1000 results about "Nano emulsion" patented technology

Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.

Polymeric nanoemulsions facilitate flow and reduce drag and friction in multiphase pipelines containing both oil and water (e.g., oil / water, oil / water / gas, oil / water / solids, and oil / water / gas / solids) such as are used for oil or gas production, gathering, and transmission; hydrotransport of oilsand or heavy oil slurries and the like. Specific examples of suitable drag reducing polymers include polyacrylamide. The emulsions have a hydrocarbon external phase, droplets of an aqueous internal phase having water-soluble polymer dissolved therein, where the droplets have an average particle size below about 200 nm, and at least one surfactant to form a stable nanoemulsion. The nanoemulsions advantageously have a low viscosity of about 200 cP or less.

The present invention describes systems and methods for treating disorders and / or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and / or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.

These objects and others may be accomplished with the present invention, the first embodiment of which provides an oil-in-water nanoemulsion, which includes:an oily phase dispersed in an aqueous phase;(i) at least one amphiphilic lipid selected from the group including nonionic amphiphilic lipids, anionic amphiphilic lipids, and combinations thereof; and(ii) at least one water-soluble nonionic polymer selected from the group including homopolymers and copolymers of ethylene oxide; polyvinyl alcohols; homopolymers and copolymers of vinylpyrrolidone; homopolymers and copolymers of vinylcaprolactam; homopolymers and copolymers of polyvinyl methyl ether; neutral acrylic homopolymers and copolymers; C1–C2 alkyl celluloses and their derivatives; C1–C3 alkyl guar; C1–C3 hydroxyalkyl guar; and combinations thereof;wherein a ratio of the weight of the oily phase to the weight of the amphiphilic lipid (i) ranges from 1.2 to 10;and wherein the oily phase includes oil globules having a number-average size of less than 100 nm. The nanoemulsion obtained is preferably transparent and stable on storage. It may form a composition for topical, preferably cosmetic or dermatological compositions, pharmaceutical compositions and ophthalmological compositions.

The invention relates to aqueous acrylic acid series wooden ware sealing paint and a method for preparing special emulsion thereof. Nano emulsion with small particle diameter and narrow distribution is prepared by using an acrylic acid monomer containing multiple polar groups as a raw material. Multiple aids are added into the emulsion serving as a basic film-forming substance to form the novel aqueous wooden ware sealing paint. The polar functional groups on polymer molecule chains have good wetting property on wood, emulsion particles are easy to permeate into wood fiber conduits and quickly form films in conduit holes, and the paint can effectively prevent the moisture in the aqueous wooden ware paint from permeating into the wood and solves the problem of surface gully caused by the water-swelling wood; and meanwhile, the paint also can effectively seal the substances which are extremely easy to permeate to the outside such as turpentine, tannin and the like acknowledged in the wooden ware industry, and solves common problems for wide application of the aqueous wooden ware paint. The aqueous sealing paint also can be used for a solvent type paint coating system, and effectively prevents a large amount of solvent in the solvent type paint from penetrating into the wood during coating.

Nanocapsule and nanoemulsion particle compositions having improved physical and pharmacological properties are provided. The nanocapsule or nanoemulsion particle composition can comprise a pharmaceutically acceptable liquid oil phase, a surfactant, and optionally a co-surfactant. The liquid oil phase can comprise a monoglyceride, a diglyceride, a triglyceride, a propylene glycol ester, or a propylene glycol diester. In certain embodiments, the nanocapsule or nanoemulsion particle composition can be lyophilized and subsequently re-hydrated without increasing the mean particle size and / or adversely affecting the potency or efficacy of a therapeutic agent (e.g., paclitaxel) present in the nanocapsules or nanoemulsion particles.

A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and / or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

The invention discloses an environmentally-friendly high-performance water-based woodware paint and a using method thereof. The environmentally-friendly high-performance water-based woodware paint comprises 40 to 70 weight percent of self-crosslinking acrylic nano-emulsion and 10 to 20 weight percent of water-based aliphatic polyurethane dispersion. The water-based woodware paint is mainly prepared from the self-crosslinking acrylic emulsion with high triglyceride (Tg) content and weather resistance, so that a paint film has high quick-drying property, chemical resistance and weather resistance, and economy; the self-crosslinking acrylic emulsion is compounded with castor oil modified aliphatic polyurethane dispersion, so that the paint film has high adhesion, hardness, fullness, weather resistance, dry heat resistance and block resistance; and diethylene glycol monobutyl ether is matched with dipropylene glycol methyl ether and propylene glycol monobutyl ether, so that the film forming property of the paint film is ensured, and high drying property is achieved.

The invention discloses a dry film lubricant based on modified epoxy resin and characterized by comprising the following components: 100 to 120 parts of epoxy resin, 1 to 5 parts of inorganic nano-particles, 0.1 to 0.5 part of coupling agent, 20 to 60 parts of lubricant, 10 to 20 parts of anti-wear agent, 1 to 4 parts of dispersing agent, 10 to 30 parts of absolute alcohol and 0 to 20 parts of deionized water. The method for preparing the dry film lubricant comprises the following steps: firstly, carrying out surface modification on the inorganic nano-particles by the coupling agent; then, adding the modified inorganic nano-particles to the epoxy resin to obtain the modified water-based epoxy resin nano-emulsion; adding the dispersing agent to the mixture of the lubricant and the anti-wear agent drop by drop; then, adding the mixture to the modified water-based epoxy resin nano-emulsion, and evenly mixing; and further adding the deionized water to adjust the viscosity of coatings, thus obtaining the dry film lubricant based on the modified epoxy resin. The invention has the advantages of low emission of organic volatile substances, good frictional properties, strength, toughness, weather resistance, corrosion resistance and other overall properties and simple preparation process.

A nanoemulsion having reversible continuous and dispersed phases. The nanoemulsion includes an aqueous phase and an oil phase, a weight ratio of the aqueous phase to the oil phase being 1:40-100:1. In the nanoemulsion, the aqueous phase is dispersed as nanosized droplets in the oil phase or the oil phase is dispersed as nanosized droplets in the aqueous phase. The aqueous phase contains water or a water solution and a water-soluble organic nanostructure stabilizer. The oil phase contains an oil or an oil solution, an organic gel thickener, and a hydrophilic surfactant having a hydrophilic-lipophilic balance value greater than 8.0. Also disclosed is a method for preparing the above-described nanoemulsion.

The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., innate and adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

The invention discloses an oil-in-water type vaccine adjuvant as well as a preparation method and application thereof. The oil-in-water type nano-emulsion vaccine adjuvant comprises the following components in percentage by mass: 0.1-10 percent of oil phase, 0.1-10 percent of emulsifier, 0.1-3 percent of stabilizer, 0.1-3 percent of complexing agent and 0.01-10 percent of immunopotentiator. The preparation method comprises the following steps: (1) uniformly dispersing the immunopotentiator, the stabilizer and the complexing agent in water, thereby obtaining an aqueous phase; (2) mixing an oil phase and an emulsifier, thereby obtaining an oil phase; (3) slowly adding the oil phase into the aqueous phase, and continuously stirring, thereby forming a stable emulsion; (4) regulating the pH value of the emulsion, and fixing the volume to obtain a primary emulsion; and (5) performing high-speed shearing and high-pressure homogenizing on the primary emulsion. The vaccine adjuvant provided by the invention is simple in preparation, convenient to use and small in side reactions, is used for diluting vaccines, particularly swine fever live vaccines and is high in stability and good in immune effect.

An organic siloxane modifier nano-class styrene-acrylate emulsion used for paint or adhesive is prepared from the functional silane monomer with multifunctional vinylalkoxy groups and the monmers of styrene, alkyl methylacrylate, hydroxyalkyl methylacrylate, alkyl acrylate and (methyl) acrylic acid through copolymerization in the manner that under the action of organic silaxane as hydrolysis inhibitor the emulsion polymerizing is inhibited. Its advantages are low content of emulsifier, high content of solid component and storage stability (more than one year), high resistance to weather, dirt, water, chemical solvent and alkali, and high adhesion and tension strength.

A composite organosilicon modified acrylatel inorganic nano emulsion features that the nano-class inorganic phase (SiO2, TiO2, ZnO and CaCo3) is contained in the particles of organosilicon modified acrylate emulsion, and is prepared through reverse emulsion polymerizing and in-situ emulsion polymerizing. Its advnatages are high mechanical, self-cleaning and antistatic performance and high stability. It can be used for paint, adhesive, polishing agent and cement modifier.

A nano-emulsion injection of prostaglandin E1 contains the nano-emulsion particles of rostaglandin E1, the oil for injection, hydrophilic emulsifier, lipophilic emulsifier, isotonic agent, and stabilizer. Its preparing process and its quality control method are also disclosed.

The present invention belongs to the field of medicine, and particularly relates to a novel curcumin pharmaceutical preparation, which comprises a solid dispersion, a micellar preparation, SMEDDS and a nanometer emulsion. According to the present invention, by increasing the solubility and the bioavailability of curcumin, the curcumin pharmaceutical preparation can effectively utilize the pharmacological effects of anti-oxidation, anti-inflammation, anti-cancer, apoptosis induction, antiangiogenesis, neuroprotection, anti-microorganism, liver and kidney protection, vascular formation inhibition, myocardial infarction prevention, blood glucose lowering, anti-rheumatism and the like of the curcumin.

The present invention relates to amino silicone nanoemulsions. More specifically, the present invention relates to amino silicone nanoemulsions that may be used to protect surfaces from being soiled or wetted.

The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscular contracture states. For example, botulinum toxin may relax facial muscles such that skin wrinkles become smoother and less noticeable. Further, the present invention contemplates a cosmetic formulation that may be self-administered, for example, in the privacy of one's home and without medical supervision.

The present invention discloses an eugenol nano emulsion compound, characterized in that the granule diameter of the nano emulsion compound is within 1 to 100nm; the raw materials with weight percentage includes 1.0 to 10.0 percent of eugenol, 0.5 to 8.0 percent of eucalyptus oil, 0.1 to 6.0 percent of pennyroyal, 0.1 to 3.0 percent of paeonol, 0.05 to 5.0 percent of citionella oil, 0.05 to 3.0 percent of camphor, 7.5 to 35.3 percent of emulsifying agent, 0.2 to 3.8 percent of co-emulsifier and the rest of water; the total weight percentage of the raw materials is 100 percent. The eugenol nano emulsion compound has the functions of dispelling mosquitoes, relieving itching, killing pain, reducing inflammation and resisting bacteria. The present invention is used to dispel mosquitoes and rapidly relieve itching and red swelling on the skin after bitten by mosquitoes. The present invention has the advantages of strong permeability, good stability, good invasive, long acting time, significant effect, simple preparation method and easy promotion and application.

The invention relates to a composition containing taxine compounds, which including taxine compounds, oil, water, surfactant, cosurfactant, stability, and an osmotic pressure regulator. The inventive composition is used in an emulsion form of oil-in-water, and the taxine grain diameter in the emulsion is nano-size, so it is called as nano-emulsion.

The invention discloses a preparation method of light-resistant waterborne polyurethane, which comprises the steps of mixing polytetramethylene ether glycol with diisocyanate in the presence of a dibutyltin dilaurate catalyst, stirring at 70-90 DEG C for reaction for 2-4h, obtaining a polyurethane prepolymer, adding a hydrophilic chain extender, a polyhydroxyl compound and butanone into the polyurethane prepolymer, stirring at 70-90 DEG C for reaction for 1.0-3.5 h, adding triethylamine for neutralizing, stirring for reaction for 40-60min, adding water for emulsification to form hydrophilic polyurethane, adding a nano emulsion into a hydrophilic polyurethane system, shearing and stirring for 40-60min under the condition that a pH value is 7, and obtaining light-resistant waterborne polyurethane. Prepared light-resistant waterborne polyurethane is environment-friendly and low in price, and can meet the demand of a market on a property of light-resistant polyurethane.

The invention belongs to the technical field of food, and discloses a vegetable protein / soybean polysaccharide nano-emulsion and a preparation method thereof. The preparation method comprises the following steps: dissolving vegetable acid soluble protein and soluble soybean polysaccharide into de-ionized water, respectively, stirring for 2-3h, adjusting the pH to be 2.0-4.0, and thus obtaining protein stock solution and polysaccharide stock solution, respectively; adding the protein stock solution into the polysaccharide stock solution, mixing uniformly to obtain a mixed solution, adding with fat, stirring, and homogenizing to obtain the emulsion; and heating the homogenized emulsion for 0.5-1h at 80-90 DEG C, so as to obtain the vegetable protein / soybean polysaccharide nano-emulsion. The vegetable protein / soybean polysaccharide nano-emulsion prepared by the preparation method provided by the invention has good stability, high oil content, small distribution particle size and good market prospect.

The nanometer miconazole nitrate emulsion medicine consists of surfactant, oil, miconazole nitrate and distilled water. Its preparation process includes the following steps: weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil phase for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly; adding dimethyl sulphoxide with dissolved miconazole nitrate into surfactant through stirring at 20-25 deg.c; adding distilled water slowly to form clear and flowing O / W type nanometer emulsion liquid. The nanometer miconazole nitrate emulsion has high skin permeability, no contamination to clothing, high dissolubility of miconazole nitrate, raised bioavailability of miconazole nitrate, delayed metabolism time and wide medicine market foreground.

Polymeric nanoemulsions facilitate flow and reduce drag and friction in multiphase pipelines containing both oil and water (e.g., oil / water, oil / water / gas, oil / water / solids, and oil / water / gas / solids) such as are used for oil or gas production, gathering, and transmission; hydrotransport of oilsand or heavy oil slurries and the like. Specific examples of suitable drag reducing polymers include polyacrylamide. The emulsions have a hydrocarbon external phase, droplets of an aqueous internal phase having water-soluble polymer dissolved therein, where the droplets have an average particle size below about 200 nm, and at least one surfactant to form a stable nanoemulsion. The nanoemulsions advantageously have a low viscosity of about 200 cP or less.

Cleaning compositions in the form of nano- or micro-emulsions and containing one or more green surfactants are disclosed. The composition may further include one or more green linkers. The presence of two or more green surfactants may synergistically improve the cleaning performance of the composition. Moreover, the presence of the one or more green linkers may also synergistically improve the soil removal or streak reduction performance of the composition. The composition may further include additional natural actives, such as natural fragrances, natural insecticides, natural insect repellants, and natural oils to provide prolonged release of the natural actives in a controlled manner. The green surfactants not only improve the ecological profile of the disclosed compositions but also allow the formation of stable micro- or nano-emulsions at room temperature with good cleaning performances.

The invention relates to a biodiesel nano-emulsion as well as a preparation method and application thereof. The biodiesel nano-emulsion comprises the following components in parts by weight: 5-40 parts of biodiesel, 5-25 parts of a nonionic surfactant and the balance of water based on the total amount of the components is 100 parts by weight. The biodiesel nano-emulsion disclosed by the invention is uniform in particle size distribution, has very good long-term stability, does not have changes of appearance after being placed for more than a half year, does not have obvious demixing and sedimentation phenomena, accords with environmental protection and various industrial requirements, and is easy to transport. The biodiesel nano-emulsion disclosed by the invention can be used as a lubricant for drilling fluid, and provides a new direction for the development of hogwash oil.

The invention provides a PVB (polyvinyl butyral) film having heat-insulating property, which comprises the following components in percentage by mass: 0.1-1% of ITO (indium tin oxide) nano emulsion, 19-40% of plasticizer, 59-80% of PVB resin powder, 0.1-2% of antioxidant and 0.05-1% of ultraviolet absorbent, wherein the ITO nano emulsion comprises the following components in percentage by mass: 65-90% of organic solvent, 5-20% of PVB resin powder and 5-15% of ITO nano powder. The invention also relates to a preparation method of the PVB film having heat-insulating property, which comprises the following steps: dissolving a small amount of PVB in organic solvent, adding a right amount of ITO powder, and repeatedly milling to a nano level with a ball mill, thus obtaining a nano emulsion; proportionally mixing the nano emulsion with the plasticizer, and adding into the PVB resin powder; and plastifying in a plastic extruding machine, and performing film formation through a mold, thus obtaining the PVB film. Thus, the invention effectively solves the aggregation problem.

The invention relates to an emulsifier combination which is free from ethoxylated emulsifiers, contains less than 20% by weight water and comprises C8-14 alkyl oligoglycoside, polyol polyhydroxystearate and C6-22 acyl glutamate. The emulsifier is suitable for the production of nanoemulsions by conventional cold / cold or hot / hot processes. The invention also relates to a process for the production of the emulsifier combination and to wipes coated with the nanoemulsions.

The invention discloses a nano-particle collecting agent for low-rank coal floatation and a preparation method. The nano-particle collecting agent is monodisperse polymer nano micro-spheres with tetrahydrofuran on the surfaces. The preparation method includes the steps that styrene, functional monomers T, a cross-linking agent and ultrapure water are added into a reaction device, nitrogen is introduced, the materials are stirred and mixed for 30 min at the rotating speed of 350 r / min, and then the temperature is raised to 70 DEG C; an initiator is added, stirring continues to be carried out at the rotating speed of 350 r / min, and the materials continue to react for 6 h under nitrogen protection; nano-emulsion obtained after the reaction is added into ultrapure water to be dispersed and then centrifugally purified, and the nano-particle collecting agent is prepared. The nano-particle collecting agent and oxygen-containing functional groups on the surface of low-rank coal can generate selective adsorption, a nano-scale rough surface is formed on the surface of the low-rank coal, the surface hydrophobicity of the low-rank coal is enhanced, and floatation indexes are increased. The preparation method of the nano-particle collecting agent has the advantages of being simple in process, easy and convenient to operate, easy to control and the like.