38 results about "Protoporphyrin" patented technology

The invention discloses an iron-supplementing compound, which comprises the following components including, by weight, 64-75 parts of organic iron, 2-4 parts of protoporphyrin and 15-18 parts of synergist. The iron-supplementing compound is suitable for livestock giving priority to pigs and poultry. The iron-supplementing compound accelerates red blood cell proliferation, improves hemoglobin synthesis and remarkably improves hematopoiesis effects. A plurality of different organic iron serves as an iron source for hematopoiesis, the iron source is absorbed by an organism to the most extent, reduction states of hemoglobin bivalent iron are protected, optimal working states of red blood cells are maintained, the bivalent iron is protected from failure caused by the fact that the bivalent iron is oxidized into trivalent iron, and maximum absorption of the bivalent iron is guaranteed.

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and / or in the form of a metal complex:in which:R and R′ are as defined in claim 1,comprising:a step of condensation, in an acidic medium, between a dipyrromethane of formula (II):in which R′b is as defined above for (I),and a dipyrromethane of formula (III):in which R″ is as defined in claim 1, and also the compounds of formula (III).

The invention relates to a bismuth sulfide-zinc protoporphyrin composite material with a tumor photodynamic therapy (PDT) property under excitation of near-infrared light as well as a preparation method and application and belongs to the field of composite materials, aiming at solving the problem that the PDT efficiency is relatively low, caused by photoelectron-hole compounding in a photodynamictherapy process of bismuth sulfide and an anti-oxidization stress capability of heme oxygenase (HO-1) in cells. The composite material is the bismuth sulfide-zinc protoporphyrin composite material which is obtained by synthesizing a polyN-isopropylacrylamide-acrylamide copolymer modified bismuth sulfide nano-material and then carrying out condensation reaction of carboxyl and amino. The prepared composite material has the effect of enhancing the photodynamic therapy efficiency through two ways of inhibiting the activity of the heme oxygenase and promoting electron-hole separation; meanwhile, the material provided by the invention has good biocompatibility, light stability, CT (Computed Tomography) imaging capability and enhanced PDT efficiency; a thought is provided for designing a novel nano diagnosis and treatment integrated system and the material has important meaning on early-stage diagnosis and treatment of cancers.

The invention provides acid-anhydride-bond-containing symmetric molecular tweezer series porphyrin compounds and a preparation method thereof. The structural formula is disclosed in the specification, wherein M=H2, Zn, MnCl, Cu, Ni or Co. The molecular formulae of the porphyrin compounds are sequentially C90H58N8O3, C90H54N8O3Zn2, C90H54N8O3Cl2Mn2, C90H54N8O3Cu2, C90H54N8O3Ni2 and C90H54N8O3Co2. The free alkali porphyrin P is prepared by carrying out intermolecular removal of one water molecule on bimolecular 5-(4-carboxylphenyl)-10,15,20-triphenylporphyrin; and the synthesized protoporphyrin reacts with MnCl2.4H2O, ZnCl2, CuCl2, NiCl2.6H2O and CoCl2.6H2O to obtain the corresponding metalloporphyrin compounds. All the synthesized series porphyrins are molecular tweezer compounds with specific cavity size, and can be further developed into sensitive materials for detecting aldehyde ketones, amines and aromatics.

The invention relates to the fields of the synthesis of medicines and pharmacokinetics, in particular to hemin containing stable isotope 58Fe and a method for synthesizing the hemin. The method comprises the following steps of: (a), oxidizing isotope 58Fe powder by using excess diluted hydrochloric acid to generate an isotope ferrous chloride solution, evaporating to remove moisture, and drying under vacuum to prepare an isotope ferrous chloride crystal; (b), reacting the prepared isotope ferrous chloride crystal with acidified protoporphyrin disodium, and controlling the pH value of a system before reaction to be 5 to 7; and (c), evaporating to remove most of reaction solvents, washing, adding an inorganic acid, regulating the pH value of the system to be 1 to 2, performing ultrasound oscillation, standing and performing suction filtration to obtain the 58Fe hemin. The invention provides a high-accuracy and high-sensitivity study method for the study of the intracorporal process of an endogenous substance, namely a core skeleton of the endogenous substance is marked by an isotope marking method, and the intracorporal process of the endogenous substance is studied quantitatively by measuring the content of the marked endogenous substance.

The invention discloses a polyamino acid sound sensitizer as well as its preparation method and application. The main chain structure of the polyamino acid sonosensitizer of the present invention is aspartic acid grafted with protoporphyrin, which has good biocompatibility, and the side bond of protoporphyrin modified on the water-soluble polyaspartic acid greatly improves The solubility of protoporphyrin is improved, the blood compatibility of the sonosensitizer in the body and the accumulation amount of the lesion are increased, so as to produce a better therapeutic effect and realize efficient and safe tumor treatment. The present invention also provides a sound sensitizer nanovesicle and its target-modified sound sensitizer nanovesicle, which has the effect of high efficiency and low toxicity, and provides a new type of sound sensitizer with excellent performance for the development of safe and efficient sonodynamic therapy. Sensitizer materials, and by modifying specific antibodies or ligands on their surface, improve their aggregation at the target site.