337 results about "Enrofloxacin" patented technology

The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is selected from the group consisting of meloxicam, carprofen, enrofloxacin, clemastine, diphenhydramine, digoxin, levothyroxine, cyclosporine, ondansetron, lysine, zolpidem, propofol, nitenpyram, ivermectin, milbemycin, and pharmaceutically acceptable salts, solvates and esters thereof. In another embodiment, the invention includes methods of treating or preventing a condition in an animal comprising transmucosally administering a composition comprising a therapeutically or prophylactically effective amount of an active agent and a pharmaceutically acceptable carrier.

The invention discloses a fluorescent microsphere immunochromatography detection card for detecting enrofloxacin and a preparation method thereof. The detection card sequentially comprises filter paper, a sample pad, a glass fiber film, a nitrocellulose film and absorbent paper, wherein a fluorescent microsphere-labeled antibody is sprayed on the glass fiber film; a detection area and a quality control area are fixed on the nitrocellulose film; a conjugate of enrofloxacin and carrier protein is sprayed in the detection area; and an anti-mouse antibody is sprayed in the quality control area. By taking core-shell bistructure luminous nano particles complexed by silica and fluorescent substances as labels and adopting immunochromatography in a competition blocking mode, the invention realizes rapid immunoassay of the enrofloxacin. In the detection process, an optimized excitation light source of the fluorescent microsphere is adopted for excitation, the emitted fluorescence passes through a light filter device, and that whether a detection line is provided with fluorescent substances is observed by naked eyes. The invention has the characteristics that: the detection card has high sensitivity and is rapid in detection, convenient to operate, and economic and practical.

The invention relates to an enrofloxacin/sulfobutylether-beta-cyclodextrin inclusion compound, a preparation method and a medicinal preparation thereof. The inclusion compound comprises sulfobutylether-beta-cyclodextrin and enrofloxacin in a weight ratio of 1-10:1, and sulfobutylether-beta-cyclodextrin respectively has the average degree of substitution of 1, 4 and 7. The preparation method comprises the following steps: (1) weighing raw materials in a mass ratio of sulfobutylether-beta-cyclodextrin to enrofloxacin of 1-10:1, and respectively dissolving in a solvent which is water, ethanol solvent or mixture of water and ethanol solvent; and (2) mixing the two liquids prepared in the step (1) to perform an inclusion reaction. The medicinal preparation can be oral preparation and injection, wherein the oral preparation can be tablets, soluble powder and oral liquid; and the injection can be injection liquid and lyophilized powder. The medicinal preparation has the advantages of remarkably improved solubility in water phase, improved stability, excellent palatability, good curative effect and low toxic and side effects.

The invention discloses a solid phase extraction and HPLC-fluorescence detection method for fluoroquinolones antibiotics. The method comprises the following steps of passing a pretreated water sample through an activated solid phase extraction column; eluting the solid phase extraction column with a Na2EDTA aqueous solution; then vacuumizing; and finally, eluting the water sample for three times by a concentrated ammonia methanol solution with a concentrated ammonia volume percent concentration of 6 percent by 0.5-2mL each time. An obtained eluent is blow-dried to 0.1-0.4mL in air flow, water is added to reach a constant column of 1.0mL so as to obtain a test sample, and then HPLC-fluorescence detection is carried out. By adopting the solid phase extraction-HPLC-fluorescence detection technology and utilizing a conventional analytical instrument, the method can simultaneously measure the contents of four typical fluoroquinolones antibiotics of ofloxacin, norfloxacin, ciprofloxacin and enrofloxacin in the water sample. The method has simple operation and low cost and can be applied to the measurement of the ultratrace of four typical fluoroquinolones antibiotics in waste water and surface water.

The invention relates to the field of pharmaceutical preparations and particularly relates to a slow-release micropill preparation containing enrofloxacin and a preparation method of the preparation. The slow-release micropill provided by the invention is formed by coating an enrofloxacin micropill; the enrofloxacin micropill comprises enrofloxacin and auxiliary material and is formed through extruding and rounding; the auxiliary material is any one or more of microcrystalline cellulose, starch, cane sugar, artificial gum, lactose and sodium carboxymethyl starch; according to weight percent, the auxiliary material in the micropill accounts for 70% to 95%; and coating is made of high-molecular enteric material, film forming material, opaquer and the like. The slow-release micropill preparation has the characteristics of slow release and high bioavailability, can be used for treating bacteria and mycoplasma infection of livestocks, and has better curative effect on chronic respiratory diseases, colibacillosis and salmonellosis, and the frequency of medicine taking can be reduced; and in addition, the slow-release micropill provided by the invention has the advantages that the stability of medicine is improved, and peculiar bitter of enrofloxacin can be covered completely, so that feeding intake of the animals is not influenced, and the recovery rate is improved.

The invention discloses a process for producing masked Enrofloxacin comprises the following steps, (1) charging gelatin into water, (1) thermally insulating 0.5-1 hour at 30-50 deg C., charging glycerin, thermally insulating at 30-50 deg C, stirring to obtain gelatine size, (2) charging 6% of p-hydroxybenzoic acid ethyl ester ethanol solution, mixing to form gelatin-plasticizer composite solution, adjusting the pH to 6.8-7.2 with alkali, (3) charging water into autoclave, heating to 70-80 deg C, charging Enrofloxacin, stirring and charging silicon dioxide, stirring to form turbid liquor, cooling down to 45-55 deg C, adjusting pH to 6.8-7.2 with alkali, (4) charging gelatin-plasticizer composite solution into the turbid liquor, hardening 25-35 minutes with 5.37% of formaldehyde solution.

The present invention relates to an enrofloxacin gelatin microsphere and its preparation method. It is characterized by that it uses type A gelatin as carrier, uses enrofloxacin as medicine to be carried and adopts an emulsification-condensation process to prepare the invented gelatin microsphere which can take the lung as target organ after intravenous injection. The average grain size of said microspheres is 12 micrometers.

The invention discloses a rabbit monoclonal antibody based ciprofloxacin residue analysis enzyme-linked immune adsorption kit. In the ciprofloxacin detection, the IC50 value of the kit is 1.41ng/mL, the linear fitting equation of an inhibition ratio curve is y = 0.0239x - 1.3159, the detection range is between 0.19 and 10ng/mL, and the lowest detection limit is 0.095ng/mL. The ciprofloxacin antibody in the kit has higher specificity, and has lower crossing-over rate with other quinolone micromolecules; and the cross reaction rates between the ciprofloxacin antibody and enrofloxacin, ofloxacin, norfloxacin, fleroxacin or pefloxacin are 28.8 percent, 13.1 percent, 11 percent, 22.6 percent and 20.4 percent respectively. The ciprofloxacin antibody has no cross reaction with other antibiotics and sulfanilamide medicaments. The kit is suitable for detecting ciprofloxacin residue in samples of milk, urine and the like. The kit can detect samples on a large scale at the same time, is convenient and quick, has quite important realistic significance for on-site supervision and trace analysis, meanwhile greatly reduces the detection cost, and has potential economic value.

The invention belongs to the environmental material preparation technical field, and relates to a preparation method of a photodegraded enrofloxacin hydrochloride floating type magnetic conductive surface molecular imprinting composite photocatalyst and an application. According to the invention, fly ash is modified, the floating type carboxyl modified fly ash hollow microspheres can be prepared, chitosan is used to perform a crosslinking preparation on magnetic Fe3O4 nano-particles to prepare the magnetic fly ash hollow microspheres, a sol-gel method is used to prepare the TiO2@magnetic fly ash hollow microspheres photocatalyst through photo-initiation polymerization, and the fly ash hollow microspheres photocatalyst is performed with ultrasonic modification, the template molecule enrofloxacin hydrochloride is added for photo polymerization, and is eluted, and leached by absolute ethyl alcohol and then dried. The prepared floating type magnetic conductive surface molecular imprinting composite photocatalyst can be used for degrading the enrofloxacin hydrochloride; the surface molecular imprinting composite photocatalyst has high selectivity on enrofloxacin hydrochloride after photocatalytic degradation no matter in a single-phase antibiotic solution or in a binary mixed phase antibiotic solution; and the magnetic separation characteristic enables convenience and high efficiency for separating and recovering.

The invention discloses a preparation method of a ciprofloxacin and enrofloxacin residue freeze-dried powder standard sample in carp muscle, which takes the carp as a research object to research a carp muscle material object standard sample containing ciprofloxacin and enrofloxacin of certain concentration in a breeding mode of adding target medicine. The key production control technology of the material object standard sample disclosed by the invention is mastered and comprises the control of content level, evenness, stability, constant value and the like, and the standard sample is produced and prepared in a standardization and scale mode. The standard sample is used for detection quality control and detection capability evaluation for residue of veterinary drug in animal-derived food and has an important significance on food safety detection.

The invention relates to a berberine hydrochloride compound preparation made from the following components in terms of weight percentage: 0.5-1% of berberine hydrochloride, 2-5% of antibacterial medicament, 0-0.1% of antiviral medicament, 1-1.5% of antibacterial synergist, 0-15% of stabilizer, 0-30% of cosolvent, 0-5% of local anodyne, 0-2% of antioxidant and balance of disperse medium. The inventive compound preparation has the following advantages: (1) the compound preparation solves the instability problem of berberine injection by making the berberine into orally taken liquid; (2) the berberine hydrochloride when used with enrofloxacin and TMP together can be used as the preferable medicament for intestinal infections, is more advantageous in treating intestinal infections caused by escherichia coli and salmonella than other single antibiotics sold in the market, especially good for drug resistant strains, is applied two times a day for three constant days, and prevention and treatment rate is up to 100%; (3) the berberine hydrochloride when used with enrofloxacin, gentamicin sulphate and TMP together is used to treat septicaemia, respiratory tract infections and intestinal infections caused by sensitive bacteria.

The invention discloses a method for preparing solid enrofloxacin nano particles, which is characterized by comprising the following steps: firstly, preparing 1 percent aqueous solution of glacial acetic acid with distilled water, and adding chitosan into the aqueous solution under a condition of magnetic stirring to dissolve the chitosan and obtain 1.5 to 2.5mg/mL solution of chitosan; secondly, adding enrofloxacin raw material medicament into the solution of chitosan, continuing performing magnetic stirring for 10min to uniformly disperse the enrofloxacin raw material medicament, adjusting the pH value to 5.0 to obtain solution of enrofloxacin chitosan; thirdly, dissolving sodium tripolyphosphate in the distilled water to prepare 1.2 to 1.8mg/mL solution of sodium tripolyphosphate, slowly dripping the solution of sodium tripolyphosphate into the solution of enrofloxacin chitosan under the condition of magnetic stirring, after dripping is finished, continuing performing magnetic stirring for 1h, immobilizing to obtain enrofloxacin chitosan nano particle suspension; and finally, filling the immobilized enrofloxacin chitosan nano particle suspension into frozen bottles, pre-freezing the bottles for 2h at the temperature of 70 DEG C below zero, vacuumizing and freeze-drying the bottles at the temperature of 50 DEG C below zero to obtain the solid enrofloxacin nano particles.

The invention relates to a fishery Chinese and western compound medicine composition as well as a premix compound, batch mixture and application thereof and discloses a fishery Chinese and western compound medicine composition. The fishery Chinese and western compound medicine composition comprises the following components, namely, rheum officinale, golden cypress, scutellaria baicalensis, coptis chinensis, radix bupleuri, liquorice, gypsum and enrofloxacin. The fishery Chinese and western compound medicine composition has remarkable curative effects and takes quick effects on common bacterial diseases, such as bacterial septicemia, gill rot and red skin disease of aquatic livestock. The fishery Chinese and western compound medicine composition is stable in quality, convenient to use and low in cost, has the advantages of small toxic and side effects, efficient broad-spectrum, safety, environmental friendliness and the like and can be used for effectively ensuring the health and safety of the aquaculture animals.