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Surface-functionalized molecularly imprinted polymer microsphere and preparation method thereof

A technology of surface functionalization and molecular imprinting, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of limited application, difficult surface functionalization of MIP microspheres, etc., and achieve wide application range, simple synthesis method and pure product Effect

Active Publication Date: 2010-06-23
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the surface functionalization of MIP microspheres obtained by ordinary precipitation polymerization methods is usually difficult, which greatly limits its application in the preparation of functionalized MIP microspheres.

Method used

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  • Surface-functionalized molecularly imprinted polymer microsphere and preparation method thereof
  • Surface-functionalized molecularly imprinted polymer microsphere and preparation method thereof
  • Surface-functionalized molecularly imprinted polymer microsphere and preparation method thereof

Examples

Experimental program
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Effect test

example 1

[0031] Add template molecule BPA (0.3424g), functional monomer 4-VP (160μL), cross-linking agent EGDMA (0.85mL), CuCl (5.2mg) and 30mL anhydrous acetonitrile into a 100mL round bottom flask, and the reaction solution was After deoxygenating with argon for 15 minutes, add the ligand PMDETA (22 μL), continue argon for 15 minutes, then add ethyl 2-chloropropionate (7.2 mg), seal the reaction bottle and place it in an oil bath at 60°C for reaction After 24 hours, filter, use a Soxhlet extractor to extract the obtained polymer microspheres with methanol / acetic acid (9:1v / v) for 48 hours, then extract them with acetonitrile for 24 hours, and dry them in vacuum at 40°C for 48 hours to obtain MIP microspheres. 62%.

[0032] Under the same conditions, but without adding BPA, the above reaction was carried out to prepare non-imprinted polymer (NIP) microspheres with a yield of 60%.

example 2

[0034] Template molecule BPA (0.3423g), functional monomer 4-VP (160μ), cross-linking agent EDMA (0.85mL), CuCl 2 (7.2mg) and 30mL of anhydrous acetonitrile were added to a 100mL round bottom flask. After deoxygenation by argon for 15 minutes, the ligand PMDETA (22 μL) was added, azobisisobutyronitrile (AIBN) (8.6 mg) was added after argon was continued for 15 minutes, and then the reaction bottle was sealed and placed in a 60° C. After reacting in an oil bath for 24 hours, filter, use a Soxhlet extractor to extract the obtained polymer microspheres with methanol / acetic acid (9:1 v / v) for 48 hours, then extract with acetonitrile for 24 hours, and dry in vacuum at 40°C for 48 hours to obtain MIP Microspheres, yield 85%.

[0035] Under the same conditions, but without adding BPA, the above reaction was carried out to prepare NIP microspheres with a yield of 81%.

example 3

[0037]Add template molecule 2,4-D (0.1105g), functional monomer 4-VP (0.2103g), crosslinker EGDMA (1.1893g), CuCl (0.0069g) and 30mL anhydrous acetonitrile into a 100mL round bottom flask middle. After deoxygenating the reaction solution with argon for 15 minutes, add the ligand Me 6 TREN (0.0484g), continued to pass argon for 15 minutes, then added ethyl 2-chloropropionate (9.6mg), sealed the reaction bottle, placed it in an oil bath at 60°C for 24 hours, and filtered it, then used a Soxhlet extractor to The obtained polymer microspheres were extracted with methanol / acetic acid (9:1 v / v) for 48 hours, then extracted with acetonitrile for 24 hours, and vacuum-dried at 40° C. for 48 hours to obtain MIP microspheres with a yield of 35%.

[0038] Under the same conditions, but without adding BPA, the above reaction was carried out to prepare NIP microspheres with a yield of 48%.

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Abstract

The invention relates to a preparation method of a surface-functionalized molecularly imprinted polymer microsphere. The crosslinking degree of the molecularly imprinted polymer microsphere is above 60 percent, and therefore, the molecularly imprinted polymer microsphere has excellent molecule recognition to a template molecule and the particle size of 1-5 microns and is provided with an active function group on the surface. The molecularly imprinted polymer microsphere is prepared by adopting a new method of controllable / active free radical deposition and polymerization. The invention has the advantages of simple method, wide application range, pure product and the like. The prepared molecularly imprinted polymer microsphere has a wide application potential in mass fields of chromatographic stationary phase, biological sample analysis, medial clinic immunity analysis, food and environment monitoring, analogy enzyme catalysis, biomimetic sensors and the like.

Description

Technical field [0001] The invention relates to a method for preparing surface-functionalized molecularly imprinted polymer microspheres, in particular to a method for preparing molecularly imprinted polymer microspheres with controllable radical polymerization initiation groups on the surface. Background technique [0002] Molecular imprinting technology is a new method for preparing polymer materials with specific molecular recognition function developed on the basis of polymer science, material science, biochemistry and supramolecular chemistry in recent years. The substances are called molecularly imprinted polymers (Molecularly imprinted polymers, MIPs). MIPs not only have high affinity and selectivity comparable to natural antibody-antigen systems, but also have excellent mechanical resistance, chemical resistance and heat resistance, as well as the advantages of easy preparation and low cost, so in solid phase Many fields such as extraction, chromatographic separatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F226/06C08F220/28C08F220/56C08F226/10C08F222/14C08F212/36C08F222/38C08F2/14C08F4/10C08F4/26C08J9/26B01J20/26B01J20/30
Inventor 张会旗祖佰祎张莹潘国庆郭先芝
Owner NANKAI UNIV
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