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39 results about "Protoporphyrin" patented technology
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Protoporphyrins are tetrapyrroles containing the following side chains: methyl propionic acid vinyl Protoporphyrin IX is a biochemically widely used carrier molecule for divalent cations. Together with iron the body of the heme- group of hemoglobin, myoglobin and many other heme-containing enzymes like cytochrome c and catalase are formed. Complexed with magnesium-ions the main part of the Chlorophylls are formed. Complexed with zinc-ions it forms Zinc protoporphyrin. The number indicates the position of different side chains, but historically, as the nomenclature has grown, it has done so systematically only in parts. Protoporphyrin IX as a direct precursor of heme is accumulated by patients of erythropoietic protoporphyria, which is one of the genetic disorders of the biosynthesis of the heme -pathway. It causes a severe photosensivity against visible light. The sensitivity of protoporphyrin IX against light is also used as a therapy against different forms of cancer. Protoporphyrins are deposited in the shells of the eggs of some birds as a brown or red pigment, either as a ground colour or as spotting.
Field-effect sensor for detecting hydroxyl free radicals and preparation method of field-effect sensor
ActiveCN108226258ARealize quantitative analysisQuick responseMaterial analysis by electric/magnetic meansSemiconductor/solid-state device manufacturingPorphyrinCadmium Cation
The invention belongs to the technical field of sensing detection and particularly discloses a method for preparing a field-effect sensor for detecting hydroxyl free radicals. The method disclosed bythe invention comprises the steps: firstly, preparing a conductive graphene film on an insulating substrate, and preparing patterned electrodes so as to obtain a field-effect device; then, plating thesurface of the graphene film with a layer of gold film, and carrying out annealing in an inert gas atmosphere, so as to obtain uniform-distributed gold nanoparticles; finally, modifying surfaces of the gold nanoparticles with protoporphyrin, thereby obtaining a protoporphyrin-gold nanoparticle modified graphene film. By using metal ions such as cadmium ions capable of being coordinated with the protoporphyrin as a current change indicator, and the surface charge concentration of graphene is changed through an oxidated bond breaking action on modified porphyrin by the hydroxyl free radicals, so that the detection on concentration of the hydroxyl free radicals is achieved. According to the field-effect sensor for detecting the hydroxyl free radicals and the preparation method of the field-effect sensor, the process is simple, high-selectivity rapid sensing can be achieved, and a foundation is laid for the application of the field-effect sensor in the fields of lives, environments, energy, safety and the like.
Owner:FUDAN UNIV
Antitumor agents and process for producing the same
InactiveUS20040234495A1High intracellular oxidative stateOrganic active ingredientsGroup 8/9/10/18 element organic compoundsAnticarcinogenPolyethylene glycol
Anticancer agents which contain as the active ingredient, a heme oxygenase inhibitory metalloporphyrin derivatives which are conjugated with amphipathic or water-soluble polymers (in particular, Zn-protoporphyrin (ZnPP) conjugated with polyethylene glycol). Because of being conjugated to amphipathic or water-soluble polymers, such as polyethylene glycol, the active ingredient can be administered by intravenous injection and can exert a remarkable anticancer effect owing to tumor selective delivery.
Owner:HIROSHI MEADA
Sodium protoporphyrin production and application
The invention relates to applications of protoporphyrin in preparing medicines used for treating or preventing immunological liver injury or D-galatosamine induced acute liver injury; moreover, the invention also relates to a preparation method of the protoporphyrin and the preparations thereof.
Owner:王利忠
Tumor targeting photosensitizers and preparation methods and applications of photosensitizers
ActiveCN103330938AGood biocompatibilityGood photochemical propertiesEnergy modified materialsPharmaceutical non-active ingredientsCancer cellTumor targeting
The invention discloses two tumor targeting photosensitizers, and preparation methods and applications of the photosensitizers. The photosensitizer HSA-(PpIX)2 is prepared by coupling reaction of HSA and PpIX. With the adoption of modification, the biocompatibility and the photochemical property of PpIX are improved; PpIX has stronger killing effect on a cancer cell; and the fluorescence of protoporphyrin is kept. In addition, HSA-(PpIX)2 can be used for adjusting the yield of active oxygen after loading fullerene derivatives. Vivo experiments of mouse breast cancer models indicate that the photosensitizer can be gathered at a tumor site efficiently due to a special EPR effect of a nanomaterial to realize high-sensitive fluorescent imaging of an in vivo level, so that a tumor is positioned accurately, and the best treatment time is monitored. The 16-day monitoring of the effect of photodynamic therapy shows that the photosensitizer can inhibit the growth of the tumor effectively.
Owner:赤峰福纳康生物技术有限公司 +1
Iron-supplementing compound and preparation method thereof
ActiveCN102524537APromote proliferationEasy to synthesizeAnimal feeding stuffBiotechnologyAnimal science
The invention discloses an iron-supplementing compound, which comprises the following components including, by weight, 64-75 parts of organic iron, 2-4 parts of protoporphyrin and 15-18 parts of synergist. The iron-supplementing compound is suitable for livestock giving priority to pigs and poultry. The iron-supplementing compound accelerates red blood cell proliferation, improves hemoglobin synthesis and remarkably improves hematopoiesis effects. A plurality of different organic iron serves as an iron source for hematopoiesis, the iron source is absorbed by an organism to the most extent, reduction states of hemoglobin bivalent iron are protected, optimal working states of red blood cells are maintained, the bivalent iron is protected from failure caused by the fact that the bivalent iron is oxidized into trivalent iron, and maximum absorption of the bivalent iron is guaranteed.
Owner:广东驱动力生物科技集团股份有限公司
Bismuth sulfide-zinc protoporphyrin composite material with tumor photodynamic therapy property under excitation of near-infrared light as well as preparation method and application
ActiveCN108175857AIncreased ability to generate active oxygenGood biocompatibilityPhotodynamic therapyX-ray constrast preparationsBismuth sulfideAntioxidative stress
The invention relates to a bismuth sulfide-zinc protoporphyrin composite material with a tumor photodynamic therapy (PDT) property under excitation of near-infrared light as well as a preparation method and application and belongs to the field of composite materials, aiming at solving the problem that the PDT efficiency is relatively low, caused by photoelectron-hole compounding in a photodynamictherapy process of bismuth sulfide and an anti-oxidization stress capability of heme oxygenase (HO-1) in cells. The composite material is the bismuth sulfide-zinc protoporphyrin composite material which is obtained by synthesizing a polyN-isopropylacrylamide-acrylamide copolymer modified bismuth sulfide nano-material and then carrying out condensation reaction of carboxyl and amino. The prepared composite material has the effect of enhancing the photodynamic therapy efficiency through two ways of inhibiting the activity of the heme oxygenase and promoting electron-hole separation; meanwhile, the material provided by the invention has good biocompatibility, light stability, CT (Computed Tomography) imaging capability and enhanced PDT efficiency; a thought is provided for designing a novel nano diagnosis and treatment integrated system and the material has important meaning on early-stage diagnosis and treatment of cancers.
Owner:中科应化(长春)科技有限公司
Filter additive for reducing nitrosamines in cigarette smoke and application of filter additive
The invention discloses filter additive for reducing nitrosamines in cigarette smoke and application of the filter additive. The filter additive is one of protoporphyrin derivatives. The filter additive with 0.05-10% of carrier weight is suspended in solvent and is sprayed to a carrier, and the carrier with the added protoporphyrin derivative is added to a stranded filter stick in strand forming to make the compound filter. The filter additive has the advantages that the protoporphyrin derivative is provided initially and has an evident effect in lowering content of TSNAs (nitrosamines) in smoke.
Owner:CHINA TOBACCO CHUANYU IND
Bovine serum albumin modified protoporphyrin/trimanganese tetroxide /carbon oxynitride nano composite material as well as preparation and application thereof
ActiveCN112057616AGood biocompatibilityEasy to prepareMaterial nanotechnologyEnergy modified materialsSonodynamic therapyManganous-manganic oxide
The invention relates to a bovine serum albumin modified protoporphyrin / trimanganese tetroxide / carbon oxynitride nano composite material as well as preparation and application thereof. The preparationmethod comprises the following steps: (1) preparing a uniformly dispersed carbon oxynitride nanosheet aqueous solution; (2) sequentially adding manganese acetate tetrahydrate and triethylamine into the carbon oxynitride nanosheet aqueous solution obtained in the step (1), performing continuous stirring, and preparing a trimanganese tetroxide-loaded carbon oxynitride nanomaterial through an in-situ growth method; and (3) loading protoporphyrin to the surface of the trimanganese tetroxide-loaded carbon oxynitride nanomaterial obtained in the step (2) by stirring, and adding bovine serum albuminfor modification. The material prepared by the method disclosed by the invention can be applied to magnetic resonance imaging and tumor sonodynamic therapy. Compared with the prior art, the bovine serum albumin modified protoporphyrin / trimanganese tetroxide / carbon oxynitride nano composite material disclosed by the invention has good biocompatibility and can be used as a magnetic resonance imaging contrast agent to guide sonodynamic therapy of tumors.
Owner:SHANGHAI NORMAL UNIVERSITY
Nano diagnosis and treatment agent material capable of efficiently crossing blood-brain barrier and targeting in-situ glioma and preparation method of nano diagnosis and treatment agent material
ActiveCN111110871APreserve integrityGood water solubilityNervous disorderEmulsion deliverySaturation transferrinGlioma
The invention relates to a nano diagnosis and treatment agent material capable of efficiently crossing a blood-brain barrier and targeting in-situ glioma and a preparation method of the nano diagnosisand treatment agent material, in particular to a transferrin-based nano material, a preparation method thereof and application of the transferrin-based nano material in preparation of a nano diagnosis and treatment agent capable of efficiently crossing the blood-brain barrier and targeting in-situ glioma. The transferrin-based nano material comprises iron-saturated transferrin holo-Tf serving asa carrier as well as MnO2 nanocrystals and protoporphyrin which are loaded in the carrier, wherein the MnO2 nanocrystals and protoporphyrin molecules are jointly wrapped by transferrin to form a core-shell-like structure.
Owner:SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Iron-supplementing compound and preparation method thereof
ActiveCN102524537BPromote proliferationEasy to synthesizeAnimal feeding stuffBiotechnologyAnimal science
The invention discloses an iron-supplementing compound, which comprises the following components including, by weight, 64-75 parts of organic iron, 2-4 parts of protoporphyrin and 15-18 parts of synergist. The iron-supplementing compound is suitable for livestock giving priority to pigs and poultry. The iron-supplementing compound accelerates red blood cell proliferation, improves hemoglobin synthesis and remarkably improves hematopoiesis effects. A plurality of different organic iron serves as an iron source for hematopoiesis, the iron source is absorbed by an organism to the most extent, reduction states of hemoglobin bivalent iron are protected, optimal working states of red blood cells are maintained, the bivalent iron is protected from failure caused by the fact that the bivalent iron is oxidized into trivalent iron, and maximum absorption of the bivalent iron is guaranteed.
Owner:GUANGDONG DRIVE BIO TECH CO LTD
Protoporphyrin-zinc aluminum hydrotalcite compound and preparation method and application thereof
InactiveCN107224587ALow priceRich sourcesOrganic active ingredientsDigestive systemSide effectHydrotalcite
The invention discloses protoporphyrin-zinc aluminum hydrotalcite compound and a preparation method and application thereof and belongs to the field of inorganic-organic compound functional materials and sustained drug release. The protoporphyrin-zinc aluminum hydrotalcite compound is prepared from zinc aluminum hydrotalcite and protoporphyrin, wherein electrostatic interaction is generated between the zinc aluminum hydrotalcite and the protoporphyrin, the protoporphyrin adsorbs on the surface of the zinc aluminum hydrotalcite, and the weight content of the protoporphyrin in the compound is 0.01 to 50%. The protoporphyrin-zinc aluminum hydrotalcite compound disclosed by the invention can slowly release the protoporphyrin under a stomach pH environment and can serve as sustained release preparation of the protoporphyrin. After the protoporphyrin and the zinc aluminum hydrotalcite form the compound, a gastric acid stimulating side effect of the protoporphyrin is overcome, phototoxicity of the protoporphyrin is effectively reduced, and obvious clinical application valve is achieved.
Owner:FUZHOU UNIV
Process for preparing porphyrin derivatives, such as protoporphyrin (IX) and synthesis intermediates
ActiveUS8026358B2Easy to industrializeInhibition formationFunctional group formation/introductionPorphyrinPyrrole
The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and / or in the form of a metal complex:in which:R and R′ are as defined in claim 1,comprising:a step of condensation, in an acidic medium, between a dipyrromethane of formula (II):in which R′b is as defined above for (I),and a dipyrromethane of formula (III):in which R″ is as defined in claim 1, and also the compounds of formula (III).
Owner:SANOFI PASTEUR SA
In-situ brain glioma microenvironment responsive nano material and preparation method and application thereof
PendingCN111870705AImprove responseEasy to operatePowder deliveryEmulsion deliveryMRI contrast agentNanocarriers
The invention discloses an in-situ brain glioma microenvironment responsive nano material, and a preparation method and application thereof, and relates to the technical field of biology. The in-situbrain glioma microenvironment responsive nano material comprises 60 parts of a nano carrier, 0.3-4 parts of manganese dioxide, and 1.2-3.6 parts of protoporphyrin; albumin serves as a bionic carrier,MnO2 nanocrystals serve as an MRI contrast agent and are loaded in an albumin cavity in a biomineralization manner, protoporphyrin serves as a therapeutic agent, and the protoporphyrin is entrapped inthe albumin cavity through an amide reaction. The loading capacity of manganese dioxide nanocrystals in albumin nanoparticles is 0.5-6.7 wt%, and the loading capacity of the protoporphyrin is 2-6wt%.After intravenous injection, the nano material can accurately and specifically display an in-situ glioma focus, and is helpful for assisting in clinical improvement of treatment accuracy and safety;Besides, oxygen is generated to improve a tumor hypoxic microenvironment, and the protoporphyrin generates active oxygen under ultrasonic excitation to specifically kill tumor cells.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
Auxiliary food liver powder for infants and preparation method of auxiliary food liver powder
InactiveCN111134325AProtectiveEnhance digestion and absorptionMetabolism disorderBird material medical ingredientsBiotechnologyAnimal science
Owner:上海伊威儿童食品有限公司
Smooth muscle relaxation
The invention relates to methods of inducing smooth muscle relaxation, for example, a method of inducing relaxation of a vascular or a non-vascular muscle or a method of inducing relaxation of the microvasculature, in a subject in need thereof by promoting the accumulation of protoporphyrin IX in the smooth muscle.
Owner:WOLIN MICHAEL
Bismuth sulfide-zinc protoporphyrin composite material with tumor photodynamic therapy properties under near-infrared light excitation and its preparation method and application
ActiveCN108175857BIncreased ability to generate active oxygenGood biocompatibilityPhotodynamic therapyX-ray constrast preparationsBismuth sulfidePhoto stability
The invention relates to a bismuth sulfide-zinc protoporphyrin composite material with a tumor photodynamic therapy (PDT) property under excitation of near-infrared light as well as a preparation method and application and belongs to the field of composite materials, aiming at solving the problem that the PDT efficiency is relatively low, caused by photoelectron-hole compounding in a photodynamictherapy process of bismuth sulfide and an anti-oxidization stress capability of heme oxygenase (HO-1) in cells. The composite material is the bismuth sulfide-zinc protoporphyrin composite material which is obtained by synthesizing a polyN-isopropylacrylamide-acrylamide copolymer modified bismuth sulfide nano-material and then carrying out condensation reaction of carboxyl and amino. The prepared composite material has the effect of enhancing the photodynamic therapy efficiency through two ways of inhibiting the activity of the heme oxygenase and promoting electron-hole separation; meanwhile, the material provided by the invention has good biocompatibility, light stability, CT (Computed Tomography) imaging capability and enhanced PDT efficiency; a thought is provided for designing a novel nano diagnosis and treatment integrated system and the material has important meaning on early-stage diagnosis and treatment of cancers.
Owner:中科应化(长春)科技有限公司
Chitosan nanoparticles with high stability and high biological safety as well as preparation method and application of chitosan nanoparticles
PendingCN114470200ANo toxicityEfficient broad-spectrum PDT antimicrobial activityAntibacterial agentsPowder deliveryBiotechnologyChitosan nanoparticles
The invention provides a preparation method of a chitosan nano material (CMCS-PEI-PpIX nano particle) with high stability and high biological safety and an application of the chitosan nano material in broad-spectrum photodynamic microbe resistance. The preparation method comprises the following steps: taking protoporphyrin (PpIX) and ethyleneimine (PEI) as raw materials, and obtaining PEI-PpIX through a one-step hydrothermal method. Then, the PEI-PpIX and carboxymethyl chitosan (CMCS) are used as raw materials, and CMCS-PEI-PpIX with negative charges is generated through EDC / NHS reaction. The CMCS-PEI-PpIX is self-assembled into nano particles in a solution, and shows a remarkably enhanced singlet oxygen yield in the solution. Therefore, the CMCS-PEI-PpIX nanoparticles have very good antibacterial PDT activity on gram-negative bacteria, gram-positive bacteria and fungi, and meanwhile, the CMCS-PEI-PpIX nanoparticles have no toxicity to normal cells and are highly stable. The invention provides an effective way for effectively killing disease microorganisms in food, medical supplies and food and medicine processing environments.
Owner:SOUTHEAST UNIV
A glass nanopore sensor for detecting oh and its preparation and application
The invention belongs to the technical field of sensing and detection of glass nanopores, and in particular relates to a glass nanopore sensor for detecting OH, its preparation and an electrochemical analysis method based on the principle of ion rectification. The method for the nanopore sensor of the present invention comprises: firstly using a drawing instrument to draw out a glass tapered nanopore, then evenly coating a layer of gold film on the inner wall of the nanopore, and finally through the strong interaction of the Au-S bond and the amide reaction, followed by modification of cysteamine molecules and protoporphyrin molecules on the gold film, and finally a functionalized glass nanopore sensor. The present invention also provides a method for detecting ·OH by the glass nanopore sensor. The technological process of the present invention is simple, does not need expensive reagents and large-scale instruments, and can realize high selectivity to OH in a complex system, high-sensitivity and fast response, and is an ideal solution for OH in the fields of food safety, medical hygiene, and environmental monitoring. Detection provides a portable and efficient detection platform and method design.
Owner:EAST CHINA NORMAL UNIV
Compound, water-soluble hematoporphyrin nano-particles and preparation method and application of water-soluble hematoporphyrin nano-particles
PendingCN114685708ATightly boundNot easy to dissociateEmulsion deliveryIn-vivo testing preparationsHeminWater chlorination
The invention discloses a compound, a water-soluble hematoporphyrin nano-particle and a preparation method and application thereof.The water-soluble hematoporphyrin nano-particle is prepared through a reaction of hemin and 2-methacrylic acid, the hemin is a complex formed by chlorination of ferric ions and protoporphyrin, the T1 longitudinal relaxation time of water protons can be greatly shortened, and the water-soluble hematoporphyrin nano-particle can be used for preparing the water-soluble hematoporphyrin nano-particle. The contrast enhancement effect is shown, so that the contrast agent can be used as a contrast agent; meanwhile, ferric ions are tightly combined with protoporphyrin and are not easy to dissociate, so that the problem of toxic hidden danger of a contrast agent is effectively avoided.
Owner:WUHAN UNITED IMAGING LIFE SCI INSTR CO LTD
Protoporphyrin liposome for nuclear delivery of chemotherapeutic drugs and preparation method and application of protoporphyrin liposome
ActiveCN111920960AEasy to prepareDoes not involve reactivityOrganic active ingredientsInorganic active ingredientsCholesterolPolyethylene glycol
The invention discloses protoporphyrin lipidosome for nuclear delivery of chemotherapeutic drugs and a preparation method and application of the protoporphyrin lipidosome. The protoporphyrin lipidosome is mainly prepared from hydrogenated soybean lecithin, distearoyl phosphatidylethanolamine-polyethylene glycol 2000, cholesterol and protoporphyrin. The liposome can be prepared by a film hydrationmethod and further ultrasonic or extrusion treatment, and can wrap various chemotherapeutic drugs to form protoporphyrin liposome loaded chemotherapeutic drugs so as to realize in-vivo long circulation and tumor delivery of the drugs. Moreover, compared with the traditional liposome, the liposome can increase the cell nucleus distribution of the chemotherapeutic drug, realizes more efficient cellnucleus drug delivery and cell killing, has good safety and good universality, and is expected to become a universal chemotherapeutic drug cell nucleus delivery carrier.
Owner:SOUTHEAST UNIV
Porphyrin compound containing acid anhydride bond symmetrical molecular tweezers series and preparation method thereof
InactiveCN103724363BImplement featuresEasy to detectChemiluminescene/bioluminescenceLuminescent compositionsPorphyrin moleculeCarboxyl radical
The invention provides acid-anhydride-bond-containing symmetric molecular tweezer series porphyrin compounds and a preparation method thereof. The structural formula is disclosed in the specification, wherein M=H2, Zn, MnCl, Cu, Ni or Co. The molecular formulae of the porphyrin compounds are sequentially C90H58N8O3, C90H54N8O3Zn2, C90H54N8O3Cl2Mn2, C90H54N8O3Cu2, C90H54N8O3Ni2 and C90H54N8O3Co2. The free alkali porphyrin P is prepared by carrying out intermolecular removal of one water molecule on bimolecular 5-(4-carboxylphenyl)-10,15,20-triphenylporphyrin; and the synthesized protoporphyrin reacts with MnCl2.4H2O, ZnCl2, CuCl2, NiCl2.6H2O and CoCl2.6H2O to obtain the corresponding metalloporphyrin compounds. All the synthesized series porphyrins are molecular tweezer compounds with specific cavity size, and can be further developed into sensitive materials for detecting aldehyde ketones, amines and aromatics.
Owner:CHONGQING UNIV
58Fe hemin, preparation method and application of 58Fe hemin to study of pharmacokinetics
The invention relates to the fields of the synthesis of medicines and pharmacokinetics, in particular to hemin containing stable isotope 58Fe and a method for synthesizing the hemin. The method comprises the following steps of: (a), oxidizing isotope 58Fe powder by using excess diluted hydrochloric acid to generate an isotope ferrous chloride solution, evaporating to remove moisture, and drying under vacuum to prepare an isotope ferrous chloride crystal; (b), reacting the prepared isotope ferrous chloride crystal with acidified protoporphyrin disodium, and controlling the pH value of a system before reaction to be 5 to 7; and (c), evaporating to remove most of reaction solvents, washing, adding an inorganic acid, regulating the pH value of the system to be 1 to 2, performing ultrasound oscillation, standing and performing suction filtration to obtain the 58Fe hemin. The invention provides a high-accuracy and high-sensitivity study method for the study of the intracorporal process of an endogenous substance, namely a core skeleton of the endogenous substance is marked by an isotope marking method, and the intracorporal process of the endogenous substance is studied quantitatively by measuring the content of the marked endogenous substance.
Owner:CHINA PHARM UNIV +1
Medicinal composition for promoting synthesis of protoporphyrin ix
ActiveUS20160136274A1Avoid problemsGood treatment effectAntibacterial agentsBiocideMedicineNovel treatment method
The object of the present invention is to elucidate the resistance mechanism in infections that show resistance to ALA-PDT that uses a single ALA, and to provide a novel treatment method against these infections. The present invention provides a pharmaceutical composition for promoting protoporphyrin IX production in ALA-PDT for treating infection, characterized in that it comprises a substance that promotes the conversion from coproporphyrinogen III to protoporphyrin IX.
Owner:SBI PHARMA CO LTD +1
A nano-therapeutic material that crosses the blood-brain barrier and targets orthotopic glioma and its preparation method
ActiveCN111110871BImprove responseEasy to controlNervous disorderEmulsion deliverySaturation transferrinNanocrystal
The invention relates to a nano-diagnosis and treatment agent material and a preparation method thereof that can efficiently cross the blood-brain barrier and target in situ brain gliomas, in particular to a transferrin-based nano-material and a preparation method thereof and in the preparation of high-efficiency cross-blood-brain barrier materials. Barrier and targeting in situ brain glioma nano-therapeutics; the transferrin-based nanomaterials include: iron-saturated transferrin holo-Tf as a carrier, and MnO loaded in the carrier 2 nanocrystals and protoporphyrin; and the MnO 2 Nanocrystals and protoporphyrin molecules are co-packed in transferrin to form a core-shell structure.
Owner:SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
Preparation method of photoelectrochemical sensor for detecting 17 beta-estradiol by using protoporphyrin modified bismuth doped strontium titanate
The invention relates to a preparation method of a photoelectrochemical sensor for detecting 17 beta-estradiol by using protoporphyrin modified bismuth doped strontium titanate. The protoporphyrin modified bismuth doped strontium titanate nano material is used as a substrate material to obtain light current, and the photoelectric conversion efficiency of the cubic bismuth tungstate sensitized by protoporphyrin and doped with bismuth ions is greatly improved. Besides, barium chromate is used as a marker to mark a 17beta-estradiol second antibody, wherein the antibody, the first antibody and an antigen are jointly modified in a 96 microwell plate, so that when diluted hydrochloric acid is used for treating the 96 microwell plate, Cr (VI) is released and interacts with quercetin in a test base solution, polarity conversion of detection light current signals is achieved, and sensitive detection of 17beta-estradiol is achieved, the detection limit being 3.5 fg / mL.
Owner:UNIV OF JINAN
Ion-modified gallium protoporphyrin compound as well as preparation method and application thereof
ActiveCN111848656AImprove targetingAvoid drug resistanceAntibacterial agentsEnergy modified materialsMinimum inhibitory concentrationOrganic synthesis
The invention belongs to the field of organic synthesis and medicines, and particularly relates to an ion-modified gallium protoporphyrin compound as well as a preparation method and application thereof. The ion-modified gallium protoporphyrin compound has a structure described in the specification, wherein m is 1, 2 or 3, n is 1, 2 or 3, R1 is ethyl or vinyl, R2 is H, COO<-> or SO<3->, and M-X isGa-Cl or Ga-NO3. After the protoporphyrin compound is complexed with gallium, the protoporphyrin compound not only has the photodynamic antibacterial property of a protoporphyrin photosensitizer, butalso is endowed with an antibacterial mechanism for blocking iron metabolism, so that the compound can resist bacteria synergistically in two ways, the minimum inhibitory concentration can be reduced, the antibacterial efficiency can be improved, the targeting property to bacteria can be enhanced, and the bacterial drug resistance can be overcome.
Owner:TIANJIN UNIV
A kind of polyamino acid sound sensitizer and its preparation method and application
ActiveCN109395105BImprove solubilityImprove performanceEchographic/ultrasound-imaging preparationsAntineoplastic agentsAntiendomysial antibodiesSonodynamic therapy
Owner:SUN YAT SEN UNIV
Application of protoporphyrin in preparation of diagnostic kit for hemocytogenic protoporphyrinosis
PendingCN114152597ARemove background noiseEasy to operateDisease diagnosisFluorescence/phosphorescenceWhole blood sampleZinc protoporphyrin
The invention provides an application of protoporphyrin in preparation of a diagnostic kit for hemocytogenic protoporphyrinosis. According to the diagnostic kit, the excitation spectrum of a fluorescence detection whole blood sample, the emission spectrum of protoporphyrin and zinc porphyrin and the fluorescence intensity of protoporphyrin and zinc porphyrin are used as diagnostic parameters respectively, and according to the wave crest conditions of the excitation spectrum and the emission spectrum, the detection sensitivity of the whole blood sample is improved. And whether the protoporphyrin is abnormally accumulated according to the comparison result of the fluorescence intensity of the protoporphyrin and the fluorescence intensity of the zinc porphyrin is taken as a diagnosis threshold value, so that whether the ferrous chelating enzyme coding gene is mutated is judged, and the diagnosis kit greatly improves the mutation detection rate of the ferrous chelating enzyme coding gene, and is simple, convenient, direct and rapid.
Owner:RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Nano gold-protoporphyrin zinc (ii) highly sensitive detection h 2 o 2 Construction and Application of Electrochemical Sensors
ActiveCN109613084BImprove reducibilityImprove stabilityMaterial nanotechnologyMaterial electrochemical variablesProtoporphyrin zincElectrochemistry
The invention discloses nano gold-protoporphyrin zinc (II) highly sensitive detection of H 2 o 2 The construction and application of electrochemical sensors, specifically related to the synthesis of a nano-gold-protoporphyrin zinc (Ⅱ) (PEI-AuNPs-ZnPP) and its effect on H in human serum 2 o 2 detection. The present invention utilizes the feature that nano-gold and protoporphyrin zinc can be connected by amide bond to synthesize, modify it on the surface of glassy carbon electrode, and detect H by electrochemical method. 2 o 2 Concentration, the results show that under optimal conditions, within a certain range of H 2 o 2 The concentration and the current signal are positively correlated, the linear equation is I(μA)=0.20412c(pmol / L)+1.93557, the correlation coefficient is 0.99534, and the detection limit is 8.540×10 ‑13 M. Its stability is better in that the current signal of the sensor is 96.8% of the initial value after 3 days, and at the same time, the sensor can measure H in the actual sample human serum 2 o 2 Also showed a high recovery rate (97.57 ~ 101.43%), can be used to detect H 2 o 2 The concentration of glucose laid the foundation for the later application in the medical field to detect the concentration of glucose.
Owner:HENAN UNIV OF CHINESE MEDICINE
A self-assembled nanomaterial and its preparation method and application
ActiveCN110508322BHigh catalytic efficiencyGood catalyticOrganic-compounds/hydrides/coordination-complexes catalystsBiological testingPtru catalystProtoporphyrins
The present invention provides a self-assembled nanomaterial and its preparation method and application. The raw materials of the nanomaterial include nucleic acid molecules, aminoglycoside molecules and metal protoporphyrin; the self-assembled nanomaterial provided by the present invention uses aminoglycoside molecules As an activator, the nanomaterial prepared by co-assembly with nucleic acid molecules and metal protoporphyrin, as a simulated enzyme catalyst, has the same order of magnitude of substrate turnover and catalytic efficiency as natural horseradish peroxidase. Because aminoglycoside molecules and metal protoporphyrin, nucleic acid metal protoporphyrin conjugates or nucleic acid metal protoporphyrin self-assembly, aminoglycoside molecules and nucleic acids have a synergistic effect on the catalytic activity of metal protoporphyrin, and have a more High catalytic activity; high application value in chemical sensors and biosensors.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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