8098results about How to "Reduce exposure" patented technology

A method for protecting at least one gonad from a blood borne cytotoxic drug, the method comprising reducing blood flow to at least one gonad of a patient undergoing cytotoxic treatment for an occlusion time interval, and allowing blood flow to the at least one gonad to resume after the occlusion time interval. Optionally the method is performed to protect an ovary during chemotherapy treatment.

An image guided catheter navigation system for navigating a region of a patient includes an imaging device, a tracking device, a controller, and a display. The imaging device generates images of the region of the patient. The tracking device tracks the location of the catheter in the region of the patient. The controller superimposes an icon representing the catheter onto the images generated from the imaging device based upon the location of the catheter. The display displays the image of the region with the catheter superimposed onto the image at the current location of the catheter.

A self-closing fastener is described that comprises a clip passable through a tissue opening. The fastener is adapted for holding by a mechanism in an open configuration for passing through the tissue, followed by releasing the fastener from the holding mechanism, allowing the clip to remain in the tissue in a shape that can clip two or more locations on the tissue. The fastener and delivery devices are particularly useful for tissue approximation, such as anastomosis. When used for anastomosis, the inventive clips provide intima-to-intima contact with a minimal amount of intraluminal exposure.

Disclosed embodiments comprise an energy harvesting computer device in association with a communication device comprising interactive user interface operatively configured with CMOS multiple antennas on chip for boosting signal receptions and for providing faster data transmission speed. Disclosed embodiment encompasses three modes of communications—the Cell phone, wireless Internet applications, and Global communication and media information. Embodiments provide communication apparatus operable to enhance mobile communication efficiency with touch sensitive display comprising energy harvesting platform in communication with a charging circuit board configured with memories, processors, sensors, and modules. Embodiments further provide a gaming device, a wireless media device configured with touch pads comprising sensors being embedded in silicon substrate and fused in nano-fiber / microfiber material having excellent electrical characteristics. Certain embodiments provide communication apparatus configured for voice enabled applications comprising human voice auditory operable to convert text into voice auditory and / or voice auditory into text applications.

A method for managing UV irradiation for treating substrates in the course of treating multiple substrates consecutively with UV light, includes: exposing a first UV sensor to the UV light at first intervals to measure illumination intensity of the UV light so as to adjust the illumination intensity to a desired level based on the measured illumination intensity; and exposing a second UV sensor to the UV light at second intervals to measure illumination intensity of the UV light so as to calibrate the first UV sensor by equalizing the illumination intensity measured by the first UV sensor substantially with the illumination intensity measured by the second UV sensor, wherein each second interval is longer than each first interval.

Transaction processing of online transactions at merchant sites determines the likelihood that such transactions are fraudulent, accounting for unreliable fields of a transaction order, which fields do not reliably identify a purchaser. A scoring server using statistical model uses multiple profiles associated with key fields, along with weights to indicate the degree to which the profiles identify the purchaser of the transaction.

Medical devices, systems and methods that are useable to facilitate transnasal insertion and positioning of guidewires and various other devices and instruments at desired locations within the ear, nose, throat, paranasal sinuses or cranium.

A tunable frangible battery pack system for use in an electric vehicle is disclosed. The tunable frangible battery pack system includes a two piece clamshell housing. The system also includes a plurality of battery cells arranged within the housing and a collector plate secured to each piece of the housing. The system also includes a wire conductor arranged between each of the battery cells and collector plates to create a frangible disconnect system when the battery pack system and electric vehicle are exposed to a predetermined mechanical or thermal force or event.

Systems and methods for measuring access risk associated with an enterprise having at least one resource accessible by at least one user with at least one entitlement to access the resource. Some embodiments implement a method of identifying the resources, users, and entitlements and associating access risk scores with the entitlements. The method can include combining the access risk scores associated with each user to form composite access risks scores and outputting the composite access risk scores. In some embodiments, the user with the highest composite access risk score can be identified and remedial action taken. The highest access risk user of some embodiments may be a department, a division, a subsidiary, or an organization. The method can occur in real time and an administrator can be alerted to changes in entitlements. Access risk scores can be adjusted for compensating controls and personal factors and attributes of the users.

A device for inserting a subcutaneous infusion device into skin of a patient. The device can include a housing, a needle hub including a needle, a sleeve, and a spring engaging the needle hub. The device can also include a cap coupled to the housing, and a retention member configured to maintain the device in a ship state prior to decoupling of the cap from the housing. In one example, the retention member can include a boss coupled to the cap and configured to engage the infusion device to maintain the infusion device in the ship state prior to decoupling of the cap from the housing. In another example, the retention member can include a tab formed by the sleeve, the tab engaging a bead on an internal surface of the cap when the sleeve moves relative to the housing while the device is in the ship state.

An image guided navigation system for navigating a region of a patient which is gated using ECG signals to confirm diastole. The navigation system includes an imaging device, a tracking device, a controller, and a display. The imaging device generates images of the region of a patient. The tracking device tracks the location of the instrument in a region of the patient. The controller superimposes an icon representative of the instrument onto the images generated from the imaging device based upon the location of the instrument. The display displays the image with the superimposed instrument. The images and a registration process may be synchronized to a physiological event.

A method for forming a magnetic tunneling junction (MJT) is provided. In some embodiments, the method may include patterning one or more magnetic layers to form an upper portion of a MTJ. The method may further include patterning one or more additional layers to form a lower portion of the MTJ. In some cases, the lower portion may include a tunneling layer of the MTJ having a width greater than the upper portion. In addition, in some embodiments the method may further include patterning an electrode below the lower portion. In some cases, the electrode may include a lowermost layer with a thickness equal to or less than approximately 100 angstroms. In addition or alternatively, the electrode may have a width greater than the width of the tunneling layer. In yet other embodiments, the method may include forming spacers along the sidewalls of the upper and / or lower portions.

A method is described for navigating in the interior of the body using three-dimensionally visualized structures. In a first step of the method, at least two two-dimensional images of the same anatomical object are provided from different perspectives, and also items of information that make it possible to draw conclusions about the respective spatial position of an imaging system relative to the anatomical object. The projections of a geometrical structure to be visualized are then created in every two-dimensional image, wherein a geometrical structure to be visualized is created in each two-dimensional image, wherein the geometrical structure to be visualized is different from the anatomical object. A cone surface is then generated in space for each image wherein the spatial positions of the cone vertex and cone directrix are determined from the respective spatial position of the imaging system and the shape of the cone directrix is determined from the shape of the projection of the geometrical structure to be visualized on the image. Finally, a spatial intersection of the individual cone surfaces is formed to determine the geometrical structure and the geometrical structure determined and / or an intersection of a plurality of geometrical structures determined are / is represented and the representation is used for navigation.

A system and method for automated handling of vials containing liquid medical specimens is disclosed. The robotic system processes the specimens for further downstream molecular analysis. The processing comprises automated vial cap removal, pipetting of the vial contents, transfer of the vial contents to a destination tray such as a multiwell plate, and recapping of the vial.

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and / or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor. The first and second precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. The disclosed methods and compositions provide a simple, easy to purify way to obtain any binary compound attached to any monomeric compound, or any trinary compound.

Medical devices, systems and methods that are useable to facilitate transnasal insertion and positioning of guidewires and various other devices and instruments at desired locations within the ear, nose, throat, paranasal sinuses or cranium. Direct viewing of such placements via an endoscope.

A wireless device having an improved antenna system is disclosed comprising one or more antenna, preferably circularly polarized antenna, for transmitting or receiving a signal, and one or more floating ground planes, wherein the floating ground plane preferably is electrically isolated from and in sufficient proximity to the antenna so that it is inductively coupled to the antenna. The floating ground plane may comprise one or more of a strip, band, foil, plate, block, wire mesh, sheet or coating of conductive material and, for example, may be a relatively thin copper strip, band, foil or coating. The circularly polarized antenna, preferably comprises a flat planar shaped radiating element sized and configured to resonate at a predetermined, desired frequency, frequencies or band of frequencies, and a flat planar shaped antenna ground, both radiating element and antenna ground formed on the same printed circuit board. The radiating element is electrically isolated from the antenna ground but sufficiently close to resonate at the desired frequencies. Preferably the floating ground plane is larger than or more massive than the antenna ground, and preferably larger than or more massive than the radiating element. In a further embodiment the wireless device comprises a housing for interfacing with a user, the housing comprising a conductive contact exposed to the exterior of the housing and configured to be contacted by a user, wherein the conductive contact is electrically connected to the floating ground plane, preferably so that the user is coupled to the antenna and becomes part of the antenna system. The floating ground plane may also preferably be configured to substantially cover or overlap the antenna, and may also be configured to distribute and propagate the electromagnetic signals away from the head of the user.

The present invention relates to the medical field, in particular relates to the practice of percutaneous vertebroplasty where a pair of syringes in the distal extreme of a lengthened hydraulic device, are united by a camera of intermediate connection of larger diameter (pressure exerting body) or modified inverted syringe tube with a bolster, a hydraulic connecting tube of flexible material that transmits the pressure of the smaller diameter manual or impulsion syringe in the proximal extreme of the device toward the intermediate cylindrical larger diameter camera (pressure exerting body), this camera is in an inverted position with regard to the first syringe (fluid control), this intermediate camera has a moving piston longitudinal to the axis of the cylinder that is controlled with the first syringe (manual) and in cooperation with the atmospheric pressure. The injecting syringe loaded with bone cement is coupled with the bolster of the body of pressure, and to the needle that drives the cement toward the interior of the bone. The intermediate camera (pressure exerting body) together with the hydraulic tube and the manual syringe form a hydraulic press system (F / A=f / a) that allows to increase in a potential way the pressure exerted in the first syringe and to make the injection of polymethylmethacrylate (PMMA) at an approximate distance of 1.0 m to 1.5 m.

The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.

A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to abuse by an individual. The coated particles may include a fat / wax and have improved controlled release and / or crush resistance. Method of making these coated particulate and dosage forms therewith are also described.