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Nanometer miconazole nitrate emulsion medicine and its prepn process

A technology of miconazole nitrate nanometer and imidium nitrate, which is applied in the field of medicine, can solve problems such as not being easy to popularize in mass production, not suitable for mass production, and increasing production costs, so as to achieve good solubilization, improve bioavailability, The effect of anti-corrosion performance improvement

Inactive Publication Date: 2007-03-21
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the temperature is not easy to control, the emulsification time is slightly longer, and it is easy to precipitate crystals, and the process is cumbersome, so it is not suitable for mass production; The grain size of the ointment prepared by this method is too coarse to meet the requirements; the third is to microcrystallize the main ingredient first, and then make an ointment with the matrix
This method increases processing procedures, equipment, and production costs, and is not easy to promote in mass production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Accurately weigh 4.5g of hydrogenated castor oil polyoxyethylene ether, 0.5g of snake oil, and 0.5g of dimethyl sulfoxide (in which 0.01g of miconazole nitrate is dissolved), and mix them thoroughly by manual stirring at room temperature of 20°C , then slowly add distilled water to it, and stir manually while adding water. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. Add and keep stirring, when the system becomes thinner suddenly, what produces this moment is O / W type colorless transparent miconazole nitrate nanoemulsion medicine, claims its weight as 10.0g.

Embodiment 2

[0050] Accurately weigh 4.0g of castor oil polyoxyethylene ether, 1.0g of isooctyl palmitate, 0.6 of dimethyl sulfoxide (0.05 of miconazole nitrate is dissolved in it), and mix them thoroughly by manual stirring at room temperature of 22°C , then slowly add distilled water to it, and stir manually while adding water. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. Add and keep stirring, when the system becomes thinner suddenly, what produces this moment is O / W type light yellow transparent miconazole nitrate nanoemulsion medicine, claims its weight as 10.00g.

Embodiment 3

[0052] Accurately weigh 4.5g of hydrogenated castor oil polyoxyethylene ether, 0.5g of olive, and 0.7g of dimethyl sulfoxide (0.1g of miconazole nitrate is dissolved in it), and mix them thoroughly by manual stirring at room temperature of 24°C. Then slowly add distilled water to it, and stir manually while adding water. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion, continue to drop And constantly stirring, when the system suddenly became thinner, what produced at this moment was the O / W type colorless and transparent miconazole nitrate nanoemulsion medicine, claiming its weight as 10.0g.

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Abstract

The nanometer miconazole nitrate emulsion medicine consists of surfactant, oil, miconazole nitrate and distilled water. Its preparation process includes the following steps: weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil phase for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly; adding dimethyl sulphoxide with dissolved miconazole nitrate into surfactant through stirring at 20-25 deg.c; adding distilled water slowly to form clear and flowing O / W type nanometer emulsion liquid. The nanometer miconazole nitrate emulsion has high skin permeability, no contamination to clothing, high dissolubility of miconazole nitrate, raised bioavailability of miconazole nitrate, delayed metabolism time and wide medicine market foreground.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a new dosage form of miconazole nitrate, a broad-spectrum antifungal medicine for external use, in particular to a miconazole nitrate nano-emulsion medicine and a preparation method thereof. Background technique [0002] Miconazole nitrate is an imidazole derivative and is a broad-spectrum antifungal drug. It can inhibit and kill skin fungi, candida, yeast and other algae, ascomycetes, cryptococcus, etc., and also has a good antibacterial effect on gram-positive cocci and bacilli. Therefore, it is commonly used clinically for skin, nail and toenail infections caused by skin fungi, yeast and other fungi, as well as angular cheilitis, otitis externa, vaginal infections and secondary infections caused by Candida and Gram-positive bacteria. Currently, miconazole nitrate is clinically available in ointment and suppository for external use. When formulating ointment, because miconazole nitrate...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/107A61K47/44A61P31/10
Inventor 欧阳五庆吴旭锦杨宝平
Owner NORTHWEST A & F UNIV
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