1838 results about "Molecularly imprinted polymer" patented technology

A class of molecularly imprinted polymers that specifically recognizes and binds to nitrosamines members of which class are useful, for example, in analysis and separation of nitrosamines from biological fluids. Such molecularly imprinted polymers are also useful in methods of treating and manufacturing tobacco products and materials.

The present invention relates to molecularly imprinted polymers comprising tailor-made recognition sites for a target in which said recognition sites are located at or close to the surface of the polymer and / or of pores in the polymer. The molecularly imprinted polymer comprising tailor-made recognition sites for a target is obtainable by polymerising functional monomers and, optionally, cross-linked, optionally in a reaction solvent, in the presence of at least one template immobilised on a support material in a polymerisation process, whereby non-covalent or covalent are formed between said functional monomers and said immobilised template(s), and removing said template(s), and said support material from the molecularly imprinted polymer.

A method for extracting a polycyclic aromatic hydrocarbon from a material such as tobacco or tobacco extracts or other materials comprises treating the material with a molecularly imprinted polymer selective for the hydrocarbon in the presence of a low polarity medium.

A class of molecularly imprinted polymers that specifically recognizes and binds to TSNAs are useful, for example, in analysis and separation of TSNAs from biological fluids. Such polymers are also useful in methods of treating and manufacturing tobacco products and materials.

Methods for synthesizing molecularly imprinted polymers (MIP) having an affinity for dietary phosphates, resulting polymers, pharmaceutical compositions and modes of administration are disclosed. The MIP compounds are useful for binding excess dietary phosphates in a patient in need thereof.

An adhesive is provided containing at least one synthetic polymer with receptor sites that enable the selective capture or release of a target molecule. A polymer is synthesized by polymerizing and cross-linking a functional monomer or functional copolymers in the presence of a target or template molecule allowing for reversible interactions between the polymer and the target molecule. The target molecule may be extracted from the polymer creating receptor sites complimentary to the target molecule. Alternatively, the target molecule may remain in the polymer network and be controllably released. The molecularly imprinted polymer is formulated into an adhesive. The adhesive can be used as a component in an in-vitro diagnostic device to release template molecules or to capture target molecules in vacated receptor sites in the synthetic polymer.

A porous, molecularly imprinted polymer and a process for its preparation are described. The porous, molecularly imprinted polymer is characterised in that it is obtainable by providing a porous silica; attaching a molecular template to the surface of the porous silica; filling the pores of the porous silica with a polymer, removing the silica and the molecular template, thereby leaving a porous, molecularly imprinted polymer. The process is characterised by the above defined process steps. Also described are a porous polymer vesicle and its preparation with the same features as defined for the porous, molecularly imprinted polymer and its preparation, except for the lack of the molecular template and thus the lack of the molecular imprint in the porous polymer.

The invention discloses a molecularly imprinted polymer specially combined with a specified glycoprotein. Substituted phenylboronic acid containing double bonds is used as a functional monomer. Under the alkali condition, the specified glycoprotein serving as a template (imprinting molecule) and the substituted phenylboronic acid (functional monomer) containing the double bonds form a complex; the complex is mixed with a cross linker, an initiator and a pore forming agent; copolymerization reaction between the functional monomer and the cross linker and in the cross linker is initiated under the irradiation of ultraviolet light to form a polymer; and the template modules (specified glycoprotein) in the polymer are removed by extraction of an acidic solution, and thus the molecularly imprinted polymer containing a phenylboronic acid site reversibly combined with the glycosyl of the glycoprotein and a cavity complementary with the shape of the template modules is obtained. The molecularly imprinted polymer specially combined with the specified glycoprotein has the advantages of high specificity, strong anti-interference capacity, wide practical sample range, good repeatability, simplicity in preparation and the like, and can be directly used for detecting antigens to be detected in a complex biological system of serum, saliva and the like. The invention discloses a preparation method for the molecularly imprinted polymer.

A preparation method and application of a molecular imprinted polymer on the silica surface for specifically adsorbing patulin belong to the technical field of bioassay. The method comprises the following steps: firstly pretreating the silica surface; siliconizing the silica surface to prepare APTS-silica and introducing amino groups; preparing ACPA-silica by dewatering and esterifying or an acyl chloride intermediate method and grafting an azo initiator on the silica surface; and finally taking the patulin analog 2-hydroxynicotinic acid as a template to replace molecules, taking acrylamide, methylacrylic acid, 4-vinyl pyridine and trifluoromethyl acrylic acid as the functional monomers and taking ethylene glycol dimethacrylate (EDMA) as a cross-linking agent to obtain the molecular imprinted polymer on the silica surface in acetonitrile and pyridine solvents by thermal initiation. The invention has the following advantages: as the pretreatment method for liquid chromatography of trace patulin in apple juice and related products, the polymer prepared by the invention can specifically adsorb the enriched patulin, the sample is simply and quickly treated and can be reused multiple times, and the polymer is resistant to acid and alkali treatment and is preserved under normal temperature, at the same time, the invention avoids the recovery loss caused by the traditional steps of removing impurities by alkaline washing by liquid-liquid extraction and removing organic solvents by rotary evaporation and reduces the usage amount of the organic solvents.

The invention provides a preparation method for a molecular imprinting material and the molecular imprinting material prepared through the preparation method. The preparation method comprises the steps that silicon oxide is coated on the surfaces of magnetic ferroferric oxide nanometer particles, the magnetic ferroferric oxide nanometer particles are modified with gamma-(methacryloyl chloride) amino propyl trimethoxy silane to obtain magnetic ferroferric oxide nanometer particles with propenyl on the surfaces, the magnetic ferroferric oxide nanometer particles with the propenyl on the surfaces serve as carriers, estrogen receptors are simulated, functional monomers are optimized, a surface imprinting technology is adopted, and then the molecular imprinting material which can simultaneously identify seven kinds of environmental endocrine disrupting chemicals is prepared. According to the preparation method, the easy separation of a magnetic nanometer material, the good water solubility of a silicon oxide nanometer material, the specific recognition ability of molecular imprinting polymers and the surface imprinting technology are mutually combined, the preparation technology is simple, the conditions are mild, the prepared molecular imprinting material is large in adsorption capacity, fast to respond, high in magnetism, good in chemical stability and high in repeating utilization rate, and the problems that at present, multiple trace, steroid and phenol environmental endocrine disrupting chemicals are difficult to simultaneously identify, separate and enrich are solved.

The present invention specifically adopts a simple method for preparing a molecularly imprinted polymer and directly applies the molecularly imprinted polymer to the extraction separation of trace substance in the complex sample pre-processing. The invention adopts a chemical coprecipitation method for preparing Fe3O4 magnetofluid. Then the surface of Fe3O4 magnetofluid is modified with oleic acid. The template molecules and functional monomers are realized with preassembling and are mixed with the cross linker and modified magnetofluid. Then the mixture is added into the polymer solvent containing dispersing agent. After the reaction is finished, magnetic field separation is executed. The polymer is dried after eluting the formwork molecules. A three-phase extraction system which is established on the base of magnetic molecularly imprinted polymer can be directly applied to the extraction separation of complex samples of food, environment and biological sample. The method of the invention has excellent selectivity and can eliminate the matrix interference in the sample. Furthermore as the polymer has excellent magnetism, the polymer can excellently realize the separation to the sample matrix after the extraction, and the polymer has broad application prospect in the complex sample pre-processing.

The invention provides a preparation of a bisphenol A submicron magnetic molecular imprint and application of the same in the detection pre-processing of packaged food, which belong to the technical field of material chemistry and food safety. A surface molecular imprinting technology and a magnetic solid-phase extraction technology are combined, and a magnetic submicron particle wrapped by a surface molecular imprint polymer (Fe3O4@MIP) is prepared by using a bisphenol A as a template molecule. A magnetic submicron material (Fe3O4) is synthesized by a hydrothermal process, the synthesized Fe3O4 is synthesized into a silicon-wrapped magnetic microsphere (Fe3O4@SiO2) by a sol gel process, the synthesized Fe3O4@SiO2 is coupled with 2-bromo-isobutyryl bromide to form Fe3O4@SiO2@Br with Br groups on the surface, and the synthesized Fe3O4@SiO2@Br is synthesized into a submicron particle with a surface molecular imprint (Fe3O4@MIP) by an atom radical transfer process. The prepared Fe3O4@MIP is used in the detection pre-processing of packaged food which comprises liquid food, liquid food containing a certain quantity of solids and solid food.

The invention discloses a triazine weedicide, and metabolite molecular engram polymer microspheres, a preparation method and an application thereof, which relate to molecular engram polymer microspheres and a preparation method and an application thereof and are used for solving the problem that the conventional molecular engram polymer can only specially absorb one kind of substance and realizing the effect of separating and enriching a plurality of triazine pesticide residues in a sample respectively. The molecular engram polymer microspheres are prepared by the following steps of: dissolving double template molecules and methacrylic acid into acetonitrile; oscillating; adding trimethylolpropane trimethylacrylate and azobisisobutyronitrile; performing ultrasonic treatment, charging nitrogen, removing oxygen and sealing; and heating in a constant-temperature water bath, cooling, grinding, sieving, eluting and drying. The molecular engram polymer microspheres are applied to a filling material of a solid phase extraction column. A product obtained in the invention has the advantages of high specificity, large absorption amount, wide application range, simple method and low cost. High specific separating and enriching characteristics on the triazine weedicide are achieved, the recovery rate is 65-110 percent, and the requirement of multiple residues can be met.

The present invention provides a downhole method and apparatus using molecularly imprinted polymers to analyze a downhole fluid sample or determine the percentage of oil based mud filtrate contamination in a formation fluid sample.

A molecularly imprinted polymeric explosives sensor is provided which possesses selective binding affinity for explosives, such as 2,4,6-trinitrotoluene (TNT) and 1,3,5-trinitrobenzene (TNB). The polymeric sensor incorporates a porphyrin which undergoes a detectable change in absorption and / or emission of electromagnetic radiation when the polymer is exposed to explosives.

The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

The invention discloses a molecularly imprinted polymer and a preparation method and application thereof. The molecularly imprinted polymer of the invention is the molecularly imprinted polymer, which is prepared by using ractopamine as a template, polymerizing the template with a functional monomer, a cross-linking agent, a pore-forming agent and an initiator to form a block polymer, grinding the block polymer, sieving the obtained powder, removing the template by using acetate methoxide and methoxide and carrying out vacuum drying on the obtained product and has high compatibility and obvious selectivity for the ractopamine. The molecularly imprinted polymer of the invention has high compatibility and selectivity for the ractopamine and has wide application prospect in analysis of a sample pretreatment solid phase extraction material of the ractopamine in substrates such as a feed, animal tissue or environment water and the like.

The invention discloses a controllable and universal directional surface printing method. The method comprises the steps as follows: template glucoprotein is anchored on the surface of a substitution boric acid functional substrate material via boron affinity interaction, the polymer formed by auto-polymerization in water phase of a compound capable of automatically polymerizing forms a printing layer, and a template is eluted under the acid condition to form a printing hollow cavity, as a result, the molecular printing polymer is obtained. The molecular printing polymer prepared via the method not only has the advantages of good specificity, high combination capacity, strong anti-interference capability, quick combination and analysis speed and the like, but also can exclusively identify the template glucoprotein with or without the boron affinity interaction, is adjustable in force of combination with the template when keeping the specificity, and is wide in application range. The method has the advantages of convenience, controllability, universality, high printing efficiency and the like. The molecular printing polymer can exclusively identify, gather, separate and detect the glucoprotein with low enrichment in a complex practical sample.

The invention relates to a preparation method of a surface-functionalized molecularly imprinted polymer microsphere. The crosslinking degree of the molecularly imprinted polymer microsphere is above 60 percent, and therefore, the molecularly imprinted polymer microsphere has excellent molecule recognition to a template molecule and the particle size of 1-5 microns and is provided with an active function group on the surface. The molecularly imprinted polymer microsphere is prepared by adopting a new method of controllable / active free radical deposition and polymerization. The invention has the advantages of simple method, wide application range, pure product and the like. The prepared molecularly imprinted polymer microsphere has a wide application potential in mass fields of chromatographic stationary phase, biological sample analysis, medial clinic immunity analysis, food and environment monitoring, analogy enzyme catalysis, biomimetic sensors and the like.

The invention discloses molecular imprinting polymer which belongs to the technical field of pesticide molecular imprinting and preparation method thereof. The molecular imprinting polymer is prepared by the following steps of: mixing a polymerization reaction monomer, a cross-linking agent, a hole inducing agent, an initiating agent and an imprinting molecule diethyl(3-methyluren)(phenyl)methyl phosphonate, carrying out in-situ polymerization reaction under the condition of thermal initiation and / or photo-initiation to obtain a polymer containing diethyl(3-methyluren)(phenyl)methyl phosphonate; washing the polymer till an imprinting molecule is not detected; and then washing by an organic solvent to neutrality and drying in vacuum to obtain the molecular imprinting polymer. The invention also discloses applications of the molecular imprinting polymer in aspects of separating, purifying and detecting organophosphorus pesticide in a sample. The applications of the polymer prevent the influence of target analyte template leakage on a following adsorption experiment, can simultaneously detect various target molecules and widen the detecting range of the target molecules.

A molecularly imprinted polymer sensor device for detecting the presence of a taggant molecular structure in a fluid is disclosed. The molecularly imprinted polymer sensor device comprises a molecularly imprinted crosslinked polymer having a crosslinked core and a plurality of polymer arms attached to the core, wherein the core has molecular sized cavities adapted to selectively receive and bind displacement molecules having the taggant molecular structure and a colorimetric indicator, said displacement molecule being selectively removed from the molecularly imprinted crosslinked polymer and replaced with the taggant molecular structure upon exposure to the fluid containing the taggant molecular structure therein, thereby indicating the presence of the taggant molecular structure in the fluid.

The invention relates to a surface plasma resonance sensor chip and a preparation method thereof, in particular to a photografting molecularly imprinted polymer membrane-based surface plasma resonance sensor chip and a preparation method thereof, and belongs to the field of surface plasma sensor chip preparation. The chip comprises a glass substrate, a gold membrane layer, a unimolecular alkyl chain layer and a molecular imprinted polymer membrane, wherein the gold membrane layer is plated on the glass substrate, the unimolecular alkyl chain layer is self-assembled on the glass substrate, and the molecular imprinted polymer membrane is grafted on the unimolecular alkyl chain layer in turn. The molecular imprinted membrane with nanoscale thickness can be conveniently and quickly prepared on the surface of the gold membrane by the preparation method and has controllable thickness; the growth changes of the molecular imprinted membrane can be dynamically monitored in real time in situ; operation steps are simple and deoxidation and nitrogen protection are not needed; and the matrix type molecular imprinted structural units are easy to prepare on the surface of the gold membrane, each unit can be different template molecules and multi-channel and multi-target molecular detection is realized.

A molecular imprinting polymer of a pyrethroid insecticide is characterized in that the polymer is prepared by the following steps: a. a pyrethroid template molecule, a functional monomer for polymerization, a cross-linker and a pore-forming agent are mixed; b. the substances are arranged in a closed container after being uniformly mixed, the pure nitrogen aeration is used for removing the oxygen, the in-situ polymerization is carried out by adopting the thermal-initiation or the photo-initiation mode after the closing, thus generating the molecular imprinting polymer; c. the molecular imprinting polymer is ground, mixed liquid of organic solvent and acid is utilized for removing the template molecule; d. and the molecular imprinting polymer which is obtained in step c is dried in the vacuum condition. The invention further discloses an application of the polymer, compared with the prior art, the molecular imprinting polymer has the advantages that: the preparation process is simple, the operatability is strong and the preparation cost is low; the prepared polymer has good selectivity and high enrichment degree, which can be widely applied in the pre-treatment process of the pyrethroid insecticide residues of the environmental, biological and food samples, etc.

The invention relates to a molecularly imprinted polymer resin characterized by a monodisperse size distribution prepared by forming monomer droplets via a membrane, polymerizing said droplets in an appropriate continuous phase, and harvesting the resulting polymer particles. The invention also relates to a method for producing a molecularly imprinted polymer resin, wherein a monomer solution is forced through a dispersing device capable of forming small droplets, the droplets are projected into a continuous phase in which a polymerization is initiated leading to solidification of the droplets into beads.

The invention discloses a molecular imprinting electroluminescent sensor for detecting veterinary drug residue by taking a battery as power and a method for detecting veterinary drug residue. A preparation method of an electrode (a schematic diagram is shown in the figure) comprises the following steps of: preparing MIP (Molecularly Imprinted Polymer)s sol of the veterinary drug residue; preparing a carbon dot and preparing a graphene nano material according to documents; and modifying graphene, the carbon dot and the MIPs sol onto the surface of the electrode of the sensor. The method for detecting the trace veterinary drug residue comprises the following steps of: connecting the modified electrode to an electrogenerated chemiluminescence instrument, and detecting the veterinary drug residue in a sample extract by taking the battery as the power. The molecular imprinting electroluminescent sensor disclosed by the invention has the advantages that the specificity of the electrode is strong and the sensitivity is high and can be up to a ng grade; only 3-5 minutes are spent on a basic detection process; and the cost is low. The method for detecting the veterinary drug residue by adopting the electrode is quick and easy to operate, the reaction is automatically completed by instruments and results are automatically recorded by the instruments.

The invention provides a preparation method and use of a graphene oxide surface molecularly imprinted sol-gel polymer and relates to the technical field of combination of polymer material science and chemical sensors. Graphene oxide as a carrier and siloxane as a functional monomer and a cross-linking agent are subjected to sol-gel method treatment in an aqueous solution at a normal temperature so that the graphene oxide surface molecularly imprinted sol-gel polymer is obtained, and the graphene oxide surface molecularly imprinted sol-gel polymer can be used in the field of electrochemical sensors and can realize fast analysis detection of a template molecule. The preparation method has the simple process of mixing the carrier, the template molecule, the functional monomer, the cross-linking agent and the solvent according to a certain ratio, has a low cost, saves energy and is environmentally friendly. The graphene oxide surface molecularly imprinted sol-gel polymer-based electrochemical sensor has the advantages of rapid response to the imprinted molecule, good selectivity, high sensitivity and good stability.

The invention discloses a preparation method of a lysozyme molecular imprinting-quantum dot nanoscale fluorescent probe. The preparation method adopts quantum dots as carriers and lysozyme as a template molecule and modifies a molecular imprinting polymer layer on surfaces of the quantum dots to synthesize the novel lysozyme molecular imprinting-quantum dot nanoscale fluorescent probe through combining selectivity of a molecular imprinting technology and fluorescent characteristics of the quantum dots. Specially, the preparation method comprises the following steps of preparing quantum dots, modifying surfaces of the quantum dots by denatured bovine serum albumin, forming a molecular imprinting layer through a polymerization reaction initiated by a selected functional monomer and cross-linking reagents, and washing away the template molecule by selected eluent. The lysozyme molecular imprinting-quantum dot nanoscale fluorescent probe can combine accuracy and specific identification characteristics of molecular imprinting and high sensitivity characteristics of quantum dot fluorescence detection and has high selectivity and sensitivity of template molecule identification. The preparation method has simple processes, good reproducibility between different batches, good application prospects in selective identification and detection of lysozyme in an actual sample.

The invention discloses a photoelectric chemical analysis method adopting a molecular imprinting functionalization modified electrode, relates to a molecular imprinting technology-based preparation method of a high-selectivity TiO2NTs modified electrode, and also relates to a method for high-selectivity and high-sensitivity detection of endocrine disrupting chemicals especially such as 2,4-dichlorophenoxyacetic acid (2,4-D) having no electrochemical activity by the high-selectivity TiO2NTs modified electrode as a photo anode. Compared with the prior art, the molecular imprinting technology-based preparation method creatively utilizes a molecularly imprinted polymer in selective modification of a photoelectric sensing electrode so that selectivity and detection sensitivity of an electrode are improved greatly; the interference caused by multiple concomitant micro-molecules is eliminated; a magnitude of a detection limit reaches to 10<-8>mol / L<-1>; the molecular imprinting functionalization modified electrode is stable; and the photoelectric chemical analysis method for detection has good reappearance.

The present invention relates to a method of preparing a molecularly imprinted polymer (MIP), which are used for the recognition of target molecules comprising: co-polymerising at least one functional monomer and at least one cross-linking monomer in the presence of at least one template, wherein oxyanions are used as template and the steric and / or electronic structure of the template is at least partly analogous to the target molecule. The target molecules may be nitro-containing compounds, such as nitroaromatic compounds, or lactones. MIPs selective for explosive nitro-aromatic substances may be produced without handling these hazardous compounds. The invention further relates to a method of determining if a sample contains nitro-containing compounds, such as nitroaromatic compounds, or lactones, MIPs selective for nitro-containing compounds and / or lactones, especially nitro-aromatic compounds and a kit, comprising a molecularly imprinted polymer selective for nitro-aromatic compounds and / or lactones. The invention also relates to use of isosteric and / or isoelectronic oxyanions for the production of MIPs for recognition of nitro-containing compounds, especially nitroaromatic compounds, and lactones.

A porous, molecularly imprinted polymer and a process for its preparation are described. The porous, molecularly imprinted polymer is characterised in that it is obtainable by providing a porous silica; attaching a molecular template to the surface of the porous silica; filling the pores of the porous silica with a polymer; removing the silica and the molecular template, thereby leaving a porous, molecularly imprinted polymer. The process is characterised by the above defined process steps. Also described are a porous polymer vesicle and its preparation with the same features as defined for the porous, molecularly imprinted polymer and its preparation, except for the lack of the molecular template and thus the lack of the molecular imprint in the porous polymer.