42 results about "Zinc protoporphyrin" patented technology

The present inventors found that a natural red pigment can be obtained from hemoglobin and myoglobin whose metalloporphyrin moiety is zinc protoporphyrin, and made meat products, whale meat products, fish meat products and fish paste products that were colored with the natural red pigment. Consequently, it was possible to obtain food products stable to oxidation and exhibiting an excellent color tone without the need to use a color fixative, e.g. nitrite.

The invention discloses an acylhydrazone zinc protoporphyrin and a zinc and cobalt complex thereof, belonging to the field of chemical synthesis. In the acylhydrazone zinc protoporphyrin, an acylhydrazone structure and a porphyrin structure form a large conjugated system which can absorb a wider range of sunlight as compared with most of porphyrin dyes; and in the zinc and cobalt complex of the acylhydrazone zinc protoporphyrin, acylhydrazone zinc protoporphyrin molecules are connected to form a chain structure or high-dimensional structure, thereby improving the electron transfer efficiency and consequently improving the photoelectric conversion efficiency. Thus, the zinc and cobalt complex can be used as a dye sensitizer for the preparation of fuel-sensitive solar cells. Photoelectric property test results show that the fuel-sensitive solar cells prepared by the invention are capable of outputting a certain current to an external load and have different degrees of photoelectric conversion efficiency under the irradiation of standard light; and for the photocell using the zinc complex of the zinc protoporphyrin acylhydrazone as the dye, the maximum IPCE (Incident Photon to Current Efficiency) value is 13.4%.

The invention provides a zinc protoporphyrin containing a heterocyclic ring as well as the synthesis and the applications of the zinc protoporphyrin containing a heterocyclic ring and a metal complex of the zinc protoporphyrin containing a heterocyclic ring, belonging to the technical field of solar cell applications. In the zinc protoporphyrin containing a heterocyclic ring, benzaldehyde, a derivant of benzaldehyde and pyrrole serve as raw materials, multiple steps of reactions, such as condensation, coordination, substitution and the like are carried out, and a zinc protoporphyrin monomer molecule containing a heterocyclic ring substituted group and a metal complex of the zinc protoporphyrin monomer molecule containing a heterocyclic ring substituted group are successfully synthesized. The photoelectric property research on the zinc protoporphyrin containing a heterocyclic ring and the metal complex of the zinc protoporphyrin containing a heterocyclic ring in preparing the sensitization crystal TiO2 solar cell shows that the zinc protoporphyrin containing a heterocyclic ring and the metal complex of the zinc protoporphyrin containing a heterocyclic ring have good application prospects in the sensitization solar cell.

Methods are described for detecting and quantifying occult blood in a biological sample using laser desorption mass spectrometry (LD MS). Biological samples that can be analyzed using various embodiments of the present invention include stool (fecal occult blood, FOB), and any bodily fluid including urine, cerebrospinal fluid and other bodily fluids. If the heme or heme metabolite is bound to protein, the sample is treated with acid before analysis to release the porphyrin. Some of the methods use LD MS with a time of flight analyzer (TOF) to detect and measure unbound heme, other hemoglobin metabolites and other molecules that have a porphyrin-based structure, e.g., bilirubin, biliverdin, protoporphyrin IX, and Zinc protoporphyrin in the biological sample. In other methods, matrix-assisted laser desorption / ionization mass spectrometry (MALDI MS) is used to detect and quantify the individual α- and β-polypeptide chains of hemoglobin.

The invention belongs to the technical field of solar cell materials, and particularly relates to a sensitizer for a dye-sensitized solar cell and a preparation method thereof. The preparation method of the photosensitizer provided by the invention comprises the following steps of: taking 5-(4-nitrophenyl)-10,15,20-tris(4-hydroxyphenyl)porphyrin as an initiator; under nitrogen conditions, dissolving the initiator in concentrated hydrochloric acid, and reducing the initiator into 5-(4-aminophenyl)-10,15,20-tris(4-hydroxyphenyl)porphyrin by using stannous chloride; then, dissolving the reduced porphyrin and zinc acetate in an inert organic solvent for coordination; finally, dissolving the generated zinc protoporphyrin and 4-carboxybenzaldehyde in a dichloromethane solvent, and heating and refluxing; and after the reaction is finished, adding petroleum ether or absolute methanol for precipitating products, and recrystallizing to obtain a corresponding product N-(5-p-phenyl)-10,15,20-tris-p-hydroxyphenyl zinc protoporphyrin-p-carboxyl benzimide. The product provided by the invention has the advantages of high molar extinction coefficient, low cost and the like.

The invention relates to a method for zinc protoporphyrin promoted catalyzed oxidation of cycloalkanes. The method comprises the following steps: mixing the cycloalkanes, a main catalyst and a cocatalyst, carrying out a reaction for 2 to 48 hours under the condition that the temperature is 100 DEG C to 160 DEG C and the O2 pressure is 0.8MPa to 2MPa, then, subjecting a reaction solution to aftertreatment, thereby obtaining oxidation products, i.e., alkyl diacid, cycloalkyl alcohol and cycloalkyl ketone. According to the novel method for catalyzed oxidation of the cycloalkanes, provided by theinvention, the selectivity of the oxidation products is high, the reaction temperature is low, and the consumption of catalysts is low; O2 serves as an oxidant, so that the method is environmentally friendly, and the catalyzed oxidation of the cycloalkanes is achieved in a high-selectivity manner; the novel method for catalyzed oxidation of the cycloalkanes further has the advantages that the operation is simple, no organic solvent is used, and the like.

The invention discloses a probiotics and microelement dietary supplement with the function of alleviating lead toxicity and belongs to the technical field of food. According to the invention, a strain undergoes freeze-drying to obtain strain powder which is used as a main drug, supplemented by an antioxidant substance and microelements, proper auxiliary materials are added, and the raw materials are treated by a direct powder compression method so as to prepare a tablet form of the probiotics and microelement dietary supplement. Active bacteria content of the probiotics and microelement dietary supplement is greater than active bacteria content of 109CFU / g of lactobacillus plantarum CGMCC 5494. The dietary supplement obtained by the method can reduce content of lead in mice exposed to lead, recover oxidative stress injury caused by lead exposure, raise activity of aminolevulinic acid dehydratase in mice exposed to lead, lower content of zinc protoporphyrin in mice exposed to lead, and recover mice exposed to lead from intellectual damage. The dietary supplement of the invention has a wide application prospect.

The invention discloses a method for rapid and visual paper sensing detection of heavy metal silver ions, and belongs to the technical field of heavy metal detection. The method specifically comprisesthe following steps of synthesis of nano gold, synthesis of tetra-(4-pyridyl) zinc protoporphyrin self-assembly body; preparation of a nano gold and nano porphyrin composite paper sensing device substrate, manufacturing of a silver ion standard colourimetric card, and comparison of the concentration, detected by the colourimetric card, of the silver ions in a to-be-tested sample. The method for detecting the silver ions based on the nano gold and nano porphyrin composite paper sensing substrate has the characteristics of easy preparation, rapid field detection, low cost, high response speed,high sensitivity and high selectivity, and the nano gold and nano porphyrin composite paper sensing substrate has a specific reaction to the silver ions, and can be used for detection of the silver ions in complex substrate water samples.

The invention relates to a preparation method for tetra-(o-pivaloyl amino phenyl) zinc protoporphyrin isomer compound, which comprises the following steps: by taking tetra-o-chloronitrobenzene protoporphyrin as a raw material and utilizing a three-step method, controlling the use amount of the raw material, reaction temperature and solvent selection to respectively synthesize four tetra-(o-pivaloyl amino phenyl) zinc protoporphyrin isomer compounds with extra high purity, wherein the tetra-(o-Pivaloyl amino phenyl) zinc protoporphyrin isomer compounds have the formula disclosed in (I). According to the preparation method, the purification process of the metal protoporphyrin compound containing the isomer is greatly simplified, and the preparation method is simple to operate and has the advantages of available raw material and high yield.

The invention discloses a method for preparing a titanium dioxide / metalloporphyrin composite nanomaterial through a laser liquid phase method. The method for preparing the titanium dioxide / metalloporphyrin composite nanomaterial through the laser liquid phase method comprises the steps of preparation of a titanium dioxide nanomaterial; preparation of a tetraphenyl zinc-protoporphyrin solution; laser radiation treatment; and aftertreatment of a product. The prepared titanium dioxide / metalloporphyrin composite nanomaterial is of a three-dimensional structure, the utilization rate of a titanium dioxide surface can be increased to a greater extent, the photocatalytic activity is improved, and large consumption of organic solvents is not needed; and the technique is simple, the safety is high, and the production efficiency is high.

The invention relates to a bismuth sulfide-zinc protoporphyrin composite material with a tumor photodynamic therapy (PDT) property under excitation of near-infrared light as well as a preparation method and application and belongs to the field of composite materials, aiming at solving the problem that the PDT efficiency is relatively low, caused by photoelectron-hole compounding in a photodynamictherapy process of bismuth sulfide and an anti-oxidization stress capability of heme oxygenase (HO-1) in cells. The composite material is the bismuth sulfide-zinc protoporphyrin composite material which is obtained by synthesizing a polyN-isopropylacrylamide-acrylamide copolymer modified bismuth sulfide nano-material and then carrying out condensation reaction of carboxyl and amino. The prepared composite material has the effect of enhancing the photodynamic therapy efficiency through two ways of inhibiting the activity of the heme oxygenase and promoting electron-hole separation; meanwhile, the material provided by the invention has good biocompatibility, light stability, CT (Computed Tomography) imaging capability and enhanced PDT efficiency; a thought is provided for designing a novel nano diagnosis and treatment integrated system and the material has important meaning on early-stage diagnosis and treatment of cancers.

Formulations and methods of use thereof that relate to biocompatible delivery of zinc protoporphyrin (ZnPP) are provided. In some embodiments, the ZnPP is formulated for oral delivery. Formulations may include microparticles of ZnPP, wherein the ZnPP active agent is admixed or coated with a pharmaceutically acceptable stabilizer providing for increased stability to acid conditions and improved solubility at neutral pH.

The invention discloses a preparation method of a ZPP (Zinc Protoporphyrin) insensitive ignition explosive, and belongs to the preparation field of initiating explosive medicaments. The preparation method comprises the following steps of: refining zirconium powder and potassium perchlorate; enabling the average particle diameter of the zirconium powder and the potassium perchlorate to be respectively less than 3mu m and 20mu m; evenly mixing the zirconium powder and the potassium perchlorate manually or mechanically; mixing the zirconium powder and the potassium perchlorate with a prepared nitrocotton acetone solution; volatilizing the acetone in a stirring manner; and collecting semi-dry medicament particles of 18 to 60 meshes and drying, thereby obtaining the ZPP insensitive ignition explosive as a finished product in the shape of a gray solid granule. The prepared ZPP insensitive ignition explosive is accurate in medicament content, can be stored for a long time and used at any time, and is suitable for the pressing charging of the medicaments in various shapes and density changes.

The invention discloses application of an HO (Heme Oxygenase)-1 inhibitor in preparing medicine for treating cardiotoxicity induced by anti-cancer medicine-doxorubicin. The HO-1 inhibitor is zinc protoporphyrin. According to the application disclosed by the invention, basis is provided for new drug research and development and innovative therapy.

The invention provides zinc protoporphyrin nano-crystals and a preparation method and applications thereof. The preparation method comprises the following steps: subjecting a zinc porphyrin oil-in-water emulsion to rapid freezing in liquid nitrogen and then vacuum freeze-drying so as to obtain zinc protoporphyrin nano-crystals. The preparation method provided by the invention prepares the nano-crystals with an ultra-small particle size and protection of surface hydrophilic polymers, solves the problem of poor solubility of zinc protoporphyrin, and can improve the stability of the zinc protoporphyrin as a contrast agent in the blood system. At the same time, the tumor targeting molecule folic acid is introduced onto the surface of nano-crystals during the preparation process so as to improve the endocytosis ability of tumor cells to zinc protoporphyrin, to realize high-efficiency tumor photoacoustic imaging and photodynamic therapy, and to have good application prospect and applicationvalue.

The invention discloses a lead poison-relieving dietary supplement containing probiotics and plant extract and belongs to the technical field of foods. Freeze-dried powder of probiotics is used as a main drug, plant extract is used as an adjuvant and appropriate auxiliary materials are added into the main drug and the adjuvant and the mixture is subjected to direct tabletting so that the dietary supplement is obtained. The dietary supplement contains more than 10<9>CFU / g of lactobacillus plantarum CGMCC 5494. The dietary supplement can reduce lead content of a mouse under exposure of lead, recover oxidative stress injury caused by exposure of lead, improve activity of aminolevulinate dehydratase in a mouse under exposure of lead, reduce zinc protoporphyrin content of a mouse under exposure of lead and recover intellectual damage to the mouse under exposure of lead. The lead poison-relieving dietary supplement has a wide market prospect.

The invention provides a preparation method and an application of a fluorescence sensor for detecting ochratoxin A. A quantum dot-nano porphyrin fluorescence 'on-off' sensor is formed with a water-soluble ZnCdSe quantum dot as a fluorescent probe and self-assembled nano porphyrin, which is prepared from a tetra-(4-pyridyl)-zincporphyrin-N,N-dimethylformamide solution and dodecyl dimethyl betaine,as a quantum dot fluorescence quencher. The OTA is combined with nano porphyrin to release quantum dots, so that the fluorescence of the quantum dots is recovered, and the quantum dot-nano porphyrin fluorescence "on-off-on" sensor is formed. The addition of other mycotoxins does not cause the change of the fluorescence intensity of the system. The fluorescence sensor realizes high-selectivity detection of OTA, effectively amplifies signals, obtains high-sensitivity and strong-specificity detection results, does not need to depend on expensive large instruments, and is simple in pretreatment and rapid in detection.

The present invention provides a polymeric agent which can incorporate a large amount of a drug, accumulate selectively in a tumor site, and has a molecular size of more than that for renal excretion.A metalloporphyrin derivative (such as zinc protoporphyrin) is associated with a styrene-maleic acid copolymer via non-covalent bond to give a SMA micelle complex, allowing provision of a polymeric pharmaceutical agent for treatment of cancer with a large amount of the drug incorporated. The SMA micelle complex can be produced by a method, wherein the metalloporphyrin derivative reacts with the styrene-maleic acid copolymer in the absence of a condensation agent under an alkaline condition, solubilized, adjusted to have a pH of 6-8, and subjected to a procedure for separating a polymer component to recover the micelle complex component for the polymeric pharmaceutical agent.

The invention discloses a method and device for measuring the concentration of a zinc protoporphyrin substance in blood. The method comprises the steps of: irradiating a sample to be measured by an excitation light source, and obtaining the characteristic fluorescence signal of the sample to be measured within a period of time; calculating the characteristic fluorescence intensity data of the sample to be measured based on the characteristic fluorescence signal of the sample to be measured within the period of time; by means of the characteristic fluorescence intensity data and the zinc protoporphyrin concentration data of multiple groups of standard samples, linearly correcting a proportional relation between the characteristic fluorescence intensity data and the zinc protoporphyrin concentration to obtain a proportional line segment correction curve; and calculating the zinc protoporphyrin concentration of the sample to be measured according to the characteristic fluorescence intensity data of the sample to be measured and the proportional line segment correction curve. The device using the method can reduce the error of data acquisition, eliminates systematic errors including a zero point error and an optical error, and improves the stability and accuracy of blood zinc proporphyrin substance concentration measurement results.

The invention belongs to the technical field of chemical analysis and detection, provides a tetrakis-(4-pyridyl) zinc porphyrin nanorod modified based on dodecyl ammonium bromide for the first time, and constructs a rapid colorimetric detection method of di(2-ethylhexyl)phthalate. Compared with traditional detection methods based on mass spectrometry, chromatography and the like, the method has the advantages of being easy to prepare and operate, rapid in reaction, high in recognition and quantification capacity on the di(2-ethylhexyl)phthalate, high in sensitivity, high in response speed andthe like, and a brand-new thought can be provided for low-cost and efficient determination of the di(2-ethylhexyl)phthalate.

The invention discloses a preparation method of a ZPP (Zinc Protoporphyrin) insensitive ignition explosive, and belongs to the preparation field of initiating explosive medicaments. The preparation method comprises the following steps of: refining zirconium powder and potassium perchlorate; enabling the average particle diameter of the zirconium powder and the potassium perchlorate to be respectively less than 3mu m and 20mu m; evenly mixing the zirconium powder and the potassium perchlorate manually or mechanically; mixing the zirconium powder and the potassium perchlorate with a prepared nitrocotton acetone solution; volatilizing the acetone in a stirring manner; and collecting semi-dry medicament particles of 18 to 60 meshes and drying, thereby obtaining the ZPP insensitive ignition explosive as a finished product in the shape of a gray solid granule. The prepared ZPP insensitive ignition explosive is accurate in medicament content, can be stored for a long time and used at any time, and is suitable for the pressing charging of the medicaments in various shapes and density changes.

The invention relates to a bismuth sulfide-zinc protoporphyrin composite material with a tumor photodynamic therapy (PDT) property under excitation of near-infrared light as well as a preparation method and application and belongs to the field of composite materials, aiming at solving the problem that the PDT efficiency is relatively low, caused by photoelectron-hole compounding in a photodynamictherapy process of bismuth sulfide and an anti-oxidization stress capability of heme oxygenase (HO-1) in cells. The composite material is the bismuth sulfide-zinc protoporphyrin composite material which is obtained by synthesizing a polyN-isopropylacrylamide-acrylamide copolymer modified bismuth sulfide nano-material and then carrying out condensation reaction of carboxyl and amino. The prepared composite material has the effect of enhancing the photodynamic therapy efficiency through two ways of inhibiting the activity of the heme oxygenase and promoting electron-hole separation; meanwhile, the material provided by the invention has good biocompatibility, light stability, CT (Computed Tomography) imaging capability and enhanced PDT efficiency; a thought is provided for designing a novel nano diagnosis and treatment integrated system and the material has important meaning on early-stage diagnosis and treatment of cancers.

The invention belongs to the technical field of solar cell materials, and particularly relates to a sensitizer for a dye-sensitized solar cell and a preparation method thereof. The preparation method of the photosensitizer provided by the invention comprises the following steps of: taking 5-(4-nitrophenyl)-10,15,20-tris(4-hydroxyphenyl)porphyrin as an initiator; under nitrogen conditions, dissolving the initiator in concentrated hydrochloric acid, and reducing the initiator into 5-(4-aminophenyl)-10,15,20-tris(4-hydroxyphenyl)porphyrin by using stannous chloride; then, dissolving the reduced porphyrin and zinc acetate in an inert organic solvent for coordination; finally, dissolving the generated zinc protoporphyrin and 4-carboxybenzaldehyde in a dichloromethane solvent, and heating and refluxing; and after the reaction is finished, adding petroleum ether or absolute methanol for precipitating products, and recrystallizing to obtain a corresponding product N-(5-p-phenyl)-10,15,20-tris-p-hydroxyphenyl zinc protoporphyrin-p-carboxyl benzimide. The product provided by the invention has the advantages of high molar extinction coefficient, low cost and the like.

The invention discloses a Cu < + > fluorescent probe based on axial coordination regulation of zinc porphyrin, and a preparation method and application of theCu < + > fluorescent probe. The method comprises the following steps: mixing 5-(2-bromoacetaminophenyl)-10, 15, 20-tris (4-sulfonyl phenyl) zinc porphyrin (o-ZSPBr), N-ethoxyethyl-3-alkyl pyridinamine derivative (N-EP), potassium carbonate and potassium iodide, dissolving the mixture in N, N '-dimethylformamide, and carrying out a heating reaction to obtain the final probe o-SZP. The probe is high in water solubility, obvious fluorescence enhancement can be displayed when Cu < + > is detected, the detection process is convenient, and a result is accurate. Interference of various metal ions is avoided. In combination with a laser confocal scanning microtechnique, fluorescence detection imaging of the probe on Cu < + > ions in living cells can be realized.

The invention provides a preparation method and an application of a fluorescence sensor for detecting ochratoxin A. A quantum dot-nano porphyrin fluorescence 'on-off' sensor is formed with a water-soluble ZnCdSe quantum dot as a fluorescent probe and self-assembled nano porphyrin, which is prepared from a tetra-(4-pyridyl)-zincporphyrin-N,N-dimethylformamide solution and dodecyl dimethyl betaine,as a quantum dot fluorescence quencher. The OTA is combined with nano porphyrin to release quantum dots, so that the fluorescence of the quantum dots is recovered, and the quantum dot-nano porphyrin fluorescence "on-off-on" sensor is formed. The addition of other mycotoxins does not cause the change of the fluorescence intensity of the system. The fluorescence sensor realizes high-selectivity detection of OTA, effectively amplifies signals, obtains high-sensitivity and strong-specificity detection results, does not need to depend on expensive large instruments, and is simple in pretreatment and rapid in detection.

The invention discloses a zinc porphyrin dye sensitizer with hydrazide as an anchoring group and a preparation method thereof. The dye molecule takes zinc porphyrin as the core and introduces three-dimensional spirobifluorene groups and long carbon chain modification The phenothiazine is the electron donor end, and the benzohydrazide containing the benzothiadiazole electron-withdrawing group is introduced as the electron acceptor end, thus obtaining a zinc porphyrin dye-sensitized dye containing a new type of anchoring group agent. This type of dye can be synthesized by simple suzuki coupling, desilication, sonogashira coupling, hydrazinolysis and other reactions. The prepared dye molecules show good photoelectric conversion performance when used in dye-sensitized solar cells. For new The development of the anchoring group has good reference significance and has a certain application prospect in the development and utilization of new energy.

The present inventors found that a natural red pigment can be obtained from hemoglobin and myoglobin whose metalloporphyrin moiety is zinc protoporphyrin, and made meat products, whale meat products, fish meat products and fish paste products that were colored with the natural red pigment. Consequently, it was possible to obtain food products stable to oxidation and exhibiting an excellent color tone without the need to use a color fixative, e.g. nitrite.

The invention relates to the field of paper chip sensing, in particular to a method for detecting carbamate pesticide based on a CdTe quantum dot paper chip substrate. The method for detecting carbamate pesticide based on the CdTe quantum dot paper chip substrate comprises the steps of 1 synthesizing a CdTe quantum dot, 2 synthesizing a tetrakis-(4-pyridyl)zinc protoporphyrin self-assembling solution, 3 preparing the CdTe quantum dot paper chip substrate, 4 manufacturing a carbamate pesticide standard color card and 5 detecting the concentration of carbamate pesticide in a to-be-tested sample.Compared with an existing carbamate pesticide detecting method, the method has the advantages that preparation is easy, on-site detection can be rapidly performed, the cost is low, the response speedis high, and sensitivity and selectivity are high; the CdTe quantum dot paper chip substrate has the specific reaction with carbamate pesticide and can be used for detecting carbamate pesticide in acomplex substrate water sample.