386 results about "Skin permeability" patented technology

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and / or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and / or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and / or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. Preferably the feedback control mechanism is an internal feedback control mechanism. In this embodiment, the abrasive tip contains two electrodes, i.e. both the source electrode and the return electrode. In another embodiment, the feedback control mechanism is an external feedback control. In the preferred embodiment for external feedback control, the device contains a co-axial or concentric arrangement of the two electrodes. In this embodiment, the abrasive tip contains the source electrode and the return electrode is located at the proximal end of the hand piece. The abrasive tip can be made of any material with a surface that can abrade skin. The material can be conductive or non-conductive. The controlled abrasion device may be provided in a kit, where the kit contains the device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time. The desired level of skin impedance, and thus the resulting permeability of the treated site, can be set at a predetermined value. Alternatively, the level of skin impedance can be selected based on the desired level of skin integrity, the subject's sensation of discomfort, or the duration of the application. The device contains a control mechanism which uses an appropriate algorithm or signal processing on the conductivity information provided by the electrodes to determine when the desired level of skin permeability has been reached. Once the desired level has been reached, the abrasion device is removed and either a drug delivery composition or device or an analyte sensor is applied to the treated site.

The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-1) and derived from IGF-1, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-1 mimicking peptides of this invention have identical functions or actions to natural-occurring IGF-1 and much better stability and skin permeation than natural-occurring IGF-1. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-1 activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.

Topically applicable, reduced-irritant dermatological / cosmetic compositions useful for the prevention / treatment of a variety of keratinization disorders, for example acne vulgaris, contain at least one naphthoic acid compound and an amount of benzoyl peroxide encapsulated in a polymeric system of porous particles for increasing cutaneous penetration of the at least one naphthoic acid compound, are formulated into topically applicable, physiologically acceptable media therefor.

The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a surface-active agent and a gelling agent. The foam carrier further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

Provided is a skin external composition, which includes tranexamic acid or a salt thereof and a skin penetration enhancer, thereby showing remarkably increased skin permeability and improved sense of use, skin irritation, and storage stability.

The invention discloses a skin-care cosmetic with functions of moisturizing skin and resisting wrinkles of the skin. The skin-care cosmetic contains a traditional skin-care cosmetic; the traditional skin-care cosmetic is a traditional skin-care lotion, a traditional whitening lotion, a traditional hairdressing essence, a traditional moisturizer, traditional foundation cream, a traditional sun block, a traditional cleansing lotion or a traditional body wash; the skin-care cosmetic contains hydrolyzed corn protein, hydrolyzed soy protein, hydrolyzed rice protein and an artemia extract, and further contains or not contains magnesium ascorbyl phosphate. The skin-care cosmetic is prepared by the following four steps: preparing raw materials; mixing, and stirring; adjusting the pH value of a mixture; and filtering, and cooling, so as to obtain the skin-care cosmetic. The skin-care cosmetic is reasonable in component combination, so that the skin-care cosmetic has relatively good skin permeability, is capable of promoting collagen protein synthesis and fibrous protein synthesis in skin, and compounding the magnesium ascorbyl phosphate, and has lasting and excellent effects of moisturizing skin and resisting wrinkles of the skin.

The invention discloses a nano-microcapsule with blumea balsamifera essential oil. The nano-microcapsule comprises a core material and a wall material, wherein the core material is blumea balsamifera essential oil, the wall material is formed by carrying out cross-linked reaction between sulfhydryl modified chitosan and a cross-linking agent, and the wall material is coated with the core material. The invention also discloses a preparation method of the nano-microcapsule with the blumea balsamifera essential oil, i.e., the blumea balsamifera nano-microcapsule is prepared by adopting a controlled release technology of the nano-microcapsule and a nano-directional skin permeability absorption technology. The problems that active ingredients of the blumea balsamifera essential oil are unstable and efficacy action time of the blumea balsamifera essential oil is short are solved; the bioavailability of the blumea balsamifera essential oil is improved and an application range of the blumea balsamifera essential oil is widened; moreover, the nano-microcapsule has the advantages of non-toxicity, security, low cost and easiness for realization of industrial production and the like, so that the nano-microcapsule has wide application values in drugs, cosmetics, skin care products and spice and flavor additives.

The invention relates to the field of cosmetics and provides an alpha-arbutin co-conveying nanometer composition. The alpha-arbutin co-conveying nanometer composition comprises alpha-arbutin, other skin-whitening active components and a nanometer medicine carrier; the alpha-arbutin accounts for 0.05 to 20.0 percent of the total mass of the co-conveying nanometer composition; other skin-whitening active components comprise at least one of a tyrosinase inhibitor outside the alpha-arbutin, a melanosomal migration inhibitor, an antioxidant, an anti-glycation active substance and an anti-inflammatory agent; the raw materials of the nanometer medicine carrier comprise an emulsifier and a co-emulsifier; and the alpha-arbutin co-conveying nanometer compositionl also comprises grease and water. Remarkable synergistic effect is achieved through compounding of different skin-whitening mechanisms and loading of the nanometer medicine carrier; the melanin content of skin is obviously reduced through multi-target-point effect; and the co-conveying nanometer composition can realize sustained release and controlled release of medicines, has large medicine carrying quantity, high stability, high water solubility, high skin permeability and excellent skin-whitening effect, and can be widely applied to cosmetics.

The present invention relates to a noggin-derived peptide and to a composition containing same for promoting hair growth, enhancing the condition of the skin, providing an anti-inflammatory function, or preventing or treating bone diseases. The noggin-derived peptide of the present invention performs a function identical or similar to that of natural human noggin, and has a superior stability and skin permeability as compared to the natural human noggin. The composition containing the peptide of the present invention as an active ingredient exhibits remarkably superior effects in treating, preventing, or improving growth factor-related symptoms, e.g. hair loss, skin conditions or stab wounds, and in treating, preventing, or improving symptoms of growth factor over-expression.; Therefore, the superior activity and stability of the peptide of the present invention are greatly advantageous for using the peptide of the present invention in medicine, quasi-drugs, and cosmetics.