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Field-effect sensor for detecting hydroxyl free radicals and preparation method of field-effect sensor

A free radical and field effect technology, applied in the field of sensing and detection, can solve the problems of expensive instruments, pollution, short life, etc., and achieve the effect of high selectivity and broad application prospects

Active Publication Date: 2018-06-29
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to its high activity, short life and easy transformation between each other, its analysis and detection have become a difficult point in research.
Traditional analytical methods, such as electron spin resonance, chromatography, and fluorescence, have the problems of expensive instruments, complicated sample pretreatment process, and possible introduction of other pollution during operation, which limits their application in certain fields to a certain extent. Applications

Method used

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  • Field-effect sensor for detecting hydroxyl free radicals and preparation method of field-effect sensor
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  • Field-effect sensor for detecting hydroxyl free radicals and preparation method of field-effect sensor

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] First, a single-layer graphene film was prepared on a 25-μm-thick copper foil by chemical vapor deposition, and the graphene was transferred to clean SiO 2 / Si substrate. Cr / Au (5 / 50 nm) source-drain electrodes were prepared by thermal evaporation, and then annealed in an Ar atmosphere at 300°C in a tube furnace for 30 minutes. Secondly, a layer of 8.0 nm gold film was evaporated on the surface of the graphene film by thermal evaporation technology, and uniformly distributed gold nanoparticles were obtained by annealing at 230 °C for 0.5 hours in a tube furnace ( figure 1 ). Then, 10 mM cysteamine was immobilized to the surface of gold nanoparticles via Au-S bonds. Finally, under the catalysis of EDC and NHS, 10 μM protoporphyrin was covalently immobilized to the electrode surface by forming amide bonds at a reaction temperature of 25 °C and a reaction time of 15 hours. Rinse with twice distilled water, and then in high-purity N 2 Blow dry, and the field effect tran...

Embodiment 2

[0027] First, a single-layer graphene film was prepared on a 25-μm-thick copper foil by chemical vapor deposition, and the graphene was transferred to clean SiO 2 / Si substrate. Cr / Au (5 / 50 nm) source-drain electrodes were prepared by thermal evaporation, and then annealed in an Ar atmosphere at 300 °C in a tube furnace for 30 minutes. Secondly, a 4.0 nm gold film was evaporated on the surface of the graphene film by thermal evaporation technology, and uniformly distributed gold nanoparticles were obtained by annealing at 200 °C for 0.5 hours in a tube furnace. Then, 10 mM cysteamine was immobilized to the gold nanoparticle surface via Au-S bonds. Finally, under the catalysis of EDC and NHS, 10 μM protoporphyrin was covalently immobilized on the electrode surface by forming amide bonds at a reaction temperature of 20 °C and a reaction time of 10 hours. Rinse with twice distilled water, and then in high-purity N 2 Blow dry, and the preparation of the field effect transistor ...

Embodiment 3

[0029] First, a single-layer graphene film was prepared on a 25-μm-thick copper foil by chemical vapor deposition, and the graphene was transferred to clean SiO 2 / Si substrate. Cr / Au (5 / 50 nm) source-drain electrodes were prepared by thermal evaporation, and then annealed in an Ar atmosphere at 300 °C in a tube furnace for 30 minutes. Secondly, a 2.0 nm gold film was evaporated on the surface of the graphene film by thermal evaporation technology, and uniformly distributed gold nanoparticles were obtained by annealing at 170 °C for 0.5 hours in a tube furnace. Then, 10 mM cysteamine was immobilized to the gold nanoparticle surface via Au-S bonds. Finally, under the catalysis of EDC and NHS, 10 μM protoporphyrin was covalently immobilized on the electrode surface by forming amide bonds at a reaction temperature of 25 °C and a reaction time of 5 hours. Rinse with twice distilled water, and then in high-purity N 2 Blow dry, that is, complete the preparation of the field effec...

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Abstract

The invention belongs to the technical field of sensing detection and particularly discloses a method for preparing a field-effect sensor for detecting hydroxyl free radicals. The method disclosed bythe invention comprises the steps: firstly, preparing a conductive graphene film on an insulating substrate, and preparing patterned electrodes so as to obtain a field-effect device; then, plating thesurface of the graphene film with a layer of gold film, and carrying out annealing in an inert gas atmosphere, so as to obtain uniform-distributed gold nanoparticles; finally, modifying surfaces of the gold nanoparticles with protoporphyrin, thereby obtaining a protoporphyrin-gold nanoparticle modified graphene film. By using metal ions such as cadmium ions capable of being coordinated with the protoporphyrin as a current change indicator, and the surface charge concentration of graphene is changed through an oxidated bond breaking action on modified porphyrin by the hydroxyl free radicals, so that the detection on concentration of the hydroxyl free radicals is achieved. According to the field-effect sensor for detecting the hydroxyl free radicals and the preparation method of the field-effect sensor, the process is simple, high-selectivity rapid sensing can be achieved, and a foundation is laid for the application of the field-effect sensor in the fields of lives, environments, energy, safety and the like.

Description

technical field [0001] The invention belongs to the technical field of sensing and detection, and in particular relates to a field-effect sensor for detecting hydroxyl radicals and a preparation method thereof. Background technique [0002] A field effect transistor is a semiconductor device that controls the output circuit current by controlling the electric field effect of the input circuit. The sensor prepared based on the field effect transistor can be detected by the change of the electrical properties of the material during the adsorption-desorption process of charged molecules and ions. Realize the detection of trace substances. Graphene is a two-dimensional carbon atom crystal discovered by Andre K. Geim of the University of Manchester in 2004. It is a single-layer or multi-layer extremely thin carbon material. Due to the high carrier mobility of graphene itself and its high sensitivity to the interference of trace charges in the external environment, field-effect s...

Claims

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Application Information

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IPC IPC(8): G01N27/414H01L29/16H01L29/772H01L21/335
CPCG01N27/4145G01N27/4146H01L29/1606H01L29/66409H01L29/772
Inventor 魏大程易孔阳王振
Owner FUDAN UNIV
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