The invention relates to human pluripotent
stem cell exosomes loaded with antitumor drugs and a preparation method and use of the human pluripotent
stem cell exosomes. According to the method, the human pluripotent
stem cell exosomes are taken as nanoscale carriers of the antitumor drugs, and by performing
RGD peptide artificial modification on the surfaces of the exosomes, the exosomes have stronger
tumor targeting, thereby constructing a natural
drug delivery system easily passing through a
blood brain barrier and having the
tumor targeting. The human pluripotent stem
cell exosomes loaded with the antitumor drugs have both the
tumor resistance, immune adjustment, inflammatory resistance and other functions of pluripotent stem
cell exosomes and the specific antitumor function of the antitumor drugs; the dual functions of the pluripotent stem
cell exosomes and the antitumor drugs can better exert the antitumor effect and greatly reduce the dosage of the antitumor drugs, thereby greatlyreducing the toxic and side effects of the antitumor drugs; by using the nanoscale properties of the exosomes, the exosomes can pass through the
blood brain barrier, thereby having unique advantagesfor the treatment of
central nervous system tumors; the human pluripotent stem cell exosomes loaded with the drugs are modified by RGD peptides, thereby greatly enhancing
tumor targeting of the exosomes.