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Method for preparing molecularly imprinted polymer enriched with trace enrofloxacin

A technology of enrofloxacin and molecular imprinting, which is applied in chemical instruments and methods, organic chemistry, and other chemical processes, can solve complex pretreatment problems, achieve simple experimental operation, fast mass transfer, and easy control of reaction conditions Effect

Inactive Publication Date: 2010-06-23
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Problems solved by technology

However, when traces of ENRO exist in food, the pretreatment of the above detection method is very complicated

Method used

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Embodiment Construction

[0011] Below in conjunction with embodiment, the present invention is further described; Following embodiment is illustrative, not limiting, can not limit protection scope of the present invention with following embodiment.

[0012] The present invention combines surface molecular imprinting technology with sol-gel technology, and imprints amino functional groups on the surface of silicon spheres, thereby synthesizing an adsorption functional material with high selectivity for enrofloxacin. The specific examples are:

[0013] (1) Accurately measure 10 mL of N, N-dimethylformamide, 0.5 g of enrofloxacin, 1000 μL of 3-aminopropyltriethoxysilane, and 0.1 g of activated silicon spheres in a round-bottomed flask. Stir and react in a water bath at ℃ for 30 min, add 1000 μL of tetraethoxysilane, 350 μL of 0.1mol / L ammonia water, and incubate at 46 °C for 14 h;

[0014] (2) Filter the above-mentioned polymerized product through methanol and age at 110°C for 10 hours, then add 10 mL of...

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Abstract

The invention relates to a method for preparing a molecularly imprinted polymer enriched with trace enrofloxacin, which comprises the main technical key point that enrofloxacin is used as a template molecule, 3-aminopropyl triethoxysilane is used as a functional monomer, tetraethoxy silane is used as a crosslinking agent, an activated silicon ball is used as a carrier, N,N-dimethylformamide is used as a pore-foaming agent, and a surface molecular imprinting technique and a sol-gel technique are utilized to synthesize an adsorptive functional material having high selectivity to the enrofloxacin. The method has a low cost and a simple synthetic process, the reaction condition is easy to control, and the prepared enrofloxacin molecularly imprinted polymer can be used for the combination of solid phase extraction enrichment and high efficiency liquid chromatography, and is suitable for performing online detection on the trance enrofloxacin in animal-based foods and performing purification treatment on various samples.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a method for preparing a molecularly imprinted polymer enriched with trace amounts of enrofloxacin. Background technique [0002] Enrofloxacin (ENRO for short) is the first third-generation fluoroquinolone drug specially used for livestock and poultry. It has a wider antibacterial spectrum and stronger antibacterial effect, and is widely used in livestock and poultry farming and fish farming. drug. It is generally believed that ENRO does not stay in animal tissues, but it has a certain accumulation when applied in large doses. Enrofloxacin and its metabolite (ciprofloxacin) have a moderate degree of damage to the kidneys. In recent years, ENRO and its metabolite ciprofloxacin There are more and more reports of toxic and side effects such as neurotoxicity, renal impairment, and allergic reactions and drug resistance caused by the clinical application of floxacin in vete...

Claims

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Application Information

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IPC IPC(8): C08G77/26C08J9/26C08L83/08B01J20/26B01J20/30C07D215/56
Inventor 王硕潘明飞王俊平方国臻
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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