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Method and device for measuring concentration of zinc protoporphyrin substance in blood

A technology for zinc protoporphyrin and substance concentration, which is applied in the field of blood zinc protoporphyrin concentration measurement, can solve the problems of low stability and accuracy of measurement results, and achieve the goals of improving authenticity and stability, accurate measurement, and reducing errors Effect

Pending Publication Date: 2019-09-24
深圳市申一科技有限公司
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Problems solved by technology

[0005] Therefore, the technical problem to be solved in the present invention is to overcome the technical problem of low stability and accuracy of the measurement results of the blood zinc protoporphyrin concentration in the prior art, thereby providing a method for measuring the zinc protoporphyrin concentration in the blood. Method and device

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  • Method and device for measuring concentration of zinc protoporphyrin substance in blood

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[0046] In order to make the purposes, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments These are some embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts shall fall within the protection scope of the present invention.

[0047] According to an embodiment of the present invention, an embodiment of a method for measuring the concentration of zinc protoporphyrin in blood is provided. It should be noted that the steps shown in the flowchart of the accompanying drawings can be executed in a set of computer-executable instructions, such as a set of computer-executab...

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Abstract

The invention discloses a method and device for measuring the concentration of a zinc protoporphyrin substance in blood. The method comprises the steps of: irradiating a sample to be measured by an excitation light source, and obtaining the characteristic fluorescence signal of the sample to be measured within a period of time; calculating the characteristic fluorescence intensity data of the sample to be measured based on the characteristic fluorescence signal of the sample to be measured within the period of time; by means of the characteristic fluorescence intensity data and the zinc protoporphyrin concentration data of multiple groups of standard samples, linearly correcting a proportional relation between the characteristic fluorescence intensity data and the zinc protoporphyrin concentration to obtain a proportional line segment correction curve; and calculating the zinc protoporphyrin concentration of the sample to be measured according to the characteristic fluorescence intensity data of the sample to be measured and the proportional line segment correction curve. The device using the method can reduce the error of data acquisition, eliminates systematic errors including a zero point error and an optical error, and improves the stability and accuracy of blood zinc proporphyrin substance concentration measurement results.

Description

technical field [0001] The invention relates to the technical field of blood zinc protoporphyrin concentration measurement, in particular to a method and a device for measuring the concentration of zinc protoporphyrin in blood. Background technique [0002] Zinc protoporphyrin (Zinc protoporphyrin hereinafter referred to as ZPP) is a substance formed by combining protoporphyrin in red blood cells with zinc; protoporphyrin is a photosensitive pigment, and zinc protoporphyrin also has a characteristic fluorescence spectrum. For example, when ZPP in blood is irradiated with excitation light of a specific wavelength (eg, 360-450 nm wavelength), the stokes shift is generated, and the emission light fluorescence is generated. There is a certain proportional relationship between the emitted light and the concentration of ZPP. [0003] The concentration of ZPP substances has always been the standard diagnostic index recommended by WHO; the clinical "Diagnosis and Efficacy Standards...

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Application Information

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IPC IPC(8): G01N21/64G01N21/01
CPCG01N21/64G01N21/01G01N2201/061
Inventor 谢军苏晓舟
Owner 深圳市申一科技有限公司
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