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Molecularly imprinted polymer and preparation method and application thereof

A molecular imprinting and polymer technology, applied in the field of material chemistry, can solve the problems of slow research progress and difficult dissolution of ractopamine, and achieve the effect of strong specific recognition ability, high affinity and selectivity, and improved specificity

Inactive Publication Date: 2010-10-20
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a molecularly imprinted polymer with high affinity and selectivity for ractopamine according to the problem that ractopamine is not easy to dissolve in the existing imprinting research on ractopamine.

Method used

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  • Molecularly imprinted polymer and preparation method and application thereof
  • Molecularly imprinted polymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Molecularly imprinted polymer for detecting ractopamine

[0037] The synthesis and preparation steps of the molecularly imprinted polymer in this example are as follows:

[0038] (1) Preparation of prepolymer

[0039] Weigh 0.169g (0.5mmol) of ractopamine template into a test tube, add 3.0mL of acetonitrile and 0.1mL of triethylamine, after ultrasonic dissolution, add 142.2mg (2mmol) of acrylamide functional monomer, ultrasonic for 5min, and stand overnight at 4°C , forming a prepolymer.

[0040] (2) Polymerization curing

[0041] Add 1.89mL (10mmol) of ethylene glycol dimethacrylate and 15mg of azobisisobutyronitrile to the above prepolymer, sonicate for 5 minutes, blow nitrogen gas under ice bath for 2 minutes, seal it, and polymerize in a water bath at 60°C for 24 hours to obtain a block Polymer, the bulk polymer is the molecularly imprinted polymer used in the detection of ractopamine in this embodiment.

[0042] Grind the blocky polymer above, pass thro...

Embodiment 2

[0044] Example 2 Molecularly imprinted polymer for detecting ractopamine

[0045] The synthesis and preparation steps of the molecularly imprinted polymer in this example are as follows:

[0046] (1) Preparation of prepolymer

[0047] Weigh 0.169g (0.5mmol) of ractopamine template into a test tube, add 3.0mL of acetonitrile and 0.1mL of triethylamine, after ultrasonic dissolution, add 142.2mg (2mmol) of acrylamide functional monomer, ultrasonic for 5min, and stand overnight at 4°C , forming a prepolymer.

[0048] (2) Polymerization curing

[0049] Add 2.835mL (15mmol) of ethylene glycol dimethacrylate and 25mg of azobisisobutyronitrile to the above prepolymer, sonicate for 5 minutes, blow nitrogen gas under ice bath for 2 minutes, seal, and polymerize in a water bath at 60°C for 24 hours to obtain a block Polymer, the bulk polymer is the molecularly imprinted polymer used in the detection of ractopamine in this embodiment.

[0050] Grind the blocky polymer above, pass thro...

Embodiment 3

[0052] Example 3 Molecularly imprinted polymer for detecting ractopamine

[0053] The synthesis and preparation steps of the molecularly imprinted polymer in this example are as follows:

[0054] (1) Preparation of prepolymer

[0055] Weigh 0.169g (0.5mmol) of ractopamine template into a test tube, add 3.0mL of acetonitrile and 0.1mL of triethylamine, after ultrasonic dissolution, add 71.08mg (1mmol) of acrylamide functional monomer, ultrasonic for 5min, and stand overnight at 4°C , forming a prepolymer.

[0056] (2) Polymerization curing

[0057] Add 1.89 mL (10 mmol) of ethylene glycol dimethacrylate and 25 mg of azobisisobutyronitrile to the above prepolymer, sonicate for 5 minutes, blow nitrogen gas under ice bath for 2 minutes, seal, and polymerize in a water bath at 60°C for 24 hours to obtain a block Polymer, the bulk polymer is the molecularly imprinted polymer used in the detection of ractopamine in this embodiment.

[0058] Grind the blocky polymer above, pass th...

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Abstract

The invention discloses a molecularly imprinted polymer and a preparation method and application thereof. The molecularly imprinted polymer of the invention is the molecularly imprinted polymer, which is prepared by using ractopamine as a template, polymerizing the template with a functional monomer, a cross-linking agent, a pore-forming agent and an initiator to form a block polymer, grinding the block polymer, sieving the obtained powder, removing the template by using acetate methoxide and methoxide and carrying out vacuum drying on the obtained product and has high compatibility and obvious selectivity for the ractopamine. The molecularly imprinted polymer of the invention has high compatibility and selectivity for the ractopamine and has wide application prospect in analysis of a sample pretreatment solid phase extraction material of the ractopamine in substrates such as a feed, animal tissue or environment water and the like.

Description

technical field [0001] The invention relates to the technical field of material chemistry, in particular to a molecularly imprinted polymer and its preparation method and application. Background technique [0002] Ractopamine (RCT) is a phenethylamine drug, which belongs to the same phenethylamine class as clenbuterol. 2 -Receptor agonist, can interact with β on the cell membrane 2 Receptor binding, selective agonism of bronchial smooth muscle beta 2 Receptor, an artificial derivative of natural catechol, is commonly used clinically as a cardiotonic drug to treat congestive heart failure, and can also be used to treat muscular dystrophy, increase muscle, and reduce fat accumulation. Commercially available ractopamine is its hydrochloride, the chemical name is 1-(4-hydroxyphenyl)-2[1-methyl-3-(4-hydroxyphenyl)-propylamino]-ethanol hydrochloride, and its molecular formula is C 18 h 23 NO 3 Cl. Studies have shown that when the amount of ractopamine added to the animal di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F222/14C08F2/44C08J9/26C08F220/06C08F226/06G01N30/02
Inventor 贺利民张青杰曾振灵刘雅红苏贻娟沈祥广郭宏斌
Owner SOUTH CHINA AGRI UNIV
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