The invention provides compound polypeptide nanometer vesicles with a skin repair function, and belongs to the technical field of cosmetics. The compound polypeptide nanometer vesicles are prepared from, by weight, 0.01-1 part of regenerated repairing active peptide, 0.01-1 part of antioxidant active peptide, 0.1-5 parts of natural moisturizing active factors, 0.01-1 part of microcirculation-promoting active ingredients, 5-20 parts of lipoid wall materials, 0.1-5 parts of cholesterol, 10-45 parts of polyhydric alcohols and 30-98 parts of water. According to the compound polypeptide nanometer vesicles, repairing components acting on different target spots are provided aiming at different repair mechanisms of the skin barrier; meanwhile, the nanometer vesicles are adopted for covering various hydrophilic and lipophilic active ingredients, a unique closed lipid bilayer structure of the vesicles is utilized, the stability of the repairing compound is significantly improved, the skin penetration amount is increased, slow release of the active ingredients is effectively controlled, and the repairing effect is improved.