3300 results about "Benzaldehyde" patented technology

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

Compounds represented by the following structure (I) are disclosed:as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

The invention relates to a method for screening a dihydrochalcone compound, which comprises the following steps: firstly combining B series of compounds of a plurality of benzaldehyde compounds into a mixture and leading the mixture to react with m types of A series of acetophenone compounds of a ketoaldehyde condensation reactant in sequence to generate corresponding m groups of dihydrochalcone mixtures; combining the m types of A series of compounds into a mixture and leading the mixture to react with B series of single compounds in sequence to generate a plurality of groups of dihydrochalcone mixtures. Respective strongest mixtures are selected from the A series of mixtures and the B series of mixtures to determine the strongest A series of acetophenone compound and the strongest B series of benzaldehyde compound; the strongest A series of acetophenone compound is reacted with a plurality of B series of compounds in sequence, and the strongest B series of benzaldehyde mixture is reacted with the m types of A series of the acetophenone compounds to commonly generate M plus N minus 1 types of dihydrochalcone; and a strongest dihydrochalcone compound secreted and acted by pancreotropichormone is screened, namely a target compound screened by the method.

A method for the preparation of treprostinil and its derivatives is described. In contrast to prior art, this method utilizes an easily scalable enzymatic resolution of a key intermediate for making these compounds. Another significant improvement of the described method over prior methods is the regioselective Claisen rearrangement of a 5-allyloxy-benzaldehyde precursor, which is facilitated by a bromo substituent in 2-position.

The invention relates to a corrosion-inhibition drag reducer for alkyl porphyrin compound natural gas pipelines of and a preparation method of the corrosion-inhibition drag reducer. The preparation method comprises the steps as follows: firstly, benzaldehyde, 4-hydroxyl benzaldehyde and pyrrole are used as raw materials to be reacted so as to prepare the mixture of six kinds of porphyrin compounds (H); then, the mixture H of the porphyrin compounds is reacted with acrylic acid long-chain alkyl esters to prepare six kinds of alkyl orphyrin compounds, wherein each kind of the compounds is 15 to 20wt%; and the prepared compounds are dissolved in 30 to 50wt% of solvent prepared with p-dioxane so as to form the corrosion-inhibition type drag reducer for the alkyl porphyrin compound natural gas pipelines. The proportion is that the mole ratio of methanal to the 4-hydroxyl benzaldehyde is (0.8:1) to (1.2:1); the mole ratio of the benzaldehyde to the pyrrole is (0.8:2) to (1.2:2); and the mole ratio of the acrylic acid long-chain alkyl esters to the pyrrole synthetizing H is (1:1) to (2:1). The drag reducer provided by the invention has the advantages of good drag reduction and anticorrosion property.

The invention discloses an inorganic dry powder architectural coating which comprises an inorganic gel system consisting of alkali metal silicate and a curing agent and organic redispersible latex powder, and can further comprise a filling material, a pigment and an auxiliary agent. The architectural coating provided in the invention has good storage stability, washability and weatherability, is convenient for transportation and does not undergo salting-out and whitening nor generate harmful substances like VOC, benzene, formaldehyde and heavy metals after film forming through curing.

Disclosed are crystalline ansolvate salts of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde (or Compound 1), such as the hydrochloride Form I.

The present invention relates to oral care compositions comprising stannous ions, a mint-type flavor oil, a protectant component that prevents generation of off odor and off taste in the composition, and orally acceptable carriers. The mint-type oils include peppermint, spearmint and corn mint. Suitable protectant components include copper salts and carbonyl compounds such as ascorbic acid; cis-jasmone; 2,5-dimethyl-4-hydroxy-3(2H)-furanone; 5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone; vanillin; ethyl vanillin; anisaldehyde; 3,4-methylenedioxybenzaldehyde; 3,4-dimethoxybenzaldehyde; 4-hydroxybenzaldehyde; 2-methyoxybenzaldehyde; 4-methoxybenzaldehyde; benzaldehyde; cinnamaldehyde (3-phenyl-2-propenal); hexyl cinnamaldehyde; α-methyl cinnamaldehyde; ortho-methoxy cinnamaldehyde; α-amyl cinnamaldehyde; and combinations thereof. The oral care composition may be a dentifrice.