposhnikovia, angelica archang lica, szechwan lovage rhizome, manchurian wildginger herb, and licorice root decoction pieces according to a certain weight ratio, and respectively crushing into crude powder; taking manchurian wildginger herb crude powder, and adopting a distillation method to collect the distilled volatile oil; taking biod magnolia flower bud crude powder, siberian cocklebur fruit crude powder, divaricate saposhnikovia crude powder, angelica archang lica crude powder, szechwan lovage rhizome crude powder, and licorice root crude powder, adding water to the crude powder to soak, and carrying out decocting of the crude powder and the distilled manchurian wildginger herb drug residue through mild fire; filtering to obtain a primary filtrate, adding water to drug residue to carry out decocting two times to obtain a secondary filtrate and a tertiary filtrate, merging the three filtrates, and heating to obtain a concentrate; merging the volatile oil and the concentrate, adding a preservative and water; and carrying out uniform stirring, filtering, filling, and sterilization to obtain the oral liquid. With the present invention, chicken infective rhinitis can be effectively treated.

The invention relates to a Chinese herbal compound prescription for relieving exterior syndrome, dispelling cold, ventilating nose, dispelling wind and relieving pain, and preparation thereof. The Chinese herbal compound prescription comprises magnolia flower, cocklebur fruit, schizonepeta, radices sileris, cordate houttuynia, radix angelicae, ligusticum wallichii, asarum and other traditional Chinese medicine, and is suitable for treating initial rhinitis and epidemic rhinitis caused by exogenous cold of chickens. The composition has reasonable prescription, no toxic or side effects, easily obtained raw materials, low cost, convenience in use, and the advantages of wide applicable scope, high bioavailability and good therapeutic effect.

The invention provides a vaccine composition for infectious rhinitis of chicken. The vaccine composition comprises an immunizing dose of Avibacterium paragallinarum type A antigen and / or Avibacterium paragallinarum type C antigen and a carrier. The invention also provides a preparation method and application of the vaccine composition. The immune effect of the vaccine composition provided by the invention is superior to the immune effect of vaccines prepared from conventional strains; the content of the antigen in the vaccine composition provided by the invention can be substantially decreased, and the vaccine composition still has good immune effect; so production cost is greatly reduced.

A process for preparing the vaccine of avian infectious rhinitis includes such steps as reanimating the chicken's parahemophilum CVCC 258 and CVCC 269, continuous passage, inoculating to chicken embryo, separating bacterial seeds, reproducing in liquid culture medium, deactivating, adding the injection containing levamisole hydrochloride, sodium selenite and VE, and preparing oily emulsion. Its advantages are quickly taking its effect (7 days) and long immune time (6 months).

The invention discloses a pharmaceutical composition used for treating infectious rhinitis of chicken, applications thereof, and a feed, and belongs to the field of veterinary drug. The pharmaceutical composition is capable of improving immunity of animals, and is used for preventing and treating infectious rhinitis of chicken. The compound traditional Chinese medicine pharmaceutical composition is prepared from following active ingredients: herba centipedae, radix platycodonis, propolis, radix angelicae, rhizoma fagopyri dibotryis, flos chrysanthemi, fructus viticis, andrographis paniculata, rhizoma phragmitis, and liquorice. The compound traditional Chinese medicine pharmaceutical composition can be added into the feed directly so as to prevent and treat infectious rhinitis of chicken, and can also be prepared into granule, tablet, oral liquid, and injection for treatment of infectious rhinitis of chicken. The compound traditional Chinese medicine pharmaceutical composition is excellent in drug effect, is convenient to use, is natural, is low in toxicity, is safe, and is friendly to the environment; effect is achieved quickly; and a preparation method is simple.

The invention relates to a traditional Chinese medicine composition for preventing and treating infectious coryza of chickens and a preparation method thereof. The traditional Chinese medicine composition is characterized by comprising the following drugs in parts by weight: 2-4 parts of magnolia flower, 2-4 parts of cocklebur fruit, 2-4 parts of phellodendron bark, 1-3 parts of costus root, 2-5 parts of radix scutellariae, 1-3 parts of radix platycodi, 1-3 parts of alum, 1-3 parts of semen lepidii, 1-4 parts of field mint, 2-4 parts of dried rehmannia root, 2-4 parts of red peony root, 1-3 parts of tuckahoe, 1-3 parts of alisma rhizome and 1-3 parts of licorice. The preparation method comprises the following steps: (1) weighing the above drugs based on the parts by weight; and (2) pulverizing and sieving the drugs with a 200-400 mesh shaking screen, and then evenly mixing to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of remarkable curative effect, no drug residues, no toxic or side effect and no drug resistance.

The invention relates to the field of poultry infectious disease epidemic prevention, in particular to a chicken infectious rhinitis subunit vaccine and a preparing method thereof. Provided avibacterium paragallinarum immunoprotecive antigen protein is characterized in that the amino acid sequence includes sixteen antigen epitopes or an epitope field shown from Seq ID No.1-16, preferably, the amino acid sequence is selected from one of Seq ID No. 17, 18, 19, 20 and 21. The invention further provides the chicken infectious rhinitis subunit vaccine. The immunity active component comprises the avibacterium paragallinarum immunoprotecive antigen protein. The vaccine can obviously improve resistance to A,B,C serotype type avibacterium paragallinarum of chicken, the protective effect of the vaccine is better than that of a whole cell inactivated vaccine, and the vaccine can be used for preventing chicken infectious rhinitis caused by avibacterium paragallinarum of different serotype types.

The invention relates to a laying hen immune process. According to the specific procedures of the laying hen immune process, Marek vaccine is injected for laying hens which are 1 day old; ND-IB vaccine and triad vaccine are injected for laying hens which are 6 to 7 days old; bursa of fabricius vaccine is injected for laying hens which are 12 days old, bird flu vaccine H5 and henpox vaccine POX are injected for laying hens which are 17 days to 18 days old, bursa of fabricius vaccine is injected for laying hens which are 22 day old, ND-IB vaccine is injected for laying hens which are 26 days old, infectious rhinitis vaccine is injected for laying hens which are 32 days old, ND-IB vaccine and infectious laryngotracheitis vaccine are injected for laying hens which are 39 days to 40 days old, bird flu vaccine H5 is injected for laying hens which are 80 days old, ND-IB vaccine is injected for laying hens which are 90 days old, vaccine H9 and brain pox vaccine are injected for laying hens which are 110 days old, bird flue H5 vaccine is injected for laying hens which are 120 days old, and ND-IB vaccine, triad vaccine and insect expelling vaccine are injected for laying hens which are 130 days old. The laying hen immune process has the advantages that the laying hen diseases can be effectively controlled, and the health of the laying hens is ensured.

The nanometer antibacterial erythromycin medicine consists of erythromycin in 0.5-1.5 wt% and nanometer emulsion matrix in 98.5-99.5 wt%. It is yellowish transparent liquid, and has medicine granularity of 1-100 nm, low viscosity, high stability, fast absorption, targeted medicine release, high bioavailability, less toxic side effect and other features. The medicine may be attached well onto bacteria and permeated into bacteria to disturb their metabolism and to reach bacteriostasis and bactericidal effect. It is used mainly for treating serious infection caused by penicillin resisting staphylococcus aureus and hemolytic streptococcus as well as chicken's chronic respiratory tract disease, malignant rhinitis, etc. The medicine has simple preparation process, less toxicity and high safety.

The invention relates to an inactivated vaccine for infectious coryza of chickens. The preparation method of the inactivated vaccine for infectious coryza of chickens comprises the following steps: using sterilized PBS (phosphate-buffered saline) to dilute inactivated haemophilus paragallinarum A type C-hpg-8 strain concentrated bacteria liquid prepared by the conventional method by a certain proportion, then mixing with vaccine adjuvants taking carbomer as a main component according to the proportion, stirring and shaking up so as to prepare the inactivated vaccine for infectious coryza of chickens. After a chicken is immunized by the inactivated vaccine for infectious coryza of chickens, the following advantages can be realized: the antibody titer generated by the inoculated chicken is high, the protection period of the antibody is long, and the protection rate against strong virus is high and the like.

The invention relates to spray for preventing infectious coryza of chickens and a preparation method for the spray, and belongs to the technical field of Chinese veterinary medicine. The spray for preventing infectious coryza of chickens is characterized by being prepared from the following raw materials in parts by weight: 20 to 25 parts of honeysuckle, 18 to 22 parts of forsythia suspensa, 19 to 23 parts of dandelions, 17 to 20 parts of tabasheer, 18 to 20 parts of poria cocos, 23 to 25 parts of herba taxilli, 13 to 18 parts of angelica dahurica, 18 to 22 parts of houttuynia cordata, 26 to 30 parts of radix isatidis and 12 to 20 parts of lancea tibetica. The spray for preventing infectious coryza of chickens is prepared by compounding various Chinese medicaments, is sprayed to the chickens twice every week to effectively inhibit the risk of bacteria to the chickens and effectively prevent the symptoms of infectious coryza and the like, and is convenient to prepare, easy to use and has no toxic or side effects, and time and cost for the vaccine injection of each chicken are reduced.

The invention relates to the antigen imitated epitope peptide of Haemophilus paragallinarum serovar C in China and its application, wherein its amino acid sequence is represented by the general formula of YX1PX2QWWX3X4X5X6X7, wherein Y represents tyrosine residue, P represents proline residue, Q represents glutamine residue, W represents tryptophan residue, X1-X7 represents any amino acids. The peptide can be used for providing an easily-manipulated serological type differential diagnosis method for chicken infectious rhinitis.

The invention provides compound traditional Chinese medicine for treating infectious rhinitis of chicken. The compound traditional Chinese medicine is composed of, by weight, 10-20 parts of Herba epimedii, 10-20 parts of burdock, 10-20 parts of Rhizoma atractylodis, 5-15 parts of Senecio scandens, 5-15 parts of Fructus xanthii, 5-15 parts of Flos carthami, 5-15 parts of Rhizoma acori tatarinowii, 5-15 parts of Radix ophiopogonis, 5-15 parts of Caulis spatholobi and 2-8 parts of Flos magnoliae. Natural medicinal materials are adopted, so that the compound traditional Chinese medicine does not contain any antibiotics and chemically synthesized medicine; the compound traditional Chinese medicine is reasonable in formulation, and the medicinal materials are synergistic in treatment effect. The compound traditional Chinese medicine has the advantages of being free of medicine residue, safe, free of toxic and side effect and good in effect and can effectively treat infectious rhinitis of chicken. The invention further discloses a preparation method of the compound traditional Chinese medicine. The preparation method is simple to operate, easy to implement and worthy of wide popularization.

The invention discloses a traditional Chinese medicinal composition used for preventing and treating infectious rhinitis of chicken, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines for animals. The traditional Chinese medicinal composition mainly comprises, by weight, 20-25 parts of Radix Astragali, 20-25 parts of safflower, 15-20 parts of Andrographis paniculata, 15-20 parts of wolfberry fruit, 15-20 parts of Polygonum multiflorum, 15-20 parts of Radix Scutellariae, 15-20 parts of epimeddium, 10-20 parts of Cortex Fraxini, 10-20 parts of Ligustri Lucidi Fructus, 10-20 parts of Atractylodes lancea, 8-15 parts of Radix Codonopsis, 8-15 parts of Liriope spicata, 30-35 parts of Folium Polygoni Tinctrorii, 15-25 parts of Herba Violae, 15-18 parts of Chinese angelica and 5-10 parts of Rhizoma Coptidis. The composition prepared by blending the above medicines according to a monarch, minister, assistant and guide principle has the efficacies of heat clearing, detoxifying, bacterium resisting, inflammation eliminating, body immunity improving and the like, and is mainly used for treating the infectious rhinitis of chicken.

The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious rhinitis.

The invention discloses a traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken. The composition is prepared from the following raw materials in parts by weight: 9-18 parts of radix lsatidis, 12-21 parts of chrysanthemum indicum, 9-24 parts of saposhnicovia divaricata, 12-18 parts of scutellaria baicalensis, 6-18 parts of peppermint, 6-12 parts of ephedra, 6-15 parts of fructus xanthii, 6-15 parts of flos magnoliae, 6-15 parts of radix angelicae, 6-15 parts of ligusticum wallichii, 6-9 parts of angelica sinensis, 6-9 parts of safflower carthamus, 6-15 parts of notopterygium root, 12-24 parts of herba houttuyniae, 9-21 parts of agastache rugosa and 6-12 parts of licorice root. The traditional Chinese medicine composition has the effects of dispelling wind and heat, reducing phlegm, inducing diuresis, relieving stuffy nose and inducing resuscitation, and has the advantages of quick pharmacological action, good effect and no medicinal residue when used for preventing infectious rhinitis and chronic respiratory diseases of chicken; and the preparation method is simple, and is easy to popularize and apply.

The invention relates to a traditional Chinese medicine compound granule for treating avian infectious rhinitis, including five medicines of siberian cocklour fruit, honeysuckle flower, wild chrysanthemum, biond magnolia flower and India madder root. The invention is mainly used for treating infectious rhinitis which is caused by haemophilus paragallinarum and other respiratory tract pathogens and is accompanied with nasal and sinus mucosa acute catarrhal inflammation and catarrhal conjunctivitis lesions, while the infectious rhinitis has the symptoms of flowing thin and clear liquid of the nasal cavity, sneezing, eyelid edema, appetite suppression, poor growth of chicks, reduced egg yield of laying hens and so on. The medicine can be prepared into the soluable granule by the combination of the special physiological structure of short reproductive tracts of birds which can not digest the wood fiber, the invention can be dissolved rapidly in the fodder drinking water, and the invention can achieve the purpose of rapid onset of action after the drinking water is absorbed by sick chickens.

The invention provides a feed additive for preventing and treating infectious rhinitis of chicken. The feed additive is prepared from the following raw materials in parts by weight: 20 to 30 parts ofradix saposhnikoviae, 20 to 30 parts of radix angelicae dahuricae, 20 to 30 parts of herba taraxaci, 20 to 30 parts of flos chrysanthemi indici, 20 to 30 parts of radix platycodonis, 15 to 20 parts offlos magnoliae, 15 to 20 parts of radix scutellariae, 15 to 20 parts of cortex phellodendri, 15 to 20 parts of radix isatidis, 15 to 20 parts of honeysuckle flower, 15 to 20 parts of garlic, 15 to 20parts of fructus forsythiae, 15 to 20 parts of herba ephedrae, 15 to 20 parts of herba asari and 8 to 12 parts of liquorice root.

The invention discloses a traditional Chinese preparation for treating acute nasopharyngitis and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The active ingredients of the traditional Chinese preparation comprise the following raw materials: asarum, tarenna, galinsoga parviflora, bidens tripartite, hispid arthraxon, purple cathoclines, Chinese olive, radix angelicae, salvia prionitis, trichilia connaroides, champac roots, Luoxing grass, mysore thorn roots, wood steamed breads, eriocaulon cinereum and luffa roots. According to the traditional Chinese preparation and the preparation method thereof, medicinal materials selected are suitable for compatibility, the traditional Chinese preparation has the double effects of treatment and conditioning and has the efficacies of clearing heat and detoxifying, diminishing inflammation and relieving swell, and relieving sore throat and relieving pain, and infectious rhinitis, pharyngalgia, mouth breathing, oropharyngeal foreign bodies and other symptoms suffered by patients can be quickly and effectively reduced and improved; natural ingredients in the traditional Chinese preparation contain rich nutrient substances, the toxic or side effectss caused by chemicals can be avoided, the taking is safe, the recurrence rate is low, and the treatment effect is lasting.

A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza. The invention further provides a gene coding for the polypeptide, a recombinant vector for expression of this gene, a host transformed with this vector, a process for preparing the polypeptide in a host, a vaccine for avian infectious coryza comprising the polypeptide as an active ingredient, a monoclonal antibody obtained using the polypeptide as an immunogen, and a diagnostic agent and a therapeutic agent for avian infectious coryza using the peptide and the antibody.

The invention discloses a slow-released preparation in treatment and prevention for rabbit malignant rhinitis and means of making thereof, belonging to the technical field for treating and prevention of livestock epidemic disease. Said preparation consists of Azithromycin and beta cyclodextrin as materials and prepares in accordance with part by weight; preparation means is, first mixing and dissolving Azithromycin and anhydrous alcohol in accordance with weight-to-volume ratio : 1g.: 7-9 ml.; mixing and grinding into paste beta cyclodextrin and distilled water in accordance with weight-to-volume ratio : 1g.: 0.5-1.5ml.; thereafter mixing, compounding, drying, grinding both described hereinabove to obtain slow-released powder; being prepared into injection when applying.

The invention provides a compound propolis composition for treating infectious rhinitis of chickens and a preparation method thereof, relating to the field of poultry medicine. The invention aims to provide a compound propolis composition for treating infectious rhinitis of chickens, which is reasonable in prescription and simple to prepare, and a preparation method thereof. The specific components and method are as follows: (1) respectively carrying out ultrafine crushing on each component in the prescription, and sieving with a 700-mesh sieve; (2) weighing 15-25 parts by weight of propolis, 10-35 parts by weight of magnolia flower and 15-30 parts by weight of dahuricae angelica root, and mixing for 5-10 minutes until the components are uniformly mixed; (3) weighing 10-25 parts by weight of Baikal skullcap root, 10-35 parts by weight of sibirian button bur, 10-25 parts by weight of liquorice and 10-35 parts by weight of Herba Patriniae, and mixing for 5-10 minutes until the components are uniformly mixed; and (4) merging the compositions prepared in the steps (2) and (3), and continuing to mix for 10-15 minutes until the compositions are uniformly mixed. The compound propolis composition is simple to prepare, and has the advantages of no toxic or side effect, no pollution, no medicine residue and no medicine resistance; due to ultrafine crushing, the bioavailability is high, and the curative effect is remarkable; and clinical application proves that the compound propolis composition has a specially good effect on the treatment of infectious rhinitis of chickens.