433 results about "Methylaniline" patented technology

The present invention relates to a new industrial process for the synthesis of solvate- free 17a-acetoxy-11ss-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB -2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. The process according to the invention is the following: i) 3-(ethylene-dioxy)-estra-5(10),9(11)-diene-17-one of formula (X) is reacted with potassium acetilyde formed in situ in dry tetrahydrofuran by known method, ii) the obtained 3-(ethylene-dioxy)-17a-ethynyl-17ss-hydroxy-estra-5(10),9(11)-diene of formula (IX) is reacted with phenylsulfenyl chloride in dichloromethane in the presence of triethylamine and acetic acid, iii) the obtained isomeric mixture of 3-(ethylene-dioxy)-21-(phenyl-sulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene of formula (VIII) is reacted first with sodium methoxide in methanol, then with trimethyl phosphite, iv) the obtained 3-(ethylene-dioxy)-17a-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene of formula (VII) is reacted with hydrogen chloride in methanol, then v) the obtained 3-(ethylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11l); -diene-20- one of formula (VI) is reacted with ethylene glycol hi dichloromethane in the presence of trimethyl orthoformate and p-toluenesulfonic acid by known method, vi) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-19-norpregna- 5(10),9(11)-diene of formula (V) is reacted with hydrogen peroxide in a mixture of pyridine and dichloromethane in the presence of hexachloroacetone by known method, vii) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-5,10-epoxy-19-norpregn-9(11)-ene of formula (IV), containing approximately a 1:1 mixture of 5a,10a- and 5ss,10ss-epoxides, is isolated from the solution and reacted with a Grignard reagent obtained from 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran.

The invention concretely relates to a synthetic technology for pyraclostrobin. The synthetic technology comprises: firstly performing cyclization to obtain 1-(4-chlorophenyl)-pyrazol-3-one, oxidizing the pyrazol ring under the effect of an oxidant to generate 1-(4-chlorophenyl)-3-hydroxypyrazole, then using 2-nitrobenzyl bromide to performing etherification to generate 1-(4-chlorophenyl)-3-[2-(nitrophenyl)methoxy]-1H-pyrazole, then using a reducing agent to perform nitro reducing, so as to generate N-hydroxyl-2-[N'-(4-chlorophenyl)pyrazol-3'-yloxymethyl]aniline, then using ClCO2CH3 to perform N-acylation reaction to generate methyl N-hydroxyl-N-2-{[N'-(4-chlorophenyl)pyrazol-3'-yloxymethyl]phenyl}formate, and finally performing hydroxyl methylation under an alkaline condition to generate pyraclostrobin. The technology enables all operations in the pyraclostrobin preparation process to be relatively controllable, helps to improve the stability of the preparation process and improve the product yield, successfully employs low-cost reagents and substantially reduces production cost, and also the employed reagents are relatively small in toxicity, is relatively beneficial for environment protection, and has no corrosivity on plastic pipes, so that the production safety is improved.

The invention relates to a method for preparing pinoxaden. The steps are as follows: 2,6-diethyl-4-methylaniline undergoes a sandmeyer reaction to obtain 2,6-diethyl-4-methylbromobenzene, and then reacts with Malononitrile is coupled under the catalysis of copper iodide to obtain 2,6-bis-ethyl-4-methylphenylmalononitrile, and finally hydrolyzed in hydrogen peroxide solution to obtain 2,6-diethyl-4 -Methylphenylmalonamide; subsequent reaction with [1,4,5]-oxadiazepine dihydrobromide in the presence of triethylamine gives 8-(2,6-diethyl- 4-methylbenzene)tetrahydropyrazole[1,2d][1,4,5]-oxadiazepine-7,9-dione, preferably reacted with pivaloyl chloride to obtain pinoxaden ester. The present invention uses low-priced catalysts to reduce production costs. In addition, hydrogen peroxide-alkali is used as the hydrolysis system in the preparation process, which greatly reduces environmental pollution.

The invention provides a method for preparing bromhexine hydrochloride, which comprises the steps as follows: (1) 2-amino-3,5-dibromo benzaldehyde and reducing agents are in a reduction reaction to generate 2-amino-3,5-dibromo benzyl alcohol; (2) 2-amino-3, 5-dibromo benzyl alcohol that is obtained in the step (1) reacts with chlorinating agents to generate 2, 4-bromine-6-chloride methylaniline; and (3) 2,4-bromine-6-chloride methylaniline obtained in the step (2) and N-methylcyclohexylamine are in an amination reaction, and then 2, 4-bromine-6-chloride methylaniline and HCl salification agents are in a salification reaction, so that bromhexine hydrochloride is obtained. The preparation method adopts multiple advanced technologies, is easy to get starting materials, and has the advantages of stable property of intermediates, extremely low environment pollution, high yield coefficient of products and high purity.

The invention provides a process for the preparation of polyamines of the diphenylmethane series. This process comprisesa) reacting aniline and formaldehyde in a molar ratio of 1.5:1 to 6:1, in the presence of an acid catalyst at temperatures of 20° C. to 100° C., in which the water content in the acid reaction mixture is <20 wt. % and a degree of protonation of <15% is established, andb) increasing the temperature of the reaction to a temperature of 110° C. to 250° C. when the ratio of the weight contents of p-aminobenzylaniline to 4,4′-MDA in the reaction mixture falls below a value of 1.00.

The invention provides a preparation method and application of an anti-soil polymer. The prepared polymer is used as a dispersant for a hydraulic cementing agent and / or an aqueous dispersion for potential hydraulic cementing agent and has good anti-soil performance. The preparation method the anti-soil polymer comprises a step of subjecting polyether macromonomer A with a special structure, monomer B containing a phosphoric acid or phosphorous acid group, optional monomer D and aldehyde C to condensation polymerization so as to prepare the anti-soil polymer, wherein the monomer D is selected from the group consisting of phenol, aniline, p- / o-aminobezene solfonic acid, p- / o-hydroxybenzoic acid, p- / o-aminobenzoic acid, p- / o-hydroxyezene solfonic acid, p- / o-toluidine and p- / o-methylphenol, a mol ratio of the polyether macromonomer A to the monomer B to the monomer D is 1: (0.5-12): (0-8.0), and a mol ratio of the polyether macromonomer A to the monomer B and the monomer D is 1: (0.5-12.0).

The invention discloses a creatinine detection reagent which is characterized by comprising a diluent and a reaction reagent, wherein the diluent is composed of buffer, surfactant, preservative, anti-bilirubin interference agent and vitamin C oxidase; and the reaction reagent is composed of buffer, creatinase, sarcosine oxidase, peroxidase, N-ethyl-N-(3-propylsulfo)-3-methylaniline, creatininase, 4-aminoantipyrine, preservative and freeze-drying protective agent. The detection reagent disclosed by the invention has favorable sensitivity, accuracy, precision and linearity, and can completely satisfy the clinical examination requirements.

The invention discloses a serum creatinine detecting reagent, and belongs to the technical field of clinical in-vitro detection. According to the serum creatinine detecting reagent, gamma-Fe2O3 nano-particles are added into a reagent R1, so that the activity of peroxidase and the specificity to a substrate are enhanced, and the interferences of reducing substances, such as ascorbic acid, uric acid, glutathione and bilirubin, are reduced; meanwhile, the gamma-Fe2O3 nano-particles also serve as a catalyst of a reaction; the interference of endogenous creatine is effectively eliminated by the combination action of the gamma-Fe2O3 nano-particles and the peroxidase. In addition, the serum creatinine detecting reagent adopts N-ethyl-N-(2-hydroxy-3-sulfonated propyl)-3-methylaniline sodium salt (TOOS) as a chromogen, so that the reagent is more stable; the analysis sensitivity is high. The substances, such as lipase and lipoprotein lipase, are also added into the reagent R1, so that the influence of lipid turbidity can be removed effectively; therefore, the reagent of the invention has higher anti-jamming capability and stability.

The invention discloses a synthesis method of pinoxaden, and belongs to the field of chemical engineering. The method comprises the following steps that 2,6-diethyl-4-methylaniline is subjected to sodium nitrite diazotization and thermal decomposition to generate 2,6-diethyl-4-methylbromobenzene; diethyl malonate is added into [1,4,5]-oxadiazepine dihydrobromide hydrate and an alkaline catalyst tosynthesize dihydro-1H-pyrazolo[1,2-d][1,4,5]-oxadiaza-7,9(2H, 8H)-diketone, the dihydro-1H-pyrazolo[1,2-d][1,4,5]-oxadiaza-7,9(2H, 8H)-diketone and 2,6-diethyl-4-bromomethyl benzene are subjected tocoupling reaction to obtain 8-(2,6-diethyl-4-methyl phenyl)tetrahydropyrazolo[1,2-d][1,4,5]xazepine-7, 9(2H, 8H)-diketone; the 8-(2,6-diethyl-4-methyl phenyl)tetrahydropyrazolo[1,2-d][1,4,5]xazepine-7, 9(2H, 8H)-diketone is reacted with pivaloyl chloride to synthesize the final product pinoxaden. According to the synthesis method of the pinoxaden, the synthesis steps are shortened, operation is simple and convenient, the cost is reduced, the economic efficiency is high, and environmental pollution is little.

The process of preparing glycidic amine type polyfunctional epoxy resin includes the following steps: 1. reaction between 4, 4'-methylene di-o-methylaniline and chloroepoxy propane in the molar ratio of 1 to 4-20 in water-alcohol solvent at 40-90 deg.c for 3-10 hr; and 2. dropping water solution of alkali metal hydroxide in the concentration of 20 % at 60 deg.c to produce desalting ring-closing reaction at 60-80 deg.c, extracting with extractant, water washing, separating, and vacuum volatizing to obtain N, N, N', N'-tetraglycidyl-4, 4'-methylene di-o-methylaniline. The present invention is one industrial process with simple operation, low cost, high product quality, high yield and less three wastes.

The invention provides a method for preparing lidocaine hydrochloride, and belongs to the technical field of anesthetic synthesis. The method comprises the following steps: by taking 2,6-xylenol as a raw material, Pd / C as a main catalyst and 2,6-dimethylcyclohexanone as a promoter, performing liquid phase amination with ammonia water at high temperature, thereby obtaining a midbody 2,6-dimethylaniline; enabling sodium methylate, 2,6-dimethylaniline and N,N-lignocaine methyl acetate as raw materials to react at 90-95 DEGC, distilling while reaction is performed to remove methanol till no methanol can be evaporated out, continuously reacting for 30 minutes, cooling to the room temperature, adding dichloroethane, washing with water, and leaving to stand to layer, thereby obtaining an organic layer, namely, a lidocaine based dichloroethane solution; further adding hydrochloric acid into the lidocaine based dichloroethane solution, adjusting the pH value to be 3.5-4 by using hydrogen chloride, adding activated carbon to reflux for 20-40 minutes, filtering, concentrating the filtrate, cooling, crystallizing, and dying, thereby obtaining lidocaine hydrochloride. The lidocaine hydrochloride prepared by using the method is simple in synthesis process and high in product purity, that is, the purity can be greater than 99%, and the total yield is greater than 84%.

The invention provides a human serum glycated albumin assay kit which comprises a reagent 1 and a reagent 2, wherein the reagent 1 comprises the following components: 20-200mmol / L of buffer solution, 5-50KU / L of protease co-expression vector, 10-50KU / L of peroxisome, 2-20mmol / L of 4-amino antipyrine, 0.01-1% of preservative and 0.01-1% of stabilizer, and the protease co-expression vector is obtained by cloning a protease gene and an ascorbic acid oxidase gene onto a same vector for performing co-expression; and the reagent 2 comprises the following components: 20-200mmol / L of buffer solution, 5-50U / mL of fructose lysine enzyme, 1-10mmol / L of N, N-bis(4-sulfobutyl ether)-3-methylaniline, 0.01-1% of preservative and 0.01-1% of stabilizer. The kit can remove the interferences of globulin and ascorbic acid in human serum and has good stability and low cost.

The invention relates to a method for preparing MBTH. The preparation process comprises synthesis of N-methyl-N-phenyl thiourea(I) with N-methyl aniline as raw materials; separation of N-methyl-N-phenyl thiourea(I) and preparation of 3-methyl-2-imino benzothiazole(II) by reacting with bromine; and preparation of targeted compound MBTH(III) by the reaction between (II) and hydrazine hydrate. The MBTH can be used for detecting the formaldehyde content in air.

A papermaking shoe press belt is formed of a reinforcing fiber base material and a polyurethane layer integrated with each other. The reinforcing fiber base material is embedded in the polyurethane layer. The papermaking shoe press belt includes, as the polyurethane layer, a polyurethane layer obtainable by curing a composition composed in combination of a urethane prepolymer and one or more curing agent. The urethane prepolymer is obtainable by reacting a p-phenylene diisocyanate compound with a long-chain polyol. The at least one curing agent is selected from 4,4′-methylene bis(2,6-diethyl-3-chloroaniline), 4,4′-methylene bis(2-chloroaniline), methylene bis(2-ethyl-6-methylaniline), 4,4′-methylene bis(2-ethylbenzeneamine), methylene bis(2,3-dichloroaniline), 4,4′-methylenedianiline, 3,5-dimethylthiotoluene-2,4-diamine, 3,5-dimethylthiotoluene-2,6-diamine, 3,5-diethyltoluene-2,4-diamine, 3,5-diethyltoluene-2,6-diamine, polytetramethylene oxide di-p-aminobenzoate, poly(tetramethylene / 3-methyl tetramethylene ether)glycol bis(4-aminobenzoate), trimethylene bis(4-aminobenzoate) and isobutyl 4-chloro-3,5-diaminobenzoate.

The invention discloses a synthetic method for 2-methyl-3-trifluoromethyl phenylamine. The method comprises the following steps: 1) preparing 3-nitro-4-methyl benzenesulfonic acid; 2) preparing 3-nitro-4-methyl-5-bromobenzenesulfonic acid; 3) preparing 2-nitro-6-bromotoluene; 4) preparing 2-nitro-6-trichloromethyl toluene; 5) preparing 2-nitro-6-trifluoromethyl toluene; 6) preparing 2-methyl-3-trifluoromethyl phenylamine, that is, adding 5% palladium-charcoal and methanol in 2-nitro-6-trifluoromethyl toluene obtained in step 5), carrying out hydrogenation reduction at a temperature of 35 DEG C and removing a catalyst so as to obtain 2-methyl-3-trifluoromethyl phenylamine. According to the invention, p-toluenesulfonic acid is used as a starting material, and therefore, disadvantages of theprior art are overcome and yield of a target product is improved.

The invention provides a small and dense low-density lipoprotein cholesterin (sdLDL-C) detection kit which comprises double liquid reagents, including a reagent R1 and a reagent R2, wherein the reagent R1 comprises an MOPS buffer liquid (the pH value is 7.0), cholesterol esterase, cholesterol oxidase, phospholipase, catalase, polyoxyethylene alkyl phenyl ether (JK-14) as a surfactant A, polyoxyethylene benzyl styrene ether (A3PK) as a protecting agent, and N-ethyl-N-(2-hydroxyl-3-sulfopropyl)-3-methylaniline sodium salt (TOOS); the reagent R2 comprises an MOPS buffer liquid (the pH value is 7.0), peroxidase, polyethylene glycol octylphenol ether (Triton X-100) as a surfactant, 4-amino antipyrine (4-AA), and sodium azide. The method provided by the invention is high in sensitivity, high in specificity, simple in reagent preparation, free of sample pretreatment, and worthy of popularization and application.

The invention relates to a method for preparing 2-methyl-4-(1,1,1,2,3,3,3-heptafluoro-2-propyl) aniline which is obtained by reaction of 2-methylaniline with heptafluoro-2-bromopropane under the effect of an initiator. According to the method, the raw materials are low in cost, the reaction condition is mild, and the process is simple and accessible, so that the method is an ideal industrialized production method.

The invention belongs to the field of organic synthesis and relates to a method for preparing 3-chloro-4-methylaniline through catalytic hydrogenation. The method comprises the steps of using 3-chloro-4-methylnitrobenzene as raw material and alcohol or alcohol-water as solvent, and performing hydrogenation reduction at the presence of a two component Pd-Fe / C catalyst to obtain the final product. The obtained 3-chloro-4-methylaniline has a selectivity of over 99.9% and a yield of over 99%. The method for preparing 3-chloro-4-methylaniline provided by the invention has the advantages of simple process, mild operating condition, little pollution, and high activity and selectivity of the used catalyst, and can effectively reduce production costs compared with the traditional process. The catalyst used can be used repeatably.

The invention relates to the field of organic synthesis, in particular to a synthesis method of a pinoxaden intermediate (2, 6-diethyl-4-methyl)phenylacetic acid. The method includes: letting 2, 6-diethyl-4-methylaniline, hydrobromic acid and sodium nitrite form a diazo salt; reacting the diazo salt with ferrous sulfate and hydrobromic acid to generate 2, 6-diethyl-4-methylbromobenzene; letting 2,6-diethyl-4-methylbromobenzene and alkyl lithium generate a lithium salt, and then reacting the obtained lithium salt with ethylene oxide or 2-halogenated ethanol to obtain (2, 6-diethyl-4-methyl)phenethyl alcohol; under the catalysis of TEMPO, adding NaClO and NaClO2 successively into the (2, 6-diethyl-4-methyl)phenethyl alcohol and performing oxidization so as to obtain (2, 6-diethyl-4-methyl)phenylacetic acid. The synthesis method provided by the invention has high yield, avoids the use of expensive palladium catalyst, reduces the cost, and has high industrial value.

The invention relates to a glycated albumin (GA) enzymatic detection kit, which comprises a GA reagent 1 and a GA reagent 2. The GA reagent 1 comprises tris(hydroxymethyl)aminomethane, aminoantipyrine (4-AAP), protease K, calcium acetate (CaAc2), potassium ferrocyanide trihydrate (K4Fe(CN)6.3H2O), copper acetate (CuAc2) and Cholic acid. The GA reagent 2 includes tris(hydroxymethyl)aminomethane, N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3-methylaniline sodium salt (TOOS), fructosaminase, Triton X-100 and peroxidase. The invention aims to provide the glycated albumin enzymatic detection kit and its detection method with the characteristics of strong specificity, high sensitivity, short time, simple operation mode, and accurate and reliable detection result.

The invention relates to a green synthesis method of anticoccidial veterinary drug Ethanamizuril, and solves the technical problems that in the prior art, an Ethanamizuril production method needs tensteps of reaction, the reaction steps are complex, the raw materials are difficult to obtain and high in price, the investment is large, the yield is low, the product quality is poor, the color is poor, and the method is not suitable for industrial production. According to the green synthesis method of anticoccidial veterinary drug Ethanamizuril, 4-chloro-3-methylaniline and EPC are taken as initial raw materials, diazo coupling, cyclization, hydrolysis, decarboxylation and condensation reaction are carried out to obtain the product Ethanamizuril. The method is widely applied to the technicalfield of veterinary drug synthesis.

The invention belongs to the technical field of catalysis, in particular to a catalyst for synthesizing methylaniline from methylbenzene by one step. The catalyst consists of active ingredients and a carrier, wherein the active ingredients are CuO and V2O5; the molar ratio of the CuO to the V2O5 is 0.1-2:1; the carrier is silicon oxide, titanium oxide, alumina or a molecular sieve; and the load of the active ingredients CuO and V2O5 is 5 to 32 percent, wherein the load refers to the weight percentage of the active ingredients CuO and V2O5 in the integral supported catalyst. Compared with the conventional catalyst for amination of methylbenzene, the catalyst prepared by the method has low consumption; in the implementation, the weight ratio of the catalyst to a raw material hydroxylamine sulphate is reduced to be 1:8.2, the catalyst has good activity, and the conversion rate of the methylbenzene and the yield of the methylaniline are respectively 66.23 percent and 61.22 percent; and the preparation process for the catalyst is simple and the raw materials are readily available.

The invention discloses a high-performance small and dense low-density lipoprotein cholesterol detection kit. The kit comprises the following raw materials in parts by weight; a reagent A: 90 to 110 mmol / L of a Good's buffer solution; 1-3 ku / L of cholesterol esterase, 1-2 ku / L of cholesterol oxidase, 0.7-0.9 ku / L of phospholipase, 400-600 ku / L of catalase, and 1-3 mmol / L N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3-methylaniline sodium salt (TOOS); and a reagent B: 90-110 mmol / L of the Good's buffer solution, 2-3 ku / L of peroxidase, 3-5 mmol / L of 4-aminoantipyrine and 0.04-0.06% of sodium azide. Theinvention relates to the technical field of lipoprotein cholesterol detection, and discloses the high-performance small and dense low-density lipoprotein cholesterol detection kit. The non-sdLDL-C components are removed through cholesterol lipase, cholesterol oxidase, phospholipase and catalase; the interference of other lipoprotein cholesterol on the detection process is avoided, the capacity ofthe small and dense low-density lipoprotein cholesterol in serum can be directly determined by using a full-automatic biochemical analyzer, and the kit is suitable for the requirements of clinical andlaboratory on the determination of the content of the small and dense low-density lipoprotein cholesterol.

The anti-knocking agent for gasoline is made up by using (by weight portion) alpha-methylaniline 46-81 portions, methyl tert-butyl ether (MTBE) 15-50 portions, toluene 2-4 portions, distilled gasoline 0.9-1.5 portions, raffinate oil 0.9-1.5 portions and 2,6-di-tert-butyl-p-cresol 0.1-0.6 portions and uniformly mixing them at plus or minus 35 deg.C and normal pressure. Said invented product can raise octane value of gasoline, and solve the knocking problem of gasoline when it is combusted.

A composition useful for activating catalysts for olefin polymerization is provided. The composition is derived from at least: carrier; organoaluminoxy compound; N,N-dimethylaniline and pentaflurophenol in amounts such that them are at least two equivalents of pentafluorophenol per equivalent of the N,N-dimethylaniline.

The invention provides a preparation method for a lanthanum-doped barium ferrite-poly-o-methylaniline composite wave-absorbing material. According to the method, nitrate and citric acid are used as raw materials, lanthanum-doped barium ferrite (BaLaxFe12-xO19, x is equal to 0.04 to 0.12) is prepared by a sol-gel self-propagating high-temperature synthesis method, and the lanthanum-doped barium ferrite-poly-o-methylaniline composite wave-absorbing material is prepared by an in-situ compounding technology. The material is good in absorption performance, and has wide application prospect in the fields of stealth technologies of military equipment, civil human safety protection, communication interference, electronic information confidentiality and the like.

The invention provides a gas chromatography-mass spectrometry detection method for a methylaniline compound. The method comprises the following steps of: A) extraction of a sample, namely adding an acid into the sample to extract the methylaniline compound into an acid liquor phase, adding alkaline into acid liquor phase extract to regulate pH to be neutral, adding methylene chloride to reextract the methylaniline compound in the neutral extract into the methylene chloride, and performing volume fixing to obtain a sample detection solution; and B) detection of the sample, namely separating the obtained sample detection solution by using a DB-1MS fused silica capillary column, and performing gas chromatography-mass spectrometry detection. The quantitative detection of the methylaniline compound is realized; the method is high in accuracy, low in detection limit, high in extraction efficiency and easy to operate, and can be widely applied to the detection of the methylaniline compound in a crude oil sample, a gasoline sample, a diesel sample and the like; the interference of other compounds in an extraction process can be eliminated; and powerful support can be provided for the environmental performance evaluation and monitoring of the sample.

The invention relates to the technical field of medical examination, and specifically relates to a triglyceride detecting kit. The kit comprises an agent R1 and an agent R2, wherein the agent R1 comprises glycerol kinase, lipoprotein lipase, peroxidase, composite chromogen and magnesium salt; the agent R2 comprises glycerophosphate oxidase, 4-ampyrone and triphosadenine; the composite chromogen comprises some of 3-methyl-N, N-aniline dipropyl sulfonate, N-ethyl-N-(3-sulfopropyl)-3-sodium methylaniline, N, N-bi(4-sulfobutyl)-3-methylaniline disodium salt, N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3-sodium methylaniline, and 2, 4, 6-tribromo-3-hydroxybenzoic acid. The kit in detecting of triglyceride is high in sensitivity, short in detecting time, and high in interference resistance.

The invention discloses a jet type membrane reactor and a method for preparing methylaniline by continuous catalytic hydrogenation. The jet type membrane reactor comprises a reactor body (1), a jet mixer (2) and a membrane assembly (3), wherein the jet mixer (2) is arranged at the top in the reactor body (1), the membrane assembly (3) is positioned below a discharging hole of the jet mixer (2) in the bottom in the reactor body (1), the jet mixer (2) is provided with a liquid phase feeding hole, a gas phase feeding hole and a circulating feeding hole, and a product discharging hole is formed in a place of the reactor body (1), which penetrates through the membrane assembly (3). The jet type membrane is compact in structure, small in occupation area and simple in process route, is reduced in energy consumption, and accords with the requirement of sustainable development.

The invention discloses a method for preparing lidocaine. The method comprises the following steps of: (1) by using 2, 6-dimethylnitrobenzene as a raw material, Pd / C as a catalyst and methanol as a solvent, carrying out reduction reaction with hydrogen at normal temperature and normal pressure to obtain an intermediate 2, 6-dimethylaniline; (2) reacting the obtained intermediate 2, 6-dimethylaniline with chloroacetyl chloride in the presence of potassium carbonate, and taking dichloromethane as a solvent to prepare an intermediate chloroacetyl-2, 6-dimethylaniline; and (3) reacting the obtained intermediate chloroacetyl-2, 6-dimethylaniline with diethylamine, taking normal hexane as a solvent, performing refluxing until the reaction is complete, performing washing with water and cooling toobtain lidocaine. The method disclosed by the invention is simple and convenient in technological process, few in operation links and relatively high in lidocaine yield, and the prepared lidocaine isgood in purity which reaches 99.5% or above, so that the method has a good industrial application prospect.