18109 results about "Ophthalmology" patented technology

An exposure apparatus includes a projection optical system for projecting a pattern on a reticle onto an object to be exposed, a reference mark that serves as a reference for an alignment between the reticle and the object, a first fluid that has a refractive index of 1 or greater, and fills a space between at least part of the projection optical system and the object and a space between at least part of the projection optical system and the reference mark, and an alignment mechanism for aligning the object by using the projection optical system and the first fluid.

Disclosed is an implant for use in an eye with glaucoma, the implant including an inlet section in fluid communication with an outlet section, the inlet section being sized and shaped to fit at least partially in the anterior chamber of the eye, and the outlet section being sized and shaped to fit at least partially in Schlemm's canal of the eye. The implant also includes an expandable substrate suitable for expansion in the eye to assist in retaining the implant in the eye.

A computer-driven system amplifies a target region based on integrating eye gaze and manual operator input, thus reducing pointing time and operator fatigue. A gaze tracking apparatus monitors operator eye orientation while the operator views a video screen. Concurrently, the computer monitors an input indicator for mechanical activation or activity by the operator. According to the operator's eye orientation, the computer calculates the operator's gaze position. Also computed is a gaze area, comprising a sub-region of the video screen that includes the gaze position. The system determines a region of the screen to expand within the current gaze area when mechanical activation of the operator input device is detected. The graphical components contained are expanded, while components immediately outside of this radius may be contracted and / or translated, in order to preserve visibility of all the graphical components at all times.

A distortion corrected panoramic vision system and method provides a visually correct composite image acquired through wide angle optics and projected onto a viewing surface. The system uses image acquisition devices to capture a scene up to 360° or 4π steradians broad. An image processor corrects for luminance or chrominance non-uniformity and applies a spatial transform to each image frame. The spatial transform is convolved by concatenating the viewing transform, acquisition geometry and optical distortion transform, and display geometry and optical transform. The distortion corrections are applied separately for red, green, and blue components to eliminate lateral color aberrations of the optics. A display system is then used to display the resulting composite image on a display device which is then projected through the projection optics and onto a viewing surface. The resulting image is visibly distortion free and matches the characteristics of the viewing surface.

A hand held electronic device having at least two displays is disclosed. At least one display is a direct-view display, like those on most cell phones or PDAs in use in 2001, for viewing at normal reading distance of approximately 12 to 24 inches (“arms'-length” viewing). At least one of the other displays is a microdisplay, a tiny display with magnifying optical elements, for viewing larger, higher-resolution images when the microdisplay is positioned close to the eye. The invention allows coordinating microdisplays and direct-view displays in ways that allow people to comfortably access and interact with full-page Web content on pocket-size devices. When a user is viewing a Web page (or other content) on a device's microdisplay held near-to-eye, the device allows the user to position a cursor or a rectangular outline (or some other indication of a “region of interest”) on a particular part of the Web page, and then when the user moves the device out to arms'-length viewing, the user should be able to view that region of interest on the direct-view display—that is, view a subset of the larger image that appeared on the microdisplay.

Methods and apparatus for rendering quantitative phase maps across and through transparent samples. A broadband source is employed in conjunction with an objective, Fourier optics, and a programmable two-dimensional phase modulator to obtain amplitude and phase information in an image plane. Methods, referred to as Fourier transform light scattering (FTLS), measure the angular scattering spectrum of the sample. FTLS combines optical microscopy and light scattering for studying inhomogeneous and dynamic media. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. Full angular information, limited only by the microscope objective, is obtained from extremely weak scatterers, such as a single micron-sized particle. A flow cytometer may employ FTLS sorting.

This invention relates to a method of reducing an irritating or adverse side effect associated with the topical use of an active ophthalmic drug comprising incorporating an effective amount of a cyclodextrin or cyclodextrin derivative into a formulation to complex the active drug such that the concentration of the free active drug is reduced below a tolerable threshold, and incorporating an effective amount of a viscosity increasing agent in said formulation such that the bioavailability of said drug is high enough to be therapeutically effective, wherein the cyclodextrin or cyclodextrin derivative is not required to solubilize the active drug. Another aspect of this invention relates to topical ophthalmic formulations comprising an active drug, a cyclodextrin or cyclodextrin derivative, and a viscosity-enhancing agent, in effective amounts as stated above.

A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.

A microlithographic projection exposure apparatus contains an illumination system (12) for generating projection light (13) and a projection lens (20; 220; 320; 420; 520; 620; 720; 820; 920; 1020; 1120) with which a reticle (24) that is capable of being arranged in an object plane (22) of the projection lens can be imaged onto a light-sensitive layer (26) that is capable of being arranged in an image plane (28) of the projection lens. The projection lens is designed for immersion mode, in which a final lens element (L5; L205; L605; L705; L805; L905; L1005; L1105) of the projection lens on the image side is immersed in an immersion liquid (34; 334a; 434a; 534a). A terminating element (44; 244; 444; 544; 644; 744; 844; 944; 1044; 1144) that is transparent in respect of the projection light (13) is fastened between the final lens element on the image side and the light-sensitive layer.

The invention provide a new lens curing method for making hydrogel contact lenses. The new lens curing method is based on actinically-induced step-growth polymerization. The invention also provides hydrogel contact lenses prepared from the method of the invention and fluid compositions for making hydrogel contact lenses based on the new lens curing method. In addition, the invention provide prepolymers capable of undergoing actinically-induced step-growth polymerization to form hydrogel contact lenses.

An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.

A method for red-eye detection in an acquired digital image comprises acquiring a first image and analyzing the first acquired image to provide a plurality of characteristics indicative of image quality. The process then determines if one or more corrective processes can be beneficially applied to the first acquired image according to the characteristics. Any such corrective processes are then applied to the first acquired image. Red-eye defects are then detected in a second acquired image using the corrected first acquired image. Defect detection can comprise applying a chain of one or more red-eye filters to the first acquired image. In this case, prior to the detecting step, it is determined if the red-eye filter chain can be adapted in accordance with the plurality of characteristics; and the red-eye filter is adapted accordingly.

An accommodating intraocular implant for locating in the capsular bag, the implant comprising a single piece of elastically deformable material constituting a central lens (1) and at least two haptic portions (2, 4) in the form of radial arms for bearing via their free ends against the equatorial zone of the capsular bag, the free end of each radial arm (2, 4) being fitted with a shoe (6, 7) of substantially toroidal outside surface enabling the implant to bear against the equatorial zone of the bag, the connection between each shoe (6, 7) and the corresponding arm (2, 4) being of the hinge type situated in the vicinity of the posterior edge of the shoe (6, 7) and being formed by a first thin portion (2d, 4d) of the arm, while the connection between each arm and the lens is of the hinge type implemented at the anterior surface of the lens by a second likewise thin portion (2c, 4c) of the arm, the plane (P1) containing the first thin portions being situated behind the plane (P2) containing the second thin portions.

Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.

A system for easily transferring an intraocular lens (IOL) from a lens case to an inserter, and then into a patient's eye. The lens case has a transfer mechanism therein which retains the IOL until engagement with the inserter. The transfer mechanism may include jaws having a closed configuration for retaining the IOL and an open configuration for releasing the IOL. Engagement of the inserter with the lens case automatically opens the jaws and transfers the IOL to the inserter. The IOL is transferred into a load chamber of a nosepiece rotatably coupled to a handpiece. After transfer of the IOL, the nosepiece is rotated from a load position to a delivery position. The IOL may have an optic and a haptic coupled to the optic, and the lens case may be capable of configuring the haptic as desired to facilitate its transfer into an inserter and / or into the eye. For instance, the lens case may fold one or both of the haptics over the optic. Preferably, the lens case maintains the haptic in this position during transfer of the intraocular lens into an inserter and / or inserter cartridge. A manifold for easily distributing a viscoelastic medium to the load chamber of the inserter is also provided.

A digital camera has an integral flash and stores and displays a digital image. Under certain conditions, a flash photograph taken with the camera may result in a red-eye phenomenon due to a reflection within an eye of a subject of the photograph. A digital apparatus has a red-eye filter which analyzes the stored image for the red-eye phenomenon and modifies the stored image to eliminate the red-eye phenomenon by changing the red area to black. The modification of the image is enabled when a photograph is taken under conditions indicative of the red-eye phenomenon. The modification is subject to anti-falsing analysis which further examines the area around the red-eye area for indicia of the eye of the subject. The detection and correction can be optimized for performance and quality by operating on subsample versions of the image when appropriate.

A digital camera has an integral flash and stores and displays a digital image. Under certain conditions, a flash photograph taken with the camera may result in a red-eye phenomenon due to a reflection within an eye of a subject of the photograph. A digital apparatus has a red-eye filter which analyzes the stored image for the red-eye phenomenon and modifies the stored image to eliminate the red-eye phenomenon by changing the red area to black. The modification of the image is enabled when a photograph is taken under conditions indicative of the red-eye phenomenon. The modification is subject to anti-falsing analysis which further examines the area around the red-eye area for indicia of the eye of the subject. The detection and correction can be optimized for performance and quality by operating on subsample versions of the image when appropriate.

The present invention is directed to systems and methods that provide enhanced eye safety for image projection systems. In particular, the instant invention provides enhanced eye safety for long throw laser projection systems.

A system for non-invasive treatment of a patient's trabecular meshwork to treat primary open-angle glaucoma. The system and technique applies energy directly to media within clogged spaces in a patient's trabecular meshwork to increase aqueous outflow facility by (i) localization of microimplantable bodies carrying a selected exogenous chromophore, such as particles with a gold surface, in deeper regions of the trabecular meshwork, and (ii) irradiation of the microimplantables with a selected coherent wavelength having a power level and pulse duration that is strongly absorbed by the surfaces of the microimplantables.

A method for measuring overlay in a sample includes obtaining an image of an overlay target that includes a series of grating stacks each having an upper and lower grating, each grating stack having a unique offset between its upper and lower grating. The image is obtained with a set of illumination and collection optics where the numerical aperture of the collection optics is larger than the numerical aperture of the illumination optics and with the numerical apertures of the illumination and collection optics are selected so that the unit cells of gratings are not resolved, the grating stacks are resolved and they appear to have a uniform color within the image of the overlay target.

Disclosed is the use of a mist of a pharmaceutical composition for ophthalmic delivery of a protein or peptide active pharmaceutical ingredient, a related method of treatment and a device useful in implementing the use and method. Disclosed is also the use of a mist for ophthalmic delivery of a pharmaceutical composition including a highly irritating penetration enhancer and an ophthalmically acceptable carrier, a related method of treatment and a device useful in implementing the use and method. Disclosed is also a device for ophthalmic administration configured to direct a mist of a pharmaceutical composition to the eye only when the eye is open. Disclosed is also a self-sterilizing device for ophthalmic administration. Disclosed is also a device and a method for increasing the bioavailability of an ophthalmically administered API in a pharmaceutical composition.

An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.

An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.

A method and apparatus determine when a subject is looking at a specific target area by estimating a divergence angle between (1) the direction in which the subject is looking and (2) the direction from the subject directly to the target area. This technique accesses whether the subject is looking at a particular area. The invention may further condition this determination according to the subject's distance from the target area, because there is less tolerance for divergent angles when the subject is farther away. In one embodiment, the divergence angle is estimated using the position of a glint of light in the subject's pupil. The glint is created by a light source located in the target area. If the glint is sufficiently central to the pupil, with the camera and light source being near the target area, the subject is looking at the target area. At long distances, when the glint is not sufficiently discernable from the pupil, another technique may be employed to estimate divergence angle. Namely, the plane of the subject's face is computed, and analyzed with respect to a vector between the subject's face and the target area. If the plane is substantially normal to the vector, the subject is looking at the target area.

The present invention relates to a novel endoscope or an optical large view endoscopic system with improved depth perception. In particular, a multiple viewpoint endoscope system comprising a multiple viewpoint camera setup and / or an intelligent or cognitive image control system and display device particularly adapted for localising internal structures within a cavity or an enclosing structure, such as an animal body, for instance the abdomen of an animal or human, or for localising a real or synthetic image of such internal structures within an overview image or on an overview 3D model.

An endoscope has a first segment with a proximal end and a distal end and is symmetric about an axis. A second segment, comprising a flexible and interconnected linkage system, is pivotably coupled to the first segment and, when subject to an applied force, is configurable along an arc having a variable radius of curvature. The linkage system is capable of articulation through an angle from zero degrees through about 280 degrees.

This invention provides an image capturing lens assembly, in order from an object side to an image side comprising: a first lens element with positive refractive power having a convex object-side surface; a second lens element; a third lens element; a fourth lens element having at least one of an object-side surface and an image-side surface thereof being aspheric; a fifth lens element with positive refractive power having a convex image-side surface, at least one of an object-side surface and the image-side surface thereof being aspheric, and the fifth lens element is made of plastic; and a sixth lens element with negative refractive power having a concave image-side surface, at least one of an object-side surface and the image-side surface thereof being aspheric, and the sixth lens element is made of plastic. By such arrangement, the photo-sensitivity and the total track length of the image capturing lens assembly can be reduced. Furthermore, the aberration and astigmatism of the assembly can be effectively corrected for obtaining higher image resolution.

A system and method for correcting distortions that occur in image capture systems is disclosed. The present invention in some preferred embodiments includes provisions to correct or change magnification differences for all causes including position errors in zoom lens positioning mechanisms as well as those caused by chromatic aberration, CCD alignment errors, lens distortion off center variations, pincushion / barrel lens distortion, magnification distortions, camera and lens misalignment errors, and lighting variations (including flash-to-flash illumination variations). A significant feature of the present invention in contrast with the prior art is that with the use of a movable calibration plate in the present invention it is possible to image capture both the calibration plate and the input object image in a single image capture, thus permitting simultaneous compensation for a variety of lighting and illumination variations not possible with the prior art.